P71715 (DNAB_MYCTU) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 1, 2013.
Version 107.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Replicative DNA helicase EC=3.6.4.12 Cleaved into the following chain:
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| Gene names |
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| Organism | Mycobacterium tuberculosis [Reference proteome] [HAMAP] | ||||||
| Taxonomic identifier | 1773 [NCBI] | ||||||
| Taxonomic lineage | Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex![]() |
Protein attributes
| Sequence length | 874 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity By similarity. The intein is an endonuclease Potential. |
| Catalytic activity | ATP + H2O = ADP + phosphate. |
| Post-translational modification | This protein undergoes a protein self splicing that involves a post-translational excision of the intervening region (intein) followed by peptide ligation. |
| Miscellaneous | Was identified as a high-confidence drug target. |
| Sequence similarities | Belongs to the helicase family. DnaB subfamily. Contains 1 DOD-type homing endonuclease domain. Contains 1 SF4 helicase domain. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | |||||||||||||||||||||
Molecule processing | ||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 399 | 399 | Replicative DNA helicase, 1st part | PRO_0000013282 | ||||||||||||||||||||||
| Chain | 400 – 815 | 416 | Endonuclease PI-MtuHIP | PRO_0000013283 | ||||||||||||||||||||||
| Chain | 816 – 874 | 59 | Replicative DNA helicase, 2nd part | PRO_0000013284 | ||||||||||||||||||||||
Regions | ||||||||||||||||||||||||||
| Domain | 195 – 462 | 268 | SF4 helicase; first part | |||||||||||||||||||||||
| Domain | 582 – 660 | 79 | DOD-type homing endonuclease | |||||||||||||||||||||||
| Domain | 612 – 874 | 263 | SF4 helicase; second part | |||||||||||||||||||||||
| Nucleotide binding | 226 – 233 | 8 | ATP Potential | |||||||||||||||||||||||
Experimental info | ||||||||||||||||||||||||||
| Sequence conflict | 552 | 1 | R → G in AAK44286. Ref.2 | |||||||||||||||||||||||
Secondary structure | ||||||||||||||||||||||||||
Helix Strand Turn | ||||||||||||||||||||||||||
| Helix | 28 – 40 | 13 | ||||||||||||||||||||||||
| Helix | 42 – 49 | 8 | ||||||||||||||||||||||||
| Helix | 60 – 74 | 15 | ||||||||||||||||||||||||
| Helix | 81 – 90 | 10 | ||||||||||||||||||||||||
| Helix | 94 – 97 | 4 | ||||||||||||||||||||||||
| Helix | 100 – 107 | 8 | ||||||||||||||||||||||||
| Helix | 113 – 115 | 3 | ||||||||||||||||||||||||
| Helix | 116 – 145 | 30 | ||||||||||||||||||||||||
| Helix | 152 – 164 | 13 | ||||||||||||||||||||||||
Sequences
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References
Cross-references
Sequence databases | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| EMBL GenBank DDBJ | BX842572 Genomic DNA. Translation: CAB02519.1. AE000516 Genomic DNA. Translation: AAK44286.1. AL123456 Genomic DNA. Translation: CCP42780.1. | ||||||||||||
| PIR | B70914. | ||||||||||||
| RefSeq | NP_214572.1. NC_000962.3. NP_334472.1. NC_002755.2. YP_006513372.1. NC_018143.1. | ||||||||||||
3D structure databases | |||||||||||||
| PDBe RCSB PDB PDBj |
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| ProteinModelPortal | P71715. | ||||||||||||
| SMR | P71715. Positions 22-497, 771-874. | ||||||||||||
| ModBase | Search... | ||||||||||||
Protein-protein interaction databases | |||||||||||||
| STRING | 83332.Rv0058. | ||||||||||||
Protein family/group databases | |||||||||||||
| MEROPS | N10.002. | ||||||||||||
Protocols and materials databases | |||||||||||||
| StructuralBiologyKnowledgebase | Search... | ||||||||||||
Genome annotation databases | |||||||||||||
| EnsemblBacteria | AAK44286; AAK44286; MT0064. | ||||||||||||
| GeneID | 13316036. 887009. 922737. | ||||||||||||
| KEGG | mtc:MT0064. mtu:Rv0058. mtv:RVBD_0058. | ||||||||||||
| PATRIC | 18121861. VBIMycTub22151_0065. | ||||||||||||
Organism-specific databases | |||||||||||||
| TubercuList | Rv0058. | ||||||||||||
Phylogenomic databases | |||||||||||||
| eggNOG | COG0305. | ||||||||||||
| HOGENOM | HOG000113195. | ||||||||||||
| KO | K02314. | ||||||||||||
| OMA | LPRHAIQ. | ||||||||||||
| ProtClustDB | PRK07773. | ||||||||||||
Family and domain databases | |||||||||||||
| Gene3D | 1.10.860.10. 1 hit. | ||||||||||||
| InterPro | IPR003593. AAA+_ATPase. IPR007692. DNA_helicase_DnaB. IPR007694. DNA_helicase_DnaB-like_C. IPR007693. DNA_helicase_DnaB-like_N. IPR016136. DNA_helicase_N/primase_C. IPR003586. Hint_dom_C. IPR003587. Hint_dom_N. IPR006142. INTEIN. IPR004042. Intein_endonuc. IPR006141. Intein_splice_site. [Graphical view] | ||||||||||||
| Pfam | PF00772. DnaB. 1 hit. PF03796. DnaB_C. 2 hits. [Graphical view] | ||||||||||||
| PRINTS | PR00379. INTEIN. | ||||||||||||
| SMART | SM00382. AAA. 1 hit. SM00305. HintC. 1 hit. SM00306. HintN. 1 hit. [Graphical view] | ||||||||||||
| SUPFAM | SSF48024. DNA_helicase_DnaB-like_N. 1 hit. | ||||||||||||
| TIGRFAMs | TIGR00665. DnaB. 1 hit. TIGR01443. intein_Cterm. 1 hit. TIGR01445. intein_Nterm. 1 hit. | ||||||||||||
| PROSITE | PS50818. INTEIN_C_TER. 1 hit. PS50819. INTEIN_ENDONUCLEASE. 1 hit. PS50817. INTEIN_N_TER. 1 hit. PS51199. SF4_HELICASE. 2 hits. [Graphical view] | ||||||||||||
| ProtoNet | Search... | ||||||||||||
Other | |||||||||||||
| ChEMBL | CHEMBL1741192. | ||||||||||||
| EvolutionaryTrace | P71715. | ||||||||||||
Entry information
| Entry name | DNAB_MYCTU | ||||||||
| Accession | Primary (citable) accession number: P71715 Secondary accession number(s): L0T2G0 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| Intein-containing proteins List of intein-containing protein entries |
| Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

Clusters with
