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P72360 (SCDA_STAA8) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Iron-sulfur cluster repair protein ScdA
Alternative name(s):
Cell wall-related protein ScdA
Gene names
Name:scdA
Ordered Locus Names:SAOUHSC_00229
OrganismStaphylococcus aureus (strain NCTC 8325) [Reference proteome] [HAMAP]
Taxonomic identifier93061 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesStaphylococcus

Protein attributes

Sequence length224 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions. Ref.1 Ref.4

Subunit structure

Homodimer. Ref.4

Subcellular location

Cytoplasm Potential HAMAP-Rule MF_01156.

Induction

In stationary-phase. Induced by hydrogen peroxide. Ref.1 Ref.3 Ref.4

Disruption phenotype

Mutant shows increased sensitivity to oxidative stress. Ref.4

Sequence similarities

Belongs to the RIC family. ScdA subfamily.

Ontologies

Keywords
   Biological processStress response
   Cellular componentCytoplasm
   LigandIron
Metal-binding
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processprotein repair

Inferred from mutant phenotype Ref.4. Source: UniProtKB

response to oxidative stress

Inferred from direct assay Ref.3. Source: UniProtKB

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 224224Iron-sulfur cluster repair protein ScdA HAMAP-Rule MF_01156
PRO_0000220340

Experimental info

Sequence conflict431E → G in AAB81287. Ref.1
Sequence conflict60 – 612EQ → NK in AAB81287. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P72360 [UniParc].

Last modified July 11, 2006. Version 2.
Checksum: EC8EBAE38DB70498

FASTA22425,485
        10         20         30         40         50         60 
MINKNDIVAD VVTDYPKAAD IFRSVGIDFC CGGQVSIEAA ALEKKNVDLN ELLQRLNDVE 

        70         80         90        100        110        120 
QTNTPGSLNP KFLNVSSLIQ YIQSAYHEPL REEFKNLTPY VTKLSKVHGP NHPYLVELKE 

       130        140        150        160        170        180 
TYDTFKNGML EHMQKEDDVD FPKLIKYEQG EVVDDINTVI DDLVSDHIAT GELLVKMSEL 

       190        200        210        220 
TSSYEPPIEA CGTWRLVYQR LKALEVLTHE HVHLENHVLF KKVS 

« Hide

References

« Hide 'large scale' references
[1]"The Staphylococcus aureus scdA gene: a novel locus that affects cell division and morphogenesis."
Brunskill E.W., de Jonge B.L.M., Bayles K.W.
Microbiology 143:2877-2882(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, INDUCTION.
Strain: NCTC 8325.
[2]"The Staphylococcus aureus NCTC8325 genome."
Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.
Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NCTC 8325.
[3]"Global transcriptome analysis of Staphylococcus aureus response to hydrogen peroxide."
Chang W., Small D.A., Toghrol F., Bentley W.E.
J. Bacteriol. 188:1648-1659(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
Strain: NCTC 8325.
[4]"Widespread distribution in pathogenic bacteria of di-iron proteins that repair oxidative and nitrosative damage to iron-sulfur centers."
Overton T.W., Justino M.C., Li Y., Baptista J.M., Melo A.M., Cole J.A., Saraiva L.M.
J. Bacteriol. 190:2004-2013(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBUNIT, INDUCTION, DISRUPTION PHENOTYPE, DI-IRON CENTER.
Strain: NCTC 8325.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U57060 Genomic DNA. Translation: AAB81287.1.
CP000253 Genomic DNA. Translation: ABD29404.1.
RefSeqYP_498824.1. NC_007795.1.

3D structure databases

ProteinModelPortalP72360.
SMRP72360. Positions 2-64.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING93061.SAOUHSC_00229.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABD29404; ABD29404; SAOUHSC_00229.
GeneID3920304.
KEGGsao:SAOUHSC_00229.
PATRIC19578068. VBIStaAur99865_0210.

Phylogenomic databases

eggNOGCOG2846.
HOGENOMHOG000286324.
KOK07322.
OMAACTTWRV.
OrthoDBEOG68DD4M.
ProtClustDBPRK13276.

Enzyme and pathway databases

BioCycSAUR93061:GIWJ-218-MONOMER.

Family and domain databases

HAMAPMF_01156. RIC_ScdA.
InterProIPR007500. DUF542_ScdA_N.
IPR012312. Haemerythrin/HHE_cat-bd_motif.
IPR019903. RIC_family.
IPR023551. RIC_family_ScdA.
[Graphical view]
PfamPF01814. Hemerythrin. 1 hit.
PF04405. ScdA_N. 1 hit.
[Graphical view]
TIGRFAMsTIGR03652. FeS_repair_RIC. 1 hit.
ProtoNetSearch...

Entry information

Entry nameSCDA_STAA8
AccessionPrimary (citable) accession number: P72360
Secondary accession number(s): Q2G1B6
Entry history
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: July 11, 2006
Last modified: March 19, 2014
This is version 73 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families