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P72360

- SCDA_STAA8

UniProt

P72360 - SCDA_STAA8

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Protein
Iron-sulfur cluster repair protein ScdA
Gene
scdA, SAOUHSC_00229
Organism
Staphylococcus aureus (strain NCTC 8325)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions.2 Publications

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. protein repair Source: UniProtKB
  2. response to oxidative stress Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Stress response

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciSAUR93061:GIWJ-218-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Iron-sulfur cluster repair protein ScdA
Alternative name(s):
Cell wall-related protein ScdA
Gene namesi
Name:scdA
Ordered Locus Names:SAOUHSC_00229
OrganismiStaphylococcus aureus (strain NCTC 8325)
Taxonomic identifieri93061 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000008816: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Disruption phenotypei

Mutant shows increased sensitivity to oxidative stress.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 224224Iron-sulfur cluster repair protein ScdAUniRule annotation
PRO_0000220340Add
BLAST

Expressioni

Inductioni

In stationary-phase. Induced by hydrogen peroxide.3 Publications

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

STRINGi93061.SAOUHSC_00229.

Structurei

3D structure databases

ProteinModelPortaliP72360.
SMRiP72360. Positions 2-64.

Family & Domainsi

Sequence similaritiesi

Belongs to the RIC family. ScdA subfamily.

Phylogenomic databases

eggNOGiCOG2846.
HOGENOMiHOG000286324.
KOiK07322.
OMAiEFEADLH.
OrthoDBiEOG68DD4M.

Family and domain databases

HAMAPiMF_01156. RIC_ScdA.
InterProiIPR012312. Haemerythrin/HHE_cat-bd_motif.
IPR019903. RIC_family.
IPR023551. ScdA.
[Graphical view]
PfamiPF01814. Hemerythrin. 1 hit.
PF04405. ScdA_N. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03652. FeS_repair_RIC. 1 hit.

Sequencei

Sequence statusi: Complete.

P72360-1 [UniParc]FASTAAdd to Basket

« Hide

MINKNDIVAD VVTDYPKAAD IFRSVGIDFC CGGQVSIEAA ALEKKNVDLN    50
ELLQRLNDVE QTNTPGSLNP KFLNVSSLIQ YIQSAYHEPL REEFKNLTPY 100
VTKLSKVHGP NHPYLVELKE TYDTFKNGML EHMQKEDDVD FPKLIKYEQG 150
EVVDDINTVI DDLVSDHIAT GELLVKMSEL TSSYEPPIEA CGTWRLVYQR 200
LKALEVLTHE HVHLENHVLF KKVS 224
Length:224
Mass (Da):25,485
Last modified:July 11, 2006 - v2
Checksum:iEC8EBAE38DB70498
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti43 – 431E → G in AAB81287. 1 Publication
Sequence conflicti60 – 612EQ → NK in AAB81287. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U57060 Genomic DNA. Translation: AAB81287.1.
CP000253 Genomic DNA. Translation: ABD29404.1.
RefSeqiYP_498824.1. NC_007795.1.

Genome annotation databases

EnsemblBacteriaiABD29404; ABD29404; SAOUHSC_00229.
GeneIDi3920304.
KEGGisao:SAOUHSC_00229.
PATRICi19578068. VBIStaAur99865_0210.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U57060 Genomic DNA. Translation: AAB81287.1 .
CP000253 Genomic DNA. Translation: ABD29404.1 .
RefSeqi YP_498824.1. NC_007795.1.

3D structure databases

ProteinModelPortali P72360.
SMRi P72360. Positions 2-64.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 93061.SAOUHSC_00229.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABD29404 ; ABD29404 ; SAOUHSC_00229 .
GeneIDi 3920304.
KEGGi sao:SAOUHSC_00229.
PATRICi 19578068. VBIStaAur99865_0210.

Phylogenomic databases

eggNOGi COG2846.
HOGENOMi HOG000286324.
KOi K07322.
OMAi EFEADLH.
OrthoDBi EOG68DD4M.

Enzyme and pathway databases

BioCyci SAUR93061:GIWJ-218-MONOMER.

Family and domain databases

HAMAPi MF_01156. RIC_ScdA.
InterProi IPR012312. Haemerythrin/HHE_cat-bd_motif.
IPR019903. RIC_family.
IPR023551. ScdA.
[Graphical view ]
Pfami PF01814. Hemerythrin. 1 hit.
PF04405. ScdA_N. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR03652. FeS_repair_RIC. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The Staphylococcus aureus scdA gene: a novel locus that affects cell division and morphogenesis."
    Brunskill E.W., de Jonge B.L.M., Bayles K.W.
    Microbiology 143:2877-2882(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, INDUCTION.
    Strain: NCTC 8325.
  2. "The Staphylococcus aureus NCTC 8325 genome."
    Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.
    (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.); Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington D.C. (2006)
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NCTC 8325.
  3. "Global transcriptome analysis of Staphylococcus aureus response to hydrogen peroxide."
    Chang W., Small D.A., Toghrol F., Bentley W.E.
    J. Bacteriol. 188:1648-1659(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
    Strain: NCTC 8325.
  4. "Widespread distribution in pathogenic bacteria of di-iron proteins that repair oxidative and nitrosative damage to iron-sulfur centers."
    Overton T.W., Justino M.C., Li Y., Baptista J.M., Melo A.M., Cole J.A., Saraiva L.M.
    J. Bacteriol. 190:2004-2013(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBUNIT, INDUCTION, DISRUPTION PHENOTYPE, DI-IRON CENTER.
    Strain: NCTC 8325.

Entry informationi

Entry nameiSCDA_STAA8
AccessioniPrimary (citable) accession number: P72360
Secondary accession number(s): Q2G1B6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: July 11, 2006
Last modified: September 3, 2014
This is version 76 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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