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P71559 (SUCC_MYCTU) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Succinyl-CoA ligase [ADP-forming] subunit beta
EC=6.2.1.5
Alternative name(s):
Succinyl-CoA synthetase subunit beta
Short name=SCS-beta
Gene names
Name:sucC
Ordered Locus Names:Rv0951, MT0978
ORF Names:MTCY10D7.23c
OrganismMycobacterium tuberculosis
Taxonomic identifier1773 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length387 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + succinate + CoA = ADP + phosphate + succinyl-CoA. HAMAP MF_00558

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity.

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1. HAMAP MF_00558

Subunit structure

Heterotetramer of two alpha and two beta subunits By similarity.

Sequence similarities

Belongs to the succinate/malate CoA ligase beta subunit family.

Contains 1 ATP-grasp domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 387387Succinyl-CoA ligase [ADP-forming] subunit beta HAMAP MF_00558
PRO_0000102840

Regions

Domain9 – 236228ATP-grasp
Nucleotide binding35 – 10066ATP By similarity

Sites

Metal binding1891Magnesium or manganese By similarity
Metal binding1911Magnesium or manganese By similarity

Sequences

Sequence LengthMass (Da)Tools
P71559 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: C3155A7CCAF98FDC

FASTA38740,926
        10         20         30         40         50         60 
MDLFEYQAKE LFAKHNVPST PGRVTDTAEG AKAIATEIGR PVMVKAQVKI GGRGKAGGVK 

        70         80         90        100        110        120 
YAATPQDAYE HAKNILGLDI KGHIVKKLLV AEASDIAEEY YLSFLLDRAN RTYLAMCSVE 

       130        140        150        160        170        180 
GGMEIEEVAA TKPERLAKVP VNAVKGVDLD FARSIAEQGH LPAEVLDTAA VTIAKLWELF 

       190        200        210        220        230        240 
VAEDATLVEV NPLVRTPDHK ILALDAKITL DGNADFRQPG HAEFEDRAAT DPLELKAKEH 

       250        260        270        280        290        300 
DLNYVKLDGQ VGIIGNGAGL VMSTLDVVAY AGEKHGGVKP ANFLDIGGGA SAEVMAAGLD 

       310        320        330        340        350        360 
VVLGDQQVKS VFVNVFGGIT SCDAVATGIV KALGMLGDEA NKPLVVRLDG NNVEEGRRIL 

       370        380 
TEANHPLVTL VATMDEAADK AAELASA

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX842575 Genomic DNA. Translation: CAB01999.1.
AE000516 Genomic DNA. Translation: AAK45226.1.
PIRE70716.
RefSeqNP_215466.1. NC_000962.2.
NP_335412.1. NC_002755.2.

3D structure databases

ProteinModelPortalP71559.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000001237; EBMYCP00000001237; EBMYCG00000001237.
EBMYCT00000072170; EBMYCP00000070229; EBMYCG00000072165.
GeneID885434.
926370.
GenomeReviewsGene locus MT0978 in contig AE000516_GR.
Gene locus Rv0951 in contig AL123456_GR.
KEGGmtc:MT0978.
mtu:Rv0951.
PATRIC18123896. VBIMycTub22151_1071.
TIGRMT0978.

Organism-specific databases

TubercuListRv0951.

Phylogenomic databases

GeneTreeEBGT00050000017263.
HOGENOMHBG315432.
OMAMSFDENA.
PhylomeDBP71559.
ProtClustDBPRK00696.

Family and domain databases

HAMAPMF_00558. Succ_CoA_beta.
[Tree]
InterProIPR011761. ATP-grasp.
IPR013650. ATP-grasp_succ-CoA_synth-type.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR005811. CoA_ligase.
IPR017866. Succ-CoA_synthase_bsu_CS.
IPR005809. Succ_CoA_synthase_bsu.
IPR016102. Succinyl-CoA_synth-like.
[Graphical view]
Gene3DG3DSA:3.30.1490.20. ATP_grasp_subdomain_1. 1 hit.
G3DSA:3.30.470.20. ATP_grasp_subdomain_2. 1 hit.
G3DSA:3.40.50.261. Succinyl-CoA_synth-like. 1 hit.
KOK01903.
PANTHERPTHR11815. CoA_lig_beta. 1 hit.
PfamPF08442. ATP-grasp_2. 1 hit.
PF00549. Ligase_CoA. 1 hit.
[Graphical view]
PIRSFPIRSF001554. SucCS_beta. 1 hit.
SUPFAMSSF52210. CoA_ligase. 1 hit.
TIGRFAMsTIGR01016. SucCoAbeta. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS01217. SUCCINYL_COA_LIG_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSUCC_MYCTU
AccessionPrimary (citable) accession number: P71559
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: January 25, 2012
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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