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Protein

FHA domain-containing protein FhaA

Gene

fhaA

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regulates cell growth and peptidoglycan synthesis by binding to MviN. May inhibit the late stages of peptidoglycan synthesis.1 Publication

Enzyme and pathway databases

BioCyciMTBRV:RV0020C-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
FHA domain-containing protein FhaA
Gene namesi
Name:fhaA
Synonyms:TB39.8
Ordered Locus Names:Rv0020c
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome

Organism-specific databases

TubercuListiRv0020c.

Subcellular locationi

GO - Cellular componenti

  • cell wall Source: MTBBASE
  • cytosol Source: MTBBASE
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi116 – 1161T → A: Lack of phosphorylation. 1 Publication
Mutagenesisi459 – 4591R → A: Abolishes phosphorylation by PknB. Strong decrease in affinity for MviN. 2 Publications
Mutagenesisi461 – 4611Q → A: Does not affect affinity for MviN. 1 Publication
Mutagenesisi473 – 4731S → A: Abolishes phosphorylation by PknB. 1 Publication
Mutagenesisi474 – 4741R → A: Decrease in affinity for MviN. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 527527FHA domain-containing protein FhaAPRO_0000419664Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei116 – 1161Phosphothreonine1 Publication

Post-translational modificationi

Phosphorylated by PknB.2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP71590.
PRIDEiP71590.

PTM databases

iPTMnetiP71590.

Interactioni

Subunit structurei

Interacts with (phosphorylated) MviN and (phosphorylated) PknB via the FHA domain. Binds to the PknB juxtamembrane domain with an affinity that is modulated by the degree and the pattern of phosphorylation of this juxtamembrane domain.2 Publications

Protein-protein interaction databases

DIPiDIP-59047N.
STRINGi83332.Rv0020c.

Structurei

Secondary structure

1
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi22 – 276Combined sources
Helixi34 – 4613Combined sources
Beta strandi61 – 677Combined sources
Helixi68 – 747Combined sources
Helixi79 – 9618Combined sources
Beta strandi105 – 1117Combined sources
Beta strandi119 – 1246Combined sources
Beta strandi127 – 1293Combined sources
Beta strandi434 – 4407Combined sources
Beta strandi442 – 4443Combined sources
Beta strandi447 – 4493Combined sources
Beta strandi452 – 4609Combined sources
Beta strandi464 – 4663Combined sources
Beta strandi468 – 4714Combined sources
Beta strandi477 – 4815Combined sources
Beta strandi486 – 4905Combined sources
Beta strandi497 – 4993Combined sources
Beta strandi505 – 5084Combined sources
Beta strandi514 – 5174Combined sources
Beta strandi520 – 5278Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2LC0NMR-A1-132[»]
2LC1NMR-A430-527[»]
3OUNX-ray2.70A390-525[»]
3PO8X-ray1.50A431-527[»]
3POAX-ray2.01A431-527[»]
ProteinModelPortaliP71590.
SMRiP71590. Positions 1-132, 433-527.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP71590.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini455 – 50450FHAPROSITE-ProRule annotationAdd
BLAST

Domaini

The structure of the N-terminal domain remains unchanged upon phosphorylation.1 Publication

Sequence similaritiesi

Contains 1 FHA domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105TV9. Bacteria.
COG1716. LUCA.
HOGENOMiHOG000235804.
InParanoidiP71590.
OMAiPQSYEQR.

