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Protein

HTH-type transcriptional regulator PtxR

Gene

ptxR

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Status
Reviewed-Annotation score: -Protein predictedi

Functioni

Transcriptional activator of the toxA (exotoxin) and regA genes.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi28 – 47H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

  • bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding Source: CollecTF
  • NAD+ ADP-ribosyltransferase activity Source: PseudoCAP
  • transcription regulatory region DNA binding Source: PseudoCAP
  • transcription regulatory region sequence-specific DNA binding Source: CollecTF

GO - Biological processi

  • negative regulation of secondary metabolite biosynthetic process Source: PseudoCAP
  • positive regulation of proteolysis Source: PseudoCAP
  • positive regulation of transcription, DNA-templated Source: PseudoCAP
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyciPAER208964:G1FZ6-2297-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator PtxR
Gene namesi
Name:ptxR
Ordered Locus Names:PA2258
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002438 Componenti: Chromosome

Organism-specific databases

PseudoCAPiPA2258

Subcellular locationi

GO - Cellular componenti

  • protein-DNA complex Source: CollecTF

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001057461 – 312HTH-type transcriptional regulator PtxRAdd BLAST312

Proteomic databases

PaxDbiP72131

Expressioni

Gene expression databases

CollecTFiEXPREG_00000bd0

Interactioni

Protein-protein interaction databases

STRINGi208964.PA2258

Structurei

3D structure databases

ProteinModelPortaliP72131
SMRiP72131
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 68HTH lysR-typePROSITE-ProRule annotationAdd BLAST58

Phylogenomic databases

eggNOGiENOG4105JQN Bacteria
ENOG410XST8 LUCA
HOGENOMiHOG000233519
InParanoidiP72131
OMAiIGWRPRP
PhylomeDBiP72131

Family and domain databases

Gene3Di1.10.10.101 hit
InterProiView protein in InterPro
IPR005119 LysR_subst-bd
IPR000847 Tscrpt_reg_HTH_LysR
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00126 HTH_1, 1 hit
PF03466 LysR_substrate, 1 hit
PRINTSiPR00039 HTHLYSR
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS50931 HTH_LYSR, 1 hit

Sequencei

Sequence statusi: Complete.

P72131-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAALERLNH LNLNHLYAFV AVAEHNSFTA AAEALGLSKS LLSEQLRRLE
60 70 80 90 100
ADLGIQLLTR TTRRMTLTDR GELLFGVAQR MLGELDGALS DVRDLQGEPS
110 120 130 140 150
GRLRITAPQD FVKWHISSVS AAFIRQFPKV QVEMLADDQF SDLVGQRIDL
160 170 180 190 200
AVRIGWPRDS GLHASKLCDF QQVAVATPGY LAGLPPVLQP HDLARCEWIG
210 220 230 240 250
HTRLSTPWTW TFERQRERAT VQTRGRLLAN NTLAVYRLVL DGAGVSVLPS
260 270 280 290 300
FLVAREIARG RLVRLLPGWR LPQGGIYALY PSARYMPVRV RAFIESLREH
310
LGREPFRLAQ SE
Length:312
Mass (Da):34,992
Last modified:February 1, 1997 - v1
Checksum:iEF6511EDCC2F6BBA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF012100 Genomic DNA Translation: AAC26481.3
AE004091 Genomic DNA Translation: AAG05646.1
PIRiS77670
RefSeqiNP_250948.1, NC_002516.2
WP_003089264.1, NC_002516.2

Genome annotation databases

EnsemblBacteriaiAAG05646; AAG05646; PA2258
GeneIDi878030
KEGGipae:PA2258
PATRICifig|208964.12.peg.2360

Similar proteinsi

Entry informationi

Entry nameiPTXR_PSEAE
AccessioniPrimary (citable) accession number: P72131
Secondary accession number(s): Q9R7G8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: February 1, 1997
Last modified: March 28, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome