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P72714

- NU2C_SYNY3

UniProt

P72714 - NU2C_SYNY3

Protein

NAD(P)H-quinone oxidoreductase subunit 2

Gene

ndhB

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient. Cyanobacterial NDH-1 also plays a role in inorganic carbon-concentration.UniRule annotation

    Catalytic activityi

    NAD(P)H + plastoquinone = NAD(P)+ + plastoquinol.UniRule annotation

    GO - Molecular functioni

    1. NADH dehydrogenase (ubiquinone) activity Source: InterPro
    2. quinone binding Source: UniProtKB-KW

    GO - Biological processi

    1. ATP synthesis coupled electron transport Source: InterPro
    2. photosynthesis, light reaction Source: UniProtKB-HAMAP
    3. transport Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Transport

    Keywords - Ligandi

    NAD, NADP, Plastoquinone

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NAD(P)H-quinone oxidoreductase subunit 2UniRule annotation (EC:1.6.5.-UniRule annotation)
    Alternative name(s):
    NAD(P)H dehydrogenase subunit 2UniRule annotation
    NADH-plastoquinone oxidoreductase subunit 2UniRule annotation
    NDH-1, subunit 2UniRule annotation
    Gene namesi
    Name:ndhBUniRule annotation
    Ordered Locus Names:sll0223
    OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
    Taxonomic identifieri1111708 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
    ProteomesiUP000001425: Chromosome

    Subcellular locationi

    Cellular thylakoid membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. thylakoid membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Thylakoid

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 521521NAD(P)H-quinone oxidoreductase subunit 2PRO_0000117685Add
    BLAST

    Keywords - PTMi

    Quinone

    Proteomic databases

    PaxDbiP72714.

    Interactioni

    Subunit structurei

    NDH-1 can be composed of about 15 different subunits; different subcomplexes with different compositions have been identified which probably have different functions.UniRule annotation

    Protein-protein interaction databases

    IntActiP72714. 9 interactions.
    STRINGi1148.sll0223.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei16 – 3621HelicalUniRule annotationAdd
    BLAST
    Transmembranei40 – 6021HelicalUniRule annotationAdd
    BLAST
    Transmembranei80 – 10021HelicalUniRule annotationAdd
    BLAST
    Transmembranei110 – 13021HelicalUniRule annotationAdd
    BLAST
    Transmembranei133 – 15321HelicalUniRule annotationAdd
    BLAST
    Transmembranei168 – 18821HelicalUniRule annotationAdd
    BLAST
    Transmembranei212 – 23221HelicalUniRule annotationAdd
    BLAST
    Transmembranei246 – 26621HelicalUniRule annotationAdd
    BLAST
    Transmembranei280 – 30021HelicalUniRule annotationAdd
    BLAST
    Transmembranei308 – 32821HelicalUniRule annotationAdd
    BLAST
    Transmembranei336 – 35621HelicalUniRule annotationAdd
    BLAST
    Transmembranei380 – 40021HelicalUniRule annotationAdd
    BLAST
    Transmembranei402 – 42221HelicalUniRule annotationAdd
    BLAST
    Transmembranei468 – 48821HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the complex I subunit 2 family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1007.
    HOGENOMiHOG000100794.
    KOiK05573.
    OMAiMVSSNHL.
    OrthoDBiEOG64JFNZ.
    PhylomeDBiP72714.

