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Protein

Translation initiation factor IF-2

Gene

infB

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi502 – 5098GTPBy similarity
Nucleotide bindingi552 – 5565GTPBy similarity
Nucleotide bindingi606 – 6094GTPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor IF-2
Gene namesi
Name:infB
Ordered Locus Names:slr0744
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
Proteomesi
  • UP000001425 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10011001Translation initiation factor IF-2PRO_0000137269Add
BLAST

Interactioni

Protein-protein interaction databases

IntActiP72689. 4 interactions.

Structurei

3D structure databases

ProteinModelPortaliP72689.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini493 – 666174tr-type GAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni502 – 5098G1By similarity
Regioni527 – 5315G2By similarity
Regioni552 – 5554G3By similarity
Regioni606 – 6094G4By similarity
Regioni642 – 6443G5By similarity

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000076906.
InParanoidiP72689.
KOiK02519.
OMAiNIAVKSH.
PhylomeDBiP72689.

Family and domain databases

Gene3Di3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00100_B. IF_2_B. 1 hit.
InterProiIPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000795. TF_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
[Graphical view]
PfamiPF11987. IF-2. 1 hit.
PF04760. IF2_N. 2 hits.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P72689-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNAKVRIYD LSKELNLENR DILDICERLN VAAKSHSSTI SESDAERIKA
60 70 80 90 100
AAEKFTPQQP KKPRVASRPE SKEDKSDPKQ QKILAIHHKQ EKSGGPSPAR
110 120 130 140 150
PTPPPRPKLQ APKAPTPPQP PVAKASAPKI QKQEEPAQEA PKSVAPPTQP
160 170 180 190 200
LAPPPVPSLQ SPPSKPAPPT PPAKKAAPAP RLAGPPGRTA SPNKTAVPAP
210 220 230 240 250
AKPKVNRPEI VSLKDNRGQA RSPGDREEKV AIAAPEPPKP KVELRRPKPP
260 270 280 290 300
RPEEDENLPE LLEFPPLSRG KGVDGDNDAD DGDLLSTEKP KPKLKRPTPP
310 320 330 340 350
RLGKPDQWED DEDEKANKAK AANKGKRRPK MDDDDDDLDI DGDNGPKPTL
360 370 380 390 400
VSLSIARPPK PKSLAAKPST PTVAKVKKPT LKSEAGSSAG GSSRSRGDRR
410 420 430 440 450
DRKEVVQKPE VIMLDRSLTV RDLADLLKIS ETDIIKRLFL KGVAVQITQT
460 470 480 490 500
LDEETARMVA ESFEVAVETP ERVAAAAKTT EMLDEADLDN LVRRPPVVTI
510 520 530 540 550
MGHVDHGKTT LLDSIRKTKV AQGEAGGITQ HIGAYHVEVE HNDKTEQIVF
560 570 580 590 600
LDTPGHEAFT AMRARGAKVT DIAILVVAAD DGVQPQTKEA ISHAKAAGVP
610 620 630 640 650
LIVAINKVDK PEANPDRIKQ ELSELGLLAE EWGGDTIMVP VSALNGDNLD
660 670 680 690 700
GLLEMILLVS EVEELVANPN RQAKGTVIEA NLDRTRGPVA TLLIQNGTLR
710 720 730 740 750
VGDAIVVGAV YGKIRAMIDD RGDKVEEASP SFAVEILGLG DVPAAGDEFE
760 770 780 790 800
VFTNEKDARL QAEARAMEDR QTRLQQAMSS RKVTLSSISA QAQEGELKEL
810 820 830 840 850
NIILKADVQG SLGAILGSLE QLPQGEVQIR VLLASPGEVT ETDVDLAAAS
860 870 880 890 900
GAIIIGFNTT LASGARQAAD QEGVDIREYD IIYKLLDDIQ GAMEGLLDPE
910 920 930 940 950
EIESSLGTAE VRAVFPVGRG NIAGCYVQSG KIIRNRNLRV RRGDQVLFEG
960 970 980 990 1000
NIDSLKRIKE DVREVNAGYE CGIGCSKFND WKEGDIIEAY EMTMKRRTLA

T
Length:1,001
Mass (Da):108,119
Last modified:February 1, 1997 - v1
Checksum:i4C7F00DEE56CE31C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA16696.1.
PIRiS74544.

Genome annotation databases

EnsemblBacteriaiBAA16696; BAA16696; BAA16696.
KEGGisyn:slr0744.
PATRICi23837108. VBISynSp132158_0129.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA16696.1.
PIRiS74544.

3D structure databases

ProteinModelPortaliP72689.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP72689. 4 interactions.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA16696; BAA16696; BAA16696.
KEGGisyn:slr0744.
PATRICi23837108. VBISynSp132158_0129.

Phylogenomic databases

HOGENOMiHOG000076906.
InParanoidiP72689.
KOiK02519.
OMAiNIAVKSH.
PhylomeDBiP72689.

Family and domain databases

Gene3Di3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00100_B. IF_2_B. 1 hit.
InterProiIPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000795. TF_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
[Graphical view]
PfamiPF11987. IF-2. 1 hit.
PF04760. IF2_N. 2 hits.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIF2_SYNY3
AccessioniPrimary (citable) accession number: P72689
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: September 7, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.