Reviewed, UniProtKB/Swiss-Prot P72800 (MSRA2_SYNY3)

Names and origin

Protein names

Recommended name:
    Peptide methionine sulfoxide reductase msrA 2
      Short name=Protein-methionine-S-oxide reductase 2
    EC=1.8.4.11
Alternative name(s):
    Peptide-methionine (S)-S-oxide reductase 2
      Short name=Peptide Met(O) reductase 2

Gene names

Name:	msrA2
Ordered Locus Names:	slr1795

Organism

Synechocystis sp. (strain PCC 6803) [Complete proteome] [HAMAP]

Taxonomic identifier

1148 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Synechocystis

Protein attributes

Sequence length	214 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine By similarity. HAMAP MF_01401
Catalytic activity	Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401 L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401
Sequence similarities	Belongs to the msrA Met sulfoxide reductase family.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW protein modification process Inferred from electronic annotation. Source: HAMAP
Molecular function	peptide-methionine-(S)-S-oxide reductase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 214	214	Peptide methionine sulfoxide reductase msrA 2 HAMAP MF_01401		PRO_0000138602
Sites
	Active site	45	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	P72800-1 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: 785DEAB941703338	FASTA	214	23,605
	10 20 30 40 50 60 MGLAIAVGSF LISPFSKVIP DPVVDINPVS TTARGTEKAV FAGGCFWGLE AMFEEVRGVK 70 80 90 100 110 120 DVQTGYSGGT EATANYARVS GGGTDHAESI EIVYDPAQVS YGELLKIFFS VGHDPTQVNR 130 140 150 160 170 180 QGVDQGRQYR SAIFATTPEQ KQVAQAYIDQ LEESQAFDQA IATEVNDFDA FYPAEDYHQD 190 200 210 FVQRNPAHPY VLVHDLPKLR KFRQQYSDKL KAQS

References

[1]

"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions." Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S. DNA Res. 3:109-136(1996) [PubMed: 8905231] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000022 Genomic DNA. Translation: BAA16815.1.
PIR	S74663.
RefSeq	NP_440135.1.
3D structure databases
SMR	P72800. Positions 33-194.
ModBase	Search...
Protein-protein interaction databases
IntAct	P72800. 1 interaction.
STRING	P72800.
Genome annotation databases
GeneID	953434.
GenomeReviews	Gene locus slr1795 in contig BA000022_GR.
KEGG	syn:slr1795.
NMPDR	fig|1148.1.peg.236.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0225.
HOGENOM	HBG748152.
OMA	PIATEIT.
PhylomeDB	P72800.
Enzyme and pathway databases
BioCyc	SSP1148:SLR1795-MONOMER.
Family and domain databases
HAMAP	MF_01401. MsrA. [Tree]
InterPro	IPR002569. Peptide_Met_Sox_Rdtase_MsrA. [Graphical view]
Gene3D	G3DSA:3.30.1060.10. MsrA. 1 hit.
Pfam	PF01625. PMSR. 1 hit. [Graphical view]
TIGRFAMs	TIGR00401. msrA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MSRA2_SYNY3

Accession

Primary (citable) accession number: P72800

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 2, 2002
Last sequence update:	February 1, 1997
Last modified:	February 9, 2010
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)