P71486 (EMBB_MYCAV) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable arabinosyltransferase B
EC=2.4.2.-

Gene names

Name:

embB

Organism

Mycobacterium avium

Taxonomic identifier

1764 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium avium complex (MAC)

Protein attributes

Sequence length	1065 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Arabinosyl transferase responsible for the polymerization of arabinose into the arabinan of arabinogalactan.
Subcellular location	Cell membrane; Multi-pass membrane protein Probable.
Sequence similarities	Belongs to the emb family.

Ontologies

Keywords
Biological process	Antibiotic resistance Cell wall biogenesis/degradation
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Glycosyltransferase Transferase
Gene Ontology (GO)
Biological process	cellular cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan biosynthetic process Inferred from electronic annotation. Source: InterPro response to antibiotic Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	transferase activity, transferring pentosyl groups Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1065	1065	Probable arabinosyltransferase B		PRO_0000220565
Regions
	Transmembrane	15 – 37	23	Helical; Potential
	Transmembrane	204 – 226	23	Helical; Potential
	Transmembrane	241 – 263	23	Helical; Potential
	Transmembrane	394 – 413	20	Helical; Potential
	Transmembrane	417 – 436	20	Helical; Potential
	Transmembrane	441 – 463	23	Helical; Potential
	Transmembrane	510 – 527	18	Helical; Potential
	Transmembrane	540 – 557	18	Helical; Potential
	Transmembrane	567 – 589	23	Helical; Potential
	Transmembrane	596 – 618	23	Helical; Potential
	Transmembrane	633 – 655	23	Helical; Potential
	Transmembrane	667 – 689	23	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	P71486 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: 3F12D113678C62BF	FASTA	1,065	114,625
	10 20 30 40 50 60 MSVSTVGGDV RVTRWVATIA GLIGFVLSVA TPLLPVVQTT ATLNWPQGGQ LNSVTAPLIS 70 80 90 100 110 120 LTPVDLTATV PCSLVRDLPP GGGVILSTGP KKGKDAALNA LFVVAHGKRV DVTDRNVVIA 130 140 150 160 170 180 SASRDQVAGA GCSRIEIAST RAGTFATFVG LTDPAGKPLG GGFPDPNLRP QIVGVFTDLT 190 200 210 220 230 240 GPAPAGLKLS ATIDTRFSTT PTTLKLAAMV TAILATIVAL VALWRLDQLD GHRMRRLIPA 250 260 270 280 290 300 NWRTFTLADV AVIFGFVLWH VIGANSSDDG YILGMARVAD RAGYMSNYFR WFGSPEDPFG 310 320 330 340 350 360 WYYNLLALMT HVSDASLWMR LPDLFAGIVC WLLLSREVLP RLGPAVAASR PANWAAGMVL 370 380 390 400 410 420 LTAWMPFDNG LRPEPIIALG SLVTYVLIER SMRYSRLTPA ALAVITAAFT LGVQPTGLIA 430 440 450 460 470 480 VAALVAGGRP ILRILVRRHR VVGTWPLVAP MLAAGTVILT VVFADQTLAT VLEATRIRTA 490 500 510 520 530 540 IGPSQAWYTE NLRYYYLILP TVDGSLSRRF GFLITALCLF TAVFIMLRRK RIPGVARGPA 550 560 570 580 590 600 WRLMGVIFGT MFFLMFTPTK WVHHFGLFAA VGAAMAALTT VLVSPAVLGW SRNRMAFLAA 610 620 630 640 650 660 LLFMMALCFA TTNGWWYVSS YGVPFNSTMP KIGGITVSTV FFSMFVAAAL YAIWLHFASR 670 680 690 700 710 720 EHGEGRLARA LTAAPVPLAA GFMALVFIAS MVAGIVRQYP TYSNAWDNLR EFSGGCGLAD 730 740 750 760 770 780 DVLVEPDSNV GYMTPLGGDY GPLGPLGGQH PVGFSPNGVP EHTVAEAIRI TPNQPGTDYD 790 800 810 820 830 840 WDAPTKLSAP GINGSTVPLP YGLDAARVPL AGSYTTGAQQ QSRLTSAWYR LPAPDDGHPL 850 860 870 880 890 900 VVVTAAGKIA GNSVLHHHTD GQTVVLEYGR PGPGGDIVPA GRLVPYDLYG EQPKAWRNLR 910 920 930 940 950 960 FARSDMPADT VAVRVVAEDL SLTPEDWIAV TPPRVPEMRS LQEYVGSTQP VLMDWAVGLA 970 980 990 1000 1010 1020 FPCQQPMLHV NGVTEIPKFR ITPDYTAKKM DTDTWEDGTN GGLLGITDLL LRAHVMSTYL 1030 1040 1050 1060 SHDWGRDWGS LRRFETIADA HPAQLDLGTA TRTGWWSPGP IRIKP

References

[1]

"The embAB genes of Mycobacterium avium encode an arabinosyl transferase involved in cell wall arabinan biosynthesis that is the target for the antimycobacterial drug ethambutol." Belanger A.E., Besra G.S., Ford M.E., Mikusova K., Belisle J.T., Brennan P.J., Inamine J.M. Proc. Natl. Acad. Sci. U.S.A. 93:11919-11924(1996) [PubMed: 8876238] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 2151.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U66560 Genomic DNA. Translation: AAC44548.1.
3D structure databases
ProteinModelPortal	P71486.
ModBase	Search...
Protein family/group databases
CAZy	GT53. Glycosyltransferase Family 53.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR007680. Mycobac_arabinan_synth. [Graphical view]
Pfam	PF04602. Arabinose_trans. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

EMBB_MYCAV

Accession

Primary (citable) accession number: P71486

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2002
Last sequence update:	February 1, 1997
Last modified:	September 21, 2011
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program