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P72830

- PFKA1_SYNY3

UniProt

P72830 - PFKA1_SYNY3

Protein

ATP-dependent 6-phosphofructokinase 1

Gene

pfkA1

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.UniRule annotation

    Catalytic activityi

    ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei14 – 141ATP; via amide nitrogenUniRule annotation
    Metal bindingi117 – 1171Magnesium; catalyticUniRule annotation
    Sitei118 – 1181Important for substrate specificity; cannot use PPi as phosphoryl donorUniRule annotation
    Active sitei142 – 1421Proton acceptorUniRule annotation
    Binding sitei177 – 1771Substrate; shared with dimeric partnerUniRule annotation
    Binding sitei237 – 2371SubstrateUniRule annotation
    Binding sitei278 – 2781Substrate; shared with dimeric partnerUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi79 – 802ATPUniRule annotation
    Nucleotide bindingi116 – 1194ATPUniRule annotation

    GO - Molecular functioni

    1. 6-phosphofructokinase activity Source: UniProtKB-EC
    2. ATP binding Source: UniProtKB-KW
    3. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. fructose 6-phosphate metabolic process Source: InterPro
    2. glycolytic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00109; UER00182.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ATP-dependent 6-phosphofructokinase 1UniRule annotation (EC:2.7.1.11UniRule annotation)
    Short name:
    ATP-PFK 1UniRule annotation
    Short name:
    Phosphofructokinase 1UniRule annotation
    Alternative name(s):
    Phosphohexokinase 1UniRule annotation
    Gene namesi
    Name:pfkA1UniRule annotation
    Synonyms:pfkA
    Ordered Locus Names:sll1196
    OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
    Taxonomic identifieri1111708 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
    ProteomesiUP000001425: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. 6-phosphofructokinase complex Source: InterPro

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 361361ATP-dependent 6-phosphofructokinase 1PRO_0000111998Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer or homotetramer.UniRule annotation

    Protein-protein interaction databases

    IntActiP72830. 1 interaction.
    STRINGi1148.sll1196.

    Structurei

    3D structure databases

    ProteinModelPortaliP72830.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni140 – 1423Substrate bindingUniRule annotation
    Regioni184 – 1863Substrate bindingUniRule annotation
    Regioni284 – 2874Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0205.
    HOGENOMiHOG000248869.
    KOiK00850.
    OMAiNEICKAM.
    OrthoDBiEOG644ZRM.
    PhylomeDBiP72830.

    Family and domain databases

    HAMAPiMF_01976. Phosphofructokinase_III.
    InterProiIPR012003. ATP_PFK_prok.
    IPR012829. PFK.
    IPR022953. Phosphofructokinase.
    IPR015912. Phosphofructokinase_CS.
    IPR000023. Phosphofructokinase_dom.
    [Graphical view]
    PfamiPF00365. PFK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000532. ATP_PFK_prok. 1 hit.
    PRINTSiPR00476. PHFRCTKINASE.
    SUPFAMiSSF53784. SSF53784. 1 hit.
    TIGRFAMsiTIGR02483. PFK_mixed. 1 hit.
    PROSITEiPS00433. PHOSPHOFRUCTOKINASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P72830-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGEIKRIGIL TSGGDCAGLN AVIRSVVHHA IGTYGWEVIG IQEATQGLME    50
    NPSKAIALHR DNIDHLLMMG GTFLGTTNKG NPFAFPMADG TVRDRTEDII 100
    AGYRQLGLDA LIGIGGDGSL AILRRIAQQG GINLVGIPKT IDNDVGATEI 150
    SIGFDTATNI ATEALDRLHF TAASHNRVMV LEVMGRDAGH IALAAGIGGG 200
    ADIILIPEIP YRIQSVCNKI RQRQAEGKNF CLVMVSEAVR TELGDQVKQI 250
    QQFGEDRYGG IGKYIAEQIA QRTGAETRVT VLGHIQRGGI PSPFDRLLGS 300
    VFGVAAVDLI AEGKFDHMVA WRNRQTISVP IEEAIQTYQT VQLDGTLVKT 350
    ARGLGICLGN D 361
    Length:361
    Mass (Da):38,588
    Last modified:February 1, 1997 - v1
    Checksum:i96A83E05F318552C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000022 Genomic DNA. Translation: BAA16845.1.
    PIRiS74694.
    RefSeqiNP_440165.1. NC_000911.1.
    YP_005650222.1. NC_017277.1.
    YP_007450048.1. NC_020286.1.

    Genome annotation databases

    EnsemblBacteriaiBAA16845; BAA16845; BAA16845.
    GeneIDi953464.
    KEGGisyn:sll1196.
    syy:SYNGTS_0269.
    syz:MYO_12710.
    PATRICi23837450. VBISynSp132158_0297.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000022 Genomic DNA. Translation: BAA16845.1 .
    PIRi S74694.
    RefSeqi NP_440165.1. NC_000911.1.
    YP_005650222.1. NC_017277.1.
    YP_007450048.1. NC_020286.1.

    3D structure databases

    ProteinModelPortali P72830.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P72830. 1 interaction.
    STRINGi 1148.sll1196.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAA16845 ; BAA16845 ; BAA16845 .
    GeneIDi 953464.
    KEGGi syn:sll1196.
    syy:SYNGTS_0269.
    syz:MYO_12710.
    PATRICi 23837450. VBISynSp132158_0297.

    Phylogenomic databases

    eggNOGi COG0205.
    HOGENOMi HOG000248869.
    KOi K00850.
    OMAi NEICKAM.
    OrthoDBi EOG644ZRM.
    PhylomeDBi P72830.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00182 .

    Family and domain databases

    HAMAPi MF_01976. Phosphofructokinase_III.
    InterProi IPR012003. ATP_PFK_prok.
    IPR012829. PFK.
    IPR022953. Phosphofructokinase.
    IPR015912. Phosphofructokinase_CS.
    IPR000023. Phosphofructokinase_dom.
    [Graphical view ]
    Pfami PF00365. PFK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000532. ATP_PFK_prok. 1 hit.
    PRINTSi PR00476. PHFRCTKINASE.
    SUPFAMi SSF53784. SSF53784. 1 hit.
    TIGRFAMsi TIGR02483. PFK_mixed. 1 hit.
    PROSITEi PS00433. PHOSPHOFRUCTOKINASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
      Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
      , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
      DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 6803 / Kazusa.

    Entry informationi

    Entry nameiPFKA1_SYNY3
    AccessioniPrimary (citable) accession number: P72830
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families
    3. Synechocystis PCC 6803
      Synechocystis (strain PCC 6803): entries and gene names

    External Data

    Dasty 3