P71405 (CYSE_HELPY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Serine acetyltransferase
Short name=SAT
EC=2.3.1.30

Gene names

Name:	cysE
Ordered Locus Names:	HP_1210

Organism

Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) [Reference proteome] [HAMAP]

Taxonomic identifier

85962 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › delta/epsilon subdivisions › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter › Helicobacter pylori

Protein attributes

Sequence length	171 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Acetyl-CoA + L-serine = CoA + O-acetyl-L-serine.
Pathway	Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-serine: step 1/2.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the transferase hexapeptide repeat family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Cysteine biosynthesis
Cellular component	Cytoplasm
Domain	Repeat
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cysteine biosynthetic process from serine Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	serine O-acetyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 171	171	Serine acetyltransferase		PRO_0000068675
Natural variations
	Natural variant	5	1	S → F in strain: 60190.
	Natural variant	110	1	K → R in strain: 60190.
	Natural variant	162	1	S → T in strain: 60190.

Sequences

	Sequence		Length	Mass (Da)
	P71405 [UniParc]. Last modified November 1, 1997. Version 2. Checksum: 28646D539C2250C3	FASTA	171	18,342
	10 20 30 40 50 60 MLDLSYSLER VLQEDPAARN KWEVLLLYPG IHALLCYRLA HALHKRRFYF IARALSQLAR 70 80 90 100 110 120 FITGIEIHPG AKIGRGLFID HGMGVVIGET TEIGDDVTIY HGVTLGGTGK FKGKRHPTLG 130 140 150 160 170 NRVVVGAGAK VLGAICVGDD VKIGANAVVL SDLPTGSTAV GSKAKTITKD R

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Expression of a novel ulcer-associated gene, iceA, by H. pylori following contact with gastric epithelium." Peek R.M. Jr., Thompson S.A., Atherton J.C., Blaser M.J., Miller G.G. Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 49503 / 60190.
[2]	"The complete genome sequence of the gastric pathogen Helicobacter pylori." Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G., Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A., Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N., Loftus B.J., Richardson D.L., Dodson R.J. , Khalak H.G., Glodek A., McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E., Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D., Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S., Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C. Nature 388:539-547(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700392 / 26695.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U43917 Genomic DNA. Translation: AAB07027.1. AE000511 Genomic DNA. Translation: AAD08254.1.
PIR	B64671.
RefSeq	NP_208002.1. NC_000915.1. YP_006935131.1. NC_018939.1.
3D structure databases
ProteinModelPortal	P71405.
ModBase	Search...
Protein-protein interaction databases
STRING	85962.HP1210.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAD08254; AAD08254; HP_1210.
GeneID	13870416. 898797.
KEGG	heo:C694_06265. hpy:HP1210.
PATRIC	20593791. VBIHelPyl33062_1268.
Phylogenomic databases
eggNOG	COG1045.
KO	K00640.
OMA	NTPGIHA.
ProtClustDB	CLSK496411.
Enzyme and pathway databases
UniPathway	UPA00136; UER00199.
Family and domain databases
InterPro	IPR001451. Hexapep_transf. IPR018357. Hexapep_transf_CS. IPR005881. Ser_O-AcTrfase. IPR011004. Trimer_LpxA-like. [Graphical view]
Pfam	PF00132. Hexapep. 2 hits. [Graphical view]
PIRSF	PIRSF000441. CysE. 1 hit.
SUPFAM	SSF51161. Trimer_LpxA_like. 1 hit.
TIGRFAMs	TIGR01172. cysE. 1 hit.
PROSITE	PS00101. HEXAPEP_TRANSFERASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CYSE_HELPY

Accession

Primary (citable) accession number: P71405

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	May 1, 2013
This is version 83 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program