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P72587

- SPEA2_SYNY3

UniProt

P72587 - SPEA2_SYNY3

Protein

Biosynthetic arginine decarboxylase 2

Gene

speA2

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    Catalyzes the biosynthesis of agmatine from arginine.By similarity

    Catalytic activityi

    L-arginine = agmatine + CO2.

    Cofactori

    Magnesium.By similarity
    Pyridoxal phosphate.By similarity

    GO - Molecular functioni

    1. arginine decarboxylase activity Source: UniProtKB-HAMAP
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. arginine catabolic process Source: InterPro
    2. spermidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Biological processi

    Polyamine biosynthesis, Spermidine biosynthesis

    Keywords - Ligandi

    Magnesium, Metal-binding, Pyridoxal phosphate

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Biosynthetic arginine decarboxylase 2 (EC:4.1.1.19)
    Short name:
    ADC 2
    Gene namesi
    Name:speA2
    Synonyms:speA
    Ordered Locus Names:slr1312
    OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
    Taxonomic identifieri1111708 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
    ProteomesiUP000001425: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 659659Biosynthetic arginine decarboxylase 2PRO_0000149982Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei119 – 1191N6-(pyridoxal phosphate)lysineBy similarity

    Proteomic databases

    PRIDEiP72587.

    Interactioni

    Protein-protein interaction databases

    STRINGi1148.slr1312.

    Structurei

    3D structure databases

    ProteinModelPortaliP72587.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni311 – 32111Substrate-bindingSequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1166.
    HOGENOMiHOG000029191.
    KOiK01585.
    OMAiCCVESAV.
    OrthoDBiEOG676Z0R.
    PhylomeDBiP72587.

    Family and domain databases

    Gene3Di2.40.37.10. 2 hits.
    3.20.20.10. 1 hit.
    HAMAPiMF_01417. SpeA.
    InterProiIPR009006. Ala_racemase/Decarboxylase_C.
    IPR002985. Arg_decrbxlase.
    IPR022643. De-COase2_C.
    IPR022644. De-COase2_N.
    IPR022653. De-COase2_pyr-phos_BS.
    IPR000183. Orn/DAP/Arg_de-COase.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF02784. Orn_Arg_deC_N. 1 hit.
    PF00278. Orn_DAP_Arg_deC. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001336. Arg_decrbxlase. 1 hit.
    PRINTSiPR01180. ARGDCRBXLASE.
    PR01179. ODADCRBXLASE.
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR01273. speA. 1 hit.
    PROSITEiPS00878. ODR_DC_2_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P72587-1 [UniParc]FASTAAdd to Basket

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    MGEEPVPADK ALGKKFKKKN ASWSIEESEA LYRVEAWGAP YFAINAAGNI    50
    TVSPNGDRGG SLDLLELVEA LRQRKLGLPL LIRFSDILAD RLERLNSCFA 100
    KAIARYNYPN TYQAVYPVKC NQQRHLVEAL VRFGQTSQCG LEAGSKPELM 150
    IALATLPPPL DRQDKHTKPL IICNGYKDQD YLETALLAKR LGHRPIIIIE 200
    QLRELEWVLH ISQQLNIKPM LGVRARLSCQ SLKSSEISSG NGDRAKLGLT 250
    MPDIVTVIHR LEENNCLDCL KMLHFHLGTQ VSDIALIKEA MREASQLYVE 300
    LVKLGAKMRY LNVGGGLAVD YDGSKTNYPA SKNYNMQNYA NDIVAAIQDA 350
    CELGQVSPPI LVSESGRAIM AHQSVLVFDV LGSNQTGFSE PHPPDENAHP 400
    LLKNLWECYE TITAEQYQEQ YHDALQLKTE ASSLFNFGYL SLTERGQAEQ 450
    IHWACCRKIF EITRQLEYIP EDFQALDKIM TDIYYVNLSV FQSAPESWSL 500
    DQLFPILPIH HLNEKPSQRV ILADLTCDSD GKIDRFIDLW DVKSYLEVHP 550
    LENDGNPYYL GMFLVGAYQE IMGNLHNLFG DINVVHIATT PQGYQIESVV 600
    RGDTMTEVLG YVQYDSDDLL EGLRRHTELA LSNGQITLEE SRRLLEDYEQ 650
    SLRRYTYLS 659
    Length:659
    Mass (Da):74,477
    Last modified:February 1, 1997 - v1
    Checksum:iE8442002C8CD4629
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000022 Genomic DNA. Translation: BAA16587.1.
    X96602 Genomic DNA. Translation: CAA65422.1.
    PIRiS74435.
    RefSeqiNP_439907.1. NC_000911.1.
    YP_005649962.1. NC_017277.1.
    YP_007449790.1. NC_020286.1.

    Genome annotation databases

    EnsemblBacteriaiBAA16587; BAA16587; BAA16587.
    GeneIDi951929.
    KEGGisyn:slr1312.
    syy:SYNGTS_0009.
    syz:MYO_190.
    PATRICi23836874. VBISynSp132158_0012.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000022 Genomic DNA. Translation: BAA16587.1 .
    X96602 Genomic DNA. Translation: CAA65422.1 .
    PIRi S74435.
    RefSeqi NP_439907.1. NC_000911.1.
    YP_005649962.1. NC_017277.1.
    YP_007449790.1. NC_020286.1.

    3D structure databases

    ProteinModelPortali P72587.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 1148.slr1312.

    Proteomic databases

    PRIDEi P72587.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAA16587 ; BAA16587 ; BAA16587 .
    GeneIDi 951929.
    KEGGi syn:slr1312.
    syy:SYNGTS_0009.
    syz:MYO_190.
    PATRICi 23836874. VBISynSp132158_0012.

    Phylogenomic databases

    eggNOGi COG1166.
    HOGENOMi HOG000029191.
    KOi K01585.
    OMAi CCVESAV.
    OrthoDBi EOG676Z0R.
    PhylomeDBi P72587.

    Family and domain databases

    Gene3Di 2.40.37.10. 2 hits.
    3.20.20.10. 1 hit.
    HAMAPi MF_01417. SpeA.
    InterProi IPR009006. Ala_racemase/Decarboxylase_C.
    IPR002985. Arg_decrbxlase.
    IPR022643. De-COase2_C.
    IPR022644. De-COase2_N.
    IPR022653. De-COase2_pyr-phos_BS.
    IPR000183. Orn/DAP/Arg_de-COase.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF02784. Orn_Arg_deC_N. 1 hit.
    PF00278. Orn_DAP_Arg_deC. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001336. Arg_decrbxlase. 1 hit.
    PRINTSi PR01180. ARGDCRBXLASE.
    PR01179. ODADCRBXLASE.
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR01273. speA. 1 hit.
    PROSITEi PS00878. ODR_DC_2_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
      Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
      , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
      DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 6803 / Kazusa.
    2. "Disruption of a spe-like open reading frame alters polyamine content and psbA-2 mRNA stability in the cyanobacterium Synechocystis sp. PCC 6803."
      Mulo P., Eloranta T., Aro E.M., Maenpaeae P.
      Bot. Acta 111:71-76(1998)
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-302.

    Entry informationi

    Entry nameiSPEA2_SYNY3
    AccessioniPrimary (citable) accession number: P72587
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 14, 2001
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Synechocystis PCC 6803
      Synechocystis (strain PCC 6803): entries and gene names

    External Data

    Dasty 3