Reviewed, UniProtKB/Swiss-Prot P73016 (FABI_SYNY3)

Names and origin

Protein names

Recommended name:
    Enoyl-[acyl-carrier-protein] reductase [NADH]
    EC=1.3.1.9
Alternative name(s):
    NADH-dependent enoyl-ACP reductase

Gene names

Name:	fabI
Synonyms:	envM
Ordered Locus Names:	slr1051

Organism

Synechocystis sp. (strain PCC 6803) [Complete proteome] [HAMAP]

Taxonomic identifier

1148 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Synechocystis

Protein attributes

Sequence length	258 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Acyl-[acyl-carrier-protein] + NAD+ = trans-2,3-dehydroacyl-[acyl-carrier-protein] + NADH.
Pathway	Lipid metabolism; fatty acid biosynthesis.
Sequence similarities	Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.

Ontologies

Keywords
Biological process	Fatty acid biosynthesis Lipid synthesis
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	fatty acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	binding Inferred from electronic annotation. Source: InterPro enoyl-[acyl-carrier-protein] reductase (NADH) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 258	258	Enoyl-[acyl-carrier-protein] reductase [NADH]		PRO_0000054912
Regions
	Nucleotide binding	10 – 36	27	NAD By similarity
Sites
	Active site	158	1	Proton acceptor By similarity

Sequences

	Sequence		Length	Mass (Da)
	P73016-1 [UniParc]. Last modified May 30, 2000. Version 2. Checksum: E912F0DF124FAE49	FASTA	258	27,626
	10 20 30 40 50 60 MLDLSGKHAF VTGIANNRSI AWGIAQQLHQ AGAEIGVSYL PDEKGRFEKK VRELTEPLHP 70 80 90 100 110 120 TLVLPGDVQD DAQVDALFHS VKEKWGKLDI LIHCLAFADK SGLTGNYTDI PKEAFSQAME 130 140 150 160 170 180 ISTYSLGRLA RGAKPLMTNG GSIITLTYFG GVKVIPNYNL MGVAKAGLEM TVRYLAAELG 190 200 210 220 230 240 PQNIRVNGIS AGPIRTLASS AVGGILDMIH HVEEVAPLKR TVTQTEVGNT AAFLASDLSS 250 GITGQIIYVD SGYEIMGM

References

[1]

"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions." Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S. DNA Res. 3:109-136(1996) [PubMed: 8905231] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000022 Genomic DNA. Translation: BAA17036.1. Different initiation.
PIR	S74996.
RefSeq	NP_440356.1.
3D structure databases
HSSP	HSSP built from PDB template 1DFI based on UniProtKB P29132.
ModBase	Search...
Genome annotation databases
GeneID	953656.
GenomeReviews	Gene locus slr1051 in contig BA000022_GR.
KEGG	syn:slr1051.
NMPDR	fig|1148.1.peg.457.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P73016.
Enzyme and pathway databases
BioCyc	SSP1148:SLR1051-MON.
Family and domain databases
InterPro	IPR002198. DH_sc/Rdtase_SDR. IPR014358. Enoyl-ACP_Rdtase_NADH. IPR002347. Glc/ribitol_DH. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR19410. ADH_short_C2. 1 hit. PTHR19410:SF12. Enoyl-ACP_rdct. 1 hit.
Pfam	PF00106. adh_short. 1 hit. [Graphical view]
PRINTS	PR00081. GDHRDH.
ProtoNet	Search...

Entry information

Entry name

FABI_SYNY3

Accession

Primary (citable) accession number: P73016

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 30, 2000
Last modified:	June 16, 2009
This is version 58 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)