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Protein

Sensor protein ChvG

Gene

chvG

Organism
Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Member of a two-component regulatory system ChvG(ExoS)/ChvI involved in regulating the production of succinoglycan. Activates ChvI by phosphorylation.

Catalytic activityi

ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.

Pathwayi: exopolysaccharide biosynthesis

This protein is involved in the pathway exopolysaccharide biosynthesis, which is part of Glycan metabolism.
View all proteins of this organism that are known to be involved in the pathway exopolysaccharide biosynthesis and in Glycan metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Exopolysaccharide synthesis, Two-component regulatory system

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.13.3. 5347.
UniPathwayiUPA00631.

Names & Taxonomyi

Protein namesi
Recommended name:
Sensor protein ChvG (EC:2.7.13.3)
Alternative name(s):
Histidine kinase sensory protein ExoS
Gene namesi
Name:chvG
Synonyms:exoS
Ordered Locus Names:R00043
ORF Names:SMc04446
OrganismiRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Taxonomic identifieri266834 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
Proteomesi
  • UP000001976 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 29CytoplasmicSequence analysisAdd BLAST29
Transmembranei30 – 50HelicalSequence analysisAdd BLAST21
Topological domaini51 – 260PeriplasmicSequence analysisAdd BLAST210
Transmembranei261 – 281HelicalSequence analysisAdd BLAST21
Topological domaini282 – 577CytoplasmicSequence analysisAdd BLAST296

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000747211 – 577Sensor protein ChvGAdd BLAST577

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei350PhosphohistidineBy similarity1

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

STRINGi266834.SMc04446.

Structurei

3D structure databases

ProteinModelPortaliP72292.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini283 – 339HAMPPROSITE-ProRule annotationAdd BLAST57
Domaini347 – 575Histidine kinasePROSITE-ProRule annotationAdd BLAST229

Sequence similaritiesi

Contains 1 HAMP domain.PROSITE-ProRule annotation
Contains 1 histidine kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105EB3. Bacteria.
COG0642. LUCA.
HOGENOMiHOG000226685.
KOiK14980.

Family and domain databases

CDDicd06225. HAMP. 1 hit.
Gene3Di1.10.287.130. 1 hit.
3.30.565.10. 1 hit.
InterProiIPR003660. HAMP_dom.
IPR003594. HATPase_C.
IPR005467. His_kinase_dom.
IPR003661. HisK_dim/P.
IPR025908. Sensor_TM1.
IPR004358. Sig_transdc_His_kin-like_C.
IPR025919. Stimulus_sens_dom.
[Graphical view]
PfamiPF00672. HAMP. 1 hit.
PF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
PF13755. Sensor_TM1. 1 hit.
PF13756. Stimulus_sens_1. 1 hit.
[Graphical view]
PRINTSiPR00344. BCTRLSENSOR.
SMARTiSM00304. HAMP. 1 hit.
SM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
[Graphical view]
SUPFAMiSSF47384. SSF47384. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiPS50885. HAMP. 1 hit.
PS50109. HIS_KIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P72292-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRGQRRWAHP FTLIRRLFGN AVFSSLTRRI VFFNLVALVV LVGGIMYLNQ
60 70 80 90 100
FREGLIDARV ESLLTQGEII AGAISASASV DTNSITIDPE KLLELQAGES
110 120 130 140 150
ITPLPSDEDL EFPIIQERVA PVLRRLISPT RTRARLFDAD ADLLLDSRHL
160 170 180 190 200
YSGGQVLRFD LPPVDPESPS LADEFGTWFN RLLQPGDLPL YKEPPGGNGS
210 220 230 240 250
IYPEVMNALT GVRGAVVRVT EKGELIVSVA VPVQRFRAVL GVLLLSTQAG
260 270 280 290 300
DIDKIVHAER LAIIRVFGVA ALVNVILSLL LSSTIANPLR RLSAAAIRVR
310 320 330 340 350
RGGAKEREEI PDFSSRQDEI GNLSVALREM TTALYDRIAA IENFAADVSH
360 370 380 390 400
ELKNPLTSLR SAVETLPLAR NEESKKRLMD VIQHDVRRLD RLISDISDAS
410 420 430 440 450
RLDAELARAD AKKVDLEKLL GDLVEISRQI RGSKKPVLLD FVVDRKDNPR
460 470 480 490 500
ASFIVSGYEL RIGQIITNLI ENARSFVPEQ NGRIVVRLTR SRLRCIVYVE
510 520 530 540 550
DNGPGIQAED IDRIFERFYT DRPEGEDFGQ NSGLGLSISR QIAEAHGGTL
560 570
RAENIAGKDG RISGARFVLS LPAGPHP
Length:577
Mass (Da):63,721
Last modified:November 2, 2001 - v3
Checksum:iBEF2DD4A4F0E2B15
GO

Sequence cautioni

The sequence CAC41430 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti136L → F in AAB96631 (PubMed:9422587).Curated1
Sequence conflicti266V → A in AAB96631 (PubMed:9422587).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF027298 Genomic DNA. Translation: AAB96631.1.
AL591688 Genomic DNA. Translation: CAC41430.1. Different initiation.
U32941 Genomic DNA. Translation: AAB07686.2.
RefSeqiNP_384149.1. NC_003047.1.

Genome annotation databases

EnsemblBacteriaiCAC41430; CAC41430; SMc04446.
GeneIDi1231668.
KEGGisme:SMc04446.
PATRICi23629239. VBISinMel96828_1397.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF027298 Genomic DNA. Translation: AAB96631.1.
AL591688 Genomic DNA. Translation: CAC41430.1. Different initiation.
U32941 Genomic DNA. Translation: AAB07686.2.
RefSeqiNP_384149.1. NC_003047.1.

3D structure databases

ProteinModelPortaliP72292.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi266834.SMc04446.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC41430; CAC41430; SMc04446.
GeneIDi1231668.
KEGGisme:SMc04446.
PATRICi23629239. VBISinMel96828_1397.

Phylogenomic databases

eggNOGiENOG4105EB3. Bacteria.
COG0642. LUCA.
HOGENOMiHOG000226685.
KOiK14980.

Enzyme and pathway databases

UniPathwayiUPA00631.
BRENDAi2.7.13.3. 5347.

Miscellaneous databases

PROiP72292.

Family and domain databases

CDDicd06225. HAMP. 1 hit.
Gene3Di1.10.287.130. 1 hit.
3.30.565.10. 1 hit.
InterProiIPR003660. HAMP_dom.
IPR003594. HATPase_C.
IPR005467. His_kinase_dom.
IPR003661. HisK_dim/P.
IPR025908. Sensor_TM1.
IPR004358. Sig_transdc_His_kin-like_C.
IPR025919. Stimulus_sens_dom.
[Graphical view]
PfamiPF00672. HAMP. 1 hit.
PF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
PF13755. Sensor_TM1. 1 hit.
PF13756. Stimulus_sens_1. 1 hit.
[Graphical view]
PRINTSiPR00344. BCTRLSENSOR.
SMARTiSM00304. HAMP. 1 hit.
SM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
[Graphical view]
SUPFAMiSSF47384. SSF47384. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiPS50885. HAMP. 1 hit.
PS50109. HIS_KIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCHVG_RHIME
AccessioniPrimary (citable) accession number: P72292
Secondary accession number(s): O31069
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 2, 2001
Last modified: November 30, 2016
This is version 125 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.