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Protein

Aspartate aminotransferase

Gene

aspC

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei36Aspartate; via amide nitrogenBy similarity1
Binding sitei132AspartateBy similarity1
Binding sitei185AspartateBy similarity1
Binding sitei376AspartateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciPAER208964:G1FZ6-3199-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartate aminotransferase (EC:2.6.1.1)
Short name:
AspAT
Alternative name(s):
Transaminase A
Gene namesi
Name:aspC
Ordered Locus Names:PA3139
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002438 Componenti: Chromosome

Organism-specific databases

PseudoCAPiPA3139

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001238451 – 398Aspartate aminotransferaseAdd BLAST398

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei248N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

PaxDbiP72173
PRIDEiP72173

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi208964.PA3139

Structurei

3D structure databases

ProteinModelPortaliP72173
SMRiP72173
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CGF Bacteria
COG1448 LUCA
HOGENOMiHOG000185899
InParanoidiP72173
KOiK00832
OMAiRVGACTI
PhylomeDBiP72173

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
InterProiView protein in InterPro
IPR004839 Aminotransferase_I/II
IPR000796 Asp_trans
IPR004838 NHTrfase_class1_PyrdxlP-BS
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR11879 PTHR11879, 1 hit
PfamiView protein in Pfam
PF00155 Aminotran_1_2, 1 hit
PRINTSiPR00799 TRANSAMINASE
SUPFAMiSSF53383 SSF53383, 1 hit
PROSITEiView protein in PROSITE
PS00105 AA_TRANSFER_CLASS_1, 1 hit

Sequencei

Sequence statusi: Complete.

P72173-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLFSAVEMA PRDPILGLNE AFNADTRPGK INLGVGVYYN EEGRIPLLRA
60 70 80 90 100
VQAAEKARIE AHAPRGYLPI EGIAAYDQGV QKLLFGNESE LLAAGRVVTT
110 120 130 140 150
QAVGGTGALK LGADFLKRLL PDATVAISDP SWENHRALFE AAGFPVQNYR
160 170 180 190 200
YYDAASNGVN RAGLLEDLNA LPARSIVVLH ACCHNPTGVD LELDDWKQVL
210 220 230 240 250
DVLKAKGHVP FLDIAYQGFG NGIEEDAAAV RLFAQSGLSF FVSSSFSKSF
260 270 280 290 300
SLYGERVGAL SIVTESRDES ARVLSQVKRV IRTNYSNPPT HGASVVSSVL
310 320 330 340 350
NSPELRALWE QELGEMRDRI RDMRLAMVEQ LAAHGAKRDF SFVGRQRGMF
360 370 380 390
SYSGLTADQV ERLKTEFGIY AVSTGRICVA ALNKSNLETI TKAIVQVL
Length:398
Mass (Da):43,319
Last modified:December 8, 2000 - v2
Checksum:i4FE1D5709BAE599F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA Translation: AAG06527.1
X93486 Genomic DNA Translation: CAA63758.1
PIRiB83252
RefSeqiNP_251829.1, NC_002516.2
WP_003104588.1, NC_002516.2

Genome annotation databases

EnsemblBacteriaiAAG06527; AAG06527; PA3139
GeneIDi882671
KEGGipae:PA3139
PATRICifig|208964.12.peg.3291

Similar proteinsi

Entry informationi

Entry nameiAAT_PSEAE
AccessioniPrimary (citable) accession number: P72173
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: December 8, 2000
Last modified: April 25, 2018
This is version 112 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health