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P72640

- LEP4_SYNY3

UniProt

P72640 - LEP4_SYNY3

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Protein

Type 4 prepilin-like proteins leader peptide-processing enzyme

Gene

hofD

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue.By similarity

Catalytic activityi

Typically cleaves a -Gly-|-Phe- bond to release an N-terminal, basic peptide of 5-8 residues from type IV prepilin, and then N-methylates the new N-terminal amino group, the methyl donor being S-adenosyl-L-methionine.

GO - Molecular functioni

  1. aspartic-type endopeptidase activity Source: InterPro
  2. methyltransferase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Methyltransferase, Protease, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Protein family/group databases

MEROPSiA24.003.

Names & Taxonomyi

Protein namesi
Recommended name:
Type 4 prepilin-like proteins leader peptide-processing enzyme
Including the following 2 domains:
Leader peptidase (EC:3.4.23.43)
Alternative name(s):
Prepilin peptidase
N-methyltransferase (EC:2.1.1.-)
Gene namesi
Name:hofD
Ordered Locus Names:slr1120
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
ProteomesiUP000001425: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 269269Type 4 prepilin-like proteins leader peptide-processing enzymePRO_0000192628Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi1148.slr1120.

Structurei

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei4 – 2421HelicalSequence AnalysisAdd
BLAST
Transmembranei100 – 12021HelicalSequence AnalysisAdd
BLAST
Transmembranei127 – 14721HelicalSequence AnalysisAdd
BLAST
Transmembranei154 – 17421HelicalSequence AnalysisAdd
BLAST
Transmembranei197 – 21721HelicalSequence AnalysisAdd
BLAST
Transmembranei238 – 25821HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase A24 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1989.
HOGENOMiHOG000248583.
InParanoidiP72640.
KOiK02654.
OMAiMMEREWH.
OrthoDBiEOG6F55M8.
PhylomeDBiP72640.

Family and domain databases

InterProiIPR010627. Pept_A24A_N.
IPR014032. Peptidase_A24A_bac.
IPR000045. Prepilin_IV_endopep_pep.
[Graphical view]
PfamiPF06750. DiS_P_DiS. 1 hit.
PF01478. Peptidase_A24. 1 hit.
[Graphical view]
PRINTSiPR00864. PREPILNPTASE.

Sequencei

Sequence statusi: Complete.

P72640 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDPLIAPLAF LLAIALGCAV GSFLNVVAYR LPEGLSLVHP PSRCPHCGHR
60 70 80 90 100
LGPKENVPVV GWLWLRGKCR WCQTAISPRY PLVEAATGFL FALTCWRFGW
110 120 130 140 150
QWQTFGYWIL ISFLISLTLI DWDTMTLPNS LTKPGLVLGL LFHLLLGWQR
160 170 180 190 200
GHWIVPLVEA IASAVLGLWL FDLIRMGGSL LLGREGMGDG DPKLASMVGA
210 220 230 240 250
WLGWPSLLLT TFIACFIGSI YGGLKLLLGT LQRRQGFPFG PFLAIGALIS
260
LFWGEKLITS YLNFVTPQF
Length:269
Mass (Da):29,767
Last modified:February 1, 1997 - v1
Checksum:i4056E0AA96654B1C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000022 Genomic DNA. Translation: BAA16642.1.
PIRiS74490.
RefSeqiNP_439962.1. NC_000911.1.
YP_005650017.1. NC_017277.1.
YP_007449845.1. NC_020286.1.

Genome annotation databases

EnsemblBacteriaiBAA16642; BAA16642; BAA16642.
GeneIDi952892.
KEGGisyn:slr1120.
syy:SYNGTS_0064.
syz:MYO_1640.
PATRICi23836990. VBISynSp132158_0070.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000022 Genomic DNA. Translation: BAA16642.1 .
PIRi S74490.
RefSeqi NP_439962.1. NC_000911.1.
YP_005650017.1. NC_017277.1.
YP_007449845.1. NC_020286.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 1148.slr1120.

Protein family/group databases

MEROPSi A24.003.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAA16642 ; BAA16642 ; BAA16642 .
GeneIDi 952892.
KEGGi syn:slr1120.
syy:SYNGTS_0064.
syz:MYO_1640.
PATRICi 23836990. VBISynSp132158_0070.

Phylogenomic databases

eggNOGi COG1989.
HOGENOMi HOG000248583.
InParanoidi P72640.
KOi K02654.
OMAi MMEREWH.
OrthoDBi EOG6F55M8.
PhylomeDBi P72640.

Family and domain databases

InterProi IPR010627. Pept_A24A_N.
IPR014032. Peptidase_A24A_bac.
IPR000045. Prepilin_IV_endopep_pep.
[Graphical view ]
Pfami PF06750. DiS_P_DiS. 1 hit.
PF01478. Peptidase_A24. 1 hit.
[Graphical view ]
PRINTSi PR00864. PREPILNPTASE.
ProtoNeti Search...

Publicationsi

  1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
    Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
    , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 6803 / Kazusa.

Entry informationi

Entry nameiLEP4_SYNY3
AccessioniPrimary (citable) accession number: P72640
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: February 1, 1997
Last modified: October 29, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

External Data

Dasty 3