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P71512

- HPPK_METEA

UniProt

P71512 - HPPK_METEA

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Protein

2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase

Gene
folK, folA, MexAM1_META1p1743
Organism
Methylobacterium extorquens (strain ATCC 14718 / DSM 1338 / AM1)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine = AMP + (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate.

Pathwayi

GO - Molecular functioni

  1. 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity Source: UniProtKB-EC
  2. ATP binding Source: UniProtKB-KW
  3. kinase activity Source: UniProtKB-KW

GO - Biological processi

  1. folic acid biosynthetic process Source: UniProtKB-KW
  2. tetrahydrofolate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Folate biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMEXT272630:GBY6-1667-MONOMER.
RETL1328306-WGS:GSTH-2344-MONOMER.
UniPathwayiUPA00077; UER00155.

Names & Taxonomyi

Protein namesi
Recommended name:
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (EC:2.7.6.3)
Alternative name(s):
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase
Short name:
PPPK
7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase
Short name:
HPPK
Gene namesi
Name:folK
Synonyms:folA
Ordered Locus Names:MexAM1_META1p1743
OrganismiMethylobacterium extorquens (strain ATCC 14718 / DSM 1338 / AM1)
Taxonomic identifieri272630 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesMethylobacteriaceaeMethylobacterium
ProteomesiUP000009081: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 1581582-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinasePRO_0000168253Add
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the HPPK family.

Phylogenomic databases

eggNOGiCOG0801.
HOGENOMiHOG000217741.
KOiK00950.
OMAiFDELSKW.
OrthoDBiEOG6XHC8G.

Family and domain databases

Gene3Di3.30.70.560. 1 hit.
InterProiIPR000550. Hppk.
[Graphical view]
PfamiPF01288. HPPK. 1 hit.
[Graphical view]
SUPFAMiSSF55083. SSF55083. 1 hit.
TIGRFAMsiTIGR01498. folK. 1 hit.
PROSITEiPS00794. HPPK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P71512-1 [UniParc]FASTAAdd to Basket

« Hide

MTRAYLGLGS NIGDKAAMLA GAVEHLAATP GIRVVARSAD YRTPPWGDTD    50
QDWFLNAAVA IDTELTPHGL LEVCLSIEAA LGRVRERRWG PRVIDIDVLA 100
YEGAQVSDER LVLPHRFVRE RAFVLVPLAE IAPDLVIGGE TVREALAKLD 150
PSGIERVE 158
Length:158
Mass (Da):17,206
Last modified:September 22, 2009 - v2
Checksum:i0C56DD5EEB13B7CD
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti87 – 871R → P in AAB58893. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U72662 Genomic DNA. Translation: AAB58893.1.
CP001510 Genomic DNA. Translation: ACS39587.1.
RefSeqiYP_002962864.1. NC_012808.1.

Genome annotation databases

EnsemblBacteriaiACS39587; ACS39587; MexAM1_META1p1743.
GeneIDi7991706.
KEGGimea:Mex_1p1743.
PATRICi22509318. VBIMetExt101010_1734.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U72662 Genomic DNA. Translation: AAB58893.1 .
CP001510 Genomic DNA. Translation: ACS39587.1 .
RefSeqi YP_002962864.1. NC_012808.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACS39587 ; ACS39587 ; MexAM1_META1p1743 .
GeneIDi 7991706.
KEGGi mea:Mex_1p1743.
PATRICi 22509318. VBIMetExt101010_1734.

Phylogenomic databases

eggNOGi COG0801.
HOGENOMi HOG000217741.
KOi K00950.
OMAi FDELSKW.
OrthoDBi EOG6XHC8G.

Enzyme and pathway databases

UniPathwayi UPA00077 ; UER00155 .
BioCyci MEXT272630:GBY6-1667-MONOMER.
RETL1328306-WGS:GSTH-2344-MONOMER.

Family and domain databases

Gene3Di 3.30.70.560. 1 hit.
InterProi IPR000550. Hppk.
[Graphical view ]
Pfami PF01288. HPPK. 1 hit.
[Graphical view ]
SUPFAMi SSF55083. SSF55083. 1 hit.
TIGRFAMsi TIGR01498. folK. 1 hit.
PROSITEi PS00794. HPPK. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular and mutational analysis of a DNA region separating two methylotrophy gene clusters in Methylobacterium extorquens AM1."
    Chistoserdova L.V., Lidstrom M.E.
    Microbiology 143:1729-1736(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 14718 / DSM 1338 / AM1.

Entry informationi

Entry nameiHPPK_METEA
AccessioniPrimary (citable) accession number: P71512
Secondary accession number(s): C5B123
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: September 22, 2009
Last modified: July 9, 2014
This is version 75 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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