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Protein

Heme oxygenase 1

Gene

pbsA1

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the opening of the heme ring with the release of iron. Key enzyme in the synthesis of the chromophoric part of the photosynthetic antennae (By similarity).By similarity

Catalytic activityi

Protoheme + 3 AH2 + 3 O2 = biliverdin + Fe2+ + CO + 3 A + 3 H2O.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi17 – 171Iron (heme axial ligand)

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Photosynthesis

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-13860.

Names & Taxonomyi

Protein namesi
Recommended name:
Heme oxygenase 1 (EC:1.14.99.3)
Gene namesi
Name:pbsA1
Ordered Locus Names:sll1184
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
ProteomesiUP000001425 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 240240Heme oxygenase 1PRO_0000209701Add
BLAST

Proteomic databases

PaxDbiP72849.

Interactioni

Protein-protein interaction databases

IntActiP72849. 2 interactions.

Structurei

Secondary structure

1
240
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi5 – 128Combined sources
Helixi14 – 218Combined sources
Helixi24 – 307Combined sources
Helixi36 – 5924Combined sources
Turni60 – 623Combined sources
Helixi66 – 694Combined sources
Helixi77 – 8812Combined sources
Helixi92 – 954Combined sources
Helixi100 – 11516Combined sources
Helixi117 – 1193Combined sources
Helixi120 – 14627Combined sources
Beta strandi149 – 1524Combined sources
Helixi154 – 1563Combined sources
Helixi164 – 17613Combined sources
Helixi182 – 20524Combined sources
Helixi207 – 22216Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WE1X-ray2.50A/B/C/D1-240[»]
ProteinModelPortaliP72849.
SMRiP72849. Positions 2-223.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP72849.

Family & Domainsi

Sequence similaritiesi

Belongs to the heme oxygenase family.Curated

Phylogenomic databases

eggNOGiCOG5398.
HOGENOMiHOG000233221.
InParanoidiP72849.
KOiK00510.
OMAiEHPVIKP.
OrthoDBiEOG69PQ2G.
PhylomeDBiP72849.

Family and domain databases

Gene3Di1.20.910.10. 1 hit.
InterProiIPR002051. Haem_Oase.
IPR016053. Haem_Oase-like.
IPR016084. Haem_Oase-like_multi-hlx.
IPR018207. Haem_oxygenase_CS.
[Graphical view]
PANTHERiPTHR10720. PTHR10720. 1 hit.
PfamiPF01126. Heme_oxygenase. 1 hit.
[Graphical view]
PIRSFiPIRSF000343. Haem_Oase. 1 hit.
PRINTSiPR00088. HAEMOXYGNASE.
SUPFAMiSSF48613. SSF48613. 1 hit.
PROSITEiPS00593. HEME_OXYGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P72849-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVNLASQLR EGTKKSHSMA ENVGFVKCFL KGVVEKNSYR KLVGNLYFVY
60 70 80 90 100
SAMEEEMAKF KDHPILSHIY FPELNRKQSL EQDLQFYYGS NWRQEVKISA
110 120 130 140 150
AGQAYVDRVR QVAATAPELL VAHSYTRYLG DLSGGQILKK IAQNAMNLHD
160 170 180 190 200
GGTAFYEFAD IDDEKAFKNT YRQAMNDLPI DQATAERIVD EANDAFAMNM
210 220 230 240
KMFNELEGNL IKAIGIMVFN SLTRRRSQGS TEVGLATSEG
Length:240
Mass (Da):27,051
Last modified:February 1, 1997 - v1
Checksum:i7F17A033768BAFA8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA16864.1.
PIRiS74713.

Genome annotation databases

EnsemblBacteriaiBAA16864; BAA16864; BAA16864.
KEGGisyy:SYNGTS_0288.
syz:MYO_12900.
PATRICi23837492. VBISynSp132158_0318.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA16864.1.
PIRiS74713.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WE1X-ray2.50A/B/C/D1-240[»]
ProteinModelPortaliP72849.
SMRiP72849. Positions 2-223.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP72849. 2 interactions.

Proteomic databases

PaxDbiP72849.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA16864; BAA16864; BAA16864.
KEGGisyy:SYNGTS_0288.
syz:MYO_12900.
PATRICi23837492. VBISynSp132158_0318.

Phylogenomic databases

eggNOGiCOG5398.
HOGENOMiHOG000233221.
InParanoidiP72849.
KOiK00510.
OMAiEHPVIKP.
OrthoDBiEOG69PQ2G.
PhylomeDBiP72849.

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-13860.

Miscellaneous databases

EvolutionaryTraceiP72849.

Family and domain databases

Gene3Di1.20.910.10. 1 hit.
InterProiIPR002051. Haem_Oase.
IPR016053. Haem_Oase-like.
IPR016084. Haem_Oase-like_multi-hlx.
IPR018207. Haem_oxygenase_CS.
[Graphical view]
PANTHERiPTHR10720. PTHR10720. 1 hit.
PfamiPF01126. Heme_oxygenase. 1 hit.
[Graphical view]
PIRSFiPIRSF000343. Haem_Oase. 1 hit.
PRINTSiPR00088. HAEMOXYGNASE.
SUPFAMiSSF48613. SSF48613. 1 hit.
PROSITEiPS00593. HEME_OXYGENASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
    Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
    , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 6803 / Kazusa.
  2. "Crystal structure of heme oxygenase-1 from cyanobacterium Synechocystis sp. PCC 6803 in complex with heme."
    Sugishima M., Migita C.T., Zhang X., Yoshida T., Fukuyama K.
    Eur. J. Biochem. 271:4517-4525(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) IN COMPLEX WITH HEME, IRON-BINDING SITE.

Entry informationi

Entry nameiHO1_SYNY3
AccessioniPrimary (citable) accession number: P72849
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: February 1, 1997
Last modified: July 22, 2015
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.