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Protein
Submitted name:

ATP-binding protein

Gene

phoR

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.SAAS annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotationImported, Transferase

Keywords - Biological processi

Two-component regulatory systemSAAS annotation

Keywords - Ligandi

ATP-bindingSAAS annotationImported, Nucleotide-binding

Enzyme and pathway databases

BioCyciMTBRV:RV0758-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
ATP-binding proteinImported
Submitted name:
Possible two component system response sensor kinase membrane associated PhoRImported
Gene namesi
Name:phoRImported
Ordered Locus Names:Rv0758Imported
ORF Names:LH57_04120Imported
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)Imported
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome
  • UP000031768 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei158 – 18023HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Keywords - PTMi

PhosphoproteinUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi83332.Rv0758.

Structurei

3D structure databases

SMRiP71815. Positions 185-467.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini181 – 23454HAMPInterPro annotationAdd
BLAST
Domaini256 – 470215Histidine kinaseInterPro annotationAdd
BLAST

Sequence similaritiesi

Contains histidine kinase domain.SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiENOG4105BZU. Bacteria.
ENOG410XNMH. LUCA.
HOGENOMiHOG000223177.
KOiK02484.
OMAiVWLQIGI.
OrthoDBiEOG6G4VQG.
PhylomeDBiP71815.

Family and domain databases

Gene3Di1.10.287.130. 1 hit.
3.30.565.10. 1 hit.
InterProiIPR003660. HAMP_dom.
IPR003594. HATPase_C.
IPR005467. His_kinase_dom.
IPR003661. HisK_dim/P.
IPR004358. Sig_transdc_His_kin-like_C.
[Graphical view]
PfamiPF00672. HAMP. 1 hit.
PF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
[Graphical view]
PRINTSiPR00344. BCTRLSENSOR.
SMARTiSM00304. HAMP. 1 hit.
SM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
[Graphical view]
SUPFAMiSSF47384. SSF47384. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiPS50885. HAMP. 1 hit.
PS50109. HIS_KIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P71815-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARHLRGRLP LRVRLVAATL ILVATGLVAS GIAVTSMLQH RLTSRIDRVL
60 70 80 90 100
LEEAQIWAQI TLPLAPDPYP GHNPDRPPSR FYVRVISPDG QSYTALNDNT
110 120 130 140 150
AIPAVPANND VGRHPTTLPS IGGSKTLWRA VSVRASDGYL TTVAIDLADV
160 170 180 190 200
RSTVRSLVLL QVGIGSAVLV VPGVAGYAVV RRSLRPLAEF EQTAAAIGAG
210 220 230 240 250
QLDRRVPQWH PRTEVGRLSL ALNGMLAQIQ RAVASAESSA EKARDSEDRM
260 270 280 290 300
RQFITDASHE LRTPLTTIRG FAELYRQGAA RDVGMLLSRI ESEASRMGLL
310 320 330 340 350
VDDLLLLARL DAHRPLELCR VDLLALASDA AHDARAMDPK RRITLEVLDG
360 370 380 390 400
PGTPEVLGDE SRLRQVLRNL VANAIQHTPE SADVTVRVGT EGDDAILEVA
410 420 430 440 450
DDGPGMSQED ALRVFERFYR ADSSRARASG GTGLGLSIVD SLVAAHGGAV
460 470 480
TVTTALGEGC CFRVSLPRVS DVDQLSLTPV VPGPP
Length:485
Mass (Da):52,016
Last modified:February 1, 1997 - v1
Checksum:iCDE2487C66C9A43B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP009480 Genomic DNA. Translation: AIR13488.1.
AL123456 Genomic DNA. Translation: CCP43505.1.
RefSeqiNP_215272.1. NC_000962.3.
WP_003916717.1. NZ_KK339370.1.

Genome annotation databases

EnsemblBacteriaiAIR13488; AIR13488; LH57_04120.
CCP43505; CCP43505; Rv0758.
GeneIDi888775.
KEGGimtu:Rv0758.
mtv:RVBD_0758.
PATRICi18150202. VBIMycTub87468_0848.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP009480 Genomic DNA. Translation: AIR13488.1.
AL123456 Genomic DNA. Translation: CCP43505.1.
RefSeqiNP_215272.1. NC_000962.3.
WP_003916717.1. NZ_KK339370.1.

3D structure databases

SMRiP71815. Positions 185-467.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi83332.Rv0758.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAIR13488; AIR13488; LH57_04120.
CCP43505; CCP43505; Rv0758.
GeneIDi888775.
KEGGimtu:Rv0758.
mtv:RVBD_0758.
PATRICi18150202. VBIMycTub87468_0848.

Phylogenomic databases

eggNOGiENOG4105BZU. Bacteria.
ENOG410XNMH. LUCA.
HOGENOMiHOG000223177.
KOiK02484.
OMAiVWLQIGI.
OrthoDBiEOG6G4VQG.
PhylomeDBiP71815.

Enzyme and pathway databases

BioCyciMTBRV:RV0758-MONOMER.

Family and domain databases

Gene3Di1.10.287.130. 1 hit.
3.30.565.10. 1 hit.
InterProiIPR003660. HAMP_dom.
IPR003594. HATPase_C.
IPR005467. His_kinase_dom.
IPR003661. HisK_dim/P.
IPR004358. Sig_transdc_His_kin-like_C.
[Graphical view]
PfamiPF00672. HAMP. 1 hit.
PF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
[Graphical view]
PRINTSiPR00344. BCTRLSENSOR.
SMARTiSM00304. HAMP. 1 hit.
SM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
[Graphical view]
SUPFAMiSSF47384. SSF47384. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiPS50885. HAMP. 1 hit.
PS50109. HIS_KIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25618 / H37RvImported and H37RvImported.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. "Phylogenetic analysis of Mycobacterial species using whole genome sequences."
    Hazbon M.H., Riojas M.A., Damon A.M., Alalade R.O., Cantwell B.J., Monaco A., King S., Sohrabi A.
    Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 27294 / TMC 102 / H37RvImported and H37RvImported.

Entry informationi

Entry nameiP71815_MYCTU
AccessioniPrimary (citable) accession number: P71815
Secondary accession number(s): I6X9R2
Entry historyi
Integrated into UniProtKB/TrEMBL: February 1, 1997
Last sequence update: February 1, 1997
Last modified: May 11, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.