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Protein

Dihydrolipoyl dehydrogenase

Gene

lpdA

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Lipoamide dehydrogenase is a component of the alpha-ketoacid dehydrogenase complexes.

Miscellaneous

The active site is a redox-active disulfide bond.

Catalytic activityi

Protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH.

Cofactori

FADBy similarityNote: Binds 1 FAD per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei53FADBy similarity1
Binding sitei119FAD; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei207NADBy similarity1
Binding sitei323FADBy similarity1
Binding sitei331FAD; via amide nitrogenBy similarity1
Active sitei459Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi36 – 44FADBy similarity9
Nucleotide bindingi184 – 188NADBy similarity5
Nucleotide bindingi275 – 278NADBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processGlycolysis
LigandFAD, Flavoprotein, NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydrolipoyl dehydrogenase (EC:1.8.1.4)
Alternative name(s):
Dihydrolipoamide dehydrogenase
Short name:
LPD
E3 component of pyruvate complex
Gene namesi
Name:lpdA
Synonyms:pdhD
Ordered Locus Names:slr1096
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesMerismopediaceaeSynechocystis
Proteomesi
  • UP000001425 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000680512 – 474Dihydrolipoyl dehydrogenaseAdd BLAST473

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi44 ↔ 49Redox-activeBy similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP72740
PRIDEiP72740

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

IntActiP72740, 2 interactors
STRINGi1148.SYNGTS_0179

Structurei

3D structure databases

ProteinModelPortaliP72740
SMRiP72740
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Redox-active center

Phylogenomic databases

HOGENOMiHOG000276708
InParanoidiP72740
KOiK00382
OMAiTMSEAVM
PhylomeDBiP72740

Family and domain databases

Gene3Di3.30.390.30, 1 hit
3.50.50.60, 3 hits
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR023753 FAD/NAD-binding_dom
IPR016156 FAD/NAD-linked_Rdtase_dimer_sf
IPR006258 Lipoamide_DH
IPR001100 Pyr_nuc-diS_OxRdtase
IPR004099 Pyr_nucl-diS_OxRdtase_dimer
IPR012999 Pyr_OxRdtase_I_AS
PfamiView protein in Pfam
PF07992 Pyr_redox_2, 1 hit
PF02852 Pyr_redox_dim, 1 hit
PIRSFiPIRSF000350 Mercury_reductase_MerA, 1 hit
SUPFAMiSSF51905 SSF51905, 3 hits
SSF55424 SSF55424, 1 hit
TIGRFAMsiTIGR01350 lipoamide_DH, 1 hit
PROSITEiView protein in PROSITE
PS00076 PYRIDINE_REDOX_1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P72740-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQDFDYDLV IIGAGVGGHG AALHAVKCGL KTAIIEAKDM GGTCVNRGCI
60 70 80 90 100
PSKALLAASG RVREMSDQDH LQQLGIQING VTFTREAIAA HANDLVSKIQ
110 120 130 140 150
SDLTNSLTRL KVDTIRGWGK VSGPQEVTVI GDNETRILKA KEIMLCPGSV
160 170 180 190 200
PFVPPGIEID HKTVFTSDEA VKLETLPQWI AIIGSGYIGL EFSDVYTALG
210 220 230 240 250
CEVTMIEALP DLMPGFDPEI AKIAERVLIK SRDIETYTGV FATKIKAGSP
260 270 280 290 300
VEIELTDAKT KEVIDTLEVD ACLVATGRIP ATKNLGLETV GVETDRRGFI
310 320 330 340 350
EVNDQMQVIK DGKPVPHLWA VGDATGKMML AHAASGQGVV AVENICGRKT
360 370 380 390 400
EVDYRAIPAA AFTHPEISYV GLTEAQAKEL GEKEGFVVST AKTYFKGNSK
410 420 430 440 450
ALAEKETDGI AKVVYRQDTG ELLGAHIIGI HASDLIQEAA QAIADRKSVR
460 470
ELAFHVHAHP TLSEVLDEAY KRAV
Length:474
Mass (Da):50,832
Last modified:January 23, 2007 - v3
Checksum:iA2EFD28D8D9C69E1
GO

Sequence cautioni

The sequence BAA16755 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA Translation: BAA16755.1 Different initiation.
Z48564 Genomic DNA Translation: CAA88451.1
PIRiS74603

Genome annotation databases

EnsemblBacteriaiBAA16755; BAA16755; BAA16755
KEGGisyn:slr1096

Similar proteinsi

Entry informationi

Entry nameiDLDH_SYNY3
AccessioniPrimary (citable) accession number: P72740
Secondary accession number(s): Q53395
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 142 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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