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P72849

- HO1_SYNY3

UniProt

P72849 - HO1_SYNY3

Protein

Heme oxygenase 1

Gene

pbsA1

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    Catalyzes the opening of the heme ring with the release of iron. Key enzyme in the synthesis of the chromophoric part of the photosynthetic antennae By similarity.By similarity

    Catalytic activityi

    Protoheme + 3 AH2 + 3 O2 = biliverdin + Fe2+ + CO + 3 A + 3 H2O.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi17 – 171Iron (heme axial ligand)

    GO - Molecular functioni

    1. heme oxygenase (decyclizing) activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. heme oxidation Source: InterPro
    2. photosynthesis Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Photosynthesis

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Enzyme and pathway databases

    BioCyciMetaCyc:MONOMER-13860.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Heme oxygenase 1 (EC:1.14.99.3)
    Gene namesi
    Name:pbsA1
    Ordered Locus Names:sll1184
    OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
    Taxonomic identifieri1111708 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
    ProteomesiUP000001425: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 240240Heme oxygenase 1PRO_0000209701Add
    BLAST

    Proteomic databases

    PaxDbiP72849.

    Interactioni

    Protein-protein interaction databases

    IntActiP72849. 2 interactions.
    STRINGi1148.sll1184.

    Structurei

    Secondary structure

    1
    240
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi5 – 128
    Helixi14 – 218
    Helixi24 – 307
    Helixi36 – 5924
    Turni60 – 623
    Helixi66 – 694
    Helixi77 – 8812
    Helixi92 – 954
    Helixi100 – 11516
    Helixi117 – 1193
    Helixi120 – 14627
    Beta strandi149 – 1524
    Helixi154 – 1563
    Helixi164 – 17613
    Helixi182 – 20524
    Helixi207 – 22216

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1WE1X-ray2.50A/B/C/D1-240[»]
    ProteinModelPortaliP72849.
    SMRiP72849. Positions 2-223.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP72849.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the heme oxygenase family.Curated

    Phylogenomic databases

    eggNOGiCOG5398.
    HOGENOMiHOG000233221.
    KOiK00510.
    OMAiIGKIPPY.
    OrthoDBiEOG69PQ2G.
    PhylomeDBiP72849.

    Family and domain databases

    Gene3Di1.20.910.10. 1 hit.
    InterProiIPR002051. Haem_Oase.
    IPR016053. Haem_Oase-like.
    IPR016084. Haem_Oase-like_multi-hlx.
    IPR018207. Haem_oxygenase_CS.
    [Graphical view]
    PANTHERiPTHR10720. PTHR10720. 1 hit.
    PfamiPF01126. Heme_oxygenase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000343. Haem_Oase. 1 hit.
    PRINTSiPR00088. HAEMOXYGNASE.
    SUPFAMiSSF48613. SSF48613. 1 hit.
    PROSITEiPS00593. HEME_OXYGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P72849-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSVNLASQLR EGTKKSHSMA ENVGFVKCFL KGVVEKNSYR KLVGNLYFVY    50
    SAMEEEMAKF KDHPILSHIY FPELNRKQSL EQDLQFYYGS NWRQEVKISA 100
    AGQAYVDRVR QVAATAPELL VAHSYTRYLG DLSGGQILKK IAQNAMNLHD 150
    GGTAFYEFAD IDDEKAFKNT YRQAMNDLPI DQATAERIVD EANDAFAMNM 200
    KMFNELEGNL IKAIGIMVFN SLTRRRSQGS TEVGLATSEG 240
    Length:240
    Mass (Da):27,051
    Last modified:February 1, 1997 - v1
    Checksum:i7F17A033768BAFA8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000022 Genomic DNA. Translation: BAA16864.1.
    PIRiS74713.
    RefSeqiNP_440184.1. NC_000911.1.
    YP_005650241.1. NC_017277.1.
    YP_007450067.1. NC_020286.1.

    Genome annotation databases

    EnsemblBacteriaiBAA16864; BAA16864; BAA16864.
    GeneIDi953483.
    KEGGisyn:sll1184.
    syy:SYNGTS_0288.
    syz:MYO_12900.
    PATRICi23837492. VBISynSp132158_0318.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000022 Genomic DNA. Translation: BAA16864.1 .
    PIRi S74713.
    RefSeqi NP_440184.1. NC_000911.1.
    YP_005650241.1. NC_017277.1.
    YP_007450067.1. NC_020286.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1WE1 X-ray 2.50 A/B/C/D 1-240 [» ]
    ProteinModelPortali P72849.
    SMRi P72849. Positions 2-223.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P72849. 2 interactions.
    STRINGi 1148.sll1184.

    Proteomic databases

    PaxDbi P72849.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAA16864 ; BAA16864 ; BAA16864 .
    GeneIDi 953483.
    KEGGi syn:sll1184.
    syy:SYNGTS_0288.
    syz:MYO_12900.
    PATRICi 23837492. VBISynSp132158_0318.

    Phylogenomic databases

    eggNOGi COG5398.
    HOGENOMi HOG000233221.
    KOi K00510.
    OMAi IGKIPPY.
    OrthoDBi EOG69PQ2G.
    PhylomeDBi P72849.

    Enzyme and pathway databases

    BioCyci MetaCyc:MONOMER-13860.

    Miscellaneous databases

    EvolutionaryTracei P72849.

    Family and domain databases

    Gene3Di 1.20.910.10. 1 hit.
    InterProi IPR002051. Haem_Oase.
    IPR016053. Haem_Oase-like.
    IPR016084. Haem_Oase-like_multi-hlx.
    IPR018207. Haem_oxygenase_CS.
    [Graphical view ]
    PANTHERi PTHR10720. PTHR10720. 1 hit.
    Pfami PF01126. Heme_oxygenase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000343. Haem_Oase. 1 hit.
    PRINTSi PR00088. HAEMOXYGNASE.
    SUPFAMi SSF48613. SSF48613. 1 hit.
    PROSITEi PS00593. HEME_OXYGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
      Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
      , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
      DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 6803 / Kazusa.
    2. "Crystal structure of heme oxygenase-1 from cyanobacterium Synechocystis sp. PCC 6803 in complex with heme."
      Sugishima M., Migita C.T., Zhang X., Yoshida T., Fukuyama K.
      Eur. J. Biochem. 271:4517-4525(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) IN COMPLEX WITH HEME, IRON-BINDING SITE.

    Entry informationi

    Entry nameiHO1_SYNY3
    AccessioniPrimary (citable) accession number: P72849
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families
    3. Synechocystis PCC 6803
      Synechocystis (strain PCC 6803): entries and gene names

    External Data

    Dasty 3