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P72800

- MSRA2_SYNY3

UniProt

P72800 - MSRA2_SYNY3

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Protein
Peptide methionine sulfoxide reductase MsrA 2
Gene
msrA2, slr1795
Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine By similarity.UniRule annotation

Catalytic activityi

Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin.UniRule annotation
L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei45 – 451 By similarity

GO - Molecular functioni

  1. peptide-methionine (S)-S-oxide reductase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. cellular protein modification process Source: UniProtKB-HAMAP
  2. protein repair Source: InterPro
  3. response to oxidative stress Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciRETL1328306-WGS:GSTH-5859-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide methionine sulfoxide reductase MsrA 2 (EC:1.8.4.11)
Short name:
Protein-methionine-S-oxide reductase 2
Alternative name(s):
Peptide-methionine (S)-S-oxide reductase 2
Short name:
Peptide Met(O) reductase 2
Gene namesi
Name:msrA2
Ordered Locus Names:slr1795
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
ProteomesiUP000001425: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 214214Peptide methionine sulfoxide reductase MsrA 2UniRule annotation
PRO_0000138602Add
BLAST

Proteomic databases

PaxDbiP72800.

Interactioni

Protein-protein interaction databases

IntActiP72800. 1 interaction.
STRINGi1148.slr1795.

Structurei

3D structure databases

ProteinModelPortaliP72800.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0225.
HOGENOMiHOG000263863.
KOiK07304.
OMAiGTETAIF.
OrthoDBiEOG6091JX.
PhylomeDBiP72800.

Family and domain databases

Gene3Di3.30.1060.10. 1 hit.
HAMAPiMF_01401. MsrA.
InterProiIPR028427. Met_Sox_Rdtase.
IPR002569. Met_Sox_Rdtase_MsrA.
[Graphical view]
PANTHERiPTHR10173. PTHR10173. 1 hit.
PfamiPF01625. PMSR. 1 hit.
[Graphical view]
SUPFAMiSSF55068. SSF55068. 1 hit.
TIGRFAMsiTIGR00401. msrA. 1 hit.

Sequencei

Sequence statusi: Complete.

P72800-1 [UniParc]FASTAAdd to Basket

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MGLAIAVGSF LISPFSKVIP DPVVDINPVS TTARGTEKAV FAGGCFWGLE    50
AMFEEVRGVK DVQTGYSGGT EATANYARVS GGGTDHAESI EIVYDPAQVS 100
YGELLKIFFS VGHDPTQVNR QGVDQGRQYR SAIFATTPEQ KQVAQAYIDQ 150
LEESQAFDQA IATEVNDFDA FYPAEDYHQD FVQRNPAHPY VLVHDLPKLR 200
KFRQQYSDKL KAQS 214
Length:214
Mass (Da):23,605
Last modified:February 1, 1997 - v1
Checksum:i785DEAB941703338
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000022 Genomic DNA. Translation: BAA16815.1.
PIRiS74663.
RefSeqiNP_440135.1. NC_000911.1.
YP_005650192.1. NC_017277.1.
YP_007450018.1. NC_020286.1.

Genome annotation databases

EnsemblBacteriaiBAA16815; BAA16815; BAA16815.
GeneIDi953434.
KEGGisyn:slr1795.
syy:SYNGTS_0239.
syz:MYO_12400.
PATRICi23837374. VBISynSp132158_0260.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000022 Genomic DNA. Translation: BAA16815.1 .
PIRi S74663.
RefSeqi NP_440135.1. NC_000911.1.
YP_005650192.1. NC_017277.1.
YP_007450018.1. NC_020286.1.

3D structure databases

ProteinModelPortali P72800.
ModBasei Search...

Protein-protein interaction databases

IntActi P72800. 1 interaction.
STRINGi 1148.slr1795.

Proteomic databases

PaxDbi P72800.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAA16815 ; BAA16815 ; BAA16815 .
GeneIDi 953434.
KEGGi syn:slr1795.
syy:SYNGTS_0239.
syz:MYO_12400.
PATRICi 23837374. VBISynSp132158_0260.

Phylogenomic databases

eggNOGi COG0225.
HOGENOMi HOG000263863.
KOi K07304.
OMAi GTETAIF.
OrthoDBi EOG6091JX.
PhylomeDBi P72800.

Enzyme and pathway databases

BioCyci RETL1328306-WGS:GSTH-5859-MONOMER.

Family and domain databases

Gene3Di 3.30.1060.10. 1 hit.
HAMAPi MF_01401. MsrA.
InterProi IPR028427. Met_Sox_Rdtase.
IPR002569. Met_Sox_Rdtase_MsrA.
[Graphical view ]
PANTHERi PTHR10173. PTHR10173. 1 hit.
Pfami PF01625. PMSR. 1 hit.
[Graphical view ]
SUPFAMi SSF55068. SSF55068. 1 hit.
TIGRFAMsi TIGR00401. msrA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
    Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
    , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 6803 / Kazusa.

Entry informationi

Entry nameiMSRA2_SYNY3
AccessioniPrimary (citable) accession number: P72800
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: February 1, 1997
Last modified: July 9, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

External Data

Dasty 3

Similar proteinsi