    Family and domain databases

    HAMAPiMF_00445. NDH1_NuoN_1.
    InterProiIPR010096. NADH-Q_OxRdtase_suN/2.
    IPR001750. NADH_UbQ/plastoQ_OxRdtase.
    [Graphical view]
    PfamiPF00361. Oxidored_q1. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR01770. NDH_I_N. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P72714-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDFSSNVAAQ LNAGTILPEG IVIVTLLLVL IVDLIGGRKV ALALPYLAIA    50
    GLLVSVGLLV TSWSMADPIG FIGAFNGDNL SIIFRAIIAL STVVTILMSV 100
    RYVQQTGTSL AEFIAILLTA TLGGMFLSAA NELVMVFISL EMLSISSYLM 150
    TGYMKRDPRS NEAALKYLLI GASSSAIFLY GLSLLYGLSG GETQLVLIAE 200
    KLVNADTVGQ SLGLAIALVF VIAGIAFKIS AVPFHQWTPD VYEGSPTPVV 250
    AFLSVGSKAA GFAVAIRLLV TAFGGITDEW HVIFTALAVL SMVLGNVVAL 300
    AQTSMKRMLA YSSIGQAGFV MIGLVAGSED GYASMVFYML IYLFMNLGAF 350
    SCIILFTLRT GSDQISDYAG LYHKDPLLTL GLSICLLSLG GIPPLAGFFG 400
    KIYIFWAGWQ SGLYGLVLLG LVTSVVSIYY YIRVVKMMVV KEPQEMSEVI 450
    KNYPAIKWNL PGMRPLQVGI VATLVATSLA GILANPLFNL ATDSVVSTKM 500
    LQTALQQTGE TPAIAISHDL P 521
    Length:521
    Mass (Da):55,355
    Last modified:February 1, 1997 - v1
    Checksum:iC18C06704C277081
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti412 – 4121G → R in BAA14330. (PubMed:1903537)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D90288 Genomic DNA. Translation: BAA14330.1.
    BA000022 Genomic DNA. Translation: BAA16721.1.
    PIRiS74569.
    RefSeqiNP_440041.1. NC_000911.1.
    YP_005650098.1. NC_017277.1.
    YP_007449924.1. NC_020286.1.

    Genome annotation databases

    EnsemblBacteriaiBAA16721; BAA16721; BAA16721.
    GeneIDi953340.
    KEGGisyn:sll0223.
    syy:SYNGTS_0145.
    syz:MYO_11440.
    PATRICi23837162. VBISynSp132158_0156.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D90288 Genomic DNA. Translation: BAA14330.1 .
    BA000022 Genomic DNA. Translation: BAA16721.1 .
    PIRi S74569.
    RefSeqi NP_440041.1. NC_000911.1.
    YP_005650098.1. NC_017277.1.
    YP_007449924.1. NC_020286.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P72714. 9 interactions.
    STRINGi 1148.sll0223.

    Proteomic databases

    PaxDbi P72714.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAA16721 ; BAA16721 ; BAA16721 .
    GeneIDi 953340.
    KEGGi syn:sll0223.
    syy:SYNGTS_0145.
    syz:MYO_11440.
    PATRICi 23837162. VBISynSp132158_0156.

    Phylogenomic databases

    eggNOGi COG1007.
    HOGENOMi HOG000100794.
    KOi K05573.
    OMAi MVSSNHL.
    OrthoDBi EOG64JFNZ.
    PhylomeDBi P72714.

    Family and domain databases

    HAMAPi MF_00445. NDH1_NuoN_1.
    InterProi IPR010096. NADH-Q_OxRdtase_suN/2.
    IPR001750. NADH_UbQ/plastoQ_OxRdtase.
    [Graphical view ]
    Pfami PF00361. Oxidored_q1. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR01770. NDH_I_N. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "A gene homologous to the subunit-2 gene of NADH dehydrogenase is essential to inorganic carbon transport of Synechocystis PCC6803."
      Ogawa T.
      Proc. Natl. Acad. Sci. U.S.A. 88:4275-4279(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
      Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
      , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
      DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 6803 / Kazusa.

    Entry informationi

    Entry nameiNU2C_SYNY3
    AccessioniPrimary (citable) accession number: P72714
    Secondary accession number(s): Q55269
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Synechocystis PCC 6803
      Synechocystis (strain PCC 6803): entries and gene names

    External Data

    Dasty 3