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P72587 (SPEA2_SYNY3) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Biosynthetic arginine decarboxylase 2

Short name=ADC 2
EC=4.1.1.19
Gene names
Name:speA2
Synonyms:speA
Ordered Locus Names:slr1312
OrganismSynechocystis sp. (strain PCC 6803 / Kazusa) [Reference proteome] [HAMAP]
Taxonomic identifier1111708 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis

Protein attributes

Sequence length659 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the biosynthesis of agmatine from arginine By similarity. HAMAP-Rule MF_01417

Catalytic activity

L-arginine = agmatine + CO2. HAMAP-Rule MF_01417

Cofactor

Magnesium By similarity. HAMAP-Rule MF_01417

Pyridoxal phosphate By similarity. HAMAP-Rule MF_01417

Sequence similarities

Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 659659Biosynthetic arginine decarboxylase 2 HAMAP-Rule MF_01417
PRO_0000149982

Regions

Region311 – 32111Substrate-binding Potential

Amino acid modifications

Modified residue1191N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
P72587 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: E8442002C8CD4629

FASTA65974,477
        10         20         30         40         50         60 
MGEEPVPADK ALGKKFKKKN ASWSIEESEA LYRVEAWGAP YFAINAAGNI TVSPNGDRGG 

        70         80         90        100        110        120 
SLDLLELVEA LRQRKLGLPL LIRFSDILAD RLERLNSCFA KAIARYNYPN TYQAVYPVKC 

       130        140        150        160        170        180 
NQQRHLVEAL VRFGQTSQCG LEAGSKPELM IALATLPPPL DRQDKHTKPL IICNGYKDQD 

       190        200        210        220        230        240 
YLETALLAKR LGHRPIIIIE QLRELEWVLH ISQQLNIKPM LGVRARLSCQ SLKSSEISSG 

       250        260        270        280        290        300 
NGDRAKLGLT MPDIVTVIHR LEENNCLDCL KMLHFHLGTQ VSDIALIKEA MREASQLYVE 

       310        320        330        340        350        360 
LVKLGAKMRY LNVGGGLAVD YDGSKTNYPA SKNYNMQNYA NDIVAAIQDA CELGQVSPPI 

       370        380        390        400        410        420 
LVSESGRAIM AHQSVLVFDV LGSNQTGFSE PHPPDENAHP LLKNLWECYE TITAEQYQEQ 

       430        440        450        460        470        480 
YHDALQLKTE ASSLFNFGYL SLTERGQAEQ IHWACCRKIF EITRQLEYIP EDFQALDKIM 

       490        500        510        520        530        540 
TDIYYVNLSV FQSAPESWSL DQLFPILPIH HLNEKPSQRV ILADLTCDSD GKIDRFIDLW 

       550        560        570        580        590        600 
DVKSYLEVHP LENDGNPYYL GMFLVGAYQE IMGNLHNLFG DINVVHIATT PQGYQIESVV 

       610        620        630        640        650 
RGDTMTEVLG YVQYDSDDLL EGLRRHTELA LSNGQITLEE SRRLLEDYEQ SLRRYTYLS 

« Hide

References

« Hide 'large scale' references
[1]"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. expand/collapse author list , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PCC 6803 / Kazusa.
[2]"Disruption of a spe-like open reading frame alters polyamine content and psbA-2 mRNA stability in the cyanobacterium Synechocystis sp. PCC 6803."
Mulo P., Eloranta T., Aro E.M., Maenpaeae P.
Bot. Acta 111:71-76(1998)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-302.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000022 Genomic DNA. Translation: BAA16587.1.
X96602 Genomic DNA. Translation: CAA65422.1.
PIRS74435.
RefSeqNP_439907.1. NC_000911.1.
YP_005649962.1. NC_017277.1.
YP_007449790.1. NC_020286.1.

3D structure databases

ProteinModelPortalP72587.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING1148.slr1312.

Proteomic databases

PRIDEP72587.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAA16587; BAA16587; BAA16587.
GeneID951929.
KEGGsyn:slr1312.
syy:SYNGTS_0009.
syz:MYO_190.
PATRIC23836874. VBISynSp132158_0012.

Phylogenomic databases

eggNOGCOG1166.
HOGENOMHOG000029191.
KOK01585.
OMACCVESAV.
OrthoDBEOG676Z0R.
PhylomeDBP72587.

Family and domain databases

Gene3D2.40.37.10. 2 hits.
3.20.20.10. 1 hit.
HAMAPMF_01417. SpeA.
InterProIPR009006. Ala_racemase/Decarboxylase_C.
IPR002985. Arg_decrbxlase.
IPR022643. De-COase2_C.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PIRSFPIRSF001336. Arg_decrbxlase. 1 hit.
PRINTSPR01180. ARGDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsTIGR01273. speA. 1 hit.
PROSITEPS00878. ODR_DC_2_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSPEA2_SYNY3
AccessionPrimary (citable) accession number: P72587
Entry history
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: February 1, 1997
Last modified: July 9, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Synechocystis PCC 6803

Synechocystis (strain PCC 6803): entries and gene names

SIMILARITY comments

Index of protein domains and families