Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Putative carboxymethylenebutenolidase

Gene

MexAM1_META1p1735

Organism
Methylobacterium extorquens (strain ATCC 14718 / DSM 1338 / JCM 2805 / NCIMB 9133 / AM1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

4-carboxymethylenebut-2-en-4-olide + H2O = 4-oxohex-2-enedioate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei170By similarity1
Active sitei227By similarity1
Active sitei259By similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Protein family/group databases

ESTHERimetex-dlhh. Dienelactone_hydrolase.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative carboxymethylenebutenolidase (EC:3.1.1.45)
Alternative name(s):
Dienelactone hydrolase
Short name:
DLH
Gene namesi
Ordered Locus Names:MexAM1_META1p1735
OrganismiMethylobacterium extorquens (strain ATCC 14718 / DSM 1338 / JCM 2805 / NCIMB 9133 / AM1)
Taxonomic identifieri272630 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesMethylobacteriaceaeMethylobacterium
Proteomesi
  • UP000009081 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 40Sequence analysisAdd BLAST40
ChainiPRO_000000724741 – 291Putative carboxymethylenebutenolidaseAdd BLAST251

Structurei

3D structure databases

ProteinModelPortaliP71505.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the dienelactone hydrolase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105CDZ. Bacteria.
COG0412. LUCA.
HOGENOMiHOG000157123.
KOiK01061.
OMAiCWGGRIS.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR002925. Dienelactn_hydro.
[Graphical view]
PfamiPF01738. DLH. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P71505-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAFDADLRS LAAQTTLSRR TVIATSLATG FALAVQPVAA QTTIATDANG
60 70 80 90 100
LIAGEVKIPM QDGVIPAYRA MPAEGGPFPT ILVVQEIFGV HEHIKDVCRR
110 120 130 140 150
LAKLGYFALA PELYARQGDV STLTNIQQIV SEVVSKVPDA QVMSDLDAAV
160 170 180 190 200
AFAKGTGKAD TARLGITGFC WGGRITWLYA AHNPAVKAGV AWYGRLVGDS
210 220 230 240 250
SALMPKNPVD VAADLKAPVL GLYGGADQGI PVATIDRMKE ACRAAGKTCD
260 270 280 290
FVVYPEAGHA FHADYRPSYR AEPAQDGWKR LQDWFRQYGV A
Length:291
Mass (Da):31,053
Last modified:September 22, 2009 - v2
Checksum:i6A51DF49220B8A98
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti125N → D in AAB58886 (PubMed:9168622).Curated1
Sequence conflicti140A → D in AAB58886 (PubMed:9168622).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U72662 Genomic DNA. Translation: AAB58886.1.
CP001510 Genomic DNA. Translation: ACS39579.1.
RefSeqiWP_003597626.1. NC_012808.1.

Genome annotation databases

EnsemblBacteriaiACS39579; ACS39579; MexAM1_META1p1735.
KEGGimea:Mex_1p1735.
PATRICi22509302. VBIMetExt101010_1726.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U72662 Genomic DNA. Translation: AAB58886.1.
CP001510 Genomic DNA. Translation: ACS39579.1.
RefSeqiWP_003597626.1. NC_012808.1.

3D structure databases

ProteinModelPortaliP71505.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

ESTHERimetex-dlhh. Dienelactone_hydrolase.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACS39579; ACS39579; MexAM1_META1p1735.
KEGGimea:Mex_1p1735.
PATRICi22509302. VBIMetExt101010_1726.

Phylogenomic databases

eggNOGiENOG4105CDZ. Bacteria.
COG0412. LUCA.
HOGENOMiHOG000157123.
KOiK01061.
OMAiCWGGRIS.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR002925. Dienelactn_hydro.
[Graphical view]
PfamiPF01738. DLH. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDLHH_METEA
AccessioniPrimary (citable) accession number: P71505
Secondary accession number(s): C5B115
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: September 22, 2009
Last modified: November 2, 2016
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.