P72703 (SPEB1_SYNY3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Agmatinase 1
EC=3.5.3.11

Alternative name(s):
Agmatine ureohydrolase 1
Short name=AUH 1

Gene names

Name:	speB1
Ordered Locus Names:	sll0228

Organism

Synechocystis sp. (strain PCC 6803 / Kazusa) [Reference proteome] [HAMAP]

Taxonomic identifier

1111708 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Cyanobacteria › Oscillatoriophycideae › Chroococcales › Synechocystis › Synechocystis sp. PCC 6803

Protein attributes

Sequence length	306 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Agmatine + H2O = putrescine + urea.
Cofactor	Manganese Potential.
Sequence similarities	Belongs to the arginase family. Agmatinase subfamily.
Caution	Was originally annotated as an arginase by the genome sequencing project.

Ontologies

Keywords
Biological process	Putrescine biosynthesis
Ligand	Manganese Metal-binding
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	putrescine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	agmatinase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 306	306	Agmatinase 1		PRO_0000173744
Sites
	Metal binding	121	1	Manganese By similarity
	Metal binding	145	1	Manganese By similarity
	Metal binding	147	1	Manganese By similarity
	Metal binding	149	1	Manganese By similarity
	Metal binding	228	1	Manganese By similarity
	Metal binding	230	1	Manganese By similarity

Sequences

	Sequence		Length	Mass (Da)
	P72703 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: 114A8A313A0C4605	FASTA	306	33,463
	10 20 30 40 50 60 MHSPNKFTSG PKQFLESEAI TSYADAAVVV VPIPYEATTS YRKGCEHGPE AVLEASDQLE 70 80 90 100 110 120 AYDEELGTSP CHDLGIYTCA PLADSNKHPA LAGDAMVTEV CDGIAPFVED GKFVVAIGGE 130 140 150 160 170 180 HAITTGVVRA MQRGTSEPFT VVQIDAHGDM RDKFEGSCHN HACVMRRVLE LGLPTLPIAI 190 200 210 220 230 240 RAICQEEADL IREKNIPVFW AREMADNPNW INEAIASITT QKVFLTIDMD GFDPGFMPGV 250 260 270 280 290 300 GTPEPGGLGW YEGLNFFRRL FQTKQVIGCD LMELAPVRGS VVSEFSTAKL AYKLMGYWGE SQRKKL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions." Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S. DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PCC 6803 / Kazusa.
[2]	"Arginine catabolism in the cyanobacterium Synechocystis sp. strain PCC 6803 involves the urea cycle and arginase pathway." Quintero M.J., Muro-Pastor A.M., Herrero A., Flores E. J. Bacteriol. 182:1008-1015(2000) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000022 Genomic DNA. Translation: BAA16710.1.
PIR	S74558.
RefSeq	NP_440030.1. NC_000911.1. YP_005650087.1. NC_017277.1. YP_007449913.1. NC_020286.1.
3D structure databases
ProteinModelPortal	P72703.
ModBase	Search...
Protein-protein interaction databases
IntAct	P72703. 1 interaction.
STRING	1148.sll0228.
Proteomic databases
PaxDb	P72703.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAA16710; BAA16710; BAA16710.
GeneID	12253920. 14615554. 953327.
KEGG	syn:sll0228. syy:SYNGTS_0134.
PATRIC	23837138. VBISynSp132158_0144.
Phylogenomic databases
eggNOG	COG0010.
KO	K01480.
OMA	KQVIGCD.
ProtClustDB	CLSK892499.
Family and domain databases
Gene3D	3.40.800.10. 1 hit.
InterPro	IPR005925. Agmatinase-rel. IPR006035. Ureohydrolase. IPR023696. Ureohydrolase_domain. IPR020855. Ureohydrolase_Mn_BS. [Graphical view]
PANTHER	PTHR11358. PTHR11358. 1 hit.
Pfam	PF00491. Arginase. 1 hit. [Graphical view]
PIRSF	PIRSF036979. Arginase. 1 hit.
TIGRFAMs	TIGR01230. agmatinase. 1 hit.
PROSITE	PS01053. ARGINASE_1. 1 hit. PS51409. ARGINASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SPEB1_SYNY3

Accession

Primary (citable) accession number: P72703

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 29, 2004
Last sequence update:	February 1, 1997
Last modified:	May 1, 2013
This is version 81 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program