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P72640

- LEP4_SYNY3

UniProt

P72640 - LEP4_SYNY3

Protein

Type 4 prepilin-like proteins leader peptide-processing enzyme

Gene

hofD

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue.By similarity

    Catalytic activityi

    Typically cleaves a -Gly-|-Phe- bond to release an N-terminal, basic peptide of 5-8 residues from type IV prepilin, and then N-methylates the new N-terminal amino group, the methyl donor being S-adenosyl-L-methionine.

    GO - Molecular functioni

    1. aspartic-type endopeptidase activity Source: InterPro
    2. methyltransferase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Methyltransferase, Protease, Transferase

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Protein family/group databases

    MEROPSiA24.003.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Type 4 prepilin-like proteins leader peptide-processing enzyme
    Including the following 2 domains:
    Leader peptidase (EC:3.4.23.43)
    Alternative name(s):
    Prepilin peptidase
    N-methyltransferase (EC:2.1.1.-)
    Gene namesi
    Name:hofD
    Ordered Locus Names:slr1120
    OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
    Taxonomic identifieri1111708 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
    ProteomesiUP000001425: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 269269Type 4 prepilin-like proteins leader peptide-processing enzymePRO_0000192628Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi1148.slr1120.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei4 – 2421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei100 – 12021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei127 – 14721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei154 – 17421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei197 – 21721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei238 – 25821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase A24 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1989.
    HOGENOMiHOG000248583.
    KOiK02654.
    OMAiMMEREWH.
    OrthoDBiEOG6F55M8.
    PhylomeDBiP72640.

    Family and domain databases

    InterProiIPR010627. Pept_A24A_N.
    IPR014032. Peptidase_A24A_bac.
    IPR000045. Prepilin_IV_endopep_pep.
    [Graphical view]
    PfamiPF06750. DiS_P_DiS. 1 hit.
    PF01478. Peptidase_A24. 1 hit.
    [Graphical view]
    PRINTSiPR00864. PREPILNPTASE.

    Sequencei

    Sequence statusi: Complete.

    P72640-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDPLIAPLAF LLAIALGCAV GSFLNVVAYR LPEGLSLVHP PSRCPHCGHR    50
    LGPKENVPVV GWLWLRGKCR WCQTAISPRY PLVEAATGFL FALTCWRFGW 100
    QWQTFGYWIL ISFLISLTLI DWDTMTLPNS LTKPGLVLGL LFHLLLGWQR 150
    GHWIVPLVEA IASAVLGLWL FDLIRMGGSL LLGREGMGDG DPKLASMVGA 200
    WLGWPSLLLT TFIACFIGSI YGGLKLLLGT LQRRQGFPFG PFLAIGALIS 250
    LFWGEKLITS YLNFVTPQF 269
    Length:269
    Mass (Da):29,767
    Last modified:February 1, 1997 - v1
    Checksum:i4056E0AA96654B1C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000022 Genomic DNA. Translation: BAA16642.1.
    PIRiS74490.
    RefSeqiNP_439962.1. NC_000911.1.
    YP_005650017.1. NC_017277.1.
    YP_007449845.1. NC_020286.1.

    Genome annotation databases

    EnsemblBacteriaiBAA16642; BAA16642; BAA16642.
    GeneIDi952892.
    KEGGisyn:slr1120.
    syy:SYNGTS_0064.
    syz:MYO_1640.
    PATRICi23836990. VBISynSp132158_0070.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000022 Genomic DNA. Translation: BAA16642.1 .
    PIRi S74490.
    RefSeqi NP_439962.1. NC_000911.1.
    YP_005650017.1. NC_017277.1.
    YP_007449845.1. NC_020286.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 1148.slr1120.

    Protein family/group databases

    MEROPSi A24.003.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAA16642 ; BAA16642 ; BAA16642 .
    GeneIDi 952892.
    KEGGi syn:slr1120.
    syy:SYNGTS_0064.
    syz:MYO_1640.
    PATRICi 23836990. VBISynSp132158_0070.

    Phylogenomic databases

    eggNOGi COG1989.
    HOGENOMi HOG000248583.
    KOi K02654.
    OMAi MMEREWH.
    OrthoDBi EOG6F55M8.
    PhylomeDBi P72640.

    Family and domain databases

    InterProi IPR010627. Pept_A24A_N.
    IPR014032. Peptidase_A24A_bac.
    IPR000045. Prepilin_IV_endopep_pep.
    [Graphical view ]
    Pfami PF06750. DiS_P_DiS. 1 hit.
    PF01478. Peptidase_A24. 1 hit.
    [Graphical view ]
    PRINTSi PR00864. PREPILNPTASE.
    ProtoNeti Search...

    Publicationsi

    1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
      Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
      , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
      DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 6803 / Kazusa.

    Entry informationi

    Entry nameiLEP4_SYNY3
    AccessioniPrimary (citable) accession number: P72640
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families
    3. Synechocystis PCC 6803
      Synechocystis (strain PCC 6803): entries and gene names

    External Data

    Dasty 3