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Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21Nucleophile; for GATase activityUniRule annotation
Active sitei626 – 6261For Fru-6P isomerization activityUniRule annotation

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbohydrate biosynthetic process Source: InterPro
  2. glutamine metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Protein family/group databases

MEROPSiC44.971.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
Alternative name(s):
D-fructose-6-phosphate amidotransferaseUniRule annotation
GFATUniRule annotation
Glucosamine-6-phosphate synthaseUniRule annotation
Hexosephosphate aminotransferaseUniRule annotation
L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
Gene namesi
Name:glmSUniRule annotation
Ordered Locus Names:sll0220
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
ProteomesiUP000001425 Componenti: Chromosome

Subcellular locationi

  1. Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedUniRule annotation
Chaini2 – 631630Glutamine--fructose-6-phosphate aminotransferase [isomerizing]PRO_0000135399Add
BLAST

Proteomic databases

PaxDbiP72720.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi1148.sll0220.

Structurei

3D structure databases

ProteinModelPortaliP72720.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 225224Glutamine amidotransferase type-2UniRule annotationAdd
BLAST
Domaini298 – 446149SIS 1UniRule annotationAdd
BLAST
Domaini480 – 621142SIS 2UniRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 glutamine amidotransferase type-2 domain.UniRule annotation
Contains 2 SIS domains.UniRule annotation

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiCOG0449.
HOGENOMiHOG000258896.
InParanoidiP72720.
KOiK00820.
OMAiSEFRYAP.
OrthoDBiEOG6KT2Q1.
PhylomeDBiP72720.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS.
InterProiIPR017932. GATase_2_dom.
IPR000583. GATase_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF00310. GATase_2. 1 hit.
PF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P72720-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCGIVGYIGT QTAVNILIEG LERLEYRGYD SAGIATVTEG KIESVRAKGK
60 70 80 90 100
LFNLKEKLEN HSNFSRLGIG HTRWATHGKP EEHNAHPHLD NQQRIAVVQN
110 120 130 140 150
GIIENYQTLR DQLKEKGYQF YSETDTEVIP ILIADILKDL PSDDPDEALL
160 170 180 190 200
EAIGKAVHQL EGAFAIAVLD AHCPEQLIVA RQQAPLILGF GQGEFFCASD
210 220 230 240 250
VTALVHHTTT VLSLENGEIA RLTPLGVEVY DFNLKRVRKL PRTLDWSATT
260 270 280 290 300
VEKQGFRHFM LKEIYEQPAV VRTCLATYLN EQWRAADHPS HSPVFLGLDP
310 320 330 340 350
QLTKNLQHIQ VLACGTSWHA GLVGKYLLEQ LAGIPTTVHY ASEFRYAAPP
360 370 380 390 400
LTPHTLTIGV TQSGETADTL AALEMEKQRR LTLEDDYKPL ILGITNRPES
410 420 430 440 450
TLATMVNEII NTHAGIEIGV AATKTFVAQV LAFYFLALDI AFQRHSLSLE
460 470 480 490 500
AIEHIMVGLR QLPAQIETIL EQQGSAIEAL AHEFAETQDF IFLGRGINFP
510 520 530 540 550
IALEGALKLK EISYIHAEGY PAGEMKHGPI ALLDAKVPVV AIAMPGSVHD
560 570 580 590 600
KVISNAQEAK ARDARLIGVT PMDDSQARSV FDDLLLVPHV EEMLSPIVAV
610 620 630
IPLQLLSYHI AARRGLDVDQ PRNLAKSVTV E
Length:631
Mass (Da):69,607
Last modified:January 23, 2007 - v3
Checksum:iA681521E28918FA6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA16727.1.
PIRiS74575.
RefSeqiNP_440047.1. NC_000911.1.
YP_005650104.1. NC_017277.1.
YP_007449930.1. NC_020286.1.

Genome annotation databases

EnsemblBacteriaiBAA16727; BAA16727; BAA16727.
KEGGisyn:sll0220.
PATRICi23837172. VBISynSp132158_0161.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA16727.1.
PIRiS74575.
RefSeqiNP_440047.1. NC_000911.1.
YP_005650104.1. NC_017277.1.
YP_007449930.1. NC_020286.1.

3D structure databases

ProteinModelPortaliP72720.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi1148.sll0220.

Protein family/group databases

MEROPSiC44.971.

Proteomic databases

PaxDbiP72720.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA16727; BAA16727; BAA16727.
KEGGisyn:sll0220.
PATRICi23837172. VBISynSp132158_0161.

Phylogenomic databases

eggNOGiCOG0449.
HOGENOMiHOG000258896.
InParanoidiP72720.
KOiK00820.
OMAiSEFRYAP.
OrthoDBiEOG6KT2Q1.
PhylomeDBiP72720.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS.
InterProiIPR017932. GATase_2_dom.
IPR000583. GATase_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF00310. GATase_2. 1 hit.
PF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
    Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
    , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 6803 / Kazusa.

Entry informationi

Entry nameiGLMS_SYNY3
AccessioniPrimary (citable) accession number: P72720
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: April 1, 2015
This is version 101 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.