P71705 (Y048_MYCTU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uncharacterized protein Rv0048c/MT0054

Gene names

Ordered Locus Names:	Rv0048c, MT0054
ORF Names:	MTCY21D4.11c

Organism

Mycobacterium tuberculosis

Taxonomic identifier

1773 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	289 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Predicted

General annotation (Comments)

Subcellular location

Cell membrane; Multi-pass membrane protein Potential.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Signal Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to plasma membrane Inferred from direct assay. Source: MTBBASE
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Chain	20 – 289	270	Uncharacterized protein Rv0048c/MT0054		PRO_0000014065
Regions
	Transmembrane	90 – 110	21	Helical; Potential
	Transmembrane	257 – 277	21	Helical; Potential
Experimental info
	Sequence conflict	248	1	E → D Ref.2
	Sequence conflict	250	1	V → A Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P71705 [UniParc]. Last modified July 1, 1997. Version 2. Checksum: C2FC916EDCC7711B	FASTA	289	30,817
	10 20 30 40 50 60 MAKWLGAPLA RGVSTATRAK DSDRQDACRI LDDALRDGEL SMEEHRERVS AATKAVTLGD 70 80 90 100 110 120 LQRLVADLQV ESAPAQMPAL KSRAKRTELG LLAAAFVASV LLGVGIGWGV YGNTRSPLDF 130 140 150 160 170 180 TSDPGAKPDG IAPVVLTPPR QLHSLGGLTG LLEQTRKRFG DTMGYRLVIY PEYASLDRVD 190 200 210 220 230 240 PADDRRVLAY TYRGGWGDAT SSAKSIADVS VVDLSKFDAK TAVGIMRGAP ETLGLKQSDV 250 260 270 280 KSMYLIVEPV KDPTTPAALS LSLYVSSDYG GGYLVFAGDG TIKHVSYPS

References

[1]

"Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence." Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K. , Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J., Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S., Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S., Barrell B.G. Nature 393:537-544(1998) [PubMed: 9634230] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25618 / H37Rv.

[2]

"Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains." Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O., Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K., Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L., Delcher A., Utterback T.R. , Weidman J.F., Khouri H.M., Gill J., Mikula A., Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M. J. Bacteriol. 184:5479-5490(2002) [PubMed: 12218036] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CDC 1551 / Oshkosh.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX842572 Genomic DNA. Translation: CAB02527.1. AE000516 Genomic DNA. Translation: AAK44276.1.
PIR	H70912.
RefSeq	NP_214562.1. NC_000962.2. NP_334462.1. NC_002755.2.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000001330; EBMYCP00000001330; EBMYCG00000001330. EBMYCT00000071015; EBMYCP00000069074; EBMYCG00000071010.
GeneID	887027. 922698.
GenomeReviews	Gene locus MT0054 in contig AE000516_GR. Gene locus Rv0048c in contig AL123456_GR.
KEGG	mtc:MT0054. mtu:Rv0048c.
PATRIC	18121841. VBIMycTub22151_0055.
TIGR	MT0054.
Organism-specific databases
TubercuList	Rv0048c.
Phylogenomic databases
GeneTree	EBGT00050000016349.
HOGENOM	HBG658416.
OMA	GRIELYP.
ProtClustDB	CLSK790222.
Family and domain databases
InterPro	IPR012551. DUF1707. [Graphical view]
Pfam	PF08044. DUF1707. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Y048_MYCTU

Accession

Primary (citable) accession number: P71705

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	July 1, 1997
Last modified:	January 25, 2012
This is version 76 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program