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Protein

Putative histidinol dehydrogenase 2

Gene

hisD2

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.By similarity

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.

Pathwayi

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-EC
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

NAD

Enzyme and pathway databases

UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative histidinol dehydrogenase 2 (EC:1.1.1.23)
Short name:
HDH 2
Gene namesi
Name:hisD2
Ordered Locus Names:slr0682
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
ProteomesiUP000001425: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 409409Putative histidinol dehydrogenase 2PRO_0000135866Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi1148.slr0682.

Structurei

3D structure databases

ProteinModelPortaliP72946.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.Curated

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OrthoDBiEOG6CVVCR.
PhylomeDBiP72946.

Family and domain databases

InterProiIPR016161. Ald_DH/histidinol_DH.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.

Sequencei

Sequence statusi: Complete.

P72946-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRLITQSGD IVQELRRLHH RPVPSPWPVM AQVVAAMEHW AAMDQDAPPR
60 70 80 90 100
VSGAELDAAY QRISQEKLSV IRQACAALEQ VYRPQLPKTQ VSFPEDGTVR
110 120 130 140 150
GQRFYPVRRA GFYLEAKRGD ALGNLLRQGM LAKTVGVAER VLVTETISST
160 170 180 190 200
ILVAAQEMGI EEIYLAAGVP AIAMLTWGAK NIAPVESITG AGCPRVMAAK
210 220 230 240 250
QLVSGVVTID QTLARTNLMV LADGEANGQW LALDLLAHAE QYPNASAVLL
260 270 280 290 300
TDRLELGEEV IQSVNRYCRE QEHSVHTEKA LAHYGLVAIV EDLEACGSWI
310 320 330 340 350
NEFCPHILLL AMEDPWTMVE KVQRAREIYI GHRSPSILGH YLSGANRLQT
360 370 380 390 400
QDGAMATASE LAFHCFLRSS QLLDYGNNPP PPWLKDLVNW QGLTAIEERL

GQLGRLKES
Length:409
Mass (Da):45,138
Last modified:February 1, 1997 - v1
Checksum:i2EC7B208A7C67073
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA16963.1.
PIRiS74923.
RefSeqiNP_440283.1. NC_000911.1.
YP_005650340.1. NC_017277.1.
YP_007450166.1. NC_020286.1.

Genome annotation databases

EnsemblBacteriaiBAA16963; BAA16963; BAA16963.
GeneIDi953582.
KEGGisyn:slr0682.
PATRICi23837700. VBISynSp132158_0420.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA16963.1.
PIRiS74923.
RefSeqiNP_440283.1. NC_000911.1.
YP_005650340.1. NC_017277.1.
YP_007450166.1. NC_020286.1.

3D structure databases

ProteinModelPortaliP72946.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi1148.slr0682.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA16963; BAA16963; BAA16963.
GeneIDi953582.
KEGGisyn:slr0682.
PATRICi23837700. VBISynSp132158_0420.

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OrthoDBiEOG6CVVCR.
PhylomeDBiP72946.

Enzyme and pathway databases

UniPathwayiUPA00031; UER00014.

Family and domain databases

InterProiIPR016161. Ald_DH/histidinol_DH.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
    Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
    , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 6803 / Kazusa.

Entry informationi

Entry nameiHISX2_SYNY3
AccessioniPrimary (citable) accession number: P72946
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: February 1, 1997
Last modified: January 7, 2015
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

Could lack activity as the potential active sites and zinc-binding sites are missing.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.