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Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei2Nucleophile; for GATase activityUniRule annotation1
Active sitei626For Fru-6P isomerization activityUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
Alternative name(s):
D-fructose-6-phosphate amidotransferaseUniRule annotation
GFATUniRule annotation
Glucosamine-6-phosphate synthaseUniRule annotation
Hexosephosphate aminotransferaseUniRule annotation
L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
Gene namesi
Name:glmSUniRule annotation
Ordered Locus Names:sll0220
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesMerismopediaceaeSynechocystis
Proteomesi
  • UP000001425 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedUniRule annotation
ChainiPRO_00001353992 – 631Glutamine--fructose-6-phosphate aminotransferase [isomerizing]Add BLAST630

Proteomic databases

PaxDbiP72720
PRIDEiP72720

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi1148.SYNGTS_0151

Structurei

3D structure databases

ProteinModelPortaliP72720
SMRiP72720
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 225Glutamine amidotransferase type-2UniRule annotationAdd BLAST224
Domaini298 – 446SIS 1UniRule annotationAdd BLAST149
Domaini480 – 621SIS 2UniRule annotationAdd BLAST142

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

HOGENOMiHOG000258896
InParanoidiP72720
KOiK00820
OMAiASEYRYA
PhylomeDBiP72720

Family and domain databases

CDDicd05008 SIS_GlmS_GlmD_1, 1 hit
cd05009 SIS_GlmS_GlmD_2, 1 hit
Gene3Di3.60.20.10, 1 hit
HAMAPiMF_00164 GlmS, 1 hit
InterProiView protein in InterPro
IPR017932 GATase_2_dom
IPR035466 GlmS/AgaS_SIS
IPR035490 GlmS/FrlB_SIS
IPR005855 GlmS_trans
IPR029055 Ntn_hydrolases_N
IPR001347 SIS
PANTHERiPTHR10937:SF0 PTHR10937:SF0, 1 hit
PfamiView protein in Pfam
PF01380 SIS, 2 hits
SUPFAMiSSF56235 SSF56235, 1 hit
TIGRFAMsiTIGR01135 glmS, 1 hit
PROSITEiView protein in PROSITE
PS51278 GATASE_TYPE_2, 1 hit
PS51464 SIS, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P72720-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCGIVGYIGT QTAVNILIEG LERLEYRGYD SAGIATVTEG KIESVRAKGK
60 70 80 90 100
LFNLKEKLEN HSNFSRLGIG HTRWATHGKP EEHNAHPHLD NQQRIAVVQN
110 120 130 140 150
GIIENYQTLR DQLKEKGYQF YSETDTEVIP ILIADILKDL PSDDPDEALL
160 170 180 190 200
EAIGKAVHQL EGAFAIAVLD AHCPEQLIVA RQQAPLILGF GQGEFFCASD
210 220 230 240 250
VTALVHHTTT VLSLENGEIA RLTPLGVEVY DFNLKRVRKL PRTLDWSATT
260 270 280 290 300
VEKQGFRHFM LKEIYEQPAV VRTCLATYLN EQWRAADHPS HSPVFLGLDP
310 320 330 340 350
QLTKNLQHIQ VLACGTSWHA GLVGKYLLEQ LAGIPTTVHY ASEFRYAAPP
360 370 380 390 400
LTPHTLTIGV TQSGETADTL AALEMEKQRR LTLEDDYKPL ILGITNRPES
410 420 430 440 450
TLATMVNEII NTHAGIEIGV AATKTFVAQV LAFYFLALDI AFQRHSLSLE
460 470 480 490 500
AIEHIMVGLR QLPAQIETIL EQQGSAIEAL AHEFAETQDF IFLGRGINFP
510 520 530 540 550
IALEGALKLK EISYIHAEGY PAGEMKHGPI ALLDAKVPVV AIAMPGSVHD
560 570 580 590 600
KVISNAQEAK ARDARLIGVT PMDDSQARSV FDDLLLVPHV EEMLSPIVAV
610 620 630
IPLQLLSYHI AARRGLDVDQ PRNLAKSVTV E
Length:631
Mass (Da):69,607
Last modified:January 23, 2007 - v3
Checksum:iA681521E28918FA6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA Translation: BAA16727.1
PIRiS74575

Genome annotation databases

EnsemblBacteriaiBAA16727; BAA16727; BAA16727
KEGGisyn:sll0220

Similar proteinsi

Entry informationi

Entry nameiGLMS_SYNY3
AccessioniPrimary (citable) accession number: P72720
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 120 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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