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Protein

Sulfite reductase [ferredoxin]

Gene

sir

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the reduction of sulfite to sulfide, a step in the biosynthesis of sulfur-containing amino acids and cofactors.By similarity

Catalytic activityi

Hydrogen sulfide + 6 oxidized ferredoxin [iron-sulfur] cluster + 3 H2O = sulfite + 6 reduced ferredoxin [iron-sulfur] cluster + 6 H+.By similarity

Cofactori

Protein has several cofactor binding sites:
  • sirohemeBy similarityNote: Binds 1 siroheme per subunit.By similarity
  • [4Fe-4S] clusterBy similarityNote: Binds 1 [4Fe-4S] cluster per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi451Iron-sulfur (4Fe-4S)By similarity1
Metal bindingi457Iron-sulfur (4Fe-4S)By similarity1
Metal bindingi496Iron-sulfur (4Fe-4S)By similarity1
Metal bindingi500Iron (siroheme axial ligand)By similarity1
Metal bindingi500Iron-sulfur (4Fe-4S)By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Ligand4Fe-4S, Heme, Iron, Iron-sulfur, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfite reductase [ferredoxin] (EC:1.8.7.1)
Gene namesi
Name:sir
Ordered Locus Names:slr0963
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesMerismopediaceaeSynechocystis
Proteomesi
  • UP000001425 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001999541 – 635Sulfite reductase [ferredoxin]Add BLAST635

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki54 ↔ 1393'-(S-cysteinyl)-tyrosine (Tyr-Cys)By similarity

Keywords - PTMi

Thioether bond

Proteomic databases

PaxDbiP72854
PRIDEiP72854

Interactioni

Subunit structurei

Monomer.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
trxAP522313EBI-862835,EBI-862916

Protein-protein interaction databases

IntActiP72854, 4 interactors
STRINGi1148.SYNGTS_0293

Structurei

3D structure databases

ProteinModelPortaliP72854
SMRiP72854
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000218417
InParanoidiP72854
KOiK00392
OMAiINRNVMA
PhylomeDBiP72854

Family and domain databases

InterProiView protein in InterPro
IPR005117 NiRdtase/SiRdtase_haem-b_fer
IPR036136 Nit/Sulf_reduc_fer_like_dom_sf
IPR006067 NO2/SO3_Rdtase_4Fe4S_dom
IPR006066 NO2/SO3_Rdtase_FeS/sirohaem_BS
IPR011787 SiR_ferredoxin-dep
PfamiView protein in Pfam
PF01077 NIR_SIR, 2 hits
PF03460 NIR_SIR_ferr, 2 hits
PRINTSiPR00397 SIROHAEM
SUPFAMiSSF55124 SSF55124, 2 hits
TIGRFAMsiTIGR02042 sir, 1 hit
PROSITEiView protein in PROSITE
PS00365 NIR_SIR, 1 hit

Sequencei

Sequence statusi: Complete.

P72854-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVTTPTAAPR KPSKVEGIKE RSNYLREPLA TELLNDANYF TDDAVQILKF
60 70 80 90 100
HGSYQQDNRD NRVKGQEKDY QFMLRTRNPG GLIPAQLYTA LDDLSKTHGN
110 120 130 140 150
QTLRVTTRQG LQIHGIVKKD LKMAIATVVN NLGSTLGACG DINRNVMAPA
160 170 180 190 200
APFRDKPEYG YAWDYANKVA DLLSPQSGAY YEIWLDGEKV ISGEEAPEVK
210 220 230 240 250
AARQKDLNGT NLNDPKEPIY GQQFMPRKFK ISVTVPGDNS IDVYTHDISL
260 270 280 290 300
VVITDRHGEL RGFNVLAGGG LGRTHNKEET FARAADPIGY VSKDDVYDLV
310 320 330 340 350
KAIVATQRDY GDRHNRRHAR MKYLLADWGV EKFRKQVETY MGKPFQSFKP
360 370 380 390 400
LPAWRYQDYL GWHEQGDGKL FFGLSVENGR IKDEGDFQLK TALRKVVDQF
410 420 430 440 450
QLPLRLTANH NILLYDINAQ DKAAIEQIFQ QHGVVTDPEA IDTLVRYSMA
460 470 480 490 500
CPALPTCGLA VTESERIMPS VNARLRDLLN SLDLPNESIV TRMTGCPNGC
510 520 530 540 550
ARPYMAEIGF VGSAPNSYQV WLGGSPNQER LAAAYTEKMP LEQLESLFEP
560 570 580 590 600
LFVYFKQSRK GKESFGDFCH RVGFTALREF SHGYTAPAKG GKNRKNQRRV
610 620 630
SLSDEMYAQL KARSERDNCP MNQIVQQALT AYLGK
Length:635
Mass (Da):71,441
Last modified:February 1, 1997 - v1
Checksum:i91F4A1B139AD7B34
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA Translation: BAA16869.1
PIRiS74718

Genome annotation databases

EnsemblBacteriaiBAA16869; BAA16869; BAA16869
KEGGisyn:slr0963

Similar proteinsi

Entry informationi

Entry nameiSIR_SYNY3
AccessioniPrimary (citable) accession number: P72854
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: May 23, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

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