P72946 (HISX2_SYNY3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative histidinol dehydrogenase 2
Short name=HDH 2
EC=1.1.1.23

Gene names

Name:	hisD2
Ordered Locus Names:	slr0682

Organism

Synechocystis sp. (strain PCC 6803 / Kazusa)

Taxonomic identifier

1111708 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Synechocystis

Protein attributes

Sequence length	409 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity. HAMAP MF_01024
Catalytic activity	L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH. HAMAP MF_01024
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9. HAMAP MF_01024
Sequence similarities	Belongs to the histidinol dehydrogenase family.
Caution	Could lack activity as the potential active sites and zinc-binding sites are missing.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NAD binding Inferred from electronic annotation. Source: InterPro histidinol dehydrogenase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 409	409	Putative histidinol dehydrogenase 2 HAMAP MF_01024		PRO_0000135866

Sequences

	Sequence		Length	Mass (Da)
	P72946 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: 2EC7B208A7C67073	FASTA	409	45,138
	10 20 30 40 50 60 MLRLITQSGD IVQELRRLHH RPVPSPWPVM AQVVAAMEHW AAMDQDAPPR VSGAELDAAY 70 80 90 100 110 120 QRISQEKLSV IRQACAALEQ VYRPQLPKTQ VSFPEDGTVR GQRFYPVRRA GFYLEAKRGD 130 140 150 160 170 180 ALGNLLRQGM LAKTVGVAER VLVTETISST ILVAAQEMGI EEIYLAAGVP AIAMLTWGAK 190 200 210 220 230 240 NIAPVESITG AGCPRVMAAK QLVSGVVTID QTLARTNLMV LADGEANGQW LALDLLAHAE 250 260 270 280 290 300 QYPNASAVLL TDRLELGEEV IQSVNRYCRE QEHSVHTEKA LAHYGLVAIV EDLEACGSWI 310 320 330 340 350 360 NEFCPHILLL AMEDPWTMVE KVQRAREIYI GHRSPSILGH YLSGANRLQT QDGAMATASE 370 380 390 400 LAFHCFLRSS QLLDYGNNPP PPWLKDLVNW QGLTAIEERL GQLGRLKES

References

[1]

"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions." Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S. DNA Res. 3:109-136(1996) [PubMed: 8905231] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 27184 / PCC 6803 / N-1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000022 Genomic DNA. Translation: BAA16963.1.
PIR	S74923.
RefSeq	NP_440283.1. NC_000911.1.
3D structure databases
ProteinModelPortal	P72946.
ModBase	Search...
Protein-protein interaction databases
STRING	P72946.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	953582.
GenomeReviews	Gene locus slr0682 in contig BA000022_GR.
KEGG	syn:slr0682.
NMPDR	fig|1148.1.peg.384.
PATRIC	23837700. VBISynSp132158_0420.
Phylogenomic databases
eggNOG	COG0141.
HOGENOM	HBG329596.
OMA	AMATASE.
PhylomeDB	P72946.
Enzyme and pathway databases
BioCyc	SSP1148:SLR0682-MONOMER.
Family and domain databases
HAMAP	MF_01024. HisD. Divergent sequence. [Tree]
InterPro	IPR016161. Ald_DH/histidinol_DH. IPR022695. Histidinol_DH_monofunct. IPR012131. Hstdl_DH. [Graphical view]
KO	K00013.
PANTHER	PTHR21256:SF2. Hstdl_DH_prok. 1 hit.
Pfam	PF00815. Histidinol_dh. 1 hit. [Graphical view]
PIRSF	PIRSF000099. Histidinol_dh. 1 hit.
PRINTS	PR00083. HOLDHDRGNASE.
SUPFAM	SSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
PROSITE	PS00611. HISOL_DEHYDROGENASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HISX2_SYNY3

Accession

Primary (citable) accession number: P72946

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 25, 2003
Last sequence update:	February 1, 1997
Last modified:	January 25, 2012
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program