P72622 (MSRA1_SYNY3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peptide methionine sulfoxide reductase MsrA 1
Short name=Protein-methionine-S-oxide reductase 1
EC=1.8.4.11

Alternative name(s):
Peptide-methionine (S)-S-oxide reductase 1
Short name=Peptide Met(O) reductase 1

Gene names

Name:	msrA1
Ordered Locus Names:	sll1394

Organism

Synechocystis sp. (strain PCC 6803 / Kazusa) [Reference proteome] [HAMAP]

Taxonomic identifier

1111708 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Cyanobacteria › Oscillatoriophycideae › Chroococcales › Synechocystis › Synechocystis sp. PCC 6803

Protein attributes

Sequence length	222 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine By similarity. HAMAP-Rule MF_01401
Catalytic activity	Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin. HAMAP-Rule MF_01401 L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. HAMAP-Rule MF_01401
Sequence similarities	Belongs to the MsrA Met sulfoxide reductase family.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular protein modification process Inferred from electronic annotation. Source: HAMAP
Molecular_function	peptide-methionine (S)-S-oxide reductase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 222	222	Peptide methionine sulfoxide reductase MsrA 1 HAMAP-Rule MF_01401		PRO_0000138601
Sites
	Active site	57	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	P72622 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: 6F4FD8FA00027AA2	FASTA	222	24,209
	10 20 30 40 50 60 MGFFDLFGKK TAMVAPNEAL PGRSATMPVP DKHFVNGNPL KAPFPQGMET ALFGLGCFWG 70 80 90 100 110 120 AERKFWQIPG VYSTAVGYAA GYTPNPTYQE VCTGMTGHNE VVLVAFDPQQ VSYDQLLKVF 130 140 150 160 170 180 WESHNPTQGM RQGNDVGTQY RSGIYTYSEA QQQAALASKQ AYQQALQQAG YGEITTEILP 190 200 210 220 APDFYYAEDY HQQYLAKNPN GYCGLGGTNV ACPIGTEVSL GA

References

[1]

"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions." Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S. DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PCC 6803 / Kazusa.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000022 Genomic DNA. Translation: BAA16624.1.
PIR	S74472.
RefSeq	NP_439944.1. NC_000911.1. YP_005649999.1. NC_017277.1. YP_007449827.1. NC_020286.1.
3D structure databases
ProteinModelPortal	P72622.
SMR	P72622. Positions 13-213.
ModBase	Search...
Protein-protein interaction databases
IntAct	P72622. 5 interactions.
STRING	1148.sll1394.
Proteomic databases
PaxDb	P72622.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAA16624; BAA16624; BAA16624.
GeneID	12253752. 14615468. 952529.
KEGG	syn:sll1394. syy:SYNGTS_0046.
PATRIC	23836952. VBISynSp132158_0051.
Phylogenomic databases
eggNOG	COG0225.
HOGENOM	HOG000263862.
KO	K07304.
OMA	SAIYCTS.
ProtClustDB	PRK00058.
Family and domain databases
Gene3D	3.30.1060.10. 1 hit.
HAMAP	MF_01401. MsrA.
InterPro	IPR002569. Met_Sox_Rdtase_MsrA. [Graphical view]
Pfam	PF01625. PMSR. 1 hit. [Graphical view]
SUPFAM	SSF55068. MsrA. 1 hit.
TIGRFAMs	TIGR00401. msrA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MSRA1_SYNY3

Accession

Primary (citable) accession number: P72622

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 11, 2001
Last sequence update:	February 1, 1997
Last modified:	May 1, 2013
This is version 85 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program