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P72640 (LEP4_SYNY3) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Type 4 prepilin-like proteins leader peptide-processing enzyme

Including the following 2 domains:

  1. Leader peptidase
    EC=3.4.23.43
    Alternative name(s):
    Prepilin peptidase
  2. N-methyltransferase
    EC=2.1.1.-
Gene names
Name:hofD
Ordered Locus Names:slr1120
OrganismSynechocystis sp. (strain PCC 6803 / Kazusa) [Reference proteome] [HAMAP]
Taxonomic identifier1111708 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis

Protein attributes

Sequence length269 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue By similarity.

Catalytic activity

Typically cleaves a -Gly-|-Phe- bond to release an N-terminal, basic peptide of 5-8 residues from type IV prepilin, and then N-methylates the new N-terminal amino group, the methyl donor being S-adenosyl-L-methionine.

Subcellular location

Cell membrane; Multi-pass membrane protein Probable.

Sequence similarities

Belongs to the peptidase A24 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 269269Type 4 prepilin-like proteins leader peptide-processing enzyme
PRO_0000192628

Regions

Transmembrane4 – 2421Helical; Potential
Transmembrane100 – 12021Helical; Potential
Transmembrane127 – 14721Helical; Potential
Transmembrane154 – 17421Helical; Potential
Transmembrane197 – 21721Helical; Potential
Transmembrane238 – 25821Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
P72640 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: 4056E0AA96654B1C

FASTA26929,767
        10         20         30         40         50         60 
MDPLIAPLAF LLAIALGCAV GSFLNVVAYR LPEGLSLVHP PSRCPHCGHR LGPKENVPVV 

        70         80         90        100        110        120 
GWLWLRGKCR WCQTAISPRY PLVEAATGFL FALTCWRFGW QWQTFGYWIL ISFLISLTLI 

       130        140        150        160        170        180 
DWDTMTLPNS LTKPGLVLGL LFHLLLGWQR GHWIVPLVEA IASAVLGLWL FDLIRMGGSL 

       190        200        210        220        230        240 
LLGREGMGDG DPKLASMVGA WLGWPSLLLT TFIACFIGSI YGGLKLLLGT LQRRQGFPFG 

       250        260 
PFLAIGALIS LFWGEKLITS YLNFVTPQF 

« Hide

References

[1]"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. expand/collapse author list , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PCC 6803 / Kazusa.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000022 Genomic DNA. Translation: BAA16642.1.
PIRS74490.
RefSeqNP_439962.1. NC_000911.1.
YP_005650017.1. NC_017277.1.
YP_007449845.1. NC_020286.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING1148.slr1120.

Protein family/group databases

MEROPSA24.003.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAA16642; BAA16642; BAA16642.
GeneID952892.
KEGGsyn:slr1120.
syy:SYNGTS_0064.
syz:MYO_1640.
PATRIC23836990. VBISynSp132158_0070.

Phylogenomic databases

eggNOGCOG1989.
HOGENOMHOG000248583.
KOK02654.
OMAMMEREWH.
OrthoDBEOG6F55M8.
PhylomeDBP72640.

Family and domain databases

InterProIPR010627. Pept_A24A_N.
IPR014032. Peptidase_A24A_bac.
IPR000045. Prepilin_IV_endopep_pep.
[Graphical view]
PfamPF06750. DiS_P_DiS. 1 hit.
PF01478. Peptidase_A24. 1 hit.
[Graphical view]
PRINTSPR00864. PREPILNPTASE.
ProtoNetSearch...

Entry information

Entry nameLEP4_SYNY3
AccessionPrimary (citable) accession number: P72640
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: February 1, 1997
Last modified: July 9, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Synechocystis PCC 6803

Synechocystis (strain PCC 6803): entries and gene names

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries