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Protein
Submitted name:

C4-dicarboxylate transporter

Gene

dctA

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
C4-dicarboxylate transporterImported
Submitted name:
Probable C4-dicarboxylate-transport transmembrane protein DctAImported
Gene namesi
Name:dctAImported
Ordered Locus Names:Rv2443Imported
ORF Names:LH57_13360Imported
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)Imported
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome
  • UP000031768 Componenti: Chromosome

Organism-specific databases

TubercuListiRv2443.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei25 – 4521HelicalSequence analysisAdd
BLAST
Transmembranei57 – 8125HelicalSequence analysisAdd
BLAST
Transmembranei93 – 11624HelicalSequence analysisAdd
BLAST
Transmembranei166 – 18419HelicalSequence analysisAdd
BLAST
Transmembranei204 – 22926HelicalSequence analysisAdd
BLAST
Transmembranei235 – 25723HelicalSequence analysisAdd
BLAST
Transmembranei347 – 37226HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • extracellular region Source: MTBBASE
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiCOG1301. LUCA.
HOGENOMiHOG000208775.
KOiK11103.
OMAiIKMERLG.
OrthoDBiEOG69GZN1.

Family and domain databases

Gene3Di1.10.3860.10. 1 hit.
InterProiIPR001991. Na-dicarboxylate_symporter.
[Graphical view]
PANTHERiPTHR11958. PTHR11958. 1 hit.
PfamiPF00375. SDF. 1 hit.
[Graphical view]
PRINTSiPR00173. EDTRNSPORT.
SUPFAMiSSF118215. SSF118215. 1 hit.

Sequencei

Sequence statusi: Complete.

P71906-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAPLDRAPV TDLPANNKGR DRTHWLYLAV IFAVIAGVIV GLTAPSTGKS
60 70 80 90 100
LTVLGTVFVN LIKMMIAPVI FCTIVLGIGS VRKAAAVGKV GGLALAYFLT
110 120 130 140 150
MSSVALGIGL IVGNLLSPGR DLHLRPGAVG SGAALAGQAA ESHGIAGFIQ
160 170 180 190 200
QIIPRSLPSA LTEGNVLQVL LVALLVGFAV QGLGPAGESI LRAVENLQKL
210 220 230 240 250
VFKVLVMVLW LAPIGAFGAI ANIVATTGFN AVTNLLLLMA GFYLTCVVFV
260 270 280 290 300
FGVLGVLLRI VSGLSIFRLL RYLAREYLLI FATSSSEVVL PRLITKMKHL
310 320 330 340 350
GVQSSTVGVV VPTGYSFNLD GTAIYLTMAS LFIADAMGHR LTWGEQIALL
360 370 380 390 400
AFMIIASKGA AGVSGAGLAT LAGGLQAHRP ELLDGVGLIV GIDRFMSEAR
410 420 430 440 450
SLTNFSGNAV ATILVASWTK TIDLSKADEV LRGRDPFDES TMVDPHDEEP
460 470 480 490
PAATPHGGGV PTNPALCDFE QVSLGGLVGR PAGPQRADVD G
Length:491
Mass (Da):50,988
Last modified:February 1, 1997 - v1
Checksum:iBA9F676DBB14E353
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP009480 Genomic DNA. Translation: AIR15210.1.
AL123456 Genomic DNA. Translation: CCP45236.1.
RefSeqiNP_216959.1. NC_000962.3.
WP_003412582.1. NZ_KK339370.1.

Genome annotation databases

EnsemblBacteriaiAIR15210; AIR15210; LH57_13360.
CCP45236; CCP45236; Rv2443.
GeneIDi885745.
KEGGimtu:Rv2443.
mtv:RVBD_2443.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP009480 Genomic DNA. Translation: AIR15210.1.
AL123456 Genomic DNA. Translation: CCP45236.1.
RefSeqiNP_216959.1. NC_000962.3.
WP_003412582.1. NZ_KK339370.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAIR15210; AIR15210; LH57_13360.
CCP45236; CCP45236; Rv2443.
GeneIDi885745.
KEGGimtu:Rv2443.
mtv:RVBD_2443.

Organism-specific databases

TubercuListiRv2443.

Phylogenomic databases

eggNOGiCOG1301. LUCA.
HOGENOMiHOG000208775.
KOiK11103.
OMAiIKMERLG.
OrthoDBiEOG69GZN1.

Family and domain databases

Gene3Di1.10.3860.10. 1 hit.
InterProiIPR001991. Na-dicarboxylate_symporter.
[Graphical view]
PANTHERiPTHR11958. PTHR11958. 1 hit.
PfamiPF00375. SDF. 1 hit.
[Graphical view]
PRINTSiPR00173. EDTRNSPORT.
SUPFAMiSSF118215. SSF118215. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25618 / H37RvImported and H37RvImported.
  2. "Phylogenetic analysis of Mycobacterial species using whole genome sequences."
    Hazbon M.H., Riojas M.A., Damon A.M., Alalade R.O., Cantwell B.J., Monaco A., King S., Sohrabi A.
    Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 27294 / TMC 102 / H37RvImported and H37RvImported.

Entry informationi

Entry nameiP71906_MYCTU
AccessioniPrimary (citable) accession number: P71906
Secondary accession number(s): F2GHM5, I6XEB9, Q7D749
Entry historyi
Integrated into UniProtKB/TrEMBL: February 1, 1997
Last sequence update: February 1, 1997
Last modified: July 6, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.