ID   ACSF1_SYNY3             Reviewed;         358 AA.
AC   P72584;
DT   16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   16-JUN-2009, entry version 56.
DE   RecName: Full=Magnesium-protoporphyrin IX monomethyl ester [oxidative] cyclase 1;
DE            Short=Mg-protoporphyrin IX monomethyl ester oxidative cyclase 1;
DE            EC=1.14.13.81;
GN   Name=acsF1; OrderedLocusNames=sll1214;
OS   Synechocystis sp. (strain PCC 6803).
OC   Bacteria; Cyanobacteria; Chroococcales; Synechocystis.
OX   NCBI_TaxID=1148;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   MEDLINE=97061201; PubMed=8905231; DOI=10.1093/dnares/3.3.109;
RA   Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y.,
RA   Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T.,
RA   Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S.,
RA   Shimpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M.,
RA   Tabata S.;
RT   "Sequence analysis of the genome of the unicellular cyanobacterium
RT   Synechocystis sp. strain PCC6803. II. Sequence determination of the
RT   entire genome and assignment of potential protein-coding regions.";
RL   DNA Res. 3:109-136(1996).
CC   -!- FUNCTION: Catalyzes the formation of the isocyclic ring in
CC       chlorophyll biosynthesis. Mediates the cyclase reaction, which
CC       results in the formation of divinylprotochlorophyllide (Pchlide)
CC       characteristic of all chlorophylls from magnesium-protoporphyrin
CC       IX 13-monomethyl ester (MgPMME) (By similarity).
CC   -!- CATALYTIC ACTIVITY: Magnesium-protoporphyrin IX 13-monomethyl
CC       ester + NADPH + O(2) = 13(1)-hydroxy-magnesium-protoporphyrin IX
CC       13-monomethyl ester + NADP(+) + H(2)O.
CC   -!- CATALYTIC ACTIVITY: 13(1)-hydroxy-magnesium-protoporphyrin IX 13-
CC       monomethyl ester + NADPH + O(2) = 13(1)-oxo-magnesium-
CC       protoporphyrin IX 13-monomethyl ester + NADP(+) + 2 H(2)O.
CC   -!- CATALYTIC ACTIVITY: 13(1)-oxo-magnesium-protoporphyrin IX 13-
CC       monomethyl ester + NADPH + O(2) = divinylprotochlorophyllide +
CC       NADP(+) + 2 H(2)O.
CC   -!- COFACTOR: Iron (By similarity).
CC   -!- PATHWAY: Porphyrin biosynthesis; chlorophyll biosynthesis (light-
CC       independent).
CC   -!- SIMILARITY: Belongs to the acsF family.
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DR   EMBL; BA000022; BAA16583.1; -; Genomic_DNA.
DR   PIR; S74431; S74431.
DR   RefSeq; NP_439903.1; -.
DR   IntAct; P72584; 8.
DR   GeneID; 951877; -.
DR   GenomeReviews; BA000022_GR; sll1214.
DR   KEGG; syn:sll1214; -.
DR   NMPDR; fig|1148.1.peg.4; -.
DR   HOGENOM; P72584; -.
DR   OMA; P72584; TAEFSGC.
DR   BioCyc; SSP1148:SLL1214-MON; -.
DR   GO; GO:0005506; F:iron ion binding; IEA:HAMAP.
DR   GO; GO:0048529; F:magnesium-protoporphyrin IX monomethyl este...; IEA:HAMAP.
DR   GO; GO:0015995; P:chlorophyll biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0015979; P:photosynthesis; IEA:HAMAP.
DR   HAMAP; MF_01840; -; 1.
DR   InterPro; IPR008434; AcsF.
DR   InterPro; IPR003251; Rubrerythrin.
DR   Pfam; PF02915; Rubrerythrin; 1.
DR   TIGRFAMs; TIGR02029; AcsF; 1.
PE   3: Inferred from homology;
KW   Chlorophyll biosynthesis; Complete proteome; Iron; Metal-binding;
KW   NADP; Oxidoreductase; Photosynthesis.
FT   CHAIN         1    358       Magnesium-protoporphyrin IX monomethyl
FT                                ester [oxidative] cyclase 1.
FT                                /FTId=PRO_0000217539.
SQ   SEQUENCE   358 AA;  42153 MW;  6E8BD879AB4767DC CRC64;
     MVNTLEKPGF DEIRPGVKTP AKETILTPRF YTTDFDEMAK MDISPNEDEL RAILEEFRVD
     YNRHHFVRNE SFNKSWDHID GEKRQLFVEF LERSCTAEFS GFLLYKELGR RLKNKNPLLA
     ECFNLMSRDE ARHAGFLNKA MSDFNLSLDL GFLTKSRKYT FFKPKFIFYA TYLSEKIGYW
     RYITIYRHLE KNPNDCIYPI FEFFENWCQD ENRHGDFFDA IMRAQPHTLN DWKAKLWCRF
     FLLSVFATMY LNDTQRADFY ACLGLEARSY DKEVIEKTNE TAGRVFPIIL DVNNPEFYNR
     LETCVSNNEQ LRAIDASGAP GVIKALRKLP IFASNGWQFI KLYLMKPIAV DQLAGAVR
//