Family and domain databases

Gene3Di2.60.200.20. 1 hit.
InterProiIPR022128. DUF3662.
IPR000253. FHA_dom.
IPR008984. SMAD_FHA_domain.
[Graphical view]
PfamiPF12401. DUF3662. 1 hit.
PF00498. FHA. 1 hit.
[Graphical view]
SMARTiSM00240. FHA. 1 hit.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 1 hit.
PROSITEiPS50006. FHA_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P71590-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSQKRLVQR VERKLEQTVG DAFARIFGGS IVPQEVEALL RREAADGIQS
60 70 80 90 100
LQGNRLLAPN EYIITLGVHD FEKLGADPEL KSTGFARDLA DYIQEQGWQT
110 120 130 140 150
YGDVVVRFEQ SSNLHTGQFR ARGTVNPDVE THPPVIDCAR PQSNHAFGAE
160 170 180 190 200
PGVAPMSDNS SYRGGQGQGR PDEYYDDRYA RPQEDPRGGP DPQGGSDPRG
210 220 230 240 250
GYPPETGGYP PQPGYPRPRH PDQGDYPEQI GYPDQGGYPE QRGYPEQRGY
260 270 280 290 300
PDQRGYQDQG RGYPDQGQGG YPPPYEQRPP VSPGPAAGYG APGYDQGYRQ
310 320 330 340 350
SGGYGPSPGG GQPGYGGYGE YGRGPARHEE GSYVPSGPPG PPEQRPAYPD
360 370 380 390 400
QGGYDQGYQQ GATTYGRQDY GGGADYTRYT ESPRVPGYAP QGGGYAEPAG
410 420 430 440 450
RDYDYGQSGA PDYGQPAPGG YSGYGQGGYG SAGTSVTLQL DDGSGRTYQL
460 470 480 490 500
REGSNIIGRG QDAQFRLPDT GVSRRHLEIR WDGQVALLAD LNSTNGTTVN
510 520
NAPVQEWQLA DGDVIRLGHS EIIVRMH
Length:527
Mass (Da):56,880
Last modified:February 1, 1997 - v1
Checksum:i2642F9CF23FE7906
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA. Translation: CCP42742.1.
PIRiB70700.
RefSeqiNP_214534.1. NC_000962.3.
WP_003912368.1. NZ_KK339370.1.

Genome annotation databases

EnsemblBacteriaiCCP42742; CCP42742; Rv0020c.
GeneIDi887067.
KEGGimtu:Rv0020c.
PATRICi18148538. VBIMycTub87468_0024.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA. Translation: CCP42742.1.
PIRiB70700.
RefSeqiNP_214534.1. NC_000962.3.
WP_003912368.1. NZ_KK339370.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2LC0NMR-A1-132[»]
2LC1NMR-A430-527[»]
3OUNX-ray2.70A390-525[»]
3PO8X-ray1.50A431-527[»]
3POAX-ray2.01A431-527[»]
ProteinModelPortaliP71590.
SMRiP71590. Positions 1-132, 433-527.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-59047N.
STRINGi83332.Rv0020c.

PTM databases

iPTMnetiP71590.

Proteomic databases

PaxDbiP71590.
PRIDEiP71590.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCCP42742; CCP42742; Rv0020c.
GeneIDi887067.
KEGGimtu:Rv0020c.
PATRICi18148538. VBIMycTub87468_0024.

Organism-specific databases

TubercuListiRv0020c.

Phylogenomic databases

eggNOGiENOG4105TV9. Bacteria.
COG1716. LUCA.
HOGENOMiHOG000235804.
InParanoidiP71590.
OMAiPQSYEQR.

Enzyme and pathway databases

BioCyciMTBRV:RV0020C-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP71590.

Family and domain databases

Gene3Di2.60.200.20. 1 hit.
InterProiIPR022128. DUF3662.
IPR000253. FHA_dom.
IPR008984. SMAD_FHA_domain.
[Graphical view]
PfamiPF12401. DUF3662. 1 hit.
PF00498. FHA. 1 hit.
[Graphical view]
SMARTiSM00240. FHA. 1 hit.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 1 hit.
PROSITEiPS50006. FHA_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFHAA_MYCTU
AccessioniPrimary (citable) accession number: P71590
Secondary accession number(s): F2GPM4, L0T599
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2012
Last sequence update: February 1, 1997
Last modified: September 7, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
    Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.