P72955 (UREG_SYNY3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Urease accessory protein UreG

Gene names

Name:	ureG
Ordered Locus Names:	sll0643

Organism

Synechocystis sp. (strain PCC 6803 / Kazusa) [Reference proteome] [HAMAP]

Taxonomic identifier

1111708 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Cyanobacteria › Oscillatoriophycideae › Chroococcales › Synechocystis › Synechocystis sp. PCC 6803

Protein attributes

Sequence length	206 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG By similarity. HAMAP-Rule MF_01389
Subunit structure	Homodimer. UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the UreG family.

Ontologies

Keywords
Biological process	Nickel insertion
Cellular component	Cytoplasm
Ligand	GTP-binding Nucleotide-binding
Molecular function	Chaperone
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: InterPro GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTPase activity Inferred from electronic annotation. Source: InterPro metallochaperone activity Inferred from electronic annotation. Source: InterPro nickel cation binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 206	206	Urease accessory protein UreG HAMAP-Rule MF_01389		PRO_0000067674
Regions
	Nucleotide binding	12 – 19	8	GTP By similarity

Sequences

	Sequence		Length	Mass (Da)
	P72955 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: 8A45AD507F49B1B1	FASTA	206	22,013
	10 20 30 40 50 60 MAQTPLRIGI AGPVGSGKTA LLEALCKALR QKYQLAVVTN DIYTQEDAQF LVRAEALTPD 70 80 90 100 110 120 RILGVETGGC PHTAIREDAS LNLAAIADLE ARFMPLDMVF LESGGDNLAA TFSPELVDLT 130 140 150 160 170 180 LYVIDVAAGD KIPRKGGPGI TKSDLLVINK IDLAPMVGAD LGIMDRDAKK MRGEKPFVFT 190 200 NLKTATGLST VVDFVEHYLP TKVLAS

References

[1]

"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions." Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S. DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PCC 6803 / Kazusa.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000022 Genomic DNA. Translation: BAA16973.1.
PIR	S74933.
RefSeq	NP_440293.1. NC_000911.1. YP_005650350.1. NC_017277.1. YP_007450176.1. NC_020286.1.
3D structure databases
ProteinModelPortal	P72955.
ModBase	Search...
Protein-protein interaction databases
STRING	1148.sll0643.
Proteomic databases
PaxDb	P72955.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAA16973; BAA16973; BAA16973.
GeneID	12256039. 14615823. 953592.
KEGG	syn:sll0643. syy:SYNGTS_0397.
PATRIC	23837720. VBISynSp132158_0430.
Phylogenomic databases
eggNOG	COG0378.
HOGENOM	HOG000236979.
KO	K03189.
OMA	LCKAMRE.
Family and domain databases
HAMAP	MF_01389. UreG.
InterPro	IPR003593. AAA+_ATPase. IPR003495. CobW/HypB/UreG_dom. IPR012202. NiFe-hyd/urease_mat_GTPase. IPR004400. Urease_accessory_UreG. [Graphical view]
Pfam	PF02492. cobW. 1 hit. [Graphical view]
PIRSF	PIRSF005624. Ni-bind_GTPase. 1 hit.
SMART	SM00382. AAA. 1 hit. [Graphical view]
TIGRFAMs	TIGR00101. ureG. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UREG_SYNY3

Accession

Primary (citable) accession number: P72955

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	February 1, 1997
Last modified:	May 1, 2013
This is version 78 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program