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Protein

Cbb3-type cytochrome c oxidase subunit FixPc

Gene

fixPc

Organism
Rhizobium leguminosarum bv. viciae
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex. FixP subunit is required for transferring electrons from donor cytochrome c via its heme groups to FixO subunit. From there, electrons are shuttled to the catalytic binuclear center of FixN subunit where oxygen reduction takes place. The complex also functions as a proton pump (By similarity).By similarity

Cofactori

heme cBy similarityNote: Binds 2 heme C groups per subunit.By similarity

Pathwayi: oxidative phosphorylation

This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.By similarity
View all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei121Heme C 1 (covalent)By similarity1
Binding sitei124Heme C 1 (covalent)By similarity1
Metal bindingi125Iron (heme C 1 axial ligand)By similarity1
Metal bindingi173Iron (heme C 2 axial ligand)By similarity1
Binding sitei216Heme C 2 (covalent)By similarity1
Binding sitei219Heme C 2 (covalent)By similarity1
Metal bindingi220Iron (heme C 2 axial ligand)By similarity1
Metal bindingi261Iron (heme C 1 axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Hydrogen ion transport, Ion transport, Respiratory chain, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cbb3-type cytochrome c oxidase subunit FixPcBy similarityImported
Short name:
Cbb3-Cox subunit FixPcBy similarity
Alternative name(s):
C-type cytochrome FixPcBy similarity
Short name:
Cyt c(FixPc)By similarity
Cytochrome c oxidase subunit IIIBy similarity
Gene namesi
Name:fixPcImported
OrganismiRhizobium leguminosarum bv. viciae
Taxonomic identifieri387 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupRhizobium

Subcellular locationi

  • Cell inner membrane Sequence analysisBy similarity; Single-pass membrane protein Sequence analysisBy similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 36CytoplasmicSequence analysisBy similarityAdd BLAST36
Transmembranei37 – 57HelicalSequence analysisAdd BLAST21
Topological domaini58 – 287PeriplasmicSequence analysisBy similarityAdd BLAST230

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004122991 – 287Cbb3-type cytochrome c oxidase subunit FixPcAdd BLAST287

Interactioni

Subunit structurei

Component of the cbb3-type cytochrome c oxidase at least composed of FixN, FixO, FixQ and FixP.By similarity

Structurei

3D structure databases

ProteinModelPortaliP72287.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini108 – 196Cytochrome c 1PROSITE-ProRule annotationAdd BLAST89
Domaini203 – 284Cytochrome c 2PROSITE-ProRule annotationAdd BLAST82

Sequence similaritiesi

Belongs to the CcoP / FixP family.Curated
Contains 2 cytochrome c domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.10.760.10. 3 hits.
InterProiIPR032858. CcoP_N.
IPR009056. Cyt_c-like_dom.
IPR008168. Cyt_C_IC.
IPR004678. Cyt_c_oxidase_cbb3_su3.
[Graphical view]
PfamiPF13442. Cytochrome_CBB3. 2 hits.
PF14715. FixP_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000006. Cbb3-Cox_fixP. 1 hit.
PRINTSiPR00605. CYTCHROMECIC.
SUPFAMiSSF46626. SSF46626. 3 hits.
TIGRFAMsiTIGR00782. ccoP. 1 hit.
PROSITEiPS51007. CYTC. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P72287-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEKHIDEFS GVETTGHEWD GIRELNNPMP RWWVWTFYAT IVWALGYAIA
60 70 80 90 100
YPAIPMITDA TKGMLGFSSR AELQQNLDQA KASQTTLHDL IAAKTVHEID
110 120 130 140 150
SDSALREFAI AGGASAFKVN CATCHGSGAS GGPGFPNLND DDWLWGGDLD
160 170 180 190 200
AIQATIAHGI RFDGDTDTHA SEMPPFAEVL DPLQTRQVAA YVWGLTNTPS
210 220 230 240 250
DPGLAEAGKQ VFVDNCAACH GDDAKGKAEM GAPDLADAIW LKARGEDAII
260 270 280
RQVAAPKHGV MPAWAGRLGD TTVKELTIFV HSLGGGT
Length:287
Mass (Da):30,688
Last modified:February 1, 1997 - v1
Checksum:iF8A55D976953E566
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z80340 Genomic DNA. Translation: CAB02452.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z80340 Genomic DNA. Translation: CAB02452.1.

3D structure databases

ProteinModelPortaliP72287.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayiUPA00705.

Family and domain databases

Gene3Di1.10.760.10. 3 hits.
InterProiIPR032858. CcoP_N.
IPR009056. Cyt_c-like_dom.
IPR008168. Cyt_C_IC.
IPR004678. Cyt_c_oxidase_cbb3_su3.
[Graphical view]
PfamiPF13442. Cytochrome_CBB3. 2 hits.
PF14715. FixP_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000006. Cbb3-Cox_fixP. 1 hit.
PRINTSiPR00605. CYTCHROMECIC.
SUPFAMiSSF46626. SSF46626. 3 hits.
TIGRFAMsiTIGR00782. ccoP. 1 hit.
PROSITEiPS51007. CYTC. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFIXP_RHILV
AccessioniPrimary (citable) accession number: P72287
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 21, 2011
Last sequence update: February 1, 1997
Last modified: November 2, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Plasmid

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.