P71512 (HPPK_METEA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EC=2.7.6.3

Alternative name(s):
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase
Short name=PPPK
7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase
Short name=HPPK

Gene names

Name:	folK
Synonyms:	folA
Ordered Locus Names:	MexAM1_META1p1743

Organism

Methylobacterium extorquens (strain ATCC 14718 / DSM 1338 / AM1) [Complete proteome] [HAMAP]

Taxonomic identifier

272630 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Methylobacteriaceae › Methylobacterium › Methylobacterium extorquens group › Methylobacterium extorquens

Protein attributes

Sequence length	158 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine = AMP + (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate.
Pathway	Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 4/4.
Sequence similarities	Belongs to the HPPK family.

Ontologies

Keywords
Biological process	Folate biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	folic acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW tetrahydrofolate biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity Inferred from electronic annotation. Source: EC ATP binding Inferred from electronic annotation. Source: UniProtKB-KW kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 158	158	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase		PRO_0000168253
Experimental info
	Sequence conflict	87	1	R → P in AAB58893. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P71512 [UniParc]. Last modified September 22, 2009. Version 2. Checksum: 0C56DD5EEB13B7CD	FASTA	158	17,206
	10 20 30 40 50 60 MTRAYLGLGS NIGDKAAMLA GAVEHLAATP GIRVVARSAD YRTPPWGDTD QDWFLNAAVA 70 80 90 100 110 120 IDTELTPHGL LEVCLSIEAA LGRVRERRWG PRVIDIDVLA YEGAQVSDER LVLPHRFVRE 130 140 150 RAFVLVPLAE IAPDLVIGGE TVREALAKLD PSGIERVE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular and mutational analysis of a DNA region separating two methylotrophy gene clusters in Methylobacterium extorquens AM1." Chistoserdova L.V., Lidstrom M.E. Microbiology 143:1729-1736(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Methylobacterium genome sequences: a reference blueprint to investigate microbial metabolism of C1 compounds from natural and industrial sources." Vuilleumier S., Chistoserdova L., Lee M.-C., Bringel F., Lajus A., Zhou Y., Gourion B., Barbe V., Chang J., Cruveiller S., Dossat C., Gillett W., Gruffaz C., Haugen E., Hourcade E., Levy R., Mangenot S., Muller E. , Nadalig T., Pagni M., Penny C., Peyraud R., Robinson D.G., Roche D., Rouy Z., Saenampechek C., Salvignol G., Vallenet D., Wu Z., Marx C.J., Vorholt J.A., Olson M.V., Kaul R., Weissenbach J., Medigue C., Lidstrom M.E. PLoS ONE 4:E5584-E5584(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 14718 / DSM 1338 / AM1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U72662 Genomic DNA. Translation: AAB58893.1. CP001510 Genomic DNA. Translation: ACS39587.1.
RefSeq	YP_002962864.1. NC_012808.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACS39587; ACS39587; MexAM1_META1p1743.
GeneID	7991706.
KEGG	mea:Mex_1p1743.
PATRIC	22509318. VBIMetExt101010_1734.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0801.
HOGENOM	HOG000217741.
KO	K00950.
OMA	DQDWFLN.
ProtClustDB	CLSK2330855.
Enzyme and pathway databases
UniPathway	UPA00077; UER00155.
Family and domain databases
Gene3D	3.30.70.560. 1 hit.
InterPro	IPR000550. Hppk. [Graphical view]
Pfam	PF01288. HPPK. 1 hit. [Graphical view]
SUPFAM	SSF55083. Hppk. 1 hit.
TIGRFAMs	TIGR01498. folK. 1 hit.
PROSITE	PS00794. HPPK. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HPPK_METEA

Accession

Primary (citable) accession number: P71512
Secondary accession number(s): C5B123

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	September 22, 2009
Last modified:	April 3, 2013
This is version 70 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program