Reviewed, UniProtKB/Swiss-Prot P72849 (HO1_SYNY3)

Names and origin

Protein names

Recommended name:
    Heme oxygenase 1
    EC=1.14.99.3

Gene names

Name:	pbsA1
Ordered Locus Names:	sll1184

Organism

Synechocystis sp. (strain PCC 6803) [Complete proteome] [HAMAP]

Taxonomic identifier

1148 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Synechocystis

Protein attributes

Sequence length	240 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Catalyzes the opening of the heme ring with the release of iron. Key enzyme in the synthesis of the chromophoric part of the photosynthetic antennae By similarity.
Catalytic activity	Heme + 3 AH2 + 3 O2 = biliverdin + Fe2+ + CO + 3 A + 3 H2O.
Sequence similarities	Belongs to the heme oxygenase family.

Ontologies

Keywords
Biological process	Photosynthesis
Ligand	Heme Iron Metal-binding
Molecular function	Oxidoreductase
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Biological process	heme oxidation Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW photosynthesis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	heme oxygenase (decyclizing) activity Inferred from electronic annotation. Source: EC iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 240

240

Heme oxygenase 1

PRO_0000209701

Sites

Metal binding

17

1

Iron (heme axial ligand)

Secondary structure

1

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240

Helix Strand Turn

Details...

Helix

5 – 12

8

Helix

14 – 21

8

Helix

24 – 30

7

Helix

36 – 59

24

Turn

60 – 62

3

Helix

66 – 69

4

Helix

77 – 88

12

Helix

92 – 95

4

Helix

100 – 115

16

Helix

117 – 119

3

Helix

120 – 146

27

Beta strand

149 – 152

4

Helix

154 – 156

3

Helix

164 – 176

13

Helix

182 – 205

24

Helix

207 – 222

16

Sequences

	Sequence		Length	Mass (Da)
	P72849-1 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: 7F17A033768BAFA8	FASTA	240	27,051
	10 20 30 40 50 60 MSVNLASQLR EGTKKSHSMA ENVGFVKCFL KGVVEKNSYR KLVGNLYFVY SAMEEEMAKF 70 80 90 100 110 120 KDHPILSHIY FPELNRKQSL EQDLQFYYGS NWRQEVKISA AGQAYVDRVR QVAATAPELL 130 140 150 160 170 180 VAHSYTRYLG DLSGGQILKK IAQNAMNLHD GGTAFYEFAD IDDEKAFKNT YRQAMNDLPI 190 200 210 220 230 240 DQATAERIVD EANDAFAMNM KMFNELEGNL IKAIGIMVFN SLTRRRSQGS TEVGLATSEG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions." Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S. DNA Res. 3:109-136(1996) [PubMed: 8905231] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"Crystal structure of heme oxygenase-1 from cyanobacterium Synechocystis sp. PCC 6803 in complex with heme." Sugishima M., Migita C.T., Zhang X., Yoshida T., Fukuyama K. Eur. J. Biochem. 271:4517-4525(2004) [PubMed: 15560792] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) IN COMPLEX WITH HEME, IRON-BINDING SITE.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBLGenBankDDBJ

BA000022 Genomic DNA. Translation: BAA16864.1.

PIR

S74713.

RefSeq

NP_440184.1.

3D structure databases

PDBPDBe

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1WE1	X-ray	2.50	A/B/C/D	1-240	[»]

ModBase

Search...

Protein-protein interaction databases

IntAct

P72849. 2 interactions.

Genome annotation databases

GeneID

953483.

GenomeReviews

Gene locus sll1184 in contig BA000022_GR.

KEGG

syn:sll1184.

NMPDR

fig|1148.1.peg.285.

Organism-specific databases

CMR

Search...

Phylogenomic databases

HOGENOM

P72849.

OMA

P72849. REGTKKS.

Enzyme and pathway databases

BioCyc

MetaCyc:MON-13860.
SSP1148:SLL1184-MON.

Family and domain databases

InterPro

IPR002051. Haem_Oase.
IPR016053. Haem_Oase-like.
IPR016084. Haem_Oase-like_multi-hlx.
IPR018207. Haem_oxygenase_CS.
[Graphical view]

Gene3D

G3DSA:1.20.910.10. Haem_Oase-like_multi-hlx. 1 hit.

PANTHER

PTHR10720. Haem_Oase. 1 hit.

Pfam

PF01126. Heme_oxygenase. 1 hit.
[Graphical view]

PIRSF

PIRSF000343. Haem_Oase. 1 hit.

PRINTS

PR00088. HAEMOXYGNASE.

PROSITE

PS00593. HEME_OXYGENASE. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

HO1_SYNY3

Accession

Primary (citable) accession number: P72849

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	February 1, 1997
Last modified:	June 16, 2009
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)