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P71405 (CYSE_HELPY) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine acetyltransferase

Short name=SAT
EC=2.3.1.30
Gene names
Name:cysE
Ordered Locus Names:HP_1210
OrganismHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) [Reference proteome] [HAMAP]
Taxonomic identifier85962 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Protein attributes

Sequence length171 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Acetyl-CoA + L-serine = CoA + O-acetyl-L-serine.

Pathway

Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-serine: step 1/2.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the transferase hexapeptide repeat family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Cysteine biosynthesis
   Cellular componentCytoplasm
   DomainRepeat
   Molecular functionAcyltransferase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcysteine biosynthetic process from serine

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionserine O-acetyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 171171Serine acetyltransferase
PRO_0000068675

Natural variations

Natural variant51S → F in strain: 60190.
Natural variant1101K → R in strain: 60190.
Natural variant1621S → T in strain: 60190.

Sequences

Sequence LengthMass (Da)Tools
P71405 [UniParc].

Last modified November 1, 1997. Version 2.
Checksum: 28646D539C2250C3

FASTA17118,342
        10         20         30         40         50         60 
MLDLSYSLER VLQEDPAARN KWEVLLLYPG IHALLCYRLA HALHKRRFYF IARALSQLAR 

        70         80         90        100        110        120 
FITGIEIHPG AKIGRGLFID HGMGVVIGET TEIGDDVTIY HGVTLGGTGK FKGKRHPTLG 

       130        140        150        160        170 
NRVVVGAGAK VLGAICVGDD VKIGANAVVL SDLPTGSTAV GSKAKTITKD R 

« Hide

References

« Hide 'large scale' references
[1]"Expression of a novel ulcer-associated gene, iceA, by H. pylori following contact with gastric epithelium."
Peek R.M. Jr., Thompson S.A., Atherton J.C., Blaser M.J., Miller G.G.
Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 49503 / 60190.
[2]"The complete genome sequence of the gastric pathogen Helicobacter pylori."
Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G., Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A., Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N., Loftus B.J., Richardson D.L., Dodson R.J. expand/collapse author list , Khalak H.G., Glodek A., McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E., Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D., Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S., Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C.
Nature 388:539-547(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700392 / 26695.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U43917 Genomic DNA. Translation: AAB07027.1.
AE000511 Genomic DNA. Translation: AAD08254.1.
PIRB64671.
RefSeqNP_208002.1. NC_000915.1.
YP_006935131.1. NC_018939.1.

3D structure databases

ProteinModelPortalP71405.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING85962.HP1210.

Proteomic databases

PRIDEP71405.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAD08254; AAD08254; HP_1210.
GeneID898797.
KEGGheo:C694_06265.
hpy:HP1210.
PATRIC20593791. VBIHelPyl33062_1268.

Phylogenomic databases

eggNOGCOG1045.
KOK00640.
OMADVILYHG.
OrthoDBEOG6HMXK6.

Enzyme and pathway databases

BioCycHPY:HP1210-MONOMER.
UniPathwayUPA00136; UER00199.

Family and domain databases

InterProIPR001451. Hexapep_transf.
IPR018357. Hexapep_transf_CS.
IPR005881. Ser_O-AcTrfase.
IPR011004. Trimer_LpxA-like.
[Graphical view]
PfamPF00132. Hexapep. 2 hits.
[Graphical view]
PIRSFPIRSF000441. CysE. 1 hit.
SUPFAMSSF51161. SSF51161. 1 hit.
TIGRFAMsTIGR01172. cysE. 1 hit.
PROSITEPS00101. HEXAPEP_TRANSFERASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCYSE_HELPY
AccessionPrimary (citable) accession number: P71405
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: July 9, 2014
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Helicobacter pylori

Helicobacter pylori (strain 26695): entries and gene names