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P73016

- FABI_SYNY3

UniProt

P73016 - FABI_SYNY3

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Protein

Enoyl-[acyl-carrier-protein] reductase [NADH] FabI

Gene

fabI

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). Involved in the elongation cycle of fatty acid which are used in the lipid metabolism (By similarity).By similarity

Catalytic activityi

An acyl-[acyl-carrier protein] + NAD+ = a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei13 – 131NAD; via carbonyl oxygenBy similarity
Binding sitei95 – 951NAD; via carbonyl oxygenBy similarity
Binding sitei98 – 981Substrate; via amide nitrogen and carbonyl oxygenBy similarity
Active sitei148 – 1481Proton acceptorBy similarity
Active sitei158 – 1581Proton acceptorBy similarity
Binding sitei165 – 1651NADBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi19 – 202NADBy similarity
Nucleotide bindingi67 – 682NADBy similarity
Nucleotide bindingi194 – 1985NADBy similarity

GO - Molecular functioni

  1. enoyl-[acyl-carrier-protein] reductase (NADH) activity Source: UniProtKB

GO - Biological processi

  1. fatty acid elongation Source: UniProtKB
  2. protein homotetramerization Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI (EC:1.3.1.9)
Short name:
ENR
Alternative name(s):
NADH-dependent enoyl-ACP reductase
Gene namesi
Name:fabI
Synonyms:envM
Ordered Locus Names:slr1051
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
ProteomesiUP000001425: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 258258Enoyl-[acyl-carrier-protein] reductase [NADH] FabIPRO_0000054912Add
BLAST

Proteomic databases

PaxDbiP73016.

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi1148.slr1051.

Structurei

3D structure databases

ProteinModelPortaliP73016.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0623.
InParanoidiP73016.
KOiK00208.
OMAiGISGEIM.
OrthoDBiEOG6HF644.
PhylomeDBiP73016.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR014358. Enoyl-ACP_Rdtase_NADH.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PIRSFiPIRSF000094. Enoyl-ACP_rdct. 1 hit.
PRINTSiPR00081. GDHRDH.

Sequencei

Sequence statusi: Complete.

P73016-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLDLSGKHAF VTGIANNRSI AWGIAQQLHQ AGAEIGVSYL PDEKGRFEKK
60 70 80 90 100
VRELTEPLHP TLVLPGDVQD DAQVDALFHS VKEKWGKLDI LIHCLAFADK
110 120 130 140 150
SGLTGNYTDI PKEAFSQAME ISTYSLGRLA RGAKPLMTNG GSIITLTYFG
160 170 180 190 200
GVKVIPNYNL MGVAKAGLEM TVRYLAAELG PQNIRVNGIS AGPIRTLASS
210 220 230 240 250
AVGGILDMIH HVEEVAPLKR TVTQTEVGNT AAFLASDLSS GITGQIIYVD

SGYEIMGM
Length:258
Mass (Da):27,626
Last modified:May 30, 2000 - v2
Checksum:iE912F0DF124FAE49
GO

Sequence cautioni

The sequence BAA17036.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000022 Genomic DNA. Translation: BAA17036.1. Different initiation.
PIRiS74996.
RefSeqiNP_440356.1. NC_000911.1.
YP_007450240.1. NC_020286.1.

Genome annotation databases

EnsemblBacteriaiBAA17036; BAA17036; BAA17036.
GeneIDi953656.
KEGGisyn:slr1051.
syz:MYO_14660.
PATRICi23837868. VBISynSp132158_0503.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000022 Genomic DNA. Translation: BAA17036.1 . Different initiation.
PIRi S74996.
RefSeqi NP_440356.1. NC_000911.1.
YP_007450240.1. NC_020286.1.

3D structure databases

ProteinModelPortali P73016.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 1148.slr1051.

Proteomic databases

PaxDbi P73016.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAA17036 ; BAA17036 ; BAA17036 .
GeneIDi 953656.
KEGGi syn:slr1051.
syz:MYO_14660.
PATRICi 23837868. VBISynSp132158_0503.

Phylogenomic databases

eggNOGi COG0623.
InParanoidi P73016.
KOi K00208.
OMAi GISGEIM.
OrthoDBi EOG6HF644.
PhylomeDBi P73016.

Enzyme and pathway databases

UniPathwayi UPA00094 .

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR014358. Enoyl-ACP_Rdtase_NADH.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PIRSFi PIRSF000094. Enoyl-ACP_rdct. 1 hit.
PRINTSi PR00081. GDHRDH.
ProtoNeti Search...

Publicationsi

  1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
    Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
    , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 6803 / Kazusa.

Entry informationi

Entry nameiFABI_SYNY3
AccessioniPrimary (citable) accession number: P73016
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: October 29, 2014
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

External Data

Dasty 3