P72391 (P72391_STRCO) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Malonyl CoA:acyl carrier protein malonyltransferase EMBL CAA60199.1

Gene names

Name:	fabD EMBL CAA60199.1
Ordered Locus Names:	SCO2387

Organism

Streptomyces coelicolor EMBL CAA60199.1

Taxonomic identifier

1902 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces

Protein attributes

Sequence length	316 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

Ontologies

Keywords
Ligand	Metal-binding PDB 1NM2 Nickel PDB 1NM2
Molecular function	Transferase EMBL CAA60199.1
Technical term	3D-structure PDB 1NM2 Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW transferase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Metal binding	49	1	Nickel PDB 1NM2
	Metal binding	51	1	Nickel PDB 1NM2

Sequences

	Sequence		Length	Mass (Da)
	P72391 [UniParc]. Last modified July 1, 1997. Version 2. Checksum: 6F2A1098752D6685	FASTA	316	32,078
	10 20 30 40 50 60 MLVLVAPGQG AQTPGFLTDW LALPGAADRV AAWSDAIGLD LAHFGTKADA DEIRDTSVAQ 70 80 90 100 110 120 PLLVAAGILS AAALGTQTSV ADATGPGFTP GAVAGHSVGE ITAAVFAGVL DDTAALSLVR 130 140 150 160 170 180 RRGLAMAEAA AVTETGMSAL LGGDPEVSVA HLERLGLTPA NVNGAGQIVA AGTMEQLAAL 190 200 210 220 230 240 NEDKPEGVRK VVPLKVAGAF HTRHMAPAVD KLAEAAKALT PADPKVTYVS NKDGRAVASG 250 260 270 280 290 300 TEVLDRLVGQ VANPVRWDLC METFKELGVT AIIEVCPGGT LTGLAKRALP GVKTLALKTP 310 DDLDAARELV AEHTQA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)." Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L., Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D., Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A., Fraser A., Goble A. , Hidalgo J., Hornsby T., Howarth S., Huang C.-H., Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E., Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D., Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A., Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A. Nature 417:141-147(2002) [PubMed: 12000953] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-471 / A3(2) / M145.
[2]	"Purification of a malonyltransferase from Streptomyces coelicolor A3(2) and analysis of its genetic determinant." Revill W.P., Bibb M.J., Hopwood D.A. J. Bacteriol. 177:3946-3952(1995) [PubMed: 7608065] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: A3 EMBL CAA60199.1.
[3]	"Catalysis, specificity, and ACP docking site of Streptomyces coelicolor malonyl-CoA:ACP transacylase." Keatinge-Clay A.T., Shelat A.A., Savage D.F., Tsai S.C., Miercke L.J., O'Connell J.D., Khosla C., Stroud R.M. Structure 11:147-154(2003) [PubMed: 12575934] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) IN COMPLEX WITH NICKEL.
[4]	"Relationships between fatty acid and polyketide synthases from Streptomyces coelicolor A3(2): characterization of the fatty acid synthase acyl carrier protein." Revill W.P., Bibb M.J., Hopwood D.A. J. Bacteriol. 178:5660-5667(1996) [PubMed: 8824610] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: A3 EMBL CAA60199.1.
[5]	Revill P. Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: A3 EMBL CAA60199.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

X86475 Genomic DNA. Translation: CAA60199.1.
AL939112 Genomic DNA. Translation: CAB62719.1.

PIR

A57356.

RefSeq

NP_626633.1. NC_003888.3.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1NM2	X-ray	2.00	A	1-316	[»]

ProteinModelPortal

P72391.

SMR

P72391. Positions 1-314.

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

GeneID

1097821.

GenomeReviews

Gene locus SCO2387 in contig AL645882_GR.

KEGG

sco:SCO2387.

NMPDR

fig|100226.1.peg.2352.

PATRIC

23734440. VBIStrCoe124346_2428.

Phylogenomic databases

HOGENOM

HBG687898.

OMA

SPVRWDL.

PhylomeDB

P72391.

ProtClustDB

CLSK2519282.

Family and domain databases

InterPro

IPR001227. Ac_transferase_dom.
IPR014043. Acyl_transferase.
IPR016035. Acyl_Trfase/lysoPLipase.
IPR024925. Malonyl_CoA-ACP_transAc.
IPR016036. Malonyl_transacylase_ACP-bd.
[Graphical view]

Gene3D

G3DSA:3.40.366.10. Ac_transferase_reg. 2 hits.

KO

K00645.

Pfam

PF00698. Acyl_transf_1. 1 hit.
[Graphical view]

PIRSF

PIRSF000446. Mct. 1 hit.

SUPFAM

SSF52151. Acyl_Trfase/lysoPlipase. 1 hit.
SSF55048. Malonyl_transacylase_ACP-bd. 1 hit.

ProtoNet

Search...

Entry information

Entry name

P72391_STRCO

Accession

Primary (citable) accession number: P72391
Secondary accession number(s): Q53916

Entry history

Integrated into UniProtKB/TrEMBL:	February 1, 1997
Last sequence update:	July 1, 1997
Last modified:	January 25, 2012
This is version 72 of the entry and version 2 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)