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Protein

Aspartate aminotransferase

Gene

aspC

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.

Cofactori

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei36 – 361Aspartate; via amide nitrogenBy similarity
Binding sitei132 – 1321AspartateBy similarity
Binding sitei185 – 1851AspartateBy similarity
Binding sitei376 – 3761AspartateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Keywords - Ligandi

Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartate aminotransferase (EC:2.6.1.1)
Short name:
AspAT
Alternative name(s):
Transaminase A
Gene namesi
Name:aspC
Ordered Locus Names:PA3139
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002438 Componenti: Chromosome

Organism-specific databases

PseudoCAPiPA3139.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 398398Aspartate aminotransferasePRO_0000123845Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei248 – 2481N6-(pyridoxal phosphate)lysineBy similarity

Proteomic databases

PaxDbiP72173.
PRIDEiP72173.

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi208964.PA3139.

Structurei

3D structure databases

ProteinModelPortaliP72173.
SMRiP72173. Positions 16-398.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CGF. Bacteria.
COG1448. LUCA.
HOGENOMiHOG000185899.
InParanoidiP72173.
KOiK00832.
OMAiWANHAAV.
PhylomeDBiP72173.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR004839. Aminotransferase_I/II.
IPR000796. Asp_trans.
IPR004838. NHTrfase_class1_PyrdxlP-BS.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11879. PTHR11879. 1 hit.
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
PRINTSiPR00799. TRANSAMINASE.
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00105. AA_TRANSFER_CLASS_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P72173-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLFSAVEMA PRDPILGLNE AFNADTRPGK INLGVGVYYN EEGRIPLLRA
60 70 80 90 100
VQAAEKARIE AHAPRGYLPI EGIAAYDQGV QKLLFGNESE LLAAGRVVTT
110 120 130 140 150
QAVGGTGALK LGADFLKRLL PDATVAISDP SWENHRALFE AAGFPVQNYR
160 170 180 190 200
YYDAASNGVN RAGLLEDLNA LPARSIVVLH ACCHNPTGVD LELDDWKQVL
210 220 230 240 250
DVLKAKGHVP FLDIAYQGFG NGIEEDAAAV RLFAQSGLSF FVSSSFSKSF
260 270 280 290 300
SLYGERVGAL SIVTESRDES ARVLSQVKRV IRTNYSNPPT HGASVVSSVL
310 320 330 340 350
NSPELRALWE QELGEMRDRI RDMRLAMVEQ LAAHGAKRDF SFVGRQRGMF
360 370 380 390
SYSGLTADQV ERLKTEFGIY AVSTGRICVA ALNKSNLETI TKAIVQVL
Length:398
Mass (Da):43,319
Last modified:December 8, 2000 - v2
Checksum:i4FE1D5709BAE599F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA. Translation: AAG06527.1.
X93486 Genomic DNA. Translation: CAA63758.1.
PIRiB83252.
RefSeqiNP_251829.1. NC_002516.2.
WP_003104588.1. NZ_ASJY01000511.1.

Genome annotation databases

EnsemblBacteriaiAAG06527; AAG06527; PA3139.
GeneIDi882671.
KEGGipae:PA3139.
PATRICi19840859. VBIPseAer58763_3291.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004091 Genomic DNA. Translation: AAG06527.1.
X93486 Genomic DNA. Translation: CAA63758.1.
PIRiB83252.
RefSeqiNP_251829.1. NC_002516.2.
WP_003104588.1. NZ_ASJY01000511.1.

3D structure databases

ProteinModelPortaliP72173.
SMRiP72173. Positions 16-398.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi208964.PA3139.

Proteomic databases

PaxDbiP72173.
PRIDEiP72173.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG06527; AAG06527; PA3139.
GeneIDi882671.
KEGGipae:PA3139.
PATRICi19840859. VBIPseAer58763_3291.

Organism-specific databases

PseudoCAPiPA3139.

Phylogenomic databases

eggNOGiENOG4105CGF. Bacteria.
COG1448. LUCA.
HOGENOMiHOG000185899.
InParanoidiP72173.
KOiK00832.
OMAiWANHAAV.
PhylomeDBiP72173.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR004839. Aminotransferase_I/II.
IPR000796. Asp_trans.
IPR004838. NHTrfase_class1_PyrdxlP-BS.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11879. PTHR11879. 1 hit.
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
PRINTSiPR00799. TRANSAMINASE.
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00105. AA_TRANSFER_CLASS_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAAT_PSEAE
AccessioniPrimary (citable) accession number: P72173
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: December 8, 2000
Last modified: September 7, 2016
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.