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P71558 (SUCD_MYCTU) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Succinyl-CoA ligase [ADP-forming] subunit alpha
EC=6.2.1.5
Alternative name(s):
Succinyl-CoA synthetase subunit alpha
Short name=SCS-alpha
Gene names
Name:sucD
Ordered Locus Names:Rv0952, MT0979
ORF Names:MTCY10D7.22c
OrganismMycobacterium tuberculosis
Taxonomic identifier1773 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length303 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + succinate + CoA = ADP + phosphate + succinyl-CoA.

Subunit structure

Heterotetramer of two alpha and two beta subunits By similarity.

Sequence similarities

Belongs to the succinate/malate CoA ligase alpha subunit family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 303303Succinyl-CoA ligase [ADP-forming] subunit alpha
PRO_0000102796

Sites

Active site2591Tele-phosphohistidine intermediate By similarity

Sequences

Sequence LengthMass (Da)Tools
P71558 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: 67769CE58DCBDB48

FASTA30331,229
        10         20         30         40         50         60 
MTHMSIFLSR DNKVIVQGIT GSEATVHTAR MLRAGTQIVG GVNARKAGTT VTHEDKGGRL 

        70         80         90        100        110        120 
IKLPVFGSVA EAMEKTGADV SIIFVPPTFA KDAIIEAIDA EIPLLVVITE GIPVQDTAYA 

       130        140        150        160        170        180 
WAYNLEAGHK TRIIGPNCPG IISPGQSLAG ITPANITGPG PIGLVSKSGT LTYQMMFELR 

       190        200        210        220        230        240 
DLGFSTAIGI GGDPVIGTTH IDAIEAFERD PDTKLIVMIG EIGGDAEERA ADFIKTNVSK 

       250        260        270        280        290        300 
PVVGYVAGFT APEGKTMGHA GAIVSGSSGT AAAKQEALEA AGVKVGKTPS ATAALAREIL 


LSL

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX842575 Genomic DNA. Translation: CAB01998.1.
AE000516 Genomic DNA. Translation: AAK45227.1.
PIRF70716.
RefSeqNP_215467.1. NC_000962.2.
NP_335413.1. NC_002755.2.

3D structure databases

ProteinModelPortalP71558.
SMRP71558. Positions 5-296.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000001760; EBMYCP00000001760; EBMYCG00000001759.
EBMYCT00000069390; EBMYCP00000067449; EBMYCG00000069385.
GeneID885426.
926371.
GenomeReviewsGene locus MT0979 in contig AE000516_GR.
Gene locus Rv0952 in contig AL123456_GR.
KEGGmtc:MT0979.
mtu:Rv0952.
PATRIC18123898. VBIMycTub22151_1072.
TIGRMT0979.

Organism-specific databases

TubercuListRv0952.

Phylogenomic databases

GeneTreeEBGT00050000016700.
HOGENOMHBG615372.
OMAAPPGRTM.
PhylomeDBP71558.
ProtClustDBPRK05678.

Family and domain databases

InterProIPR017440. Cit_synth/succinyl-CoA_lig_AS.
IPR003781. CoA-bd.
IPR005810. CoA_lig_alpha.
IPR005811. CoA_ligase.
IPR016040. NAD(P)-bd_dom.
IPR016102. Succinyl-CoA_synth-like.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
G3DSA:3.40.50.261. Succinyl-CoA_synth-like. 1 hit.
KOK01902.
PfamPF02629. CoA_binding. 1 hit.
PF00549. Ligase_CoA. 1 hit.
[Graphical view]
PIRSFPIRSF001553. SucCS_alpha. 1 hit.
PRINTSPR01798. SCOASYNTHASE.
SMARTSM00881. CoA_binding. 1 hit.
[Graphical view]
SUPFAMSSF52210. CoA_ligase. 1 hit.
TIGRFAMsTIGR01019. SucCoAalpha. 1 hit.
PROSITEPS01216. SUCCINYL_COA_LIG_1. 1 hit.
PS00399. SUCCINYL_COA_LIG_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSUCD_MYCTU
AccessionPrimary (citable) accession number: P71558
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: January 25, 2012
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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