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P72659

- PNP_SYNY3

UniProt

P72659 - PNP_SYNY3

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Protein
Polyribonucleotide nucleotidyltransferase
Gene
pnp, sll1043
Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction By similarity.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi497 – 4971Magnesium By similarity
Metal bindingi503 – 5031Magnesium By similarity

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. RNA binding Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. RNA processing Source: InterPro
  2. mRNA catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferase (EC:2.7.7.8)
Alternative name(s):
Polynucleotide phosphorylase
Short name:
PNPase
Gene namesi
Name:pnp
Ordered Locus Names:sll1043
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
ProteomesiUP000001425: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 718718Polyribonucleotide nucleotidyltransferaseUniRule annotation
PRO_0000329905Add
BLAST

Proteomic databases

PaxDbiP72659.

Interactioni

Protein-protein interaction databases

IntActiP72659. 3 interactions.
STRINGi1148.sll1043.

Structurei

3D structure databases

ProteinModelPortaliP72659.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini564 – 62360KH
Add
BLAST
Domaini633 – 70169S1 motif
Add
BLAST

Sequence similaritiesi

Contains 1 KH domain.
Contains 1 S1 motif domain.

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiGTENTIC.
OrthoDBiEOG6WT8CC.
PhylomeDBiP72659.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P72659-1 [UniParc]FASTAAdd to Basket

« Hide

MQEFDKSISF DGRDIRLKMG TLAPQAGGSV LIQSGDTAVL VTATRAKGRD    50
GIDFLPLTVD YEGRLYAAGR IPGGFLRREG RPPEKATLIS RLIDRPLRPL 100
FPHWLRDELQ IVATTLSMDE EVPPDVLAVT GASVAVILAQ IPFKGPMAAV 150
RVGLVGDDFI INPTYREVHN GDLDLVVAGT PAGIVMVEAG ANQLPEQDII 200
EAIDFGYEAV QDLINAQREL MTDLGITLAT SEPPPVNTAV EEFIANRASK 250
KIITVLGQFD LGKDGRDAAL DEIKATEVET AIAELPETDP VKQSVEEDPK 300
LVGNLYKALT KKLMRKQIVD DGVRVDGRKL EQVRPISCEV GFLPRRVHGS 350
GLFNRGLTQV LSLATLGSPG DAQDLADDLH PEDEKRYLHH YNFPPYSVGE 400
ARPMRSPGRR EIGHGALAER AIIPVLPPQE DFPYVVRVVS EVLSSNGSTS 450
MGSVCGSTLA LMDAGVPIKK PVSGAAMGLI KEGDEIRILT DIQGIEDFLG 500
DMDFKVAGTD SGITALQMDM KIDGLSMEVV SKAIMQALPA RLHILDKMLA 550
TIREPRPELS PFAPRLLTLK IEPEHIGMVI GPGGKTIKGI TEQTSCKIDI 600
ADDGTVTIAS SEGERAERAR QMIYNMTRKL NEGEVYLGRV TRIIPIGAFV 650
EVLPGKEGMI HISQLTEGRV GKVEDEVGVG DEVIVKVREI DSKGRLNLTR 700
LGIHPDEAAE ARRNASRG 718
Length:718
Mass (Da):77,831
Last modified:February 1, 1997 - v1
Checksum:i138A985B4AC76FEB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000022 Genomic DNA. Translation: BAA16661.1.
PIRiS74509.
RefSeqiNP_439981.1. NC_000911.1.
YP_005650036.1. NC_017277.1.
YP_007449864.1. NC_020286.1.

Genome annotation databases

EnsemblBacteriaiBAA16661; BAA16661; BAA16661.
GeneIDi953146.
KEGGisyn:sll1043.
syy:SYNGTS_0083.
syz:MYO_1830.
PATRICi23837032. VBISynSp132158_0091.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000022 Genomic DNA. Translation: BAA16661.1 .
PIRi S74509.
RefSeqi NP_439981.1. NC_000911.1.
YP_005650036.1. NC_017277.1.
YP_007449864.1. NC_020286.1.

3D structure databases

ProteinModelPortali P72659.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P72659. 3 interactions.
STRINGi 1148.sll1043.

Proteomic databases

PaxDbi P72659.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAA16661 ; BAA16661 ; BAA16661 .
GeneIDi 953146.
KEGGi syn:sll1043.
syy:SYNGTS_0083.
syz:MYO_1830.
PATRICi 23837032. VBISynSp132158_0091.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218326.
KOi K00962.
OMAi GTENTIC.
OrthoDBi EOG6WT8CC.
PhylomeDBi P72659.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
    Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
    , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 6803 / Kazusa.

Entry informationi

Entry nameiPNP_SYNY3
AccessioniPrimary (citable) accession number: P72659
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: February 1, 1997
Last modified: July 9, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

External Data

Dasty 3

Similar proteinsi