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Protein

D-alanyl-D-alanine endopeptidase

Gene

pbpG

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Cell wall formation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei66 – 661Acyl-ester intermediateBy similarity
Active sitei69 – 691Proton acceptorBy similarity
Active sitei123 – 1231By similarity
Binding sitei230 – 2301SubstrateBy similarity

GO - Molecular functioni

  • endopeptidase activity Source: GO_Central
  • serine-type D-Ala-D-Ala carboxypeptidase activity Source: CACAO

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Protein family/group databases

MEROPSiS11.002.

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanyl-D-alanine endopeptidase (EC:3.4.21.-)
Short name:
DD-endopeptidase
Alternative name(s):
Penicillin-binding protein 5
Short name:
PBP-5
Gene namesi
Name:pbpG
Ordered Locus Names:PA0869
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002438 Componenti: Chromosome

Organism-specific databases

PseudoCAPiPA0869.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Periplasm

Pathology & Biotechi

Chemistry

DrugBankiDB00438. Ceftazidime.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence analysisAdd
BLAST
Chaini24 – 310287D-alanyl-D-alanine endopeptidasePRO_0000027239Add
BLAST

Proteomic databases

PaxDbiP72161.

Interactioni

Protein-protein interaction databases

STRINGi208964.PA0869.

Structurei

3D structure databases

ProteinModelPortaliP72161.
SMRiP72161. Positions 31-304.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S11 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG41061WM. Bacteria.
COG1686. LUCA.
HOGENOMiHOG000199620.
InParanoidiP72161.
KOiK07262.
OMAiWDIKLTK.
OrthoDBiEOG6RJV2H.
PhylomeDBiP72161.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR018044. Peptidase_S11.
IPR001967. Peptidase_S11_N.
[Graphical view]
PfamiPF00768. Peptidase_S11. 1 hit.
[Graphical view]
PRINTSiPR00725. DADACBPTASE1.
SUPFAMiSSF56601. SSF56601. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P72161-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRNRLLSLVT LFLSLSVATA VSASPPPKAG LPLQQELASG SALVTDQNTG
60 70 80 90 100
KVLYSRNPDL VVPIASITKL MTAMVVLDSK LPLDEVLPIA ISETSEMRGV
110 120 130 140 150
FSRVRVGSQI SRRDMLLLAL MSSENRAAAS LAQNYPGGKN AFVKAMNAKA
160 170 180 190 200
HALGMKNTRY VEPTGLSLHN VSTARDLTRL LVASRQYPLL SQWSTTPEKT
210 220 230 240 250
VAFRHPNYTL GFRNTNHLIN NKTWNIQLTK TGFTNEAGHC LVMRTTINRS
260 270 280 290 300
PVNLVVLDAF GKYTHFADAT RLRRWLETGQ VTAIPAAAKA YRLQRDRERG
310
LGQPVAQAVR
Length:310
Mass (Da):34,046
Last modified:December 8, 2000 - v2
Checksum:iB1F62A3A2F9EF641
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti296 – 2961D → DD in AAC46341 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U62582 Genomic DNA. Translation: AAC46341.1.
AE004091 Genomic DNA. Translation: AAG04258.1.
PIRiB83538.
RefSeqiNP_249560.1. NC_002516.2.
WP_003114239.1. NZ_ASJY01000128.1.

Genome annotation databases

EnsemblBacteriaiAAG04258; AAG04258; PA0869.
GeneIDi877694.
KEGGipae:PA0869.
PATRICi19836022. VBIPseAer58763_0903.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U62582 Genomic DNA. Translation: AAC46341.1.
AE004091 Genomic DNA. Translation: AAG04258.1.
PIRiB83538.
RefSeqiNP_249560.1. NC_002516.2.
WP_003114239.1. NZ_ASJY01000128.1.

3D structure databases

ProteinModelPortaliP72161.
SMRiP72161. Positions 31-304.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi208964.PA0869.

Chemistry

DrugBankiDB00438. Ceftazidime.

Protein family/group databases

MEROPSiS11.002.

Proteomic databases

PaxDbiP72161.

Protocols and materials databases

DNASUi877694.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG04258; AAG04258; PA0869.
GeneIDi877694.
KEGGipae:PA0869.
PATRICi19836022. VBIPseAer58763_0903.

Organism-specific databases

PseudoCAPiPA0869.

Phylogenomic databases

eggNOGiENOG41061WM. Bacteria.
COG1686. LUCA.
HOGENOMiHOG000199620.
InParanoidiP72161.
KOiK07262.
OMAiWDIKLTK.
OrthoDBiEOG6RJV2H.
PhylomeDBiP72161.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR018044. Peptidase_S11.
IPR001967. Peptidase_S11_N.
[Graphical view]
PfamiPF00768. Peptidase_S11. 1 hit.
[Graphical view]
PRINTSiPR00725. DADACBPTASE1.
SUPFAMiSSF56601. SSF56601. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Song J., Jensen R.A.
    Submitted (JUN-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.

Entry informationi

Entry nameiPBP5_PSEAE
AccessioniPrimary (citable) accession number: P72161
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: December 8, 2000
Last modified: June 8, 2016
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.