P71855 (P71855_MYCTU) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Probable acetyl-CoA acetyltransferase FadA5 (Acetoacetyl-CoA thiolase) EMBL CCP46368.1

Submitted name:
Thiolase EMBL AAK48009.1

Gene names

Name:	fadA5 EMBL CCP46368.1
Ordered Locus Names:	MT3650, Rv3546 EMBL CCP46368.1

Organism

Mycobacterium tuberculosis [Reference proteome] [HAMAP]

Taxonomic identifier

1773 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	391 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Sequence similarities

Belongs to the thiolase family. RuleBase RU003557

Ontologies

Keywords
Molecular function	Transferase EMBL CCP46368.1
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cholesterol catabolic process Inferred from direct assay PubMed 19822665. Source: MTBBASE
Molecular_function	acetyl-CoA C-acetyltransferase activity Inferred from direct assay PubMed 19822665. Source: MTBBASE
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	P71855 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: D0B4C64729B00D76	FASTA	391	41,329
	10 20 30 40 50 60 MGYPVIVEAT RSPIGKRNGW LSGLHATELL GAVQKAVVDK AGIQSGLHAG DVEQVIGGCV 70 80 90 100 110 120 TQFGEQSNNI SRVAWLTAGL PEHVGATTVD CQCGSGQQAN HLIAGLIAAG AIDVGIACGI 130 140 150 160 170 180 EAMSRVGLGA NAGPDRSLIR AQSWDIDLPN QFEAAERIAK RRGITREDVD VFGLESQRRA 190 200 210 220 230 240 QRAWAEGRFD REISPIQAPV LDEQNQPTGE RRLVFRDQGL RETTMAGLGE LKPVLEGGIH 250 260 270 280 290 300 TAGTSSQISD GAAAVLWMDE AVARAHGLTP RARIVAQALV GAEPYYHLDG PVQSTAKVLE 310 320 330 340 350 360 KAGMKIGDID IVEINEAFAS VVLSWARVHE PDMDRVNVNG GAIALGHPVG CTGSRLITTA 370 380 390 LHELERTDQS LALITMCAGG ALSTGTIIER I

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence." Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K. , Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J., Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S., Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S., Barrell B.G. Nature 393:537-544(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25618 / H37Rv and H37Rv EMBL CCP46368.1.
[2]	"Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains." Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O., Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K., Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L., Delcher A., Utterback T.R. , Weidman J.F., Khouri H.M., Gill J., Mikula A., Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M. J. Bacteriol. 184:5479-5490(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CDC 1551 / Oshkosh.
[3]	"Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv." Camus J.C., Pryor M.J., Medigue C., Cole S.T. Microbiology 148:2967-2973(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: H37Rv EMBL CCP46368.1.
[4]	"TubercuList--10 years after." Lew J.M., Kapopoulou A., Jones L.M., Cole S.T. Tuberculosis 91:1-7(2011) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: H37Rv EMBL CCP46368.1.
[5]	Lew J.M. Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: H37Rv EMBL CCP46368.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000516 Genomic DNA. Translation: AAK48009.1. AL123456 Genomic DNA. Translation: CCP46368.1.
PIR	C70677.
RefSeq	NP_218063.1. NC_000962.3. NP_338195.1. NC_002755.2. YP_006517035.1. NC_018143.1.
3D structure databases
HSSP	HSSP built from PDB template 1AFW based on UniProtKB P27796.
SMR	P71855. Positions 6-389.
ModBase	Search...
Protein-protein interaction databases
STRING	83332.Rv3546.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAK48009; AAK48009; MT3650.
GeneID	13317154. 887360. 922843.
KEGG	mtc:MT3650. mtu:Rv3546. mtv:RVBD_3546.
PATRIC	18129784. VBIMycTub22151_3987.
Organism-specific databases
TubercuList	Rv3546.
Phylogenomic databases
HOGENOM	HOG000012239.
KO	K00626.
OMA	KMGDIDI.
ProtClustDB	PRK07850.
Enzyme and pathway databases
BioCyc	MetaCyc:MONOMER-16900.
Family and domain databases
Gene3D	3.40.47.10. 4 hits.
InterPro	IPR002155. Thiolase. IPR016039. Thiolase-like. IPR016038. Thiolase-like_subgr. IPR020617. Thiolase_C. IPR020613. Thiolase_CS. IPR020616. Thiolase_N. [Graphical view]
PANTHER	PTHR18919. PTHR18919. 1 hit.
Pfam	PF02803. Thiolase_C. 1 hit. PF00108. Thiolase_N. 1 hit. [Graphical view]
PIRSF	PIRSF000429. Ac-CoA_Ac_transf. 1 hit.
SUPFAM	SSF53901. Thiolase-like. 2 hits.
TIGRFAMs	TIGR01930. AcCoA-C-Actrans. 1 hit.
PROSITE	PS00737. THIOLASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

P71855_MYCTU

Accession

Primary (citable) accession number: P71855
Secondary accession number(s): F2GEQ6, Q7D5B3

Entry history

Integrated into UniProtKB/TrEMBL:	February 1, 1997
Last sequence update:	February 1, 1997
Last modified:	May 1, 2013
This is version 88 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)