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P72800

- MSRA2_SYNY3

UniProt

P72800 - MSRA2_SYNY3

Protein

Peptide methionine sulfoxide reductase MsrA 2

Gene

msrA2

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine By similarity.By similarity

    Catalytic activityi

    Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin.
    L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei45 – 451By similarity

    GO - Molecular functioni

    1. peptide-methionine (S)-S-oxide reductase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cellular protein modification process Source: UniProtKB-HAMAP
    2. protein repair Source: InterPro
    3. response to oxidative stress Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Enzyme and pathway databases

    BioCyciRETL1328306-WGS:GSTH-5859-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peptide methionine sulfoxide reductase MsrA 2 (EC:1.8.4.11)
    Short name:
    Protein-methionine-S-oxide reductase 2
    Alternative name(s):
    Peptide-methionine (S)-S-oxide reductase 2
    Short name:
    Peptide Met(O) reductase 2
    Gene namesi
    Name:msrA2
    Ordered Locus Names:slr1795
    OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
    Taxonomic identifieri1111708 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
    ProteomesiUP000001425: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 214214Peptide methionine sulfoxide reductase MsrA 2PRO_0000138602Add
    BLAST

    Proteomic databases

    PaxDbiP72800.

    Interactioni

    Protein-protein interaction databases

    IntActiP72800. 1 interaction.
    STRINGi1148.slr1795.

    Structurei

    3D structure databases

    ProteinModelPortaliP72800.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0225.
    HOGENOMiHOG000263863.
    KOiK07304.
    OMAiGTETAIF.
    OrthoDBiEOG6091JX.
    PhylomeDBiP72800.

    Family and domain databases

    Gene3Di3.30.1060.10. 1 hit.
    HAMAPiMF_01401. MsrA.
    InterProiIPR028427. Met_Sox_Rdtase.
    IPR002569. Met_Sox_Rdtase_MsrA.
    [Graphical view]
    PANTHERiPTHR10173. PTHR10173. 1 hit.
    PfamiPF01625. PMSR. 1 hit.
    [Graphical view]
    SUPFAMiSSF55068. SSF55068. 1 hit.
    TIGRFAMsiTIGR00401. msrA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P72800-1 [UniParc]FASTAAdd to Basket

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    MGLAIAVGSF LISPFSKVIP DPVVDINPVS TTARGTEKAV FAGGCFWGLE    50
    AMFEEVRGVK DVQTGYSGGT EATANYARVS GGGTDHAESI EIVYDPAQVS 100
    YGELLKIFFS VGHDPTQVNR QGVDQGRQYR SAIFATTPEQ KQVAQAYIDQ 150
    LEESQAFDQA IATEVNDFDA FYPAEDYHQD FVQRNPAHPY VLVHDLPKLR 200
    KFRQQYSDKL KAQS 214
    Length:214
    Mass (Da):23,605
    Last modified:February 1, 1997 - v1
    Checksum:i785DEAB941703338
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000022 Genomic DNA. Translation: BAA16815.1.
    PIRiS74663.
    RefSeqiNP_440135.1. NC_000911.1.
    YP_005650192.1. NC_017277.1.
    YP_007450018.1. NC_020286.1.

    Genome annotation databases

    EnsemblBacteriaiBAA16815; BAA16815; BAA16815.
    GeneIDi953434.
    KEGGisyn:slr1795.
    syy:SYNGTS_0239.
    syz:MYO_12400.
    PATRICi23837374. VBISynSp132158_0260.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000022 Genomic DNA. Translation: BAA16815.1 .
    PIRi S74663.
    RefSeqi NP_440135.1. NC_000911.1.
    YP_005650192.1. NC_017277.1.
    YP_007450018.1. NC_020286.1.

    3D structure databases

    ProteinModelPortali P72800.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P72800. 1 interaction.
    STRINGi 1148.slr1795.

    Proteomic databases

    PaxDbi P72800.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAA16815 ; BAA16815 ; BAA16815 .
    GeneIDi 953434.
    KEGGi syn:slr1795.
    syy:SYNGTS_0239.
    syz:MYO_12400.
    PATRICi 23837374. VBISynSp132158_0260.

    Phylogenomic databases

    eggNOGi COG0225.
    HOGENOMi HOG000263863.
    KOi K07304.
    OMAi GTETAIF.
    OrthoDBi EOG6091JX.
    PhylomeDBi P72800.

    Enzyme and pathway databases

    BioCyci RETL1328306-WGS:GSTH-5859-MONOMER.

    Family and domain databases

    Gene3Di 3.30.1060.10. 1 hit.
    HAMAPi MF_01401. MsrA.
    InterProi IPR028427. Met_Sox_Rdtase.
    IPR002569. Met_Sox_Rdtase_MsrA.
    [Graphical view ]
    PANTHERi PTHR10173. PTHR10173. 1 hit.
    Pfami PF01625. PMSR. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55068. SSF55068. 1 hit.
    TIGRFAMsi TIGR00401. msrA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
      Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
      , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
      DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 6803 / Kazusa.

    Entry informationi

    Entry nameiMSRA2_SYNY3
    AccessioniPrimary (citable) accession number: P72800
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 2, 2002
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Synechocystis PCC 6803
      Synechocystis (strain PCC 6803): entries and gene names

    External Data

    Dasty 3