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P72849

- HO1_SYNY3

UniProt

P72849 - HO1_SYNY3

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Protein
Heme oxygenase 1
Gene
pbsA1, sll1184
Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the opening of the heme ring with the release of iron. Key enzyme in the synthesis of the chromophoric part of the photosynthetic antennae By similarity.

Catalytic activityi

Protoheme + 3 AH2 + 3 O2 = biliverdin + Fe2+ + CO + 3 A + 3 H2O.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi17 – 171Iron (heme axial ligand)

GO - Molecular functioni

  1. heme oxygenase (decyclizing) activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. heme oxidation Source: InterPro
  2. photosynthesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Photosynthesis

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-13860.

Names & Taxonomyi

Protein namesi
Recommended name:
Heme oxygenase 1 (EC:1.14.99.3)
Gene namesi
Name:pbsA1
Ordered Locus Names:sll1184
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
ProteomesiUP000001425: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 240240Heme oxygenase 1
PRO_0000209701Add
BLAST

Proteomic databases

PaxDbiP72849.

Interactioni

Protein-protein interaction databases

IntActiP72849. 2 interactions.
STRINGi1148.sll1184.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi5 – 128
Helixi14 – 218
Helixi24 – 307
Helixi36 – 5924
Turni60 – 623
Helixi66 – 694
Helixi77 – 8812
Helixi92 – 954
Helixi100 – 11516
Helixi117 – 1193
Helixi120 – 14627
Beta strandi149 – 1524
Helixi154 – 1563
Helixi164 – 17613
Helixi182 – 20524
Helixi207 – 22216

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WE1X-ray2.50A/B/C/D1-240[»]
ProteinModelPortaliP72849.
SMRiP72849. Positions 2-223.

Miscellaneous databases

EvolutionaryTraceiP72849.

Family & Domainsi

Sequence similaritiesi

Belongs to the heme oxygenase family.

Phylogenomic databases

eggNOGiCOG5398.
HOGENOMiHOG000233221.
KOiK00510.
OMAiIGKIPPY.
OrthoDBiEOG69PQ2G.
PhylomeDBiP72849.

Family and domain databases

Gene3Di1.20.910.10. 1 hit.
InterProiIPR002051. Haem_Oase.
IPR016053. Haem_Oase-like.
IPR016084. Haem_Oase-like_multi-hlx.
IPR018207. Haem_oxygenase_CS.
[Graphical view]
PANTHERiPTHR10720. PTHR10720. 1 hit.
PfamiPF01126. Heme_oxygenase. 1 hit.
[Graphical view]
PIRSFiPIRSF000343. Haem_Oase. 1 hit.
PRINTSiPR00088. HAEMOXYGNASE.
SUPFAMiSSF48613. SSF48613. 1 hit.
PROSITEiPS00593. HEME_OXYGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P72849-1 [UniParc]FASTAAdd to Basket

« Hide

MSVNLASQLR EGTKKSHSMA ENVGFVKCFL KGVVEKNSYR KLVGNLYFVY    50
SAMEEEMAKF KDHPILSHIY FPELNRKQSL EQDLQFYYGS NWRQEVKISA 100
AGQAYVDRVR QVAATAPELL VAHSYTRYLG DLSGGQILKK IAQNAMNLHD 150
GGTAFYEFAD IDDEKAFKNT YRQAMNDLPI DQATAERIVD EANDAFAMNM 200
KMFNELEGNL IKAIGIMVFN SLTRRRSQGS TEVGLATSEG 240
Length:240
Mass (Da):27,051
Last modified:February 1, 1997 - v1
Checksum:i7F17A033768BAFA8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000022 Genomic DNA. Translation: BAA16864.1.
PIRiS74713.
RefSeqiNP_440184.1. NC_000911.1.
YP_005650241.1. NC_017277.1.
YP_007450067.1. NC_020286.1.

Genome annotation databases

EnsemblBacteriaiBAA16864; BAA16864; BAA16864.
GeneIDi953483.
KEGGisyn:sll1184.
syy:SYNGTS_0288.
syz:MYO_12900.
PATRICi23837492. VBISynSp132158_0318.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000022 Genomic DNA. Translation: BAA16864.1 .
PIRi S74713.
RefSeqi NP_440184.1. NC_000911.1.
YP_005650241.1. NC_017277.1.
YP_007450067.1. NC_020286.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1WE1 X-ray 2.50 A/B/C/D 1-240 [» ]
ProteinModelPortali P72849.
SMRi P72849. Positions 2-223.
ModBasei Search...

Protein-protein interaction databases

IntActi P72849. 2 interactions.
STRINGi 1148.sll1184.

Proteomic databases

PaxDbi P72849.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAA16864 ; BAA16864 ; BAA16864 .
GeneIDi 953483.
KEGGi syn:sll1184.
syy:SYNGTS_0288.
syz:MYO_12900.
PATRICi 23837492. VBISynSp132158_0318.

Phylogenomic databases

eggNOGi COG5398.
HOGENOMi HOG000233221.
KOi K00510.
OMAi IGKIPPY.
OrthoDBi EOG69PQ2G.
PhylomeDBi P72849.

Enzyme and pathway databases

BioCyci MetaCyc:MONOMER-13860.

Miscellaneous databases

EvolutionaryTracei P72849.

Family and domain databases

Gene3Di 1.20.910.10. 1 hit.
InterProi IPR002051. Haem_Oase.
IPR016053. Haem_Oase-like.
IPR016084. Haem_Oase-like_multi-hlx.
IPR018207. Haem_oxygenase_CS.
[Graphical view ]
PANTHERi PTHR10720. PTHR10720. 1 hit.
Pfami PF01126. Heme_oxygenase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000343. Haem_Oase. 1 hit.
PRINTSi PR00088. HAEMOXYGNASE.
SUPFAMi SSF48613. SSF48613. 1 hit.
PROSITEi PS00593. HEME_OXYGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
    Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
    , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 6803 / Kazusa.
  2. "Crystal structure of heme oxygenase-1 from cyanobacterium Synechocystis sp. PCC 6803 in complex with heme."
    Sugishima M., Migita C.T., Zhang X., Yoshida T., Fukuyama K.
    Eur. J. Biochem. 271:4517-4525(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) IN COMPLEX WITH HEME, IRON-BINDING SITE.

Entry informationi

Entry nameiHO1_SYNY3
AccessioniPrimary (citable) accession number: P72849
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: February 1, 1997
Last modified: July 9, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

External Data

Dasty 3

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