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Protein

Putative serine protease HhoA

Gene

hhoA

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

A putative protease, its function overlaps that of the related putative proteases HhoB and HtrA.1 Publication

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • serine-type endopeptidase activity Source: InterPro

Keywordsi

Molecular functionHydrolase, Protease

Protein family/group databases

MEROPSiS01.482.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative serine protease HhoA
Gene namesi
Name:hhoA
Ordered Locus Names:sll1679
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesMerismopediaceaeSynechocystis
Proteomesi
  • UP000001425 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

  • outer membrane-bounded periplasmic space Source: UniProtKB

Keywords - Cellular componenti

Periplasm

Pathology & Biotechi

Disruption phenotypei

No effect in a single knockout, but growth is inhibited at high light (120 µmol photons/m2/s) or at elevated temperature in a triple protease knockout mutant (hhoA, hhoB and htrA). Triple mutants are not phototactic. No effect on the PSII repair cycle, even in the triple protease knockout strain.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000040042425 – 394Putative serine protease HhoAAdd BLAST370

Proteomic databases

PRIDEiP72780.

Expressioni

Inductioni

Slight induction by UV-B light.1 Publication

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-1610232,EBI-1610232

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

IntActiP72780. 13 interactors.

Structurei

Secondary structure

1394
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi57 – 65Combined sources9
Helixi66 – 68Combined sources3
Beta strandi69 – 73Combined sources5
Beta strandi112 – 118Combined sources7
Turni119 – 121Combined sources3
Beta strandi122 – 125Combined sources4
Helixi127 – 130Combined sources4
Beta strandi134 – 139Combined sources6
Beta strandi145 – 154Combined sources10
Turni155 – 158Combined sources4
Beta strandi159 – 163Combined sources5
Helixi179 – 181Combined sources3
Beta strandi187 – 192Combined sources6
Beta strandi194 – 198Combined sources5
Beta strandi200 – 208Combined sources9
Beta strandi226 – 228Combined sources3
Turni234 – 238Combined sources5
Beta strandi239 – 242Combined sources4
Beta strandi248 – 253Combined sources6
Beta strandi263 – 267Combined sources5
Helixi268 – 279Combined sources12
Beta strandi291 – 296Combined sources6
Helixi298 – 306Combined sources9
Beta strandi310 – 312Combined sources3
Beta strandi316 – 325Combined sources10
Helixi330 – 333Combined sources4
Beta strandi341 – 349Combined sources9
Helixi353 – 363Combined sources11
Beta strandi368 – 374Combined sources7
Beta strandi379 – 385Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5B6LX-ray2.80A56-394[»]
5GNDX-ray2.50A56-394[»]
5T63X-ray2.50A35-394[»]
5T69X-ray2.10A35-394[»]
ProteinModelPortaliP72780.
SMRiP72780.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini293 – 377PDZPROSITE-ProRule annotationAdd BLAST85

Sequence similaritiesi

Belongs to the peptidase S1C family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000223641.
InParanoidiP72780.
OMAiIAKEHNQ.
PhylomeDBiP72780.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiView protein in InterPro
IPR001478. PDZ.
IPR009003. Peptidase_S1_PA.
IPR001940. Peptidase_S1C.
PfamiView protein in Pfam
PF13180. PDZ_2. 1 hit.
PRINTSiPR00834. PROTEASES2C.
SMARTiView protein in SMART
SM00228. PDZ. 1 hit.
SUPFAMiSSF50156. SSF50156. 1 hit.
SSF50494. SSF50494. 1 hit.
PROSITEiView protein in PROSITE
PS50106. PDZ. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P72780-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKYPTWLRRI GGYLLAFAVG TAFGIANLPH AVAAADDLPP APVITAQASV
60 70 80 90 100
PLTSESFVAA AVSRSGPAVV RIDTETVVTR RTDPILDDPF FQEFFGRSFP
110 120 130 140 150
VPPRERRIAG QGSGFIIDNS GIILTNAHVV DGASKVVVTL RDGRTFDGQV
160 170 180 190 200
RGTDEVTDLA VVKIEPQGSA LPVAPLGTSS NLQVGDWAIA VGNPVGLDNT
210 220 230 240 250
VTLGIISTLG RSAAQAGIPD KRVEFIQTDA AINPGNSGGP LLNARGEVIG
260 270 280 290 300
INTAIRADAT GIGFAIPIDQ AKAIQNTLAA GGTVPHPYIG VQMMNITVDQ
310 320 330 340 350
AQQNNRNPNS PFIIPEVDGI LVMRVLPGTP AERAGIRRGD VIVAVDGTPI
360 370 380 390
SDGARLQRIV EQAGLNKALK LDLLRGDRRL SLTVQTAQLR NPTS
Length:394
Mass (Da):41,336
Last modified:February 1, 1997 - v1
Checksum:iAD59D94811B8F57B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA16795.1.
PIRiS74643.

Genome annotation databases

EnsemblBacteriaiBAA16795; BAA16795; BAA16795.
KEGGisyn:sll1679.
PATRICi23837324. VBISynSp132158_0236.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA16795.1.
PIRiS74643.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5B6LX-ray2.80A56-394[»]
5GNDX-ray2.50A56-394[»]
5T63X-ray2.50A35-394[»]
5T69X-ray2.10A35-394[»]
ProteinModelPortaliP72780.
SMRiP72780.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP72780. 13 interactors.

Protein family/group databases

MEROPSiS01.482.

Proteomic databases

PRIDEiP72780.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA16795; BAA16795; BAA16795.
KEGGisyn:sll1679.
PATRICi23837324. VBISynSp132158_0236.

Phylogenomic databases

HOGENOMiHOG000223641.
InParanoidiP72780.
OMAiIAKEHNQ.
PhylomeDBiP72780.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiView protein in InterPro
IPR001478. PDZ.
IPR009003. Peptidase_S1_PA.
IPR001940. Peptidase_S1C.
PfamiView protein in Pfam
PF13180. PDZ_2. 1 hit.
PRINTSiPR00834. PROTEASES2C.
SMARTiView protein in SMART
SM00228. PDZ. 1 hit.
SUPFAMiSSF50156. SSF50156. 1 hit.
SSF50494. SSF50494. 1 hit.
PROSITEiView protein in PROSITE
PS50106. PDZ. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiHHOA_SYNY3
AccessioniPrimary (citable) accession number: P72780
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2010
Last sequence update: February 1, 1997
Last modified: April 12, 2017
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.