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P73016

- FABI_SYNY3

UniProt

P73016 - FABI_SYNY3

Protein

Enoyl-[acyl-carrier-protein] reductase [NADH] FabI

Gene

fabI

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 2 (30 May 2000)
      Previous versions | rss
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    Functioni

    Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). Involved in the elongation cycle of fatty acid which are used in the lipid metabolism By similarity.By similarity

    Catalytic activityi

    An acyl-[acyl-carrier protein] + NAD+ = a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei13 – 131NAD; via carbonyl oxygenBy similarity
    Binding sitei95 – 951NAD; via carbonyl oxygenBy similarity
    Binding sitei98 – 981Substrate; via amide nitrogen and carbonyl oxygenBy similarity
    Active sitei148 – 1481Proton acceptorBy similarity
    Active sitei158 – 1581Proton acceptorBy similarity
    Binding sitei165 – 1651NADBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi19 – 202NADBy similarity
    Nucleotide bindingi67 – 682NADBy similarity
    Nucleotide bindingi194 – 1985NADBy similarity

    GO - Molecular functioni

    1. enoyl-[acyl-carrier-protein] reductase (NADH) activity Source: UniProtKB

    GO - Biological processi

    1. fatty acid elongation Source: UniProtKB
    2. protein homotetramerization Source: UniProtKB

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    UniPathwayiUPA00094.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Enoyl-[acyl-carrier-protein] reductase [NADH] FabI (EC:1.3.1.9)
    Short name:
    ENR
    Alternative name(s):
    NADH-dependent enoyl-ACP reductase
    Gene namesi
    Name:fabI
    Synonyms:envM
    Ordered Locus Names:slr1051
    OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
    Taxonomic identifieri1111708 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
    ProteomesiUP000001425: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 258258Enoyl-[acyl-carrier-protein] reductase [NADH] FabIPRO_0000054912Add
    BLAST

    Proteomic databases

    PaxDbiP73016.

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Protein-protein interaction databases

    STRINGi1148.slr1051.

    Structurei

    3D structure databases

    ProteinModelPortaliP73016.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0623.
    KOiK00208.
    OMAiGISGEIM.
    OrthoDBiEOG6HF644.
    PhylomeDBiP73016.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR014358. Enoyl-ACP_Rdtase_NADH.
    IPR002347. Glc/ribitol_DH.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PIRSFiPIRSF000094. Enoyl-ACP_rdct. 1 hit.
    PRINTSiPR00081. GDHRDH.

    Sequencei

    Sequence statusi: Complete.

    P73016-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLDLSGKHAF VTGIANNRSI AWGIAQQLHQ AGAEIGVSYL PDEKGRFEKK    50
    VRELTEPLHP TLVLPGDVQD DAQVDALFHS VKEKWGKLDI LIHCLAFADK 100
    SGLTGNYTDI PKEAFSQAME ISTYSLGRLA RGAKPLMTNG GSIITLTYFG 150
    GVKVIPNYNL MGVAKAGLEM TVRYLAAELG PQNIRVNGIS AGPIRTLASS 200
    AVGGILDMIH HVEEVAPLKR TVTQTEVGNT AAFLASDLSS GITGQIIYVD 250
    SGYEIMGM 258
    Length:258
    Mass (Da):27,626
    Last modified:May 30, 2000 - v2
    Checksum:iE912F0DF124FAE49
    GO

    Sequence cautioni

    The sequence BAA17036.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000022 Genomic DNA. Translation: BAA17036.1. Different initiation.
    PIRiS74996.
    RefSeqiNP_440356.1. NC_000911.1.
    YP_007450240.1. NC_020286.1.

    Genome annotation databases

    EnsemblBacteriaiBAA17036; BAA17036; BAA17036.
    GeneIDi953656.
    KEGGisyn:slr1051.
    syz:MYO_14660.
    PATRICi23837868. VBISynSp132158_0503.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000022 Genomic DNA. Translation: BAA17036.1 . Different initiation.
    PIRi S74996.
    RefSeqi NP_440356.1. NC_000911.1.
    YP_007450240.1. NC_020286.1.

    3D structure databases

    ProteinModelPortali P73016.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 1148.slr1051.

    Proteomic databases

    PaxDbi P73016.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAA17036 ; BAA17036 ; BAA17036 .
    GeneIDi 953656.
    KEGGi syn:slr1051.
    syz:MYO_14660.
    PATRICi 23837868. VBISynSp132158_0503.

    Phylogenomic databases

    eggNOGi COG0623.
    KOi K00208.
    OMAi GISGEIM.
    OrthoDBi EOG6HF644.
    PhylomeDBi P73016.

    Enzyme and pathway databases

    UniPathwayi UPA00094 .

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR014358. Enoyl-ACP_Rdtase_NADH.
    IPR002347. Glc/ribitol_DH.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PIRSFi PIRSF000094. Enoyl-ACP_rdct. 1 hit.
    PRINTSi PR00081. GDHRDH.
    ProtoNeti Search...

    Publicationsi

    1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
      Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
      , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
      DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 6803 / Kazusa.

    Entry informationi

    Entry nameiFABI_SYNY3
    AccessioniPrimary (citable) accession number: P73016
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 30, 2000
    Last modified: October 1, 2014
    This is version 100 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families
    3. Synechocystis PCC 6803
      Synechocystis (strain PCC 6803): entries and gene names

    External Data

    Dasty 3