Reviewed, UniProtKB/Swiss-Prot P72660 (LEP1_SYNY3)

Names and origin

Protein names

Recommended name:
    Probable signal peptidase I-1
      Short name=SPase I-1
    EC=3.4.21.89
Alternative name(s):
    Leader peptidase I-1

Gene names

Name:	lepB1
Ordered Locus Names:	sll0716

Organism

Synechocystis sp. (strain PCC 6803) [Complete proteome] [HAMAP]

Taxonomic identifier

1148 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Synechocystis

Protein attributes

Sequence length	196 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.
Subcellular location	Cell membrane; Single-pass type II membrane protein Potential.
Sequence similarities	Belongs to the peptidase S26 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Molecular function	Hydrolase Protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	serine-type peptidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 196	196	Probable signal peptidase I-1		PRO_0000109535
Regions
	Topological domain	1 – 16	16	Cytoplasmic Potential
	Transmembrane	17 – 35	19	Potential
	Topological domain	36 – 196	161	Periplasmic Potential
Sites
	Active site	44	1	By similarity
	Active site	94	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	P72660-1 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: EB02533BF7341573	FASTA	196	22,230
	10 20 30 40 50 60 MQNSPIPSPW QFIKENIPLL MVALVLALLL RFFVAEPRYI PSDSMLPTLE QGDRLVVEKV 70 80 90 100 110 120 SYHFHPPQVG DIIVFHPPEL LQVQGYDLGQ AFIKRVIALP GQTVEVNNGI VYRDGQPLQE 130 140 150 160 170 180 EYILEPPQYN LPAVRVPDGQ VFVMGDNRNN SNDSHVWGFL PQQNIIGHAL FRFFPASRWG 190 QLGSFTFVPA RTIINT

References

[1]

"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions." Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S. DNA Res. 3:109-136(1996) [PubMed: 8905231] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000022 Genomic DNA. Translation: BAA16662.1.
PIR	S74510.
RefSeq	NP_439982.1.
3D structure databases
SMR	P72660. Positions 31-185.
ModBase	Search...
Protein-protein interaction databases
IntAct	P72660. 3 interactions.
STRING	P72660.
Protein family/group databases
MEROPS	S26.008.
Genome annotation databases
GeneID	953147.
GenomeReviews	Gene locus sll0716 in contig BA000022_GR.
KEGG	syn:sll0716.
NMPDR	fig|1148.1.peg.83.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0681.
HOGENOM	HBG596607.
OMA	DFLIINR.
Enzyme and pathway databases
BioCyc	SSP1148:SLL0716-MONOMER.
Family and domain databases
InterPro	IPR000223. Pept_S26A_signal_pept_1. IPR019758. Pept_S26A_signal_pept_1_CS. IPR019757. Pept_S26A_signal_pept_1_Lys-AS. IPR019756. Pept_S26A_signal_pept_1_Ser-AS. IPR019759. Peptidase_S24_S26_cons-reg. IPR015927. Peptidase_S24_S26A/B/C. IPR011056. Peptidase_S24_S26A/B/C_b-rbn. [Graphical view]
Gene3D	G3DSA:2.10.109.10. Pept_S24_S26_C. 1 hit.
Pfam	PF00717. Peptidase_S24. 1 hit. [Graphical view]
PRINTS	PR00727. LEADERPTASE.
TIGRFAMs	TIGR02227. sigpep_I_bact. 1 hit.
PROSITE	PS00501. SPASE_I_1. 1 hit. PS00760. SPASE_I_2. 1 hit. PS00761. SPASE_I_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LEP1_SYNY3

Accession

Primary (citable) accession number: P72660

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	February 1, 1997
Last modified:	February 9, 2010
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)