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P72946

- HISX2_SYNY3

UniProt

P72946 - HISX2_SYNY3

Protein

Putative histidinol dehydrogenase 2

Gene

hisD2

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.By similarity

    Catalytic activityi

    L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.

    Pathwayi

    GO - Molecular functioni

    1. histidinol dehydrogenase activity Source: UniProtKB-EC
    2. NAD binding Source: InterPro
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    UniPathwayiUPA00031; UER00014.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative histidinol dehydrogenase 2 (EC:1.1.1.23)
    Short name:
    HDH 2
    Gene namesi
    Name:hisD2
    Ordered Locus Names:slr0682
    OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
    Taxonomic identifieri1111708 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
    ProteomesiUP000001425: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 409409Putative histidinol dehydrogenase 2PRO_0000135866Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi1148.slr0682.

    Structurei

    3D structure databases

    ProteinModelPortaliP72946.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histidinol dehydrogenase family.Curated

    Phylogenomic databases

    eggNOGiCOG0141.
    HOGENOMiHOG000243914.
    KOiK00013.
    OMAiNIAPVES.
    OrthoDBiEOG6CVVCR.
    PhylomeDBiP72946.

    Family and domain databases

    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view]
    PfamiPF00815. Histidinol_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
    PRINTSiPR00083. HOLDHDRGNASE.
    SUPFAMiSSF53720. SSF53720. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P72946-1 [UniParc]FASTAAdd to Basket

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    MLRLITQSGD IVQELRRLHH RPVPSPWPVM AQVVAAMEHW AAMDQDAPPR    50
    VSGAELDAAY QRISQEKLSV IRQACAALEQ VYRPQLPKTQ VSFPEDGTVR 100
    GQRFYPVRRA GFYLEAKRGD ALGNLLRQGM LAKTVGVAER VLVTETISST 150
    ILVAAQEMGI EEIYLAAGVP AIAMLTWGAK NIAPVESITG AGCPRVMAAK 200
    QLVSGVVTID QTLARTNLMV LADGEANGQW LALDLLAHAE QYPNASAVLL 250
    TDRLELGEEV IQSVNRYCRE QEHSVHTEKA LAHYGLVAIV EDLEACGSWI 300
    NEFCPHILLL AMEDPWTMVE KVQRAREIYI GHRSPSILGH YLSGANRLQT 350
    QDGAMATASE LAFHCFLRSS QLLDYGNNPP PPWLKDLVNW QGLTAIEERL 400
    GQLGRLKES 409
    Length:409
    Mass (Da):45,138
    Last modified:February 1, 1997 - v1
    Checksum:i2EC7B208A7C67073
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000022 Genomic DNA. Translation: BAA16963.1.
    PIRiS74923.
    RefSeqiNP_440283.1. NC_000911.1.
    YP_005650340.1. NC_017277.1.
    YP_007450166.1. NC_020286.1.

    Genome annotation databases

    EnsemblBacteriaiBAA16963; BAA16963; BAA16963.
    GeneIDi953582.
    KEGGisyn:slr0682.
    syy:SYNGTS_0387.
    syz:MYO_13910.
    PATRICi23837700. VBISynSp132158_0420.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000022 Genomic DNA. Translation: BAA16963.1 .
    PIRi S74923.
    RefSeqi NP_440283.1. NC_000911.1.
    YP_005650340.1. NC_017277.1.
    YP_007450166.1. NC_020286.1.

    3D structure databases

    ProteinModelPortali P72946.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 1148.slr0682.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAA16963 ; BAA16963 ; BAA16963 .
    GeneIDi 953582.
    KEGGi syn:slr0682.
    syy:SYNGTS_0387.
    syz:MYO_13910.
    PATRICi 23837700. VBISynSp132158_0420.

    Phylogenomic databases

    eggNOGi COG0141.
    HOGENOMi HOG000243914.
    KOi K00013.
    OMAi NIAPVES.
    OrthoDBi EOG6CVVCR.
    PhylomeDBi P72946.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00014 .

    Family and domain databases

    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view ]
    Pfami PF00815. Histidinol_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
    PRINTSi PR00083. HOLDHDRGNASE.
    SUPFAMi SSF53720. SSF53720. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
      Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
      , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
      DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 6803 / Kazusa.

    Entry informationi

    Entry nameiHISX2_SYNY3
    AccessioniPrimary (citable) accession number: P72946
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 25, 2003
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Caution

    Could lack activity as the potential active sites and zinc-binding sites are missing.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families
    3. Synechocystis PCC 6803
      Synechocystis (strain PCC 6803): entries and gene names

    External Data

    Dasty 3