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Protein

Cbb3-type cytochrome c oxidase subunit FixPc

Gene

fixPc

Organism
Rhizobium leguminosarum bv. viciae
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex. FixP subunit is required for transferring electrons from donor cytochrome c via its heme groups to FixO subunit. From there, electrons are shuttled to the catalytic binuclear center of FixN subunit where oxygen reduction takes place. The complex also functions as a proton pump (By similarity).By similarity

Cofactori

heme cBy similarityNote: Binds 2 heme C groups per subunit.By similarity

Pathwayi: oxidative phosphorylation

This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.By similarity
View all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei121 – 1211Heme C 1 (covalent)By similarity
Binding sitei124 – 1241Heme C 1 (covalent)By similarity
Metal bindingi125 – 1251Iron (heme C 1 axial ligand)By similarity
Metal bindingi173 – 1731Iron (heme C 2 axial ligand)By similarity
Binding sitei216 – 2161Heme C 2 (covalent)By similarity
Binding sitei219 – 2191Heme C 2 (covalent)By similarity
Metal bindingi220 – 2201Iron (heme C 2 axial ligand)By similarity
Metal bindingi261 – 2611Iron (heme C 1 axial ligand)By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Hydrogen ion transport, Ion transport, Respiratory chain, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciRETL1328306-WGS:GSTH-4456-MONOMER.
RETL1328306-WGS:GSTH-5781-MONOMER.
UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cbb3-type cytochrome c oxidase subunit FixPcBy similarityImported
Short name:
Cbb3-Cox subunit FixPcBy similarity
Alternative name(s):
C-type cytochrome FixPcBy similarity
Short name:
Cyt c(FixPc)By similarity
Cytochrome c oxidase subunit IIIBy similarity
Gene namesi
Name:fixPcImported
OrganismiRhizobium leguminosarum bv. viciae
Taxonomic identifieri387 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupRhizobium

Subcellular locationi

  • Cell inner membrane Sequence analysisBy similarity; Single-pass membrane protein Sequence analysisBy similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3636CytoplasmicSequence analysisBy similarityAdd
BLAST
Transmembranei37 – 5721HelicalSequence analysisAdd
BLAST
Topological domaini58 – 287230PeriplasmicSequence analysisBy similarityAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 287287Cbb3-type cytochrome c oxidase subunit FixPcPRO_0000412299Add
BLAST

Interactioni

Subunit structurei

Component of the cbb3-type cytochrome c oxidase at least composed of FixN, FixO, FixQ and FixP.By similarity

Structurei

3D structure databases

ProteinModelPortaliP72287.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini108 – 19689Cytochrome c 1PROSITE-ProRule annotationAdd
BLAST
Domaini203 – 28482Cytochrome c 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the CcoP / FixP family.Curated
Contains 2 cytochrome c domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.10.760.10. 3 hits.
InterProiIPR032858. CcoP_N.
IPR009056. Cyt_c-like_dom.
IPR008168. Cyt_C_IC.
IPR004678. Cyt_c_oxidase_cbb3_su3.
[Graphical view]
PfamiPF13442. Cytochrome_CBB3. 2 hits.
PF14715. FixP_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000006. Cbb3-Cox_fixP. 1 hit.
PRINTSiPR00605. CYTCHROMECIC.
SUPFAMiSSF46626. SSF46626. 3 hits.
TIGRFAMsiTIGR00782. ccoP. 1 hit.
PROSITEiPS51007. CYTC. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P72287-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEKHIDEFS GVETTGHEWD GIRELNNPMP RWWVWTFYAT IVWALGYAIA
60 70 80 90 100
YPAIPMITDA TKGMLGFSSR AELQQNLDQA KASQTTLHDL IAAKTVHEID
110 120 130 140 150
SDSALREFAI AGGASAFKVN CATCHGSGAS GGPGFPNLND DDWLWGGDLD
160 170 180 190 200
AIQATIAHGI RFDGDTDTHA SEMPPFAEVL DPLQTRQVAA YVWGLTNTPS
210 220 230 240 250
DPGLAEAGKQ VFVDNCAACH GDDAKGKAEM GAPDLADAIW LKARGEDAII
260 270 280
RQVAAPKHGV MPAWAGRLGD TTVKELTIFV HSLGGGT
Length:287
Mass (Da):30,688
Last modified:February 1, 1997 - v1
Checksum:iF8A55D976953E566
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z80340 Genomic DNA. Translation: CAB02452.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z80340 Genomic DNA. Translation: CAB02452.1.

3D structure databases

ProteinModelPortaliP72287.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayiUPA00705.
BioCyciRETL1328306-WGS:GSTH-4456-MONOMER.
RETL1328306-WGS:GSTH-5781-MONOMER.

Family and domain databases

Gene3Di1.10.760.10. 3 hits.
InterProiIPR032858. CcoP_N.
IPR009056. Cyt_c-like_dom.
IPR008168. Cyt_C_IC.
IPR004678. Cyt_c_oxidase_cbb3_su3.
[Graphical view]
PfamiPF13442. Cytochrome_CBB3. 2 hits.
PF14715. FixP_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000006. Cbb3-Cox_fixP. 1 hit.
PRINTSiPR00605. CYTCHROMECIC.
SUPFAMiSSF46626. SSF46626. 3 hits.
TIGRFAMsiTIGR00782. ccoP. 1 hit.
PROSITEiPS51007. CYTC. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Functional and regulatory analysis of the two copies of the fixNOQP operon of Rhizobium leguminosarum strain VF39."
    Schluter A., Patschkowski T., Quandt J., Selinger L.B., Weidner S., Kramer M., Zhou L., Hynes M.F., Priefer U.B.
    Mol. Plant Microbe Interact. 10:605-616(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: VF39Imported.

Entry informationi

Entry nameiFIXP_RHILV
AccessioniPrimary (citable) accession number: P72287
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 21, 2011
Last sequence update: February 1, 1997
Last modified: January 20, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Plasmid

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.