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Protein

Serine acetyltransferase

Gene

cysE

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Acetyl-CoA + L-serine = CoA + O-acetyl-L-serine.

Pathwayi: L-cysteine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-cysteine from L-serine.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Serine acetyltransferase (cysE)
  2. Cysteine synthase (cysM)
This subpathway is part of the pathway L-cysteine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-cysteine from L-serine, the pathway L-cysteine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processAmino-acid biosynthesis, Cysteine biosynthesis

Enzyme and pathway databases

BioCyciHPY:HP1210-MONOMER.
UniPathwayiUPA00136; UER00199.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine acetyltransferase (EC:2.3.1.30)
Short name:
SAT
Gene namesi
Name:cysE
Ordered Locus Names:HP_1210
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000429 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000686751 – 171Serine acetyltransferaseAdd BLAST171

Proteomic databases

PaxDbiP71405.

Interactioni

Protein-protein interaction databases

STRINGi85962.HP1210.

Structurei

3D structure databases

ProteinModelPortaliP71405.
SMRiP71405.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4105D7W. Bacteria.
COG1045. LUCA.
KOiK00640.
OMAiGDDVMLY.

Family and domain databases

InterProiView protein in InterPro
IPR001451. Hexapep.
IPR018357. Hexapep_transf_CS.
IPR005881. Ser_O-AcTrfase.
IPR011004. Trimer_LpxA-like.
PfamiView protein in Pfam
PF00132. Hexapep. 2 hits.
PIRSFiPIRSF000441. CysE. 1 hit.
SUPFAMiSSF51161. SSF51161. 1 hit.
TIGRFAMsiTIGR01172. cysE. 1 hit.
PROSITEiView protein in PROSITE
PS00101. HEXAPEP_TRANSFERASES. 1 hit.