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P71512

- HPPK_METEA

UniProt

P71512 - HPPK_METEA

Protein

2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase

Gene

folK

Organism
Methylobacterium extorquens (strain ATCC 14718 / DSM 1338 / AM1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 2 (22 Sep 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine = AMP + (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate.

    Pathwayi

    GO - Molecular functioni

    1. 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity Source: UniProtKB-EC
    2. ATP binding Source: UniProtKB-KW
    3. kinase activity Source: UniProtKB-KW

    GO - Biological processi

    1. folic acid biosynthetic process Source: UniProtKB-KW
    2. tetrahydrofolate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Folate biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMEXT272630:GBY6-1667-MONOMER.
    RETL1328306-WGS:GSTH-2344-MONOMER.
    UniPathwayiUPA00077; UER00155.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (EC:2.7.6.3)
    Alternative name(s):
    6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase
    Short name:
    PPPK
    7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase
    Short name:
    HPPK
    Gene namesi
    Name:folK
    Synonyms:folA
    Ordered Locus Names:MexAM1_META1p1743
    OrganismiMethylobacterium extorquens (strain ATCC 14718 / DSM 1338 / AM1)
    Taxonomic identifieri272630 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesMethylobacteriaceaeMethylobacterium
    ProteomesiUP000009081: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 1581582-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinasePRO_0000168253Add
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the HPPK family.Curated

    Phylogenomic databases

    eggNOGiCOG0801.
    HOGENOMiHOG000217741.
    KOiK00950.
    OMAiFDELSKW.
    OrthoDBiEOG6XHC8G.

    Family and domain databases

    Gene3Di3.30.70.560. 1 hit.
    InterProiIPR000550. Hppk.
    [Graphical view]
    PfamiPF01288. HPPK. 1 hit.
    [Graphical view]
    SUPFAMiSSF55083. SSF55083. 1 hit.
    TIGRFAMsiTIGR01498. folK. 1 hit.
    PROSITEiPS00794. HPPK. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P71512-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTRAYLGLGS NIGDKAAMLA GAVEHLAATP GIRVVARSAD YRTPPWGDTD    50
    QDWFLNAAVA IDTELTPHGL LEVCLSIEAA LGRVRERRWG PRVIDIDVLA 100
    YEGAQVSDER LVLPHRFVRE RAFVLVPLAE IAPDLVIGGE TVREALAKLD 150
    PSGIERVE 158
    Length:158
    Mass (Da):17,206
    Last modified:September 22, 2009 - v2
    Checksum:i0C56DD5EEB13B7CD
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti87 – 871R → P in AAB58893. (PubMed:9168622)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U72662 Genomic DNA. Translation: AAB58893.1.
    CP001510 Genomic DNA. Translation: ACS39587.1.
    RefSeqiYP_002962864.1. NC_012808.1.

    Genome annotation databases

    EnsemblBacteriaiACS39587; ACS39587; MexAM1_META1p1743.
    GeneIDi7991706.
    KEGGimea:Mex_1p1743.
    PATRICi22509318. VBIMetExt101010_1734.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U72662 Genomic DNA. Translation: AAB58893.1 .
    CP001510 Genomic DNA. Translation: ACS39587.1 .
    RefSeqi YP_002962864.1. NC_012808.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACS39587 ; ACS39587 ; MexAM1_META1p1743 .
    GeneIDi 7991706.
    KEGGi mea:Mex_1p1743.
    PATRICi 22509318. VBIMetExt101010_1734.

    Phylogenomic databases

    eggNOGi COG0801.
    HOGENOMi HOG000217741.
    KOi K00950.
    OMAi FDELSKW.
    OrthoDBi EOG6XHC8G.

    Enzyme and pathway databases

    UniPathwayi UPA00077 ; UER00155 .
    BioCyci MEXT272630:GBY6-1667-MONOMER.
    RETL1328306-WGS:GSTH-2344-MONOMER.

    Family and domain databases

    Gene3Di 3.30.70.560. 1 hit.
    InterProi IPR000550. Hppk.
    [Graphical view ]
    Pfami PF01288. HPPK. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55083. SSF55083. 1 hit.
    TIGRFAMsi TIGR01498. folK. 1 hit.
    PROSITEi PS00794. HPPK. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular and mutational analysis of a DNA region separating two methylotrophy gene clusters in Methylobacterium extorquens AM1."
      Chistoserdova L.V., Lidstrom M.E.
      Microbiology 143:1729-1736(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 14718 / DSM 1338 / AM1.

    Entry informationi

    Entry nameiHPPK_METEA
    AccessioniPrimary (citable) accession number: P71512
    Secondary accession number(s): C5B123
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: September 22, 2009
    Last modified: October 1, 2014
    This is version 76 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3