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P72800 (MSRA2_SYNY3) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Peptide methionine sulfoxide reductase MsrA 2

Short name=Protein-methionine-S-oxide reductase 2
EC=1.8.4.11
Alternative name(s):
Peptide-methionine (S)-S-oxide reductase 2
Short name=Peptide Met(O) reductase 2
Gene names
Name:msrA2
Ordered Locus Names:slr1795
OrganismSynechocystis sp. (strain PCC 6803 / Kazusa) [Reference proteome] [HAMAP]
Taxonomic identifier1111708 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis

Protein attributes

Sequence length214 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine By similarity. HAMAP-Rule MF_01401

Catalytic activity

Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin. HAMAP-Rule MF_01401

L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. HAMAP-Rule MF_01401

Sequence similarities

Belongs to the MsrA Met sulfoxide reductase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 214214Peptide methionine sulfoxide reductase MsrA 2 HAMAP-Rule MF_01401
PRO_0000138602

Sites

Active site451 By similarity

Sequences

Sequence LengthMass (Da)Tools
P72800 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: 785DEAB941703338

FASTA21423,605
        10         20         30         40         50         60 
MGLAIAVGSF LISPFSKVIP DPVVDINPVS TTARGTEKAV FAGGCFWGLE AMFEEVRGVK 

        70         80         90        100        110        120 
DVQTGYSGGT EATANYARVS GGGTDHAESI EIVYDPAQVS YGELLKIFFS VGHDPTQVNR 

       130        140        150        160        170        180 
QGVDQGRQYR SAIFATTPEQ KQVAQAYIDQ LEESQAFDQA IATEVNDFDA FYPAEDYHQD 

       190        200        210 
FVQRNPAHPY VLVHDLPKLR KFRQQYSDKL KAQS 

« Hide

References

[1]"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. expand/collapse author list , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PCC 6803 / Kazusa.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000022 Genomic DNA. Translation: BAA16815.1.
PIRS74663.
RefSeqNP_440135.1. NC_000911.1.
YP_005650192.1. NC_017277.1.
YP_007450018.1. NC_020286.1.

3D structure databases

ProteinModelPortalP72800.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP72800. 1 interaction.
STRING1148.slr1795.

Proteomic databases

PaxDbP72800.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAA16815; BAA16815; BAA16815.
GeneID953434.
KEGGsyn:slr1795.
syy:SYNGTS_0239.
syz:MYO_12400.
PATRIC23837374. VBISynSp132158_0260.

Phylogenomic databases

eggNOGCOG0225.
HOGENOMHOG000263863.
KOK07304.
OMAGTETAIF.
OrthoDBEOG6091JX.
PhylomeDBP72800.

Enzyme and pathway databases

BioCycRETL1328306-WGS:GSTH-5859-MONOMER.

Family and domain databases

Gene3D3.30.1060.10. 1 hit.
HAMAPMF_01401. MsrA.
InterProIPR028427. Met_Sox_Rdtase.
IPR002569. Met_Sox_Rdtase_MsrA.
[Graphical view]
PANTHERPTHR10173. PTHR10173. 1 hit.
PfamPF01625. PMSR. 1 hit.
[Graphical view]
SUPFAMSSF55068. SSF55068. 1 hit.
TIGRFAMsTIGR00401. msrA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMSRA2_SYNY3
AccessionPrimary (citable) accession number: P72800
Entry history
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: February 1, 1997
Last modified: July 9, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Synechocystis PCC 6803

Synechocystis (strain PCC 6803): entries and gene names

SIMILARITY comments

Index of protein domains and families