P71575 (Y007_MYCTU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uncharacterized protein Rv0007/MT0007

Gene names

Ordered Locus Names:	Rv0007, MT0007
ORF Names:	MTCY10H4.05

Organism

Mycobacterium tuberculosis

Taxonomic identifier

1773 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	304 AA.
Sequence status	Complete.
Protein existence	Predicted

General annotation (Comments)

Subcellular location	Cell membrane; Multi-pass membrane protein Potential.
Sequence similarities	To M.leprae ML0007.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to plasma membrane Inferred from direct assay. Source: MTBBASE
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 304	304	Uncharacterized protein Rv0007/MT0007		PRO_0000103637
Regions
	Transmembrane	206 – 226	21	Helical; Potential
	Transmembrane	265 – 285	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	P71575 [UniParc]. Last modified July 1, 1997. Version 2. Checksum: F620BFAD2FB91B39	FASTA	304	31,073
	10 20 30 40 50 60 MTAPNEPGAL SKGDGPNADG LVDRGGAHRA ATGPGRIPDA GDPPPWQRAA TRQSQAGHRQ 70 80 90 100 110 120 PPPVSHPEGR PTNPPAAADA RLNRFISGAS APVTGPAAAV RTPQPDPDAS LGCGDGSPAE 130 140 150 160 170 180 AYASELPDLS GPTPRAPQRN PAPARPAEGG AGSRGDSAAG SSGGRSITAE SRDARVQLSA 190 200 210 220 230 240 RRSRGPVRAS MQIRRIDPWS TLKVSLLLSV ALFFVWMITV AFLYLVLGGM GVWAKLNSNV 250 260 270 280 290 300 GDLLNNASGS SAELVSSGTI FGGAFLIGLV NIVLMTALAT IGAFVYNLIT DLIGGIEVTL ADRD

References

[1]

"Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence." Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K. , Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J., Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S., Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S., Barrell B.G. Nature 393:537-544(1998) [PubMed: 9634230] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25618 / H37Rv.

[2]

"Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains." Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O., Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K., Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L., Delcher A., Utterback T.R. , Weidman J.F., Khouri H.M., Gill J., Mikula A., Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M. J. Bacteriol. 184:5479-5490(2002) [PubMed: 12218036] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CDC 1551 / Oshkosh.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX842572 Genomic DNA. Translation: CAB02428.1. AE000516 Genomic DNA. Translation: AAK44230.1.
PIR	E70698.
RefSeq	NP_214521.1. NC_000962.2. NP_334416.1. NC_002755.2.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000001570; EBMYCP00000001570; EBMYCG00000001570. EBMYCT00000071909; EBMYCP00000069968; EBMYCG00000071904.
GeneID	885982. 922438.
GenomeReviews	Gene locus MT0007 in contig AE000516_GR. Gene locus Rv0007 in contig AL123456_GR.
KEGG	mtc:MT0007. mtu:Rv0007.
PATRIC	18121740. VBIMycTub22151_0008.
TIGR	MT0007.
Organism-specific databases
TubercuList	Rv0007.
Phylogenomic databases
GeneTree	EBGT00050000015351.
HOGENOM	HBG634393.
OMA	IYNLATD.
ProtClustDB	CLSK790187.
Family and domain databases
InterPro	IPR021949. DUF3566_TM. [Graphical view]
Pfam	PF12089. DUF3566. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Y007_MYCTU

Accession

Primary (citable) accession number: P71575

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 2, 2001
Last sequence update:	July 1, 1997
Last modified:	January 25, 2012
This is version 73 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program