Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase

Gene

folK

Organism
Methylobacterium extorquens (strain ATCC 14718 / DSM 1338 / AM1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine = AMP + (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate.

Pathwayi

GO - Molecular functioni

  1. 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity Source: UniProtKB-EC
  2. ATP binding Source: UniProtKB-KW
  3. kinase activity Source: UniProtKB-KW

GO - Biological processi

  1. folic acid biosynthetic process Source: UniProtKB-KW
  2. tetrahydrofolate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Folate biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMEXT272630:GBY6-1667-MONOMER.
RETL1328306-WGS:GSTH-2344-MONOMER.
UniPathwayiUPA00077; UER00155.

Names & Taxonomyi

Protein namesi
Recommended name:
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (EC:2.7.6.3)
Alternative name(s):
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase
Short name:
PPPK
7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase
Short name:
HPPK
Gene namesi
Name:folK
Synonyms:folA
Ordered Locus Names:MexAM1_META1p1743
OrganismiMethylobacterium extorquens (strain ATCC 14718 / DSM 1338 / AM1)
Taxonomic identifieri272630 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesMethylobacteriaceaeMethylobacterium
ProteomesiUP000009081: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 1581582-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinasePRO_0000168253Add
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the HPPK family.Curated

Phylogenomic databases

eggNOGiCOG0801.
HOGENOMiHOG000217741.
KOiK00950.
OMAiDVLAYEG.
OrthoDBiEOG6XHC8G.

Family and domain databases

Gene3Di3.30.70.560. 1 hit.
InterProiIPR000550. Hppk.
[Graphical view]
PfamiPF01288. HPPK. 1 hit.
[Graphical view]
SUPFAMiSSF55083. SSF55083. 1 hit.
TIGRFAMsiTIGR01498. folK. 1 hit.
PROSITEiPS00794. HPPK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P71512-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTRAYLGLGS NIGDKAAMLA GAVEHLAATP GIRVVARSAD YRTPPWGDTD
60 70 80 90 100
QDWFLNAAVA IDTELTPHGL LEVCLSIEAA LGRVRERRWG PRVIDIDVLA
110 120 130 140 150
YEGAQVSDER LVLPHRFVRE RAFVLVPLAE IAPDLVIGGE TVREALAKLD

PSGIERVE
Length:158
Mass (Da):17,206
Last modified:September 22, 2009 - v2
Checksum:i0C56DD5EEB13B7CD
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti87 – 871R → P in AAB58893. (PubMed:9168622)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U72662 Genomic DNA. Translation: AAB58893.1.
CP001510 Genomic DNA. Translation: ACS39587.1.
RefSeqiYP_002962864.1. NC_012808.1.

Genome annotation databases

EnsemblBacteriaiACS39587; ACS39587; MexAM1_META1p1743.
GeneIDi7991706.
KEGGimea:Mex_1p1743.
PATRICi22509318. VBIMetExt101010_1734.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U72662 Genomic DNA. Translation: AAB58893.1.
CP001510 Genomic DNA. Translation: ACS39587.1.
RefSeqiYP_002962864.1. NC_012808.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACS39587; ACS39587; MexAM1_META1p1743.
GeneIDi7991706.
KEGGimea:Mex_1p1743.
PATRICi22509318. VBIMetExt101010_1734.

Phylogenomic databases

eggNOGiCOG0801.
HOGENOMiHOG000217741.
KOiK00950.
OMAiDVLAYEG.
OrthoDBiEOG6XHC8G.

Enzyme and pathway databases

UniPathwayiUPA00077; UER00155.
BioCyciMEXT272630:GBY6-1667-MONOMER.
RETL1328306-WGS:GSTH-2344-MONOMER.

Family and domain databases

Gene3Di3.30.70.560. 1 hit.
InterProiIPR000550. Hppk.
[Graphical view]
PfamiPF01288. HPPK. 1 hit.
[Graphical view]
SUPFAMiSSF55083. SSF55083. 1 hit.
TIGRFAMsiTIGR01498. folK. 1 hit.
PROSITEiPS00794. HPPK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular and mutational analysis of a DNA region separating two methylotrophy gene clusters in Methylobacterium extorquens AM1."
    Chistoserdova L.V., Lidstrom M.E.
    Microbiology 143:1729-1736(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 14718 / DSM 1338 / AM1.

Entry informationi

Entry nameiHPPK_METEA
AccessioniPrimary (citable) accession number: P71512
Secondary accession number(s): C5B123
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: September 22, 2009
Last modified: January 7, 2015
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.