Ribokinase RbsK - Mycobacterium tuberculosis

Preferred order of sections

Names and origin

Protein names

Submitted name:
Ribokinase RbsK EMBL CCP45228.1

Gene names

Name:	rbsK EMBL CCP45228.1
Ordered Locus Names:	Rv2436 EMBL CCP45228.1

Organism

Mycobacterium tuberculosis [Reference proteome] [HAMAP]

Taxonomic identifier

1773 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	304 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

Ontologies

Keywords
Ligand	Magnesium PDB 3GO6 PDB 3GO7 Metal-binding PDB 3GO6 PDB 3GO7 Nucleotide-binding PDB 3GO6
Molecular function	Kinase SAAS SAAS011611 EMBL CCP45228.1 Transferase
Technical term	3D-structure PDB 3GO6 PDB 3GO7 Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	D-ribose metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	ribokinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Regions

Nucleotide binding

212 – 215

4

ADP PDB 3GO6

Nucleotide binding

270 – 273

4

ADP PDB 3GO6

Sites

Metal binding

236

1

Magnesium; via carbonyl oxygen PDB 3GO6 PDB 3GO7

Metal binding

238

1

Magnesium; via carbonyl oxygen PDB 3GO6 PDB 3GO7

Metal binding

276

1

Magnesium; via carbonyl oxygen PDB 3GO6 PDB 3GO7

Metal binding

279

1

Magnesium; via carbonyl oxygen PDB 3GO6 PDB 3GO7

Metal binding

281

1

Magnesium; via carbonyl oxygen PDB 3GO6 PDB 3GO7

Binding site

237

1

ADP; via carbonyl oxygen PDB 3GO6

Binding site

241

1

ADP; via amide nitrogen PDB 3GO6

Sequences

Sequence

Length

Mass (Da)

Tools

P71913 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: D1990AADD9F1BA7A
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FASTA

304

30,280

        10         20         30         40         50         60 
MANASETNVG PMAPRVCVVG SVNMDLTFVV DALPRPGETV LAASLTRTPG GKGANQAVAA 

        70         80         90        100        110        120 
ARAGAQVQFS GAFGDDPAAA QLRAHLRANA VGLDRTVTVP GPSGTAIIVV DASAENTVLV 

       130        140        150        160        170        180 
APGANAHLTP VPSAVANCDV LLTQLEIPVA TALAAARAAQ SADAVVMVNA SPAGQDRSSL 

       190        200        210        220        230        240 
QDLAAIADVV IANEHEANDW PSPPTHFVIT LGVRGARYVG ADGVFEVPAP TVTPVDTAGA 

       250        260        270        280        290        300 
GDVFAGVLAA NWPRNPGSPA ERLRALRRAC AAGALATLVS GVGDCAPAAA AIDAALRANR 


HNGS

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence." Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K. Barrell B.G. Nature 393:537-544(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25618 / H37Rv.
[2]	"Crystal structure and biochemical characterization of M.tuberculosis ribokinase (Rv2436)." Masters E.I., Sun Y., Wang Y., Parker W.B., Li R Submitted (MAR-2009) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (1.98 ANGSTROMS) OF 2-304 IN COMPLEX WITH ADP AND MAGNESIUM.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AL123456 Genomic DNA. Translation: CCP45228.1.

RefSeq

NP_216952.1. NC_000962.3.
YP_006515872.1. NC_018143.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3GO6	X-ray	1.98	A/B	2-304	[»]
3GO7	X-ray	2.50	A/B	2-304	[»]

SMR

P71913. Positions 13-285.

ModBase

Search...

Protein-protein interaction databases

STRING

83332.Rv2436.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

GeneID

13319145.
885671.

KEGG

mtu:Rv2436.
mtv:RVBD_2436.

PATRIC

18154013. VBIMycTub87468_2730.

Phylogenomic databases

KO

K00852.

ProtClustDB

CLSK791851.

Family and domain databases

InterPro

IPR011611. PfkB_dom.
IPR002139. Ribokinase.
[Graphical view]

Pfam

PF00294. PfkB. 1 hit.
[Graphical view]

PRINTS

PR00990. RIBOKINASE.

ProtoNet

Search...

Entry information

Entry name

P71913_MYCTU

Accession

Primary (citable) accession number: P71913

Entry history

Integrated into UniProtKB/TrEMBL:	February 1, 1997
Last sequence update:	February 1, 1997
Last modified:	May 1, 2013
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)