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Protein

Iron-sulfur cluster repair protein ScdA

Gene

scdA

Organism
Staphylococcus aureus (strain NCTC 8325)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions.2 Publications

GO - Molecular functioni

GO - Biological processi

  • protein repair Source: UniProtKB
  • response to oxidative stress Source: UniProtKB

Keywordsi

Biological processStress response
LigandIron, Metal-binding

Enzyme and pathway databases

BioCyciSAUR93061:G1G5Y-213-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Iron-sulfur cluster repair protein ScdA
Alternative name(s):
Cell wall-related protein ScdA
Gene namesi
Name:scdA
Ordered Locus Names:SAOUHSC_00229
OrganismiStaphylococcus aureus (strain NCTC 8325)
Taxonomic identifieri93061 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000008816 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Disruption phenotypei

Mutant shows increased sensitivity to oxidative stress.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002203401 – 224Iron-sulfur cluster repair protein ScdAAdd BLAST224

Expressioni

Inductioni

In stationary-phase. Induced by hydrogen peroxide.3 Publications

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

STRINGi93061.SAOUHSC_00229

Structurei

3D structure databases

ProteinModelPortaliP72360
SMRiP72360
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RIC family. ScdA subfamily.Curated

Phylogenomic databases

eggNOGiENOG4105FJH Bacteria
COG2846 LUCA
HOGENOMiHOG000286324
KOiK07322
OMAiACTTWRV

Family and domain databases

Gene3Di1.10.3910.10, 1 hit
HAMAPiMF_01156 RIC_ScdA, 1 hit
InterProiView protein in InterPro
IPR012312 Haemerythrin-like
IPR019903 RIC_family
IPR023551 ScdA
IPR038062 ScdA-like_N_sf
PANTHERiPTHR36438 PTHR36438, 1 hit
PfamiView protein in Pfam
PF01814 Hemerythrin, 1 hit
PF04405 ScdA_N, 1 hit
SUPFAMiSSF140683 SSF140683, 1 hit
TIGRFAMsiTIGR03652 FeS_repair_RIC, 1 hit

Sequencei

Sequence statusi: Complete.

P72360-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MINKNDIVAD VVTDYPKAAD IFRSVGIDFC CGGQVSIEAA ALEKKNVDLN
60 70 80 90 100
ELLQRLNDVE QTNTPGSLNP KFLNVSSLIQ YIQSAYHEPL REEFKNLTPY
110 120 130 140 150
VTKLSKVHGP NHPYLVELKE TYDTFKNGML EHMQKEDDVD FPKLIKYEQG
160 170 180 190 200
EVVDDINTVI DDLVSDHIAT GELLVKMSEL TSSYEPPIEA CGTWRLVYQR
210 220
LKALEVLTHE HVHLENHVLF KKVS
Length:224
Mass (Da):25,485
Last modified:July 11, 2006 - v2
Checksum:iEC8EBAE38DB70498
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti43E → G in AAB81287 (PubMed:9308171).Curated1
Sequence conflicti60 – 61EQ → NK in AAB81287 (PubMed:9308171).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U57060 Genomic DNA Translation: AAB81287.1
CP000253 Genomic DNA Translation: ABD29404.1
RefSeqiWP_000608826.1, NC_007795.1
YP_498824.1, NC_007795.1

Genome annotation databases

EnsemblBacteriaiABD29404; ABD29404; SAOUHSC_00229
GeneIDi3920304
KEGGisao:SAOUHSC_00229
PATRICifig|93061.5.peg.210

Similar proteinsi

Entry informationi

Entry nameiSCDA_STAA8
AccessioniPrimary (citable) accession number: P72360
Secondary accession number(s): Q2G1B6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: July 11, 2006
Last modified: March 28, 2018
This is version 93 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health