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P72933 (GLO2_SYNY3) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hydroxyacylglutathione hydrolase

EC=3.1.2.6
Alternative name(s):
Glyoxalase II
Short name=Glx II
Gene names
Name:gloB
Ordered Locus Names:sll1019
OrganismSynechocystis sp. (strain PCC 6803 / Kazusa) [Reference proteome] [HAMAP]
Taxonomic identifier1111708 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis

Protein attributes

Sequence length257 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid By similarity. HAMAP-Rule MF_01374

Catalytic activity

S-(2-hydroxyacyl)glutathione + H2O = glutathione + a 2-hydroxy carboxylate. HAMAP-Rule MF_01374

Cofactor

Binds 2 zinc ions per subunit By similarity. HAMAP-Rule MF_01374

Pathway

Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 2/2. HAMAP-Rule MF_01374

Subunit structure

Monomer By similarity. HAMAP-Rule MF_01374

Sequence similarities

Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.

Ontologies

Keywords
   LigandMetal-binding
Zinc
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processglutathione biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionhydroxyacylglutathione hydrolase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 257257Hydroxyacylglutathione hydrolase HAMAP-Rule MF_01374
PRO_0000192356

Sites

Metal binding541Zinc 1 By similarity
Metal binding561Zinc 1 By similarity
Metal binding581Zinc 2 By similarity
Metal binding591Zinc 2 By similarity
Metal binding1131Zinc 1 By similarity
Metal binding1371Zinc 1 By similarity
Metal binding1371Zinc 2 By similarity
Metal binding1751Zinc 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
P72933 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: 34672EC7EB7B1734

FASTA25728,724
        10         20         30         40         50         60 
MDIHRLPALA DNYIFLLHDR QRNQAAVVDP AEAKPVLDCL ETLGADLVTI YNTHHHGDHV 

        70         80         90        100        110        120 
GANRELLAKY PNLEVYGGVE DQGRIPGQTV FLRDGDRLSF ADREATVYFV PGHTRGHIAY 

       130        140        150        160        170        180 
YFAPGSGETI GDLFCGDTIF AGGCGRLFEG TPAQMVQSIG KLRQLPDQTR LWCAHEYTLG 

       190        200        210        220        230        240 
NLKFALTVDP SNKDLQERFQ TVQGDRQRGQ ATIPSWLGTE KRTNPFLRWD NPAIQARVGM 

       250 
TEPARVFGKL RGMKDNF 

« Hide

References

[1]"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. expand/collapse author list , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PCC 6803 / Kazusa.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000022 Genomic DNA. Translation: BAA16950.1.
PIRS74799.
RefSeqNP_440270.1. NC_000911.1.
YP_005650327.1. NC_017277.1.
YP_007450153.1. NC_020286.1.

3D structure databases

ProteinModelPortalP72933.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING1148.sll1019.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAA16950; BAA16950; BAA16950.
GeneID12256016.
14615800.
953569.
KEGGsyn:sll1019.
syy:SYNGTS_0374.
syz:MYO_13780.
PATRIC23837668. VBISynSp132158_0404.

Phylogenomic databases

eggNOGCOG0491.
HOGENOMHOG000058041.
KOK01069.
OMANYIWLLQ.
OrthoDBEOG69GZQ4.
PhylomeDBP72933.

Enzyme and pathway databases

UniPathwayUPA00619; UER00676.

Family and domain databases

Gene3D3.60.15.10. 1 hit.
HAMAPMF_01374. Glyoxalase_2.
InterProIPR001279. Beta-lactamas-like.
IPR017782. Hydroxyacylglutathione_Hdrlase.
[Graphical view]
PANTHERPTHR11935:SF7. PTHR11935:SF7. 1 hit.
PfamPF00753. Lactamase_B. 1 hit.
[Graphical view]
PIRSFPIRSF005457. Glx. 1 hit.
SMARTSM00849. Lactamase_B. 1 hit.
[Graphical view]
SUPFAMSSF56281. SSF56281. 1 hit.
TIGRFAMsTIGR03413. GSH_gloB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGLO2_SYNY3
AccessionPrimary (citable) accession number: P72933
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: April 16, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Synechocystis PCC 6803

Synechocystis (strain PCC 6803): entries and gene names

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways