ID   SCDA_STAA8              Reviewed;         224 AA.
AC   P72360; Q2G1B6;
DT   04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2006, sequence version 2.
DT   27-MAR-2024, entry version 113.
DE   RecName: Full=Iron-sulfur cluster repair protein ScdA;
DE   AltName: Full=Cell wall-related protein ScdA;
GN   Name=scdA; OrderedLocusNames=SAOUHSC_00229;
OS   Staphylococcus aureus (strain NCTC 8325 / PS 47).
OC   Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=93061;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND INDUCTION.
RC   STRAIN=NCTC 8325 / PS 47;
RX   PubMed=9308171; DOI=10.1099/00221287-143-9-2877;
RA   Brunskill E.W., de Jonge B.L.M., Bayles K.W.;
RT   "The Staphylococcus aureus scdA gene: a novel locus that affects cell
RT   division and morphogenesis.";
RL   Microbiology 143:2877-2882(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC 8325 / PS 47;
RA   Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.;
RT   "The Staphylococcus aureus NCTC 8325 genome.";
RL   (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.);
RL   Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington
RL   D.C. (2006).
RN   [3]
RP   INDUCTION.
RC   STRAIN=NCTC 8325 / PS 47;
RX   PubMed=16452450; DOI=10.1128/jb.188.4.1648-1659.2006;
RA   Chang W., Small D.A., Toghrol F., Bentley W.E.;
RT   "Global transcriptome analysis of Staphylococcus aureus response to
RT   hydrogen peroxide.";
RL   J. Bacteriol. 188:1648-1659(2006).
RN   [4]
RP   FUNCTION, SUBUNIT, INDUCTION, DISRUPTION PHENOTYPE, AND DI-IRON CENTER.
RC   STRAIN=NCTC 8325 / PS 47;
RX   PubMed=18203837; DOI=10.1128/jb.01733-07;
RA   Overton T.W., Justino M.C., Li Y., Baptista J.M., Melo A.M., Cole J.A.,
RA   Saraiva L.M.;
RT   "Widespread distribution in pathogenic bacteria of di-iron proteins that
RT   repair oxidative and nitrosative damage to iron-sulfur centers.";
RL   J. Bacteriol. 190:2004-2013(2008).
CC   -!- FUNCTION: Di-iron-containing protein involved in the repair of iron-
CC       sulfur clusters damaged by oxidative and nitrosative stress conditions.
CC       {ECO:0000269|PubMed:18203837, ECO:0000269|PubMed:9308171}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000269|PubMed:18203837}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- INDUCTION: In stationary-phase. Induced by hydrogen peroxide.
CC       {ECO:0000269|PubMed:16452450, ECO:0000269|PubMed:18203837,
CC       ECO:0000269|PubMed:9308171}.
CC   -!- DISRUPTION PHENOTYPE: Mutant shows increased sensitivity to oxidative
CC       stress. {ECO:0000269|PubMed:18203837}.
CC   -!- SIMILARITY: Belongs to the RIC family. ScdA subfamily. {ECO:0000305}.
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DR   EMBL; U57060; AAB81287.1; -; Genomic_DNA.
DR   EMBL; CP000253; ABD29404.1; -; Genomic_DNA.
DR   RefSeq; WP_000608826.1; NZ_LS483365.1.
DR   RefSeq; YP_498824.1; NC_007795.1.
DR   AlphaFoldDB; P72360; -.
DR   SMR; P72360; -.
DR   STRING; 93061.SAOUHSC_00229; -.
DR   PaxDb; 1280-SAXN108_0239; -.
DR   GeneID; 3920304; -.
DR   KEGG; sao:SAOUHSC_00229; -.
DR   PATRIC; fig|93061.5.peg.210; -.
DR   eggNOG; COG2846; Bacteria.
DR   HOGENOM; CLU_076075_0_1_9; -.
DR   OrthoDB; 9797132at2; -.
DR   PRO; PR:P72360; -.
DR   Proteomes; UP000008816; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0030091; P:protein repair; IMP:UniProtKB.
DR   GO; GO:0051409; P:response to nitrosative stress; IEA:UniProtKB-UniRule.
DR   GO; GO:0006979; P:response to oxidative stress; IDA:UniProtKB.
DR   Gene3D; 1.20.120.520; nmb1532 protein domain like; 1.
DR   Gene3D; 1.10.3910.10; SP0561-like; 1.
DR   HAMAP; MF_01156; RIC_ScdA; 1.
DR   InterPro; IPR012312; Hemerythrin-like.
DR   InterPro; IPR019903; RIC_family.
DR   InterPro; IPR023551; ScdA.
DR   InterPro; IPR038062; ScdA-like_N_sf.
DR   NCBIfam; TIGR03652; FeS_repair_RIC; 1.
DR   PANTHER; PTHR36438; IRON-SULFUR CLUSTER REPAIR PROTEIN YTFE; 1.
DR   PANTHER; PTHR36438:SF1; IRON-SULFUR CLUSTER REPAIR PROTEIN YTFE; 1.
DR   Pfam; PF01814; Hemerythrin; 1.
DR   Pfam; PF04405; ScdA_N; 1.
DR   SUPFAM; SSF140683; SP0561-like; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Iron; Metal-binding; Reference proteome; Stress response.
FT   CHAIN           1..224
FT                   /note="Iron-sulfur cluster repair protein ScdA"
FT                   /id="PRO_0000220340"
FT   CONFLICT        43
FT                   /note="E -> G (in Ref. 1; AAB81287)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        60..61
FT                   /note="EQ -> NK (in Ref. 1; AAB81287)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   224 AA;  25485 MW;  EC8EBAE38DB70498 CRC64;
     MINKNDIVAD VVTDYPKAAD IFRSVGIDFC CGGQVSIEAA ALEKKNVDLN ELLQRLNDVE
     QTNTPGSLNP KFLNVSSLIQ YIQSAYHEPL REEFKNLTPY VTKLSKVHGP NHPYLVELKE
     TYDTFKNGML EHMQKEDDVD FPKLIKYEQG EVVDDINTVI DDLVSDHIAT GELLVKMSEL
     TSSYEPPIEA CGTWRLVYQR LKALEVLTHE HVHLENHVLF KKVS
//