P72648 (KGUA_SYNY3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Guanylate kinase
EC=2.7.4.8

Alternative name(s):
GMP kinase

Gene names

Name:	gmk
Ordered Locus Names:	slr1123

Organism

Synechocystis sp. (strain PCC 6803 / Kazusa) [Reference proteome] [HAMAP]

Taxonomic identifier

1111708 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Cyanobacteria › Oscillatoriophycideae › Chroococcales › Synechocystis › Synechocystis sp. PCC 6803

Protein attributes

Sequence length	191 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Essential for recycling GMP and indirectly, cGMP By similarity. HAMAP-Rule MF_00328
Catalytic activity	ATP + GMP = ADP + GDP. HAMAP-Rule MF_00328
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the guanylate kinase family. Contains 1 guanylate kinase-like domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	purine nucleotide metabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW guanylate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 191	191	Guanylate kinase HAMAP-Rule MF_00328		PRO_0000170629
Regions
	Domain	10 – 188	179	Guanylate kinase-like
	Nucleotide binding	17 – 24	8	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	P72648 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: E92B5FCC6602FBB9	FASTA	191	21,427
	10 20 30 40 50 60 MAPDQTSVKG QLIVLTGPSG VGKGTLVQLL LERQPHWFLS ISATTRSPRA GEVDGQSYYF 70 80 90 100 110 120 LTKEEFQTWI GEEKLLEWAE YAGNYYGTPR QPVEEQIAQG KTVLLEIEVL GARQIKQTFP 130 140 150 160 170 180 SARRIFILPP SVEVLEERLR GRGSDSETAI AKRLAQAQQE LQAAAEFDYQ VVNDDLDQAL 190 HRLVKLIGEE E

References

[1]

"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions." Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S. DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PCC 6803 / Kazusa.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000022 Genomic DNA. Translation: BAA16650.1.
PIR	S74498.
RefSeq	NP_439970.1. NC_000911.1. YP_005650025.1. NC_017277.1. YP_007449853.1. NC_020286.1.
3D structure databases
ProteinModelPortal	P72648.
ModBase	Search...
Protein-protein interaction databases
STRING	1148.slr1123.
Proteomic databases
PaxDb	P72648.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAA16650; BAA16650; BAA16650.
GeneID	12253778. 14615494. 953117.
KEGG	syn:slr1123. syy:SYNGTS_0072.
PATRIC	23837010. VBISynSp132158_0080.
Phylogenomic databases
eggNOG	COG0194.
HOGENOM	HOG000037640.
KO	K00942.
OMA	EWAEFAG.
ProtClustDB	PRK00300.
Family and domain databases
HAMAP	MF_00328. Guanylate_kinase.
InterPro	IPR008144. Guanylate_kin. IPR008145. Guanylate_kin/L-typ_Ca_channel. IPR020590. Guanylate_kinase_CS. IPR017665. Guanylate_kinase_sub. [Graphical view]
Pfam	PF00625. Guanylate_kin. 1 hit. [Graphical view]
SMART	SM00072. GuKc. 1 hit. [Graphical view]
TIGRFAMs	TIGR03263. guanyl_kin. 1 hit.
PROSITE	PS00856. GUANYLATE_KINASE_1. 1 hit. PS50052. GUANYLATE_KINASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KGUA_SYNY3

Accession

Primary (citable) accession number: P72648

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	February 1, 1997
Last modified:	May 1, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program