Reviewed, UniProtKB/Swiss-Prot P72622 (MSRA1_SYNY3)

Names and origin

Protein names

Recommended name:
    Peptide methionine sulfoxide reductase msrA 1
      Short name=Protein-methionine-S-oxide reductase 1
    EC=1.8.4.11
Alternative name(s):
    Peptide-methionine (S)-S-oxide reductase 1
      Short name=Peptide Met(O) reductase 1

Gene names

Name:	msrA1
Ordered Locus Names:	sll1394

Organism

Synechocystis sp. (strain PCC 6803) [Complete proteome] [HAMAP]

Taxonomic identifier

1148 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Synechocystis

Protein attributes

Sequence length	222 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine By similarity.
Catalytic activity	Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401 L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401
Sequence similarities	Belongs to the msrA Met sulfoxide reductase family.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW protein modification process Inferred from electronic annotation. Source: HAMAP
Molecular function	peptide-methionine-(S)-S-oxide reductase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 222	222	Peptide methionine sulfoxide reductase msrA 1 HAMAP MF_01401		PRO_0000138601
Sites
	Active site	57	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	P72622-1 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: 6F4FD8FA00027AA2	FASTA	222	24,209
	10 20 30 40 50 60 MGFFDLFGKK TAMVAPNEAL PGRSATMPVP DKHFVNGNPL KAPFPQGMET ALFGLGCFWG 70 80 90 100 110 120 AERKFWQIPG VYSTAVGYAA GYTPNPTYQE VCTGMTGHNE VVLVAFDPQQ VSYDQLLKVF 130 140 150 160 170 180 WESHNPTQGM RQGNDVGTQY RSGIYTYSEA QQQAALASKQ AYQQALQQAG YGEITTEILP 190 200 210 220 APDFYYAEDY HQQYLAKNPN GYCGLGGTNV ACPIGTEVSL GA

References

[1]

"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions." Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S. DNA Res. 3:109-136(1996) [PubMed: 8905231] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000022 Genomic DNA. Translation: BAA16624.1.
PIR	S74472.
RefSeq	NP_439944.1.
3D structure databases
HSSP	HSSP built from PDB template 1FVA based on UniProtKB P54149.
ModBase	Search...
Protein-protein interaction databases
IntAct	P72622. 5 interactions.
Genome annotation databases
GeneID	952529.
GenomeReviews	Gene locus sll1394 in contig BA000022_GR.
KEGG	syn:sll1394.
NMPDR	fig|1148.1.peg.45.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P72622.
OMA	P72622. VYFAEAY.
Enzyme and pathway databases
BioCyc	SSP1148:SLL1394-MON.
Family and domain databases
HAMAP	MF_01401. [Tree]
InterPro	IPR002569. MsrA. [Graphical view]
Gene3D	G3DSA:3.30.1060.10. MsrA. 1 hit.
Pfam	PF01625. PMSR. 1 hit. [Graphical view]
ProDom	PD003489. PMSR. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00401. msrA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MSRA1_SYNY3

Accession

Primary (citable) accession number: P72622

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 11, 2001
Last sequence update:	February 1, 1997
Last modified:	June 16, 2009
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)