P71832 (P71832_MYCTU) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Adenylosuccinate lyase EMBL AAK45043.1
EC=4.3.2.2 EMBL AAK45043.1

Submitted name:
PROBABLE ADENYLOSUCCINATE LYASE PURB (ADENYLOSUCCINASE) (ASL) (ASASE) EMBL CAB02389.1
EC=4.3.2.2 EMBL CAB02389.1

Gene names

Name:	purB EMBL CAB02389.1
Ordered Locus Names:	MT0801, Rv0777

Organism

Mycobacterium tuberculosis

Taxonomic identifier

1773 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	472 AA.
Sequence status	Complete.
Protein existence	Predicted

Ontologies

Keywords
Molecular function	Lyase EMBL CAB02389.1
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	purine ribonucleotide biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cell wall Inferred from direct assay. Source: MTBBASE plasma membrane Inferred from direct assay. Source: MTBBASE
Molecular function	(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity Inferred from electronic annotation. Source: EC N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	P71832 [UniParc]. Last modified July 1, 1997. Version 2. Checksum: 9BDEA09FE3010F10	FASTA	472	51,040
	10 20 30 40 50 60 MSIPNVLATR YASAEMVAIW SPEAKVVSER RLWLAVLRAQ AELGVAVADS VLADYERVVD 70 80 90 100 110 120 DVDLASISAR ERVLRHDVKA RIEEFNALAG HEHVHKGMTS RDLTENVEQL QIRRSLEVIF 130 140 150 160 170 180 AHGVAAVARL AERAVSYRDL IMAGRSHNVA AQATTLGKRF ASAAQEMMIA LRRLRELIDR 190 200 210 220 230 240 YPLRGIKGPM GTGQDMLDLL GGDRAALADL ERRVADFLGF ATVFNSVGQV YPRSLDHDVV 250 260 270 280 290 300 SALVQLGAGP SSLAHTIRLM AGHELATEGF APGQVGSSAM PHKMNTRSCE RVNGLQVVLR 310 320 330 340 350 360 GYASMVAELA GAQWNEGDVF CSVVRRVALP DSFFAVDGQI ETFLTVLDEF GAYPAVIGRE 370 380 390 400 410 420 LDRYLPFLAT TKVLMAAVRA GMGRESAHRL ISEHAVATAL AMREHGAEPD LLDRLAADPR 430 440 450 460 470 LTLGRDALEA ALADKKAFAG AAGDQVDDVV AMVDALVSRY PDAAKYTPGA IL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence." Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K. , Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J., Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S., Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S., Barrell B.G. Nature 393:537-544(1998) [PubMed: 9634230] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25618 / H37Rv.
[2]	"Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains." Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O., Peterson J., DeBoy R., Dodson R., Gwinn M., Haft D., Hickey E., Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M., Salzberg S.L., Delcher A., Utterback T. , Weidman J., Khouri H., Gill J., Mikula A., Bishai W., Jacobs Jr W.R. Jr, Venter J.C., Fraser C.M. J. Bacteriol. 184:5479-5490(2002) [PubMed: 12218036] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CDC 1551 / Oshkosh.
[3]	"Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv." Camus J.-C., Pryor M.J., Medigue C., Cole S.T. Microbiology 148:2967-2973(2002) [PubMed: 12368430] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: H37Rv.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000516 Genomic DNA. Translation: AAK45043.1. BX842574 Genomic DNA. Translation: CAB02389.1.
PIR	D70708.
RefSeq	NP_215291.1. NC_000962.2. NP_335229.1. NC_002755.2.
3D structure databases
HSSP	HSSP built from PDB template 1DOF based on UniProtKB Q8ZY28.
ProteinModelPortal	P71832.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000000584; EBMYCP00000000584; EBMYCG00000000584. EBMYCT00000069207; EBMYCP00000067266; EBMYCG00000069202.
GeneID	888929. 926104.
GenomeReviews	Gene locus MT0801 in contig AE000516_GR. Gene locus Rv0777 in contig AL123456_GR.
KEGG	mtc:MT0801. mtu:Rv0777.
PATRIC	18123502. VBIMycTub22151_0879.
TIGR	MT0801.
Organism-specific databases
TubercuList	Rv0777.
Phylogenomic databases
GeneTree	EBGT00050000016254.
HOGENOM	HBG302411.
OMA	KPTIAKY.
PhylomeDB	P71832.
ProtClustDB	PRK08937.
Family and domain databases
InterPro	IPR019468. AdenyloSucc_lyase_C. IPR000362. Fumarate_lyase. IPR020557. Fumarate_lyase_CS. IPR008948. L-Aspartase-like. IPR024083. L-Aspartase-like_N. IPR022761. Lyase1_N. IPR004769. Pur_lyase. [Graphical view]
Gene3D	G3DSA:1.10.275.10. G3DSA:1.10.275.10. 1 hit.
KO	K01756.
PANTHER	PTHR11444:SF2. PTHR11444:SF2. 1 hit.
Pfam	PF10397. ADSL_C. 1 hit. PF00206. Lyase_1. 1 hit. [Graphical view]
PRINTS	PR00149. FUMRATELYASE.
SMART	SM00998. ADSL_C. 1 hit. [Graphical view]
SUPFAM	SSF48557. L-Aspartase-like. 1 hit.
TIGRFAMs	TIGR00928. PurB. 1 hit.
PROSITE	PS00163. FUMARATE_LYASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

P71832_MYCTU

Accession

Primary (citable) accession number: P71832
Secondary accession number(s): Q7D9A5

Entry history

Integrated into UniProtKB/TrEMBL:	February 1, 1997
Last sequence update:	July 1, 1997
Last modified:	January 25, 2012
This is version 83 of the entry and version 2 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)