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P72933

- GLO2_SYNY3

UniProt

P72933 - GLO2_SYNY3

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Protein

Hydroxyacylglutathione hydrolase

Gene
gloB, sll1019
Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid By similarity.UniRule annotation

Catalytic activityi

S-(2-hydroxyacyl)glutathione + H2O = glutathione + a 2-hydroxy carboxylate.UniRule annotation

Cofactori

Binds 2 zinc ions per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi54 – 541Zinc 1 By similarity
Metal bindingi56 – 561Zinc 1 By similarity
Metal bindingi58 – 581Zinc 2 By similarity
Metal bindingi59 – 591Zinc 2 By similarity
Metal bindingi113 – 1131Zinc 1 By similarity
Metal bindingi137 – 1371Zinc 1 By similarity
Metal bindingi137 – 1371Zinc 2 By similarity
Metal bindingi175 – 1751Zinc 2 By similarity

GO - Molecular functioni

  1. hydroxyacylglutathione hydrolase activity Source: UniProtKB-HAMAP
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. glutathione biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00619; UER00676.

Names & Taxonomyi

Protein namesi
Recommended name:
Hydroxyacylglutathione hydrolase (EC:3.1.2.6)
Alternative name(s):
Glyoxalase II
Short name:
Glx II
Gene namesi
Name:gloB
Ordered Locus Names:sll1019
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
ProteomesiUP000001425: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 257257Hydroxyacylglutathione hydrolaseUniRule annotationPRO_0000192356Add
BLAST

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi1148.sll1019.

Structurei

3D structure databases

ProteinModelPortaliP72933.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0491.
HOGENOMiHOG000058041.
KOiK01069.
OMAiCLTDNFG.
OrthoDBiEOG69GZQ4.
PhylomeDBiP72933.

Family and domain databases

Gene3Di3.60.15.10. 1 hit.
HAMAPiMF_01374. Glyoxalase_2.
InterProiIPR001279. Beta-lactamas-like.
IPR017782. Hydroxyacylglutathione_Hdrlase.
[Graphical view]
PANTHERiPTHR11935:SF7. PTHR11935:SF7. 1 hit.
PfamiPF00753. Lactamase_B. 1 hit.
[Graphical view]
PIRSFiPIRSF005457. Glx. 1 hit.
SMARTiSM00849. Lactamase_B. 1 hit.
[Graphical view]
SUPFAMiSSF56281. SSF56281. 1 hit.
TIGRFAMsiTIGR03413. GSH_gloB. 1 hit.

Sequencei

Sequence statusi: Complete.

P72933-1 [UniParc]FASTAAdd to Basket

« Hide

MDIHRLPALA DNYIFLLHDR QRNQAAVVDP AEAKPVLDCL ETLGADLVTI    50
YNTHHHGDHV GANRELLAKY PNLEVYGGVE DQGRIPGQTV FLRDGDRLSF 100
ADREATVYFV PGHTRGHIAY YFAPGSGETI GDLFCGDTIF AGGCGRLFEG 150
TPAQMVQSIG KLRQLPDQTR LWCAHEYTLG NLKFALTVDP SNKDLQERFQ 200
TVQGDRQRGQ ATIPSWLGTE KRTNPFLRWD NPAIQARVGM TEPARVFGKL 250
RGMKDNF 257
Length:257
Mass (Da):28,724
Last modified:February 1, 1997 - v1
Checksum:i34672EC7EB7B1734
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000022 Genomic DNA. Translation: BAA16950.1.
PIRiS74799.
RefSeqiNP_440270.1. NC_000911.1.
YP_005650327.1. NC_017277.1.
YP_007450153.1. NC_020286.1.

Genome annotation databases

EnsemblBacteriaiBAA16950; BAA16950; BAA16950.
GeneIDi953569.
KEGGisyn:sll1019.
syy:SYNGTS_0374.
syz:MYO_13780.
PATRICi23837668. VBISynSp132158_0404.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000022 Genomic DNA. Translation: BAA16950.1 .
PIRi S74799.
RefSeqi NP_440270.1. NC_000911.1.
YP_005650327.1. NC_017277.1.
YP_007450153.1. NC_020286.1.

3D structure databases

ProteinModelPortali P72933.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 1148.sll1019.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAA16950 ; BAA16950 ; BAA16950 .
GeneIDi 953569.
KEGGi syn:sll1019.
syy:SYNGTS_0374.
syz:MYO_13780.
PATRICi 23837668. VBISynSp132158_0404.

Phylogenomic databases

eggNOGi COG0491.
HOGENOMi HOG000058041.
KOi K01069.
OMAi CLTDNFG.
OrthoDBi EOG69GZQ4.
PhylomeDBi P72933.

Enzyme and pathway databases

UniPathwayi UPA00619 ; UER00676 .

Family and domain databases

Gene3Di 3.60.15.10. 1 hit.
HAMAPi MF_01374. Glyoxalase_2.
InterProi IPR001279. Beta-lactamas-like.
IPR017782. Hydroxyacylglutathione_Hdrlase.
[Graphical view ]
PANTHERi PTHR11935:SF7. PTHR11935:SF7. 1 hit.
Pfami PF00753. Lactamase_B. 1 hit.
[Graphical view ]
PIRSFi PIRSF005457. Glx. 1 hit.
SMARTi SM00849. Lactamase_B. 1 hit.
[Graphical view ]
SUPFAMi SSF56281. SSF56281. 1 hit.
TIGRFAMsi TIGR03413. GSH_gloB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
    Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
    , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 6803 / Kazusa.

Entry informationi

Entry nameiGLO2_SYNY3
AccessioniPrimary (citable) accession number: P72933
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: July 9, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

External Data

Dasty 3

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