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P71512 (HPPK_METEA) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase

EC=2.7.6.3
Alternative name(s):
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase
Short name=PPPK
7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase
Short name=HPPK
Gene names
Name:folK
Synonyms:folA
Ordered Locus Names:MexAM1_META1p1743
OrganismMethylobacterium extorquens (strain ATCC 14718 / DSM 1338 / AM1) [Complete proteome] [HAMAP]
Taxonomic identifier272630 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesMethylobacteriaceaeMethylobacterium

Protein attributes

Sequence length158 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine = AMP + (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate.

Pathway

Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 4/4.

Sequence similarities

Belongs to the HPPK family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 1581582-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
PRO_0000168253

Experimental info

Sequence conflict871R → P in AAB58893. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P71512 [UniParc].

Last modified September 22, 2009. Version 2.
Checksum: 0C56DD5EEB13B7CD

FASTA15817,206
        10         20         30         40         50         60 
MTRAYLGLGS NIGDKAAMLA GAVEHLAATP GIRVVARSAD YRTPPWGDTD QDWFLNAAVA 

        70         80         90        100        110        120 
IDTELTPHGL LEVCLSIEAA LGRVRERRWG PRVIDIDVLA YEGAQVSDER LVLPHRFVRE 

       130        140        150 
RAFVLVPLAE IAPDLVIGGE TVREALAKLD PSGIERVE 

« Hide

References

« Hide 'large scale' references
[1]"Molecular and mutational analysis of a DNA region separating two methylotrophy gene clusters in Methylobacterium extorquens AM1."
Chistoserdova L.V., Lidstrom M.E.
Microbiology 143:1729-1736(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Methylobacterium genome sequences: a reference blueprint to investigate microbial metabolism of C1 compounds from natural and industrial sources."
Vuilleumier S., Chistoserdova L., Lee M.-C., Bringel F., Lajus A., Zhou Y., Gourion B., Barbe V., Chang J., Cruveiller S., Dossat C., Gillett W., Gruffaz C., Haugen E., Hourcade E., Levy R., Mangenot S., Muller E. expand/collapse author list , Nadalig T., Pagni M., Penny C., Peyraud R., Robinson D.G., Roche D., Rouy Z., Saenampechek C., Salvignol G., Vallenet D., Wu Z., Marx C.J., Vorholt J.A., Olson M.V., Kaul R., Weissenbach J., Medigue C., Lidstrom M.E.
PLoS ONE 4:E5584-E5584(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 14718 / DSM 1338 / AM1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U72662 Genomic DNA. Translation: AAB58893.1.
CP001510 Genomic DNA. Translation: ACS39587.1.
RefSeqYP_002962864.1. NC_012808.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACS39587; ACS39587; MexAM1_META1p1743.
GeneID7991706.
KEGGmea:Mex_1p1743.
PATRIC22509318. VBIMetExt101010_1734.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0801.
HOGENOMHOG000217741.
KOK00950.
OMAFDELSKW.
OrthoDBEOG6XHC8G.

Enzyme and pathway databases

BioCycMEXT272630:GBY6-1667-MONOMER.
RETL1328306-WGS:GSTH-2344-MONOMER.
UniPathwayUPA00077; UER00155.

Family and domain databases

Gene3D3.30.70.560. 1 hit.
InterProIPR000550. Hppk.
[Graphical view]
PfamPF01288. HPPK. 1 hit.
[Graphical view]
SUPFAMSSF55083. SSF55083. 1 hit.
TIGRFAMsTIGR01498. folK. 1 hit.
PROSITEPS00794. HPPK. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHPPK_METEA
AccessionPrimary (citable) accession number: P71512
Secondary accession number(s): C5B123
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: September 22, 2009
Last modified: July 9, 2014
This is version 75 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways