P72622 (MSRA1_SYNY3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peptide methionine sulfoxide reductase MsrA 1
Short name=Protein-methionine-S-oxide reductase 1
EC=1.8.4.11

Alternative name(s):
Peptide-methionine (S)-S-oxide reductase 1
Short name=Peptide Met(O) reductase 1

Gene names

Name:	msrA1
Ordered Locus Names:	sll1394

Organism

Synechocystis sp. (strain PCC 6803 / Kazusa)

Taxonomic identifier

1111708 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Synechocystis

Protein attributes

Sequence length	222 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine By similarity. HAMAP MF_01401
Catalytic activity	Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401 L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401
Sequence similarities	Belongs to the MsrA Met sulfoxide reductase family.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	protein metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	peptide-methionine-(S)-S-oxide reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 222	222	Peptide methionine sulfoxide reductase MsrA 1 HAMAP MF_01401		PRO_0000138601
Sites
	Active site	57	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	P72622 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: 6F4FD8FA00027AA2	FASTA	222	24,209
	10 20 30 40 50 60 MGFFDLFGKK TAMVAPNEAL PGRSATMPVP DKHFVNGNPL KAPFPQGMET ALFGLGCFWG 70 80 90 100 110 120 AERKFWQIPG VYSTAVGYAA GYTPNPTYQE VCTGMTGHNE VVLVAFDPQQ VSYDQLLKVF 130 140 150 160 170 180 WESHNPTQGM RQGNDVGTQY RSGIYTYSEA QQQAALASKQ AYQQALQQAG YGEITTEILP 190 200 210 220 APDFYYAEDY HQQYLAKNPN GYCGLGGTNV ACPIGTEVSL GA

References

[1]

"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions." Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S. DNA Res. 3:109-136(1996) [PubMed: 8905231] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 27184 / PCC 6803 / N-1.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000022 Genomic DNA. Translation: BAA16624.1.
PIR	S74472.
RefSeq	NP_439944.1. NC_000911.1.
3D structure databases
ProteinModelPortal	P72622.
SMR	P72622. Positions 13-213.
ModBase	Search...
Protein-protein interaction databases
IntAct	P72622. 5 interactions.
STRING	P72622.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	952529.
GenomeReviews	Gene locus sll1394 in contig BA000022_GR.
KEGG	syn:sll1394.
NMPDR	fig|1148.1.peg.45.
PATRIC	23836952. VBISynSp132158_0051.
Phylogenomic databases
eggNOG	COG0225.
HOGENOM	HBG748152.
OMA	SAIYCTS.
PhylomeDB	P72622.
ProtClustDB	PRK00058.
Enzyme and pathway databases
BioCyc	SSP1148:SLL1394-MONOMER.
Family and domain databases
HAMAP	MF_01401. MsrA. [Tree]
InterPro	IPR002569. Peptide_Met_Sox_Rdtase_MsrA. [Graphical view]
Gene3D	G3DSA:3.30.1060.10. MsrA. 1 hit.
KO	K07304.
Pfam	PF01625. PMSR. 1 hit. [Graphical view]
SUPFAM	SSF55068. MsrA. 1 hit.
TIGRFAMs	TIGR00401. MsrA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MSRA1_SYNY3

Accession

Primary (citable) accession number: P72622

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 11, 2001
Last sequence update:	February 1, 1997
Last modified:	January 25, 2012
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program