P72584 (ACSF1_SYNY3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Magnesium-protoporphyrin IX monomethyl ester [oxidative] cyclase 1
Short name=Mg-protoporphyrin IX monomethyl ester oxidative cyclase 1
EC=1.14.13.81

Gene names

Name:	acsF1
Ordered Locus Names:	sll1214

Organism

Synechocystis sp. (strain PCC 6803 / Kazusa) [Reference proteome] [HAMAP]

Taxonomic identifier

1111708 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Cyanobacteria › Oscillatoriophycideae › Chroococcales › Synechocystis › Synechocystis sp. PCC 6803

Protein attributes

Sequence length	358 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) By similarity. HAMAP-Rule MF_01840
Catalytic activity	Magnesium-protoporphyrin IX 13-monomethyl ester + 3 NADPH + 3 O2 = divinylprotochlorophyllide + 3 NADP+ + 5 H2O. HAMAP-Rule MF_01840
Cofactor	Iron By similarity.
Pathway	Porphyrin biosynthesis; chlorophyll biosynthesis (light-independent). HAMAP-Rule MF_01840
Sequence similarities	Belongs to the AcsF family.

Ontologies

Keywords
Biological process	Chlorophyll biosynthesis Photosynthesis
Ligand	Iron Metal-binding NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	light-independent chlorophyll biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway photosynthesis Inferred from electronic annotation. Source: HAMAP
Molecular_function	iron ion binding Inferred from electronic annotation. Source: HAMAP magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 358	358	Magnesium-protoporphyrin IX monomethyl ester [oxidative] cyclase 1 HAMAP-Rule MF_01840		PRO_0000217539

Sequences

	Sequence		Length	Mass (Da)
	P72584 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: 6E8BD879AB4767DC	FASTA	358	42,153
	10 20 30 40 50 60 MVNTLEKPGF DEIRPGVKTP AKETILTPRF YTTDFDEMAK MDISPNEDEL RAILEEFRVD 70 80 90 100 110 120 YNRHHFVRNE SFNKSWDHID GEKRQLFVEF LERSCTAEFS GFLLYKELGR RLKNKNPLLA 130 140 150 160 170 180 ECFNLMSRDE ARHAGFLNKA MSDFNLSLDL GFLTKSRKYT FFKPKFIFYA TYLSEKIGYW 190 200 210 220 230 240 RYITIYRHLE KNPNDCIYPI FEFFENWCQD ENRHGDFFDA IMRAQPHTLN DWKAKLWCRF 250 260 270 280 290 300 FLLSVFATMY LNDTQRADFY ACLGLEARSY DKEVIEKTNE TAGRVFPIIL DVNNPEFYNR 310 320 330 340 350 LETCVSNNEQ LRAIDASGAP GVIKALRKLP IFASNGWQFI KLYLMKPIAV DQLAGAVR

References

[1]

"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions." Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S. DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PCC 6803 / Kazusa.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000022 Genomic DNA. Translation: BAA16583.1.
PIR	S74431.
RefSeq	NP_439903.1. NC_000911.1. YP_005649958.1. NC_017277.1. YP_007449786.1. NC_020286.1.
3D structure databases
ProteinModelPortal	P72584.
ModBase	Search...
Protein-protein interaction databases
IntAct	P72584. 8 interactions.
STRING	1148.sll1214.
Proteomic databases
PaxDb	P72584.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAA16583; BAA16583; BAA16583.
GeneID	12255294. 14615427. 951877.
KEGG	syn:sll1214. syy:SYNGTS_0005.
PATRIC	23836862. VBISynSp132158_0006.
Phylogenomic databases
eggNOG	NOG10633.
HOGENOM	HOG000233491.
KO	K04035.
OMA	NPLLAEC.
ProtClustDB	PRK13654.
Enzyme and pathway databases
BioCyc	MetaCyc:MONOMER-17787.
UniPathway	UPA00670.
Family and domain databases
HAMAP	MF_01840. AcsF.
InterPro	IPR008434. AcsF. IPR009078. Ferritin-like_SF. IPR003251. Rubrerythrin. [Graphical view]
Pfam	PF02915. Rubrerythrin. 1 hit. [Graphical view]
SUPFAM	SSF47240. Ferritin/RR_like. 1 hit.
TIGRFAMs	TIGR02029. AcsF. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ACSF1_SYNY3

Accession

Primary (citable) accession number: P72584

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 16, 2005
Last sequence update:	February 1, 1997
Last modified:	May 1, 2013
This is version 89 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program