UniProtKB - P72131 (PTXR_PSEAE)
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Protein
HTH-type transcriptional regulator PtxR
Gene
ptxR
Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Status
Functioni
Transcriptional activator of the toxA (exotoxin) and regA genes.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 28 – 47 | H-T-H motifPROSITE-ProRule annotationAdd BLAST | 20 |
GO - Molecular functioni
- bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding Source: CollecTF
- NAD+ ADP-ribosyltransferase activity Source: PseudoCAP
- transcription regulatory region DNA binding Source: PseudoCAP
- transcription regulatory region sequence-specific DNA binding Source: CollecTF
GO - Biological processi
- negative regulation of secondary metabolite biosynthetic process Source: PseudoCAP
- positive regulation of proteolysis Source: PseudoCAP
- positive regulation of transcription, DNA-templated Source: PseudoCAP
- transcription, DNA-templated Source: UniProtKB-KW
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
BioCyci | PAER208964:G1FZ6-2297-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: HTH-type transcriptional regulator PtxR |
Gene namesi | Name:ptxR Ordered Locus Names:PA2258 |
Organismi | Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) |
Taxonomic identifieri | 208964 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas › |
Proteomesi |
|
Organism-specific databases
PseudoCAPi | PA2258 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000105746 | 1 – 312 | HTH-type transcriptional regulator PtxRAdd BLAST | 312 |
Proteomic databases
PaxDbi | P72131 |
Structurei
3D structure databases
ProteinModelPortali | P72131 |
SMRi | P72131 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 11 – 68 | HTH lysR-typePROSITE-ProRule annotationAdd BLAST | 58 |
Phylogenomic databases
eggNOGi | ENOG4105JQN Bacteria ENOG410XST8 LUCA |
HOGENOMi | HOG000233519 |
InParanoidi | P72131 |
OMAi | IGWRPRP |
PhylomeDBi | P72131 |
Family and domain databases
Gene3Di | 1.10.10.101 hit |
InterProi | View protein in InterPro IPR005119 LysR_subst-bd IPR000847 Tscrpt_reg_HTH_LysR IPR036388 WH-like_DNA-bd_sf IPR036390 WH_DNA-bd_sf |
Pfami | View protein in Pfam PF00126 HTH_1, 1 hit PF03466 LysR_substrate, 1 hit |
PRINTSi | PR00039 HTHLYSR |
SUPFAMi | SSF46785 SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS50931 HTH_LYSR, 1 hit |
i Sequence
Sequence statusi: Complete.
P72131-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSAALERLNH LNLNHLYAFV AVAEHNSFTA AAEALGLSKS LLSEQLRRLE
60 70 80 90 100
ADLGIQLLTR TTRRMTLTDR GELLFGVAQR MLGELDGALS DVRDLQGEPS
110 120 130 140 150
GRLRITAPQD FVKWHISSVS AAFIRQFPKV QVEMLADDQF SDLVGQRIDL
160 170 180 190 200
AVRIGWPRDS GLHASKLCDF QQVAVATPGY LAGLPPVLQP HDLARCEWIG
210 220 230 240 250
HTRLSTPWTW TFERQRERAT VQTRGRLLAN NTLAVYRLVL DGAGVSVLPS
260 270 280 290 300
FLVAREIARG RLVRLLPGWR LPQGGIYALY PSARYMPVRV RAFIESLREH
310
LGREPFRLAQ SE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF012100 Genomic DNA Translation: AAC26481.3 AE004091 Genomic DNA Translation: AAG05646.1 |
PIRi | S77670 |
RefSeqi | NP_250948.1, NC_002516.2 WP_003089264.1, NC_002516.2 |
Genome annotation databases
EnsemblBacteriai | AAG05646; AAG05646; PA2258 |
GeneIDi | 878030 |
KEGGi | pae:PA2258 |
PATRICi | fig|208964.12.peg.2360 |
Similar proteinsi
Entry informationi
Entry namei | PTXR_PSEAE | |
Accessioni | P72131Primary (citable) accession number: P72131 Secondary accession number(s): Q9R7G8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 29, 2001 |
Last sequence update: | February 1, 1997 | |
Last modified: | March 28, 2018 | |
This is version 107 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |