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Protein

Serine acetyltransferase

Gene

cysE

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Acetyl-CoA + L-serine = CoA + O-acetyl-L-serine.

Pathwayi

GO - Molecular functioni

  1. serine O-acetyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. cysteine biosynthetic process from serine Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Cysteine biosynthesis

Enzyme and pathway databases

BioCyciHPY:HP1210-MONOMER.
UniPathwayiUPA00136; UER00199.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine acetyltransferase (EC:2.3.1.30)
Short name:
SAT
Gene namesi
Name:cysE
Ordered Locus Names:HP_1210
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 171171Serine acetyltransferasePRO_0000068675Add
BLAST

Proteomic databases

PRIDEiP71405.

Interactioni

Protein-protein interaction databases

STRINGi85962.HP1210.

Structurei

3D structure databases

ProteinModelPortaliP71405.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG1045.
KOiK00640.
OMAiFVPYGTP.
OrthoDBiEOG6HMXK6.

Family and domain databases

InterProiIPR001451. Hexapep_transf.
IPR018357. Hexapep_transf_CS.
IPR005881. Ser_O-AcTrfase.
IPR011004. Trimer_LpxA-like.
[Graphical view]
PfamiPF00132. Hexapep. 2 hits.
[Graphical view]
PIRSFiPIRSF000441. CysE. 1 hit.
SUPFAMiSSF51161. SSF51161. 1 hit.
TIGRFAMsiTIGR01172. cysE. 1 hit.
PROSITEiPS00101. HEXAPEP_TRANSFERASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P71405-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLDLSYSLER VLQEDPAARN KWEVLLLYPG IHALLCYRLA HALHKRRFYF
60 70 80 90 100
IARALSQLAR FITGIEIHPG AKIGRGLFID HGMGVVIGET TEIGDDVTIY
110 120 130 140 150
HGVTLGGTGK FKGKRHPTLG NRVVVGAGAK VLGAICVGDD VKIGANAVVL
160 170
SDLPTGSTAV GSKAKTITKD R
Length:171
Mass (Da):18,342
Last modified:November 1, 1997 - v2
Checksum:i28646D539C2250C3
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti5 – 51S → F in strain: 60190.
Natural varianti110 – 1101K → R in strain: 60190.
Natural varianti162 – 1621S → T in strain: 60190.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43917 Genomic DNA. Translation: AAB07027.1.
AE000511 Genomic DNA. Translation: AAD08254.1.
PIRiB64671.
RefSeqiNP_208002.1. NC_000915.1.
YP_006935131.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD08254; AAD08254; HP_1210.
GeneIDi13870416.
898797.
KEGGiheo:C694_06265.
hpy:HP1210.
PATRICi20593791. VBIHelPyl33062_1268.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43917 Genomic DNA. Translation: AAB07027.1.
AE000511 Genomic DNA. Translation: AAD08254.1.
PIRiB64671.
RefSeqiNP_208002.1. NC_000915.1.
YP_006935131.1. NC_018939.1.

3D structure databases

ProteinModelPortaliP71405.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi85962.HP1210.

Proteomic databases

PRIDEiP71405.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD08254; AAD08254; HP_1210.
GeneIDi13870416.
898797.
KEGGiheo:C694_06265.
hpy:HP1210.
PATRICi20593791. VBIHelPyl33062_1268.

Phylogenomic databases

eggNOGiCOG1045.
KOiK00640.
OMAiFVPYGTP.
OrthoDBiEOG6HMXK6.

Enzyme and pathway databases

UniPathwayiUPA00136; UER00199.
BioCyciHPY:HP1210-MONOMER.

Family and domain databases

InterProiIPR001451. Hexapep_transf.
IPR018357. Hexapep_transf_CS.
IPR005881. Ser_O-AcTrfase.
IPR011004. Trimer_LpxA-like.
[Graphical view]
PfamiPF00132. Hexapep. 2 hits.
[Graphical view]
PIRSFiPIRSF000441. CysE. 1 hit.
SUPFAMiSSF51161. SSF51161. 1 hit.
TIGRFAMsiTIGR01172. cysE. 1 hit.
PROSITEiPS00101. HEXAPEP_TRANSFERASES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Expression of a novel ulcer-associated gene, iceA, by H. pylori following contact with gastric epithelium."
    Peek R.M. Jr., Thompson S.A., Atherton J.C., Blaser M.J., Miller G.G.
    Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 49503 / 60190.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiCYSE_HELPY
AccessioniPrimary (citable) accession number: P71405
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: January 7, 2015
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.