Reviewed, UniProtKB/Swiss-Prot P72314 (AHPC_RHORU)

Names and origin

Protein names

Recommended name:
    Alkyl hydroperoxide reductase subunit C
    EC=1.11.1.15
Alternative name(s):
    Peroxiredoxin
    Thioredoxin peroxidase
    Alkyl hydroperoxide reductase protein C22

Gene names

Name:

ahpC

Organism

Rhodospirillum rubrum

Taxonomic identifier

1085 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhodospirillales › Rhodospirillaceae › Rhodospirillum

Protein attributes

Sequence length	68 AA.
Sequence status	Fragment.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Directly reduces organic hydroperoxides in its reduced dithiol form.
Catalytic activity	2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the ahpC/TSA family. Contains 1 thioredoxin domain.

Ontologies

Keywords
Domain	Redox-active center
Molecular function	Oxidoreductase Peroxidase
Gene Ontology (GO)
Biological process	cell redox homeostasis Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	peroxiredoxin activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›68	›68	Alkyl hydroperoxide reductase subunit C		PRO_0000135118
Regions
	Domain	2 – ›68	›67	Thioredoxin
Sites
	Active site	47	1	By similarity
Experimental info
	Non-terminal residue	68	1

Sequences

	Sequence		Length	Mass (Da)
	P72314-1 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: 94964FAC42451B9F	FASTA	68	7,659
	10 20 30 40 50 60 MSLIGSEVKP FKADAFKAGK FVTVTDDTLK GKWSVVFFYP ADFTFVCPTE LEDLAENYAE FQRLGVEI

References

[1]	"Characterization of the region encoding the CO-induced hydrogenase of Rhodospirillum rubrum." Fox D.J., He Y., Shelver D., Roberts G.P., Ludden P.W. J. Bacteriol. 178:6200-6208(1996) [PubMed: 8892819] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: UR1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U65510 Genomic DNA. Translation: AAC45114.1.
PIR	T51312.
3D structure databases
SMR	P72314. Positions 2-68.
ModBase	Search...
Enzyme and pathway databases
BRENDA	1.11.1.15. 1671.
Family and domain databases
InterPro	IPR000866. Alkyl_hydroperoxide_Rdtase. IPR017936. Thioredoxin-like. IPR012336. Thioredoxin-like_fold. IPR012335. Thioredoxin_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
Pfam	PF00578. AhpC-TSA. 1 hit. [Graphical view]
PROSITE	PS51352. THIOREDOXIN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AHPC_RHORU

Accession

Primary (citable) accession number: P72314

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 15, 2002
Last sequence update:	February 1, 1997
Last modified:	January 19, 2010
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)