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Protein

Putative serine protease HhoA

Gene

hhoA

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

A putative protease, its function overlaps that of the related putative proteases HhoB and HtrA.1 Publication

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • serine-type endopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease

Protein family/group databases

MEROPSiS01.482.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative serine protease HhoA
Gene namesi
Name:hhoA
Ordered Locus Names:sll1679
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
Proteomesi
  • UP000001425 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

  • outer membrane-bounded periplasmic space Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Periplasm

Pathology & Biotechi

Disruption phenotypei

No effect in a single knockout, but growth is inhibited at high light (120 µmol photons/m2/s) or at elevated temperature in a triple protease knockout mutant (hhoA, hhoB and htrA). Triple mutants are not phototactic. No effect on the PSII repair cycle, even in the triple protease knockout strain.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence analysisAdd
BLAST
Chaini25 – 394370Putative serine protease HhoAPRO_0000400424Add
BLAST

Expressioni

Inductioni

Slight induction by UV-B light.1 Publication

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-1610232,EBI-1610232

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

IntActiP72780. 13 interactions.

Structurei

3D structure databases

ProteinModelPortaliP72780.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini293 – 37785PDZPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S1C family.Curated
Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000223641.
InParanoidiP72780.
OMAiEVVHPYI.
OrthoDBiEOG61ZTDN.
PhylomeDBiP72780.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
IPR009003. Peptidase_S1_PA.
IPR001940. Peptidase_S1C.
[Graphical view]
PfamiPF13180. PDZ_2. 1 hit.
[Graphical view]
PRINTSiPR00834. PROTEASES2C.
SMARTiSM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
SSF50494. SSF50494. 1 hit.
PROSITEiPS50106. PDZ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P72780-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKYPTWLRRI GGYLLAFAVG TAFGIANLPH AVAAADDLPP APVITAQASV
60 70 80 90 100
PLTSESFVAA AVSRSGPAVV RIDTETVVTR RTDPILDDPF FQEFFGRSFP
110 120 130 140 150
VPPRERRIAG QGSGFIIDNS GIILTNAHVV DGASKVVVTL RDGRTFDGQV
160 170 180 190 200
RGTDEVTDLA VVKIEPQGSA LPVAPLGTSS NLQVGDWAIA VGNPVGLDNT
210 220 230 240 250
VTLGIISTLG RSAAQAGIPD KRVEFIQTDA AINPGNSGGP LLNARGEVIG
260 270 280 290 300
INTAIRADAT GIGFAIPIDQ AKAIQNTLAA GGTVPHPYIG VQMMNITVDQ
310 320 330 340 350
AQQNNRNPNS PFIIPEVDGI LVMRVLPGTP AERAGIRRGD VIVAVDGTPI
360 370 380 390
SDGARLQRIV EQAGLNKALK LDLLRGDRRL SLTVQTAQLR NPTS
Length:394
Mass (Da):41,336
Last modified:February 1, 1997 - v1
Checksum:iAD59D94811B8F57B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA16795.1.
PIRiS74643.

Genome annotation databases

EnsemblBacteriaiBAA16795; BAA16795; BAA16795.
KEGGisyn:sll1679.
PATRICi23837324. VBISynSp132158_0236.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA16795.1.
PIRiS74643.

3D structure databases

ProteinModelPortaliP72780.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP72780. 13 interactions.

Protein family/group databases

MEROPSiS01.482.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA16795; BAA16795; BAA16795.
KEGGisyn:sll1679.
PATRICi23837324. VBISynSp132158_0236.

Phylogenomic databases

HOGENOMiHOG000223641.
InParanoidiP72780.
OMAiEVVHPYI.
OrthoDBiEOG61ZTDN.
PhylomeDBiP72780.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
IPR009003. Peptidase_S1_PA.
IPR001940. Peptidase_S1C.
[Graphical view]
PfamiPF13180. PDZ_2. 1 hit.
[Graphical view]
PRINTSiPR00834. PROTEASES2C.
SMARTiSM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
SSF50494. SSF50494. 1 hit.
PROSITEiPS50106. PDZ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
    Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
    , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 6803 / Kazusa.
  2. "Proteomics of Synechocystis sp. strain PCC 6803. Identification of periplasmic proteins in cells grown at low and high salt concentrations."
    Fulda S., Huang F., Nilsson F., Hagemann M., Norling B.
    Eur. J. Biochem. 267:5900-5907(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  3. "The deg proteases protect Synechocystis sp. PCC 6803 during heat and light stresses but are not essential for removal of damaged D1 protein during the photosystem two repair cycle."
    Barker M., de Vries R., Nield J., Komenda J., Nixon P.J.
    J. Biol. Chem. 281:30347-30355(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN PHOTOPROTECTION, PROTECTION AGAINST HEAT STRESS, DISRUPTION PHENOTYPE.
  4. "The role of the FtsH and Deg proteases in the repair of UV-B radiation-damaged Photosystem II in the cyanobacterium Synechocystis PCC 6803."
    Cheregi O., Sicora C., Kos P.B., Barker M., Nixon P.J., Vass I.
    Biochim. Biophys. Acta 1767:820-828(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiHHOA_SYNY3
AccessioniPrimary (citable) accession number: P72780
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2010
Last sequence update: February 1, 1997
Last modified: May 11, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.