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P71909 (OBG_MYCTU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
GTPase obg
Alternative name(s):
GTP-binding protein obg
Gene names
Name:obg
Ordered Locus Names:Rv2440c, MT2516
OrganismMycobacterium tuberculosis [Reference proteome] [HAMAP]
Taxonomic identifier1773 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length479 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate By similarity. It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control Potential. HAMAP-Rule MF_01454

Cofactor

Magnesium Potential.

Subunit structure

Monomer By similarity. HAMAP-Rule MF_01454

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_01454.

Sequence similarities

Belongs to the GTP1/OBG family.

Contains 1 G (guanine nucleotide-binding) domain.

Sequence caution

The sequence AAK46813.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 479479GTPase obg HAMAP-Rule MF_01454
PRO_0000386062

Regions

Domain171 – 293123G
Nucleotide binding166 – 1738GTP By similarity
Nucleotide binding212 – 2165GTP By similarity
Nucleotide binding292 – 2954GTP By similarity

Experimental info

Sequence conflict11M → MKGSSV in AAK46813. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P71909 [UniParc].

Last modified July 5, 2004. Version 4.
Checksum: CC8D8741D9D40053

FASTA47950,461
        10         20         30         40         50         60 
MPRFVDRVVI HTRAGSGGNG CASVHREKFK PLGGPDGGNG GRGGSIVFVV DPQVHTLLDF 

        70         80         90        100        110        120 
HFRPHLTAAS GKHGMGNNRD GAAGADLEVK VPEGTVVLDE NGRLLADLVG AGTRFEAAAG 

       130        140        150        160        170        180 
GRGGLGNAAL ASRVRKAPGF ALLGEKGQSR DLTLELKTVA DVGLVGFPSA GKSSLVSAIS 

       190        200        210        220        230        240 
AAKPKIADYP FTTLVPNLGV VSAGEHAFTV ADVPGLIPGA SRGRGLGLDF LRHIERCAVL 

       250        260        270        280        290        300 
VHVVDCATAE PGRDPISDID ALETELACYT PTLQGDAALG DLAARPRAVV LNKIDVPEAR 

       310        320        330        340        350        360 
ELAEFVRDDI AQRGWPVFCV STATRENLQP LIFGLSQMIS DYNAARPVAV PRRPVIRPIP 

       370        380        390        400        410        420 
VDDSGFTVEP DGHGGFVVSG ARPERWIDQT NFDNDEAVGY LADRLARLGV EEELLRLGAR 

       430        440        450        460        470 
SGCAVTIGEM TFDWEPQTPA GEPVAMSGRG TDPRLDSNKR VGAAERKAAR SRRREHGDG

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE000516 Genomic DNA. Translation: AAK46813.1. Different initiation.
AL123456 Genomic DNA. Translation: CCP45233.1.
PIRF70680.
RefSeqNP_216956.1. NC_000962.3.
NP_336999.2. NC_002755.2.
YP_006515877.1. NC_018143.1.

3D structure databases

ProteinModelPortalP71909.
SMRP71909. Positions 4-437.
ModBaseSearch...

Protein-protein interaction databases

STRING83332.Rv2440c.

Proteomic databases

PRIDEP71909.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK46813; AAK46813; MT2516.
GeneID13319150.
885900.
925790.
KEGGmtc:MT2516.
mtu:Rv2440c.
PATRIC18127282. VBIMycTub22151_2749.

Organism-specific databases

TubercuListRv2440c.

Phylogenomic databases

eggNOGCOG0536.
HOGENOMHOG000019083.
KOK03979.
OMATKMDMPD.
ProtClustDBPRK12296.

Family and domain databases

Gene3D2.70.210.12. 1 hit.
HAMAPMF_01454. GTPase_Obg.
InterProIPR014100. GTP-bd_Obg/CgtA.
IPR015349. GTP-bd_prot_GTP1/OBG_C.
IPR006074. GTP1-OBG_CS.
IPR006169. GTP1_OBG_dom.
IPR006073. GTP_binding_domain.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERPTHR11702:SF3. PTHR11702:SF3. 1 hit.
PfamPF09269. DUF1967. 1 hit.
PF01018. GTP1_OBG. 1 hit.
PF01926. MMR_HSR1. 1 hit.
[Graphical view]
PIRSFPIRSF002401. GTP_bd_Obg/CgtA. 1 hit.
PRINTSPR00326. GTP1OBG.
SUPFAMSSF102741. GTP-bd_prot_GTP1/OBG_C. 1 hit.
SSF82051. GTP1_OBG_sub. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR02729. Obg_CgtA. 1 hit.
TIGR03595. Obg_CgtA_exten. 1 hit.
PROSITEPS00905. GTP1_OBG. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameOBG_MYCTU
AccessionPrimary (citable) accession number: P71909
Secondary accession number(s): L0TCC8, Q7D750
Entry history
Integrated into UniProtKB/Swiss-Prot: October 13, 2009
Last sequence update: July 5, 2004
Last modified: May 29, 2013
This is version 85 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh

Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names

SIMILARITY comments

Index of protein domains and families

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