Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P72933

- GLO2_SYNY3

UniProt

P72933 - GLO2_SYNY3

Protein

Hydroxyacylglutathione hydrolase

Gene

gloB

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.UniRule annotation

    Catalytic activityi

    S-(2-hydroxyacyl)glutathione + H2O = glutathione + a 2-hydroxy carboxylate.UniRule annotation

    Cofactori

    Binds 2 zinc ions per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi54 – 541Zinc 1UniRule annotation
    Metal bindingi56 – 561Zinc 1UniRule annotation
    Metal bindingi58 – 581Zinc 2UniRule annotation
    Metal bindingi59 – 591Zinc 2UniRule annotation
    Metal bindingi113 – 1131Zinc 1UniRule annotation
    Metal bindingi137 – 1371Zinc 1UniRule annotation
    Metal bindingi137 – 1371Zinc 2UniRule annotation
    Metal bindingi175 – 1751Zinc 2UniRule annotation

    GO - Molecular functioni

    1. hydroxyacylglutathione hydrolase activity Source: UniProtKB-HAMAP
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. glutathione biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    UniPathwayiUPA00619; UER00676.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hydroxyacylglutathione hydrolaseUniRule annotation (EC:3.1.2.6UniRule annotation)
    Alternative name(s):
    Glyoxalase IIUniRule annotation
    Short name:
    Glx IIUniRule annotation
    Gene namesi
    Name:gloBUniRule annotation
    Ordered Locus Names:sll1019
    OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
    Taxonomic identifieri1111708 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
    ProteomesiUP000001425: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 257257Hydroxyacylglutathione hydrolasePRO_0000192356Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi1148.sll1019.

    Structurei

    3D structure databases

    ProteinModelPortaliP72933.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0491.
    HOGENOMiHOG000058041.
    KOiK01069.
    OMAiCLTDNFG.
    OrthoDBiEOG69GZQ4.
    PhylomeDBiP72933.

    Family and domain databases

    Gene3Di3.60.15.10. 1 hit.
    HAMAPiMF_01374. Glyoxalase_2.
    InterProiIPR001279. Beta-lactamas-like.
    IPR017782. Hydroxyacylglutathione_Hdrlase.
    [Graphical view]
    PANTHERiPTHR11935:SF7. PTHR11935:SF7. 1 hit.
    PfamiPF00753. Lactamase_B. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005457. Glx. 1 hit.
    SMARTiSM00849. Lactamase_B. 1 hit.
    [Graphical view]
    SUPFAMiSSF56281. SSF56281. 1 hit.
    TIGRFAMsiTIGR03413. GSH_gloB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P72933-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDIHRLPALA DNYIFLLHDR QRNQAAVVDP AEAKPVLDCL ETLGADLVTI    50
    YNTHHHGDHV GANRELLAKY PNLEVYGGVE DQGRIPGQTV FLRDGDRLSF 100
    ADREATVYFV PGHTRGHIAY YFAPGSGETI GDLFCGDTIF AGGCGRLFEG 150
    TPAQMVQSIG KLRQLPDQTR LWCAHEYTLG NLKFALTVDP SNKDLQERFQ 200
    TVQGDRQRGQ ATIPSWLGTE KRTNPFLRWD NPAIQARVGM TEPARVFGKL 250
    RGMKDNF 257
    Length:257
    Mass (Da):28,724
    Last modified:February 1, 1997 - v1
    Checksum:i34672EC7EB7B1734
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000022 Genomic DNA. Translation: BAA16950.1.
    PIRiS74799.
    RefSeqiNP_440270.1. NC_000911.1.
    YP_005650327.1. NC_017277.1.
    YP_007450153.1. NC_020286.1.

    Genome annotation databases

    EnsemblBacteriaiBAA16950; BAA16950; BAA16950.
    GeneIDi953569.
    KEGGisyn:sll1019.
    syy:SYNGTS_0374.
    syz:MYO_13780.
    PATRICi23837668. VBISynSp132158_0404.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000022 Genomic DNA. Translation: BAA16950.1 .
    PIRi S74799.
    RefSeqi NP_440270.1. NC_000911.1.
    YP_005650327.1. NC_017277.1.
    YP_007450153.1. NC_020286.1.

    3D structure databases

    ProteinModelPortali P72933.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 1148.sll1019.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAA16950 ; BAA16950 ; BAA16950 .
    GeneIDi 953569.
    KEGGi syn:sll1019.
    syy:SYNGTS_0374.
    syz:MYO_13780.
    PATRICi 23837668. VBISynSp132158_0404.

    Phylogenomic databases

    eggNOGi COG0491.
    HOGENOMi HOG000058041.
    KOi K01069.
    OMAi CLTDNFG.
    OrthoDBi EOG69GZQ4.
    PhylomeDBi P72933.

    Enzyme and pathway databases

    UniPathwayi UPA00619 ; UER00676 .

    Family and domain databases

    Gene3Di 3.60.15.10. 1 hit.
    HAMAPi MF_01374. Glyoxalase_2.
    InterProi IPR001279. Beta-lactamas-like.
    IPR017782. Hydroxyacylglutathione_Hdrlase.
    [Graphical view ]
    PANTHERi PTHR11935:SF7. PTHR11935:SF7. 1 hit.
    Pfami PF00753. Lactamase_B. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005457. Glx. 1 hit.
    SMARTi SM00849. Lactamase_B. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56281. SSF56281. 1 hit.
    TIGRFAMsi TIGR03413. GSH_gloB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
      Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
      , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
      DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 6803 / Kazusa.

    Entry informationi

    Entry nameiGLO2_SYNY3
    AccessioniPrimary (citable) accession number: P72933
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families
    3. Synechocystis PCC 6803
      Synechocystis (strain PCC 6803): entries and gene names

    External Data

    Dasty 3