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Protein

HTH-type transcriptional regulator PtxR

Gene

ptxR

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Transcriptional activator of the toxA (exotoxin) and regA genes.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi28 – 4720H-T-H motifPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • NAD+ ADP-ribosyltransferase activity Source: PseudoCAP
  • transcription factor activity, sequence-specific DNA binding Source: InterPro
  • transcription regulatory region DNA binding Source: PseudoCAP

GO - Biological processi

  • negative regulation of secondary metabolite biosynthetic process Source: PseudoCAP
  • positive regulation of proteolysis Source: PseudoCAP
  • positive regulation of transcription, DNA-templated Source: PseudoCAP
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator PtxR
Gene namesi
Name:ptxR
Ordered Locus Names:PA2258
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002438 Componenti: Chromosome

Organism-specific databases

PseudoCAPiPA2258.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 312312HTH-type transcriptional regulator PtxRPRO_0000105746Add
BLAST

Proteomic databases

PaxDbiP72131.

Expressioni

Gene expression databases

CollecTFiEXPREG_00000bd0.

Interactioni

Protein-protein interaction databases

STRINGi208964.PA2258.

Structurei

3D structure databases

ProteinModelPortaliP72131.
SMRiP72131. Positions 11-302.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini11 – 6858HTH lysR-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HTH lysR-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105JQN. Bacteria.
ENOG410XST8. LUCA.
HOGENOMiHOG000233519.
InParanoidiP72131.
OMAiDVWRFTN.
OrthoDBiEOG6CVV98.
PhylomeDBiP72131.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR005119. LysR_subst-bd.
IPR000847. Tscrpt_reg_HTH_LysR.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00126. HTH_1. 1 hit.
PF03466. LysR_substrate. 1 hit.
[Graphical view]
PRINTSiPR00039. HTHLYSR.
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS50931. HTH_LYSR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P72131-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAALERLNH LNLNHLYAFV AVAEHNSFTA AAEALGLSKS LLSEQLRRLE
60 70 80 90 100
ADLGIQLLTR TTRRMTLTDR GELLFGVAQR MLGELDGALS DVRDLQGEPS
110 120 130 140 150
GRLRITAPQD FVKWHISSVS AAFIRQFPKV QVEMLADDQF SDLVGQRIDL
160 170 180 190 200
AVRIGWPRDS GLHASKLCDF QQVAVATPGY LAGLPPVLQP HDLARCEWIG
210 220 230 240 250
HTRLSTPWTW TFERQRERAT VQTRGRLLAN NTLAVYRLVL DGAGVSVLPS
260 270 280 290 300
FLVAREIARG RLVRLLPGWR LPQGGIYALY PSARYMPVRV RAFIESLREH
310
LGREPFRLAQ SE
Length:312
Mass (Da):34,992
Last modified:February 1, 1997 - v1
Checksum:iEF6511EDCC2F6BBA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF012100 Genomic DNA. Translation: AAC26481.3.
AE004091 Genomic DNA. Translation: AAG05646.1.
PIRiS77670.
RefSeqiNP_250948.1. NC_002516.2.
WP_003089264.1. NZ_ASJY01000340.1.

Genome annotation databases

EnsemblBacteriaiAAG05646; AAG05646; PA2258.
GeneIDi878030.
KEGGipae:PA2258.
PATRICi19838960. VBIPseAer58763_2360.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF012100 Genomic DNA. Translation: AAC26481.3.
AE004091 Genomic DNA. Translation: AAG05646.1.
PIRiS77670.
RefSeqiNP_250948.1. NC_002516.2.
WP_003089264.1. NZ_ASJY01000340.1.

3D structure databases

ProteinModelPortaliP72131.
SMRiP72131. Positions 11-302.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi208964.PA2258.

Proteomic databases

PaxDbiP72131.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG05646; AAG05646; PA2258.
GeneIDi878030.
KEGGipae:PA2258.
PATRICi19838960. VBIPseAer58763_2360.

Organism-specific databases

PseudoCAPiPA2258.

Phylogenomic databases

eggNOGiENOG4105JQN. Bacteria.
ENOG410XST8. LUCA.
HOGENOMiHOG000233519.
InParanoidiP72131.
OMAiDVWRFTN.
OrthoDBiEOG6CVV98.
PhylomeDBiP72131.

Gene expression databases

CollecTFiEXPREG_00000bd0.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR005119. LysR_subst-bd.
IPR000847. Tscrpt_reg_HTH_LysR.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00126. HTH_1. 1 hit.
PF03466. LysR_substrate. 1 hit.
[Graphical view]
PRINTSiPR00039. HTHLYSR.
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS50931. HTH_LYSR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of a Pseudomonas aeruginosa gene, ptxR, which positively regulates exotoxin A production."
    Hamood A.N., Colmer J.A., Ochsner U.A., Vasil M.L.
    Mol. Microbiol. 21:97-110(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.

Entry informationi

Entry nameiPTXR_PSEAE
AccessioniPrimary (citable) accession number: P72131
Secondary accession number(s): Q9R7G8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: February 1, 1997
Last modified: January 20, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.