Reviewed, UniProtKB/Swiss-Prot P72314 (AHPC_RHORU)

Names and origin

Protein names

Recommended name:
    Alkyl hydroperoxide reductase subunit C
    EC=1.11.1.15
Alternative name(s):
    Peroxiredoxin
    Thioredoxin peroxidase
    Alkyl hydroperoxide reductase protein C22

Gene names

Name:

ahpC

Organism

Rhodospirillum rubrum

Taxonomic identifier

1085 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhodospirillales › Rhodospirillaceae › Rhodospirillum

Protein attributes

Sequence length	68 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Directly reduces organic hydroperoxides in its reduced dithiol form.
Catalytic activity	2 R'-SH + ROOH = R'-S-S-R' + H(2)O + ROH.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the ahpC/TSA family. Contains 1 thioredoxin domain.

Ontologies

Keywords
Domain	Redox-active center
Molecular function	Oxidoreductase Peroxidase
Gene Ontology (GO)
Biological process	cell redox homeostasis Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	peroxiredoxin activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›68	›68	Alkyl hydroperoxide reductase subunit C		PRO_0000135118
Regions
	Domain	2 – ›68	›67	Thioredoxin
Sites
	Active site	47	1	By similarity
Experimental info
	Non-terminal residue	68	1

Sequences

	Sequence		Length	Mass (Da)
	P72314-1 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: 94964FAC42451B9F	FASTA	68	7,659
	10 20 30 40 50 60 MSLIGSEVKP FKADAFKAGK FVTVTDDTLK GKWSVVFFYP ADFTFVCPTE LEDLAENYAE FQRLGVEI

References

[1]	"Characterization of the region encoding the CO-induced hydrogenase of Rhodospirillum rubrum." Fox D.J., He Y., Shelver D., Roberts G.P., Ludden P.W. J. Bacteriol. 178:6200-6208(1996) [PubMed: 8892819] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: UR1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U65510 Genomic DNA. Translation: AAC45114.1.
PIR	T51312.
3D structure databases
HSSP	HSSP built from PDB template 1KYG based on UniProtKB P19479.
ModBase	Search...
Family and domain databases
InterPro	IPR000866. AhpC-TSA. IPR012335. Thioredoxin_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
Pfam	PF00578. AhpC-TSA. 1 hit. [Graphical view]
PROSITE	PS51352. THIOREDOXIN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AHPC_RHORU

Accession

Primary (citable) accession number: P72314

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 15, 2002
Last sequence update:	February 1, 1997
Last modified:	November 25, 2008
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)