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P72714 (NU2C_SYNY3) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
NAD(P)H-quinone oxidoreductase subunit 2
EC=1.6.5.-
Alternative name(s):
NAD(P)H dehydrogenase subunit 2
NADH-plastoquinone oxidoreductase subunit 2
NDH-1, subunit 2
Gene names
Name:ndhB
Ordered Locus Names:sll0223
OrganismSynechocystis sp. (strain PCC 6803 / Kazusa) [Reference proteome] [HAMAP]
Taxonomic identifier1111708 [NCBI]
Taxonomic lineageBacteria › Cyanobacteria › Oscillatoriophycideae › Chroococcales › Synechocystis ›

Protein attributes

Sequence length521 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient. Cyanobacterial NDH-1 also plays a role in inorganic carbon-concentration By similarity. HAMAP-Rule MF_00445

Catalytic activity

NAD(P)H + plastoquinone = NAD(P)+ + plastoquinol. HAMAP-Rule MF_00445

Subunit structure

NDH-1 can be composed of about 15 different subunits; different subcomplexes with different compositions have been identified which probably have different functions By similarity.

Subcellular location

Cellular thylakoid membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_00445.

Sequence similarities

Belongs to the complex I subunit 2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 521521NAD(P)H-quinone oxidoreductase subunit 2 HAMAP-Rule MF_00445
PRO_0000117685

Regions

Transmembrane16 – 3621Helical; Potential
Transmembrane40 – 6021Helical; Potential
Transmembrane80 – 10021Helical; Potential
Transmembrane110 – 13021Helical; Potential
Transmembrane133 – 15321Helical; Potential
Transmembrane168 – 18821Helical; Potential
Transmembrane212 – 23221Helical; Potential
Transmembrane246 – 26621Helical; Potential
Transmembrane280 – 30021Helical; Potential
Transmembrane308 – 32821Helical; Potential
Transmembrane336 – 35621Helical; Potential
Transmembrane380 – 40021Helical; Potential
Transmembrane402 – 42221Helical; Potential
Transmembrane468 – 48821Helical; Potential

Experimental info

Sequence conflict4121G → R in BAA14330. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P72714 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: C18C06704C277081

FASTA52155,355
        10         20         30         40         50         60 
MDFSSNVAAQ LNAGTILPEG IVIVTLLLVL IVDLIGGRKV ALALPYLAIA GLLVSVGLLV 

        70         80         90        100        110        120 
TSWSMADPIG FIGAFNGDNL SIIFRAIIAL STVVTILMSV RYVQQTGTSL AEFIAILLTA 

       130        140        150        160        170        180 
TLGGMFLSAA NELVMVFISL EMLSISSYLM TGYMKRDPRS NEAALKYLLI GASSSAIFLY 

       190        200        210        220        230        240 
GLSLLYGLSG GETQLVLIAE KLVNADTVGQ SLGLAIALVF VIAGIAFKIS AVPFHQWTPD 

       250        260        270        280        290        300 
VYEGSPTPVV AFLSVGSKAA GFAVAIRLLV TAFGGITDEW HVIFTALAVL SMVLGNVVAL 

       310        320        330        340        350        360 
AQTSMKRMLA YSSIGQAGFV MIGLVAGSED GYASMVFYML IYLFMNLGAF SCIILFTLRT 

       370        380        390        400        410        420 
GSDQISDYAG LYHKDPLLTL GLSICLLSLG GIPPLAGFFG KIYIFWAGWQ SGLYGLVLLG 

       430        440        450        460        470        480 
LVTSVVSIYY YIRVVKMMVV KEPQEMSEVI KNYPAIKWNL PGMRPLQVGI VATLVATSLA 

       490        500        510        520 
GILANPLFNL ATDSVVSTKM LQTALQQTGE TPAIAISHDL P

« Hide

References

« Hide 'large scale' references
[1]"A gene homologous to the subunit-2 gene of NADH dehydrogenase is essential to inorganic carbon transport of Synechocystis PCC6803."
Ogawa T.
Proc. Natl. Acad. Sci. U.S.A. 88:4275-4279(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. expand/collapse author list , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PCC 6803 / Kazusa.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		D90288 Genomic DNA. Translation: BAA14330.1.
BA000022 Genomic DNA. Translation: BAA16721.1.
PIRS74569.
RefSeqNP_440041.1. NC_000911.1.
YP_005650098.1. NC_017277.1.
YP_007449924.1. NC_020286.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

IntActP72714. 9 interactions.
STRING1148.sll0223.

Proteomic databases

PaxDbP72714.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAA16721; BAA16721; BAA16721.
GeneID12253932.
14615566.
953340.
KEGGsyn:sll0223.
syy:SYNGTS_0145.
PATRIC23837162. VBISynSp132158_0156.

Phylogenomic databases

eggNOGCOG1007.
HOGENOMHOG000100794.
KOK05573.
OMALMTITIP.
ProtClustDBPRK02504.

Family and domain databases

HAMAPMF_00445. NDH1_NuoN_1.
InterProIPR010096. NADH-Q_OxRdtase_suN/2.
IPR001750. NADH_UbQ/plastoQ_OxRdtase.
[Graphical view]
PfamPF00361. Oxidored_q1. 1 hit.
[Graphical view]
TIGRFAMsTIGR01770. NDH_I_N. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNU2C_SYNY3
AccessionPrimary (citable) accession number: P72714
Secondary accession number(s): Q55269
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: May 1, 2013
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Synechocystis PCC 6803

Synechocystis (strain PCC 6803): entries and gene names

SIMILARITY comments

Index of protein domains and families

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