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Protein

Sulfite reductase [ferredoxin]

Gene

sir

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the reduction of sulfite to sulfide, a step in the biosynthesis of sulfur-containing amino acids and cofactors.By similarity

Catalytic activityi

Hydrogen sulfide + 6 oxidized ferredoxin [iron-sulfur] cluster + 3 H2O = sulfite + 6 reduced ferredoxin [iron-sulfur] cluster + 6 H+.By similarity

Cofactori

Protein has several cofactor binding sites:
  • sirohemeBy similarityNote: Binds 1 siroheme per subunit.By similarity
  • [4Fe-4S] clusterBy similarityNote: Binds 1 [4Fe-4S] cluster per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi451 – 4511Iron-sulfur (4Fe-4S)By similarity
Metal bindingi457 – 4571Iron-sulfur (4Fe-4S)By similarity
Metal bindingi496 – 4961Iron-sulfur (4Fe-4S)By similarity
Metal bindingi500 – 5001Iron (siroheme axial ligand)By similarity
Metal bindingi500 – 5001Iron-sulfur (4Fe-4S)By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

4Fe-4S, Heme, Iron, Iron-sulfur, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfite reductase [ferredoxin] (EC:1.8.7.1)
Gene namesi
Name:sir
Ordered Locus Names:slr0963
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
Proteomesi
  • UP000001425 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 635635Sulfite reductase [ferredoxin]PRO_0000199954Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki54 ↔ 1393'-(S-cysteinyl)-tyrosine (Tyr-Cys)By similarity

Keywords - PTMi

Thioether bond

Interactioni

Subunit structurei

Monomer.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
trxAP522313EBI-862835,EBI-862916

Protein-protein interaction databases

IntActiP72854. 4 interactions.

Structurei

3D structure databases

ProteinModelPortaliP72854.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000218417.
InParanoidiP72854.
KOiK00392.
OMAiGKYNMYL.
PhylomeDBiP72854.

Family and domain databases

Gene3Di3.90.480.10. 2 hits.
InterProiIPR005117. NiRdtase/SiRdtase_haem-b_fer.
IPR006067. NO2/SO3_Rdtase_4Fe4S_dom.
IPR006066. NO2/SO3_Rdtase_FeS/sirohaem_BS.
IPR011787. SiR_ferredoxin-dep.
[Graphical view]
PfamiPF01077. NIR_SIR. 2 hits.
PF03460. NIR_SIR_ferr. 2 hits.
[Graphical view]
PRINTSiPR00397. SIROHAEM.
SUPFAMiSSF55124. SSF55124. 2 hits.
TIGRFAMsiTIGR02042. sir. 1 hit.
PROSITEiPS00365. NIR_SIR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P72854-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVTTPTAAPR KPSKVEGIKE RSNYLREPLA TELLNDANYF TDDAVQILKF
60 70 80 90 100
HGSYQQDNRD NRVKGQEKDY QFMLRTRNPG GLIPAQLYTA LDDLSKTHGN
110 120 130 140 150
QTLRVTTRQG LQIHGIVKKD LKMAIATVVN NLGSTLGACG DINRNVMAPA
160 170 180 190 200
APFRDKPEYG YAWDYANKVA DLLSPQSGAY YEIWLDGEKV ISGEEAPEVK
210 220 230 240 250
AARQKDLNGT NLNDPKEPIY GQQFMPRKFK ISVTVPGDNS IDVYTHDISL
260 270 280 290 300
VVITDRHGEL RGFNVLAGGG LGRTHNKEET FARAADPIGY VSKDDVYDLV
310 320 330 340 350
KAIVATQRDY GDRHNRRHAR MKYLLADWGV EKFRKQVETY MGKPFQSFKP
360 370 380 390 400
LPAWRYQDYL GWHEQGDGKL FFGLSVENGR IKDEGDFQLK TALRKVVDQF
410 420 430 440 450
QLPLRLTANH NILLYDINAQ DKAAIEQIFQ QHGVVTDPEA IDTLVRYSMA
460 470 480 490 500
CPALPTCGLA VTESERIMPS VNARLRDLLN SLDLPNESIV TRMTGCPNGC
510 520 530 540 550
ARPYMAEIGF VGSAPNSYQV WLGGSPNQER LAAAYTEKMP LEQLESLFEP
560 570 580 590 600
LFVYFKQSRK GKESFGDFCH RVGFTALREF SHGYTAPAKG GKNRKNQRRV
610 620 630
SLSDEMYAQL KARSERDNCP MNQIVQQALT AYLGK
Length:635
Mass (Da):71,441
Last modified:February 1, 1997 - v1
Checksum:i91F4A1B139AD7B34
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA16869.1.
PIRiS74718.

Genome annotation databases

EnsemblBacteriaiBAA16869; BAA16869; BAA16869.
KEGGisyn:slr0963.
PATRICi23837504. VBISynSp132158_0323.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA16869.1.
PIRiS74718.

3D structure databases

ProteinModelPortaliP72854.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP72854. 4 interactions.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA16869; BAA16869; BAA16869.
KEGGisyn:slr0963.
PATRICi23837504. VBISynSp132158_0323.

Phylogenomic databases

HOGENOMiHOG000218417.
InParanoidiP72854.
KOiK00392.
OMAiGKYNMYL.
PhylomeDBiP72854.

Family and domain databases

Gene3Di3.90.480.10. 2 hits.
InterProiIPR005117. NiRdtase/SiRdtase_haem-b_fer.
IPR006067. NO2/SO3_Rdtase_4Fe4S_dom.
IPR006066. NO2/SO3_Rdtase_FeS/sirohaem_BS.
IPR011787. SiR_ferredoxin-dep.
[Graphical view]
PfamiPF01077. NIR_SIR. 2 hits.
PF03460. NIR_SIR_ferr. 2 hits.
[Graphical view]
PRINTSiPR00397. SIROHAEM.
SUPFAMiSSF55124. SSF55124. 2 hits.
TIGRFAMsiTIGR02042. sir. 1 hit.
PROSITEiPS00365. NIR_SIR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSIR_SYNY3
AccessioniPrimary (citable) accession number: P72854
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: September 7, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.