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P73016 (FABI_SYNY3) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI

Short name=ENR
EC=1.3.1.9
Alternative name(s):
NADH-dependent enoyl-ACP reductase
Gene names
Name:fabI
Synonyms:envM
Ordered Locus Names:slr1051
OrganismSynechocystis sp. (strain PCC 6803 / Kazusa) [Reference proteome] [HAMAP]
Taxonomic identifier1111708 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis

Protein attributes

Sequence length258 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). Involved in the elongation cycle of fatty acid which are used in the lipid metabolism By similarity.

Catalytic activity

An acyl-[acyl-carrier protein] + NAD+ = a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH.

Pathway

Lipid metabolism; fatty acid biosynthesis.

Subunit structure

Homotetramer By similarity.

Sequence similarities

Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.

Sequence caution

The sequence BAA17036.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 258258Enoyl-[acyl-carrier-protein] reductase [NADH] FabI
PRO_0000054912

Regions

Nucleotide binding19 – 202NAD By similarity
Nucleotide binding67 – 682NAD By similarity
Nucleotide binding194 – 1985NAD By similarity

Sites

Active site1481Proton acceptor By similarity
Active site1581Proton acceptor By similarity
Binding site131NAD; via carbonyl oxygen By similarity
Binding site951NAD; via carbonyl oxygen By similarity
Binding site981Substrate; via amide nitrogen and carbonyl oxygen By similarity
Binding site1651NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
P73016 [UniParc].

Last modified May 30, 2000. Version 2.
Checksum: E912F0DF124FAE49

FASTA25827,626
        10         20         30         40         50         60 
MLDLSGKHAF VTGIANNRSI AWGIAQQLHQ AGAEIGVSYL PDEKGRFEKK VRELTEPLHP 

        70         80         90        100        110        120 
TLVLPGDVQD DAQVDALFHS VKEKWGKLDI LIHCLAFADK SGLTGNYTDI PKEAFSQAME 

       130        140        150        160        170        180 
ISTYSLGRLA RGAKPLMTNG GSIITLTYFG GVKVIPNYNL MGVAKAGLEM TVRYLAAELG 

       190        200        210        220        230        240 
PQNIRVNGIS AGPIRTLASS AVGGILDMIH HVEEVAPLKR TVTQTEVGNT AAFLASDLSS 

       250 
GITGQIIYVD SGYEIMGM 

« Hide

References

[1]"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. expand/collapse author list , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PCC 6803 / Kazusa.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000022 Genomic DNA. Translation: BAA17036.1. Different initiation.
PIRS74996.
RefSeqNP_440356.1. NC_000911.1.
YP_007450240.1. NC_020286.1.

3D structure databases

ProteinModelPortalP73016.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING1148.slr1051.

Proteomic databases

PaxDbP73016.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAA17036; BAA17036; BAA17036.
GeneID14615888.
953656.
KEGGsyn:slr1051.
syz:MYO_14660.
PATRIC23837868. VBISynSp132158_0503.

Phylogenomic databases

eggNOGCOG0623.
KOK00208.
OMAGILDMIH.
OrthoDBEOG6HF644.
PhylomeDBP73016.
ProtClustDBPRK07370.

Enzyme and pathway databases

UniPathwayUPA00094.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
InterProIPR014358. Enoyl-ACP_Rdtase_NADH.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PIRSFPIRSF000094. Enoyl-ACP_rdct. 1 hit.
PRINTSPR00081. GDHRDH.
ProtoNetSearch...

Entry information

Entry nameFABI_SYNY3
AccessionPrimary (citable) accession number: P73016
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: April 16, 2014
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Synechocystis PCC 6803

Synechocystis (strain PCC 6803): entries and gene names

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways