Reviewed,
UniProtKB/Swiss-Prot P72849 (HO1_SYNY3)
Last modified
June 16, 2009.
Version 63.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Heme oxygenase 1 EC=1.14.99.3 | ||||
| Gene names |
| ||||
| Organism | Synechocystis sp. (strain PCC 6803) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 1148 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Cyanobacteria › Chroococcales › Synechocystis |
Protein attributes
| Sequence length | 240 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Catalyzes the opening of the heme ring with the release of iron. Key enzyme in the synthesis of the chromophoric part of the photosynthetic antennae By similarity. |
| Catalytic activity | Heme + 3 AH2 + 3 O2 = biliverdin + Fe2+ + CO + 3 A + 3 H2O. |
| Sequence similarities | Belongs to the heme oxygenase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Photosynthesis |
| Ligand | Heme Iron Metal-binding |
| Molecular function | Oxidoreductase |
| Technical term | 3D-structure Complete proteome |
| Gene Ontology (GO) | |
| Biological process | heme oxidation Inferred from electronic annotation. Source: InterPro oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW photosynthesisInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | heme oxygenase (decyclizing) activity Inferred from electronic annotation. Source: EC iron ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||||||||||||||||||||||||||||||
Molecule processing | |||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 240 | 240 | Heme oxygenase 1 | PRO_0000209701 | |||||||||||||||||||||||||||||||||||
Sites | |||||||||||||||||||||||||||||||||||||||
| Metal binding | 17 | 1 | Iron (heme axial ligand) | ||||||||||||||||||||||||||||||||||||
Secondary structure | |||||||||||||||||||||||||||||||||||||||
Helix Strand Turn | |||||||||||||||||||||||||||||||||||||||
| Helix | 5 – 12 | 8 | |||||||||||||||||||||||||||||||||||||
| Helix | 14 – 21 | 8 | |||||||||||||||||||||||||||||||||||||
| Helix | 24 – 30 | 7 | |||||||||||||||||||||||||||||||||||||
| Helix | 36 – 59 | 24 | |||||||||||||||||||||||||||||||||||||
| Turn | 60 – 62 | 3 | |||||||||||||||||||||||||||||||||||||
| Helix | 66 – 69 | 4 | |||||||||||||||||||||||||||||||||||||
| Helix | 77 – 88 | 12 | |||||||||||||||||||||||||||||||||||||
| Helix | 92 – 95 | 4 | |||||||||||||||||||||||||||||||||||||
| Helix | 100 – 115 | 16 | |||||||||||||||||||||||||||||||||||||
| Helix | 117 – 119 | 3 | |||||||||||||||||||||||||||||||||||||
| Helix | 120 – 146 | 27 | |||||||||||||||||||||||||||||||||||||
| Beta strand | 149 – 152 | 4 | |||||||||||||||||||||||||||||||||||||
| Helix | 154 – 156 | 3 | |||||||||||||||||||||||||||||||||||||
| Helix | 164 – 176 | 13 | |||||||||||||||||||||||||||||||||||||
| Helix | 182 – 205 | 24 | |||||||||||||||||||||||||||||||||||||
| Helix | 207 – 222 | 16 | |||||||||||||||||||||||||||||||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions." Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. Tabata S.DNA Res. 3:109-136(1996) [PubMed: 8905231] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [2] | "Crystal structure of heme oxygenase-1 from cyanobacterium Synechocystis sp. PCC 6803 in complex with heme." Sugishima M., Migita C.T., Zhang X., Yoshida T., Fukuyama K. Eur. J. Biochem. 271:4517-4525(2004) [PubMed: 15560792] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) IN COMPLEX WITH HEME, IRON-BINDING SITE. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BA000022 Genomic DNA. Translation: BAA16864.1. | |||||||||||||
| PIR | S74713. | ||||||||||||
| RefSeq | NP_440184.1. | ||||||||||||
3D structure databases | |||||||||||||
| |||||||||||||
| ModBase | Search... | ||||||||||||
Protein-protein interaction databases | |||||||||||||
| IntAct | P72849. 2 interactions. | ||||||||||||
Genome annotation databases | |||||||||||||
| GeneID | 953483. | ||||||||||||
| GenomeReviews | Gene locus sll1184 in contig BA000022_GR. | ||||||||||||
| KEGG | syn:sll1184. | ||||||||||||
| NMPDR | fig|1148.1.peg.285. | ||||||||||||
Organism-specific databases | |||||||||||||
| CMR | Search... | ||||||||||||
Phylogenomic databases | |||||||||||||
| HOGENOM | P72849. | ||||||||||||
| OMA | P72849. REGTKKS. | ||||||||||||
Enzyme and pathway databases | |||||||||||||
| BioCyc | MetaCyc:MON-13860. SSP1148:SLL1184-MON. | ||||||||||||
Family and domain databases | |||||||||||||
| InterPro | IPR002051. Haem_Oase. IPR016053. Haem_Oase-like. IPR016084. Haem_Oase-like_multi-hlx. IPR018207. Haem_oxygenase_CS. [Graphical view] | ||||||||||||
| Gene3D | G3DSA:1.20.910.10. Haem_Oase-like_multi-hlx. 1 hit. | ||||||||||||
| PANTHER | PTHR10720. Haem_Oase. 1 hit. | ||||||||||||
| Pfam | PF01126. Heme_oxygenase. 1 hit. [Graphical view] | ||||||||||||
| PIRSF | PIRSF000343. Haem_Oase. 1 hit. | ||||||||||||
| PRINTS | PR00088. HAEMOXYGNASE. | ||||||||||||
| PROSITE | PS00593. HEME_OXYGENASE. 1 hit. [Graphical view] | ||||||||||||
| ProtoNet | Search... | ||||||||||||
Entry information
| Entry name | HO1_SYNY3 | ||||||||
| Accession | Primary (citable) accession number: P72849 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |
| Synechocystis PCC 6803 Synechocystis (strain PCC 6803): entries and gene names |

Clusters with


