ID   GLGA2_SYNY3             Reviewed;         491 AA.
AC   P72623;
DT   16-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   27-MAR-2024, entry version 129.
DE   RecName: Full=Probable glycogen synthase 2;
DE            EC=2.4.1.21;
DE   AltName: Full=Starch [bacterial glycogen] synthase 2;
GN   Name=glgA2; OrderedLocusNames=sll1393;
OS   Synechocystis sp. (strain PCC 6803 / Kazusa).
OC   Bacteria; Cyanobacteriota; Cyanophyceae; Synechococcales; Merismopediaceae;
OC   Synechocystis.
OX   NCBI_TaxID=1111708;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PCC 6803 / Kazusa;
RX   PubMed=8905231; DOI=10.1093/dnares/3.3.109;
RA   Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y.,
RA   Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T.,
RA   Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.,
RA   Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT   "Sequence analysis of the genome of the unicellular cyanobacterium
RT   Synechocystis sp. strain PCC6803. II. Sequence determination of the entire
RT   genome and assignment of potential protein-coding regions.";
RL   DNA Res. 3:109-136(1996).
CC   -!- FUNCTION: Synthesizes alpha-1,4-glucan chains using ADP-glucose.
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[(1->4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1->4)-
CC         alpha-D-glucosyl](n+1) + ADP + H(+); Xref=Rhea:RHEA:18189, Rhea:RHEA-
CC         COMP:9584, Rhea:RHEA-COMP:9587, ChEBI:CHEBI:15378, ChEBI:CHEBI:15444,
CC         ChEBI:CHEBI:57498, ChEBI:CHEBI:456216; EC=2.4.1.21;
CC   -!- PATHWAY: Glycan biosynthesis; glycogen biosynthesis.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase 1 family.
CC       Bacterial/plant glycogen synthase subfamily. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BA000022; BAA16625.1; -; Genomic_DNA.
DR   PIR; S74473; S74473.
DR   AlphaFoldDB; P72623; -.
DR   SMR; P72623; -.
DR   IntAct; P72623; 6.
DR   STRING; 1148.gene:10497480; -.
DR   CAZy; GT5; Glycosyltransferase Family 5.
DR   PaxDb; 1148-1651697; -.
DR   EnsemblBacteria; BAA16625; BAA16625; BAA16625.
DR   KEGG; syn:sll1393; -.
DR   eggNOG; COG0297; Bacteria.
DR   InParanoid; P72623; -.
DR   PhylomeDB; P72623; -.
DR   UniPathway; UPA00164; -.
DR   Proteomes; UP000001425; Chromosome.
DR   GO; GO:0033201; F:alpha-1,4-glucan synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004373; F:glycogen (starch) synthase activity; IEA:InterPro.
DR   GO; GO:0009011; F:starch synthase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005978; P:glycogen biosynthetic process; IEA:UniProtKB-UniRule.
DR   CDD; cd03791; GT5_Glycogen_synthase_DULL1-like; 1.
DR   Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 2.
DR   HAMAP; MF_00484; Glycogen_synth; 1.
DR   InterPro; IPR001296; Glyco_trans_1.
DR   InterPro; IPR011835; GS/SS.
DR   InterPro; IPR013534; Starch_synth_cat_dom.
DR   NCBIfam; TIGR02095; glgA; 1.
DR   PANTHER; PTHR46083; -; 1.
DR   PANTHER; PTHR46083:SF1; GLYCOGEN SYNTHASE 2-RELATED; 1.
DR   Pfam; PF08323; Glyco_transf_5; 1.
DR   Pfam; PF00534; Glycos_transf_1; 1.
DR   SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 1.
PE   3: Inferred from homology;
KW   Glycogen biosynthesis; Glycosyltransferase; Reference proteome;
KW   Transferase.
FT   CHAIN           1..491
FT                   /note="Probable glycogen synthase 2"
FT                   /id="PRO_0000188656"
FT   BINDING         15
FT                   /ligand="ADP-alpha-D-glucose"
FT                   /ligand_id="ChEBI:CHEBI:57498"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   491 AA;  56225 MW;  9AE25BB6D0CF4B5A CRC64;
     MYIVQIASEC APVIKAGGLG DVIYGLSREL ELRGHCVELI LPMYDCMRYD HIWGLHDAYR
     NLEVPWYGSS IFCDVFCGWV HGRLCFFIQP KSSDNFFNRG HYYGALDDHM RFAFFSKAAM
     EFLLRSNKRP DIIHCHDWQT GLVPVLLYEI YRFHGMDHQR VCYTIHNFKH QGIAGANILH
     ATGLNNDSYY FSYDRLQDNF NPNAINFMKG GIVYSNYVNT VSPHHAWEAR FSDISCGLGH
     TLEIHQQKFG GILNGLDYEV WNPEIDPLLA SNFSVKTFGD KAKNKQALRE RLLLETDDKK
     PMLCFIGRLD GQKGVHLVHH SIYYALSQGA QFVLLGSATE PNLSKWFWHE KQHLNDNPNV
     HLELGFDEEL AHLIYGAADI IVVPSNYEPC GLTQMIGLRY GAVPVVRGVG GLVNTVFDRD
     YDQNHPPEKR NGFVFYQPDE YALETALSRA IALYKDDPVA FKTLALQGMA YDYSWNKPGL
     QYVEAYEYIR A
//