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P72659

- PNP_SYNY3

UniProt

P72659 - PNP_SYNY3

Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    • Comment

    Functioni

    Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

    Catalytic activityi

    RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi497 – 4971MagnesiumUniRule annotation
    Metal bindingi503 – 5031MagnesiumUniRule annotation

    GO - Molecular functioni

    1. 3'-5'-exoribonuclease activity Source: InterPro
    2. magnesium ion binding Source: UniProtKB-HAMAP
    3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
    4. RNA binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. mRNA catabolic process Source: UniProtKB-HAMAP
    2. RNA processing Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Ligandi

    Magnesium, Metal-binding, RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
    Alternative name(s):
    Polynucleotide phosphorylaseUniRule annotation
    Short name:
    PNPaseUniRule annotation
    Gene namesi
    Name:pnpUniRule annotation
    Ordered Locus Names:sll1043
    OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
    Taxonomic identifieri1111708 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
    ProteomesiUP000001425: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 718718Polyribonucleotide nucleotidyltransferasePRO_0000329905Add
    BLAST

    Proteomic databases

    PaxDbiP72659.

    Interactioni

    Protein-protein interaction databases

    IntActiP72659. 3 interactions.
    STRINGi1148.sll1043.

    Structurei

    3D structure databases

    ProteinModelPortaliP72659.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini564 – 62360KHUniRule annotationAdd
    BLAST
    Domaini633 – 70169S1 motifUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
    Contains 1 KH domain.UniRule annotation
    Contains 1 S1 motif domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1185.
    HOGENOMiHOG000218326.
    KOiK00962.
    OMAiGTENTIC.
    OrthoDBiEOG6WT8CC.
    PhylomeDBiP72659.

    Family and domain databases

    Gene3Di1.10.10.400. 1 hit.
    2.40.50.140. 1 hit.
    3.30.1370.10. 1 hit.
    3.30.230.70. 2 hits.
    HAMAPiMF_01595. PNPase.
    InterProiIPR001247. ExoRNase_PH_dom1.
    IPR015847. ExoRNase_PH_dom2.
    IPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    IPR012340. NA-bd_OB-fold.
    IPR012162. PNPase.
    IPR027408. PNPase/RNase_PH_dom.
    IPR015848. PNPase_PH_RNA-bd_bac/org-type.
    IPR003029. Rbsml_prot_S1_RNA-bd_dom.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR022967. RNA-binding_domain_S1.
    [Graphical view]
    PANTHERiPTHR11252. PTHR11252. 1 hit.
    PfamiPF00013. KH_1. 1 hit.
    PF03726. PNPase. 1 hit.
    PF01138. RNase_PH. 2 hits.
    PF03725. RNase_PH_C. 2 hits.
    PF00575. S1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005499. PNPase. 1 hit.
    SMARTiSM00322. KH. 1 hit.
    SM00316. S1. 1 hit.
    [Graphical view]
    SUPFAMiSSF50249. SSF50249. 1 hit.
    SSF54211. SSF54211. 2 hits.
    SSF54791. SSF54791. 1 hit.
    SSF55666. SSF55666. 2 hits.
    TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
    PROSITEiPS50084. KH_TYPE_1. 1 hit.
    PS50126. S1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P72659-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQEFDKSISF DGRDIRLKMG TLAPQAGGSV LIQSGDTAVL VTATRAKGRD    50
    GIDFLPLTVD YEGRLYAAGR IPGGFLRREG RPPEKATLIS RLIDRPLRPL 100
    FPHWLRDELQ IVATTLSMDE EVPPDVLAVT GASVAVILAQ IPFKGPMAAV 150
    RVGLVGDDFI INPTYREVHN GDLDLVVAGT PAGIVMVEAG ANQLPEQDII 200
    EAIDFGYEAV QDLINAQREL MTDLGITLAT SEPPPVNTAV EEFIANRASK 250
    KIITVLGQFD LGKDGRDAAL DEIKATEVET AIAELPETDP VKQSVEEDPK 300
    LVGNLYKALT KKLMRKQIVD DGVRVDGRKL EQVRPISCEV GFLPRRVHGS 350
    GLFNRGLTQV LSLATLGSPG DAQDLADDLH PEDEKRYLHH YNFPPYSVGE 400
    ARPMRSPGRR EIGHGALAER AIIPVLPPQE DFPYVVRVVS EVLSSNGSTS 450
    MGSVCGSTLA LMDAGVPIKK PVSGAAMGLI KEGDEIRILT DIQGIEDFLG 500
    DMDFKVAGTD SGITALQMDM KIDGLSMEVV SKAIMQALPA RLHILDKMLA 550
    TIREPRPELS PFAPRLLTLK IEPEHIGMVI GPGGKTIKGI TEQTSCKIDI 600
    ADDGTVTIAS SEGERAERAR QMIYNMTRKL NEGEVYLGRV TRIIPIGAFV 650
    EVLPGKEGMI HISQLTEGRV GKVEDEVGVG DEVIVKVREI DSKGRLNLTR 700
    LGIHPDEAAE ARRNASRG 718
    Length:718
    Mass (Da):77,831
    Last modified:February 1, 1997 - v1
    Checksum:i138A985B4AC76FEB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000022 Genomic DNA. Translation: BAA16661.1.
    PIRiS74509.
    RefSeqiNP_439981.1. NC_000911.1.
    YP_005650036.1. NC_017277.1.
    YP_007449864.1. NC_020286.1.

    Genome annotation databases

    EnsemblBacteriaiBAA16661; BAA16661; BAA16661.
    GeneIDi953146.
    KEGGisyn:sll1043.
    syy:SYNGTS_0083.
    syz:MYO_1830.
    PATRICi23837032. VBISynSp132158_0091.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000022 Genomic DNA. Translation: BAA16661.1 .
    PIRi S74509.
    RefSeqi NP_439981.1. NC_000911.1.
    YP_005650036.1. NC_017277.1.
    YP_007449864.1. NC_020286.1.

    3D structure databases

    ProteinModelPortali P72659.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P72659. 3 interactions.
    STRINGi 1148.sll1043.

    Proteomic databases

    PaxDbi P72659.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAA16661 ; BAA16661 ; BAA16661 .
    GeneIDi 953146.
    KEGGi syn:sll1043.
    syy:SYNGTS_0083.
    syz:MYO_1830.
    PATRICi 23837032. VBISynSp132158_0091.

    Phylogenomic databases

    eggNOGi COG1185.
    HOGENOMi HOG000218326.
    KOi K00962.
    OMAi GTENTIC.
    OrthoDBi EOG6WT8CC.
    PhylomeDBi P72659.

    Family and domain databases

    Gene3Di 1.10.10.400. 1 hit.
    2.40.50.140. 1 hit.
    3.30.1370.10. 1 hit.
    3.30.230.70. 2 hits.
    HAMAPi MF_01595. PNPase.
    InterProi IPR001247. ExoRNase_PH_dom1.
    IPR015847. ExoRNase_PH_dom2.
    IPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    IPR012340. NA-bd_OB-fold.
    IPR012162. PNPase.
    IPR027408. PNPase/RNase_PH_dom.
    IPR015848. PNPase_PH_RNA-bd_bac/org-type.
    IPR003029. Rbsml_prot_S1_RNA-bd_dom.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR022967. RNA-binding_domain_S1.
    [Graphical view ]
    PANTHERi PTHR11252. PTHR11252. 1 hit.
    Pfami PF00013. KH_1. 1 hit.
    PF03726. PNPase. 1 hit.
    PF01138. RNase_PH. 2 hits.
    PF03725. RNase_PH_C. 2 hits.
    PF00575. S1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005499. PNPase. 1 hit.
    SMARTi SM00322. KH. 1 hit.
    SM00316. S1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50249. SSF50249. 1 hit.
    SSF54211. SSF54211. 2 hits.
    SSF54791. SSF54791. 1 hit.
    SSF55666. SSF55666. 2 hits.
    TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
    PROSITEi PS50084. KH_TYPE_1. 1 hit.
    PS50126. S1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
      Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
      , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
      DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 6803 / Kazusa.

    Entry informationi

    Entry nameiPNP_SYNY3
    AccessioniPrimary (citable) accession number: P72659
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Synechocystis PCC 6803
      Synechocystis (strain PCC 6803): entries and gene names

    External Data

    Dasty 3