P72012 (RPIA_METTH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ribose-5-phosphate isomerase A
EC=5.3.1.6

Alternative name(s):
Phosphoriboisomerase A
Short name=PRI

Gene names

Name:	rpiA
Ordered Locus Names:	MTH_608

Organism

Methanobacterium thermoautotrophicum (strain Delta H)

Taxonomic identifier

187420 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanobacteria › Methanobacteriales › Methanobacteriaceae › Methanothermobacter

Protein attributes

Sequence length	226 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-ribose 5-phosphate = D-ribulose 5-phosphate. HAMAP MF_00170
Pathway	Carbohydrate degradation; pentose phosphate pathway; D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1. HAMAP MF_00170
Sequence similarities	Belongs to the ribose 5-phosphate isomerase family.

Ontologies

Keywords
Molecular function	Isomerase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	pentose-phosphate shunt, non-oxidative branch Inferred from electronic annotation. Source: InterPro
Molecular function	ribose-5-phosphate isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 226	226	Ribose-5-phosphate isomerase A HAMAP MF_00170		PRO_0000158513

Sequences

	Sequence		Length	Mass (Da)
	P72012 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: F5EE6E929C08792B	FASTA	226	23,785
	10 20 30 40 50 60 MEVFMNLKKM AALRAVDEID DGDVVGLGTG STTHYFIEEL GRRVREEGLE VMGVPTSYQS 70 80 90 100 110 120 MFLAAESGIK VTSLAEHDVD VAVDGADEVD PDLNLIKGGG AAHTLEKIVD SSAASFIVIV 130 140 150 160 170 180 DESKLVERLG AFPLPVEVIP AACRPVKLKL ESMGASVNIR SSEGKDGPVV TDNGNFVLDA 190 200 210 220 AFGVIDDPGA MESRLNNIPG VVENGIFAGI ADMVIAGTSE GLKILR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Did archaeal and bacterial cells arise independently from noncellular precursors? A hypothesis stating that the advent of membrane phospholipid with enantiomeric glycerophosphate backbones caused the separation of the two lines of descent." Koga Y., Kyuragi T., Nishihara M., Sone N. J. Mol. Evol. 46:54-63(1998) [PubMed: 9419225] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Delta H.
[2]	Erratum Koga Y., Kyuragi T., Nishihara M., Sone N. J. Mol. Evol. 47:631-631(1998) [PubMed: 9797414] [Abstract]
[3]	"Complete genome sequence of Methanobacterium thermoautotrophicum deltaH: functional analysis and comparative genomics." Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J., Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K., Harrison D., Hoang L., Keagle P., Lumm W., Pothier B., Qiu D., Spadafora R., Vicare R. , Wang Y., Wierzbowski J., Gibson R., Jiwani N., Caruso A., Bush D., Safer H., Patwell D., Prabhakar S., McDougall S., Shimer G., Goyal A., Pietrovski S., Church G.M., Daniels C.J., Mao J.-I., Rice P., Noelling J., Reeve J.N. J. Bacteriol. 179:7135-7155(1997) [PubMed: 9371463] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Delta H.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D88555 Genomic DNA. Translation: BAA13646.1. AE000666 Genomic DNA. Translation: AAB85114.1.
PIR	G69180.
RefSeq	NP_275751.1. NC_000916.1.
3D structure databases
ProteinModelPortal	P72012.
SMR	P72012. Positions 5-226.
ModBase	Search...
Protein-protein interaction databases
STRING	P72012.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1470569.
GenomeReviews	Gene locus MTH_608 in contig AE000666_GR.
KEGG	mth:MTH608.
NMPDR	fig|187420.1.peg.606.
Phylogenomic databases
eggNOG	arNOG07879.
HOGENOM	HBG515603.
OMA	GGAQKPV.
PhylomeDB	P72012.
ProtClustDB	PRK00702.
Enzyme and pathway databases
BioCyc	MTHE187420:MTH608-MONOMER.
Family and domain databases
HAMAP	MF_00170. Rib_5P_isom_A. [Tree]
InterPro	IPR004788. Ribose5P_isomerase_typA. IPR020672. Ribose5P_isomerase_typA_subgr. [Graphical view]
KO	K01807.
PANTHER	PTHR11934. RpiA. 1 hit.
Pfam	PF06026. Rib_5-P_isom_A. 1 hit. [Graphical view]
TIGRFAMs	TIGR00021. RpiA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

RPIA_METTH

Accession

Primary (citable) accession number: P72012

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	February 1, 1997
Last modified:	November 16, 2011
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program