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Protein

Protein translocase subunit SecA 1

Gene

secA1

Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi98 – 105ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Translocation, Transport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMSME246196:G1H7P-1893-MONOMER
BRENDAi3.6.3.B1 3512

Names & Taxonomyi

Protein namesi
Recommended name:
Protein translocase subunit SecA 1UniRule annotation
Gene namesi
Name:secA1UniRule annotation
Ordered Locus Names:MSMEG_1881, MSMEI_1840
OrganismiMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Taxonomic identifieri246196 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium fortuitum complex
Proteomesi
  • UP000006158 Componenti: Chromosome
  • UP000000757 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Cytoplasmic side UniRule annotation
  • Cytoplasm UniRule annotation
  • Note: Distribution is 50-50.UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Disruption phenotypei

Essential, it cannot be disrupted.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001095971 – 953Protein translocase subunit SecA 1Add BLAST953

Proteomic databases

PRIDEiP71533

Interactioni

Subunit structurei

Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.UniRule annotation

Protein-protein interaction databases

STRINGi246196.MSMEG_1881

Structurei

3D structure databases

ProteinModelPortaliP71533
SMRiP71533
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SecA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CI6 Bacteria
COG0653 LUCA
HOGENOMiHOG000218168
KOiK03070
OMAiFEYDEVM
OrthoDBiPOG091H01RS

Family and domain databases

HAMAPiMF_01382 SecA, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR000185 SecA
IPR020937 SecA_CS
IPR011115 SecA_DEAD
IPR014018 SecA_motor_DEAD
IPR011130 SecA_preprotein_X-link_dom
IPR011116 SecA_Wing/Scaffold
IPR036266 SecA_Wing/Scaffold_sf
IPR036670 SecA_X-link_sf
PANTHERiPTHR30612 PTHR30612, 2 hits
PfamiView protein in Pfam
PF07517 SecA_DEAD, 1 hit
PF01043 SecA_PP_bind, 1 hit
PF07516 SecA_SW, 1 hit
PRINTSiPR00906 SECA
SMARTiView protein in SMART
SM00957 SecA_DEAD, 1 hit
SM00958 SecA_PP_bind, 1 hit
SUPFAMiSSF52540 SSF52540, 3 hits
SSF81767 SSF81767, 1 hit
SSF81886 SSF81886, 1 hit
TIGRFAMsiTIGR00963 secA, 1 hit
PROSITEiView protein in PROSITE
PS01312 SECA, 1 hit
PS51196 SECA_MOTOR_DEAD, 1 hit

Sequencei

Sequence statusi: Complete.

P71533-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSKLLRLGE GRMVKRLRKV ADYVNALSDD VEKLSDAELR AKTEEFKKRV
60 70 80 90 100
ADGEDLDDLL PEAFAVAREA AWRVLNQRHF DVQVMGGAAL HFGNVAEMKT
110 120 130 140 150
GEGKTLTAVL PSYLNALSGK GVHVVTVNDY LARRDSEWMG RVHRFLGLDV
160 170 180 190 200
GVILSGMTPD ERRAAYAADI TYGTNNEFGF DYLRDNMAHS VDDMVQRGHN
210 220 230 240 250
FAIVDEVDSI LIDEARTPLI ISGPADGASH WYQEFARIVP MMEKDVHYEV
260 270 280 290 300
DLRKRTVGVH ELGVEFVEDQ LGIDNLYEAA NSPLVSYLNN ALKAKELFQR
310 320 330 340 350
DKDYIVRNGE VLIVDEFTGR VLMGRRYNEG MHQAIEAKER VEIKAENQTL
360 370 380 390 400
ATITLQNYFR LYDKLSGMTG TAETEAAELH EIYKLGVVPI PTNKPMVRQD
410 420 430 440 450
QSDLIYKTEE AKFLAVVDDV AERHAKGQPV LIGTTSVERS EYLSKMLTKR
460 470 480 490 500
RVPHNVLNAK YHEQEANIIA EAGRRGAVTV ATNMAGRGTD IVLGGNVDFL
510 520 530 540 550
ADKRLRERGL DPVETPEEYE AAWHEVLPQV KAECAKEAEQ VIEAGGLYVL
560 570 580 590 600
GTERHESRRI DNQLRGRSGR QGDPGESRFY LSLGDELMRR FNGATLETLL
610 620 630 640 650
TRLNLPDDVP IEAKMVSRAI KSAQTQVEQQ NFEVRKNVLK YDEVMNQQRK
660 670 680 690 700
VIYAERRRIL EGENLAEQAH KMLVDVITAY VDGATAEGYA EDWDLETLWT
710 720 730 740 750
ALKTLYPVGI DHRDLIDSDA VGEPGELTRE ELLDALIKDA ERAYAEREKQ
760 770 780 790 800
IEAIAGEGAM RQLERNVLLN VIDRKWREHL YEMDYLKEGI GLRAMAQRDP
810 820 830 840 850
LVEYQREGYD MFVGMLEALK EESVGFLFNV QVEAAPQQPQ VAPQAPPPTL
860 870 880 890 900
SEFAAAAAAK ASDSAAKPDS GSVATKERAE AERPAPALRA KGIDNEAPPL
910 920 930 940 950
TYTGPSEDGT AQVQRSGNGG RHAAPAGGSR RERREAARKQ AKADRPAKSH

RKG
Length:953
Mass (Da):106,488
Last modified:February 5, 2008 - v2
Checksum:i4D1AB93BC0752221
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti260H → HVGVH in AAB06754 (PubMed:11717254).Curated1
Sequence conflicti752E → K in AAB06754 (PubMed:11717254).Curated1
Sequence conflicti775K → Q in AAB06754 (PubMed:11717254).Curated1
Sequence conflicti908 – 909DG → ER in AAB06754 (PubMed:11717254).Curated2
Sequence conflicti912Q → H in AAB06754 (PubMed:11717254).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66081 Genomic DNA Translation: AAB06754.1
CP000480 Genomic DNA Translation: ABK74020.1
CP001663 Genomic DNA Translation: AFP38312.1
RefSeqiWP_011727975.1, NZ_CP009494.1
YP_886246.1, NC_008596.1

Genome annotation databases

EnsemblBacteriaiABK74020; ABK74020; MSMEG_1881
AFP38312; AFP38312; MSMEI_1840
GeneIDi4536291
KEGGimsb:LJ00_09385
msg:MSMEI_1840
msm:MSMEG_1881
PATRICifig|246196.19.peg.1862

Similar proteinsi

Entry informationi

Entry nameiSECA1_MYCS2
AccessioniPrimary (citable) accession number: P71533
Secondary accession number(s): A0QTK8, I7FYZ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 5, 2008
Last modified: May 23, 2018
This is version 119 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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