Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Heme oxygenase 1

Gene

pbsA1

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the opening of the heme ring with the release of iron. Key enzyme in the synthesis of the chromophoric part of the photosynthetic antennae.By similarity

Catalytic activityi

Protoheme + 3 [reduced NADPH--hemoprotein reductase] + 3 O2 = biliverdin + Fe2+ + CO + 3 [oxidized NADPH--hemoprotein reductase] + 3 H2O.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi17Iron (heme axial ligand)1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Photosynthesis

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-13860.

Names & Taxonomyi

Protein namesi
Recommended name:
Heme oxygenase 1 (EC:1.14.14.18By similarity)
Gene namesi
Name:pbsA1
Ordered Locus Names:sll1184
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesMerismopediaceaeSynechocystis
Proteomesi
  • UP000001425 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002097011 – 240Heme oxygenase 1Add BLAST240

Interactioni

Protein-protein interaction databases

IntActiP72849. 2 interactors.

Structurei

Secondary structure

1240
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi5 – 12Combined sources8
Helixi14 – 21Combined sources8
Helixi24 – 30Combined sources7
Helixi36 – 59Combined sources24
Turni60 – 62Combined sources3
Helixi66 – 69Combined sources4
Helixi77 – 88Combined sources12
Helixi92 – 95Combined sources4
Helixi100 – 115Combined sources16
Helixi117 – 119Combined sources3
Helixi120 – 146Combined sources27
Beta strandi149 – 152Combined sources4
Helixi154 – 156Combined sources3
Helixi164 – 176Combined sources13
Helixi182 – 205Combined sources24
Helixi207 – 222Combined sources16

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WE1X-ray2.50A/B/C/D1-240[»]
ProteinModelPortaliP72849.
SMRiP72849.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP72849.

Family & Domainsi

Sequence similaritiesi

Belongs to the heme oxygenase family.Curated

Phylogenomic databases

HOGENOMiHOG000233221.
InParanoidiP72849.
KOiK00510.
OMAiEHPVIKP.
PhylomeDBiP72849.

Family and domain databases

Gene3Di1.20.910.10. 1 hit.
InterProiIPR002051. Haem_Oase.
IPR016053. Haem_Oase-like.
IPR016084. Haem_Oase-like_multi-hlx.
IPR018207. Haem_oxygenase_CS.
[Graphical view]
PANTHERiPTHR10720. PTHR10720. 1 hit.
PfamiPF01126. Heme_oxygenase. 1 hit.
[Graphical view]
PIRSFiPIRSF000343. Haem_Oase. 1 hit.
PRINTSiPR00088. HAEMOXYGNASE.
SUPFAMiSSF48613. SSF48613. 1 hit.
PROSITEiPS00593. HEME_OXYGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P72849-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVNLASQLR EGTKKSHSMA ENVGFVKCFL KGVVEKNSYR KLVGNLYFVY
60 70 80 90 100
SAMEEEMAKF KDHPILSHIY FPELNRKQSL EQDLQFYYGS NWRQEVKISA
110 120 130 140 150
AGQAYVDRVR QVAATAPELL VAHSYTRYLG DLSGGQILKK IAQNAMNLHD
160 170 180 190 200
GGTAFYEFAD IDDEKAFKNT YRQAMNDLPI DQATAERIVD EANDAFAMNM
210 220 230 240
KMFNELEGNL IKAIGIMVFN SLTRRRSQGS TEVGLATSEG
Length:240
Mass (Da):27,051
Last modified:February 1, 1997 - v1
Checksum:i7F17A033768BAFA8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA16864.1.
PIRiS74713.

Genome annotation databases

EnsemblBacteriaiBAA16864; BAA16864; BAA16864.
KEGGisyn:sll1184.
PATRICi23837492. VBISynSp132158_0318.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA16864.1.
PIRiS74713.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WE1X-ray2.50A/B/C/D1-240[»]
ProteinModelPortaliP72849.
SMRiP72849.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP72849. 2 interactors.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA16864; BAA16864; BAA16864.
KEGGisyn:sll1184.
PATRICi23837492. VBISynSp132158_0318.

Phylogenomic databases

HOGENOMiHOG000233221.
InParanoidiP72849.
KOiK00510.
OMAiEHPVIKP.
PhylomeDBiP72849.

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-13860.

Miscellaneous databases

EvolutionaryTraceiP72849.

Family and domain databases

Gene3Di1.20.910.10. 1 hit.
InterProiIPR002051. Haem_Oase.
IPR016053. Haem_Oase-like.
IPR016084. Haem_Oase-like_multi-hlx.
IPR018207. Haem_oxygenase_CS.
[Graphical view]
PANTHERiPTHR10720. PTHR10720. 1 hit.
PfamiPF01126. Heme_oxygenase. 1 hit.
[Graphical view]
PIRSFiPIRSF000343. Haem_Oase. 1 hit.
PRINTSiPR00088. HAEMOXYGNASE.
SUPFAMiSSF48613. SSF48613. 1 hit.
PROSITEiPS00593. HEME_OXYGENASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHO1_SYNY3
AccessioniPrimary (citable) accession number: P72849
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: February 1, 1997
Last modified: November 30, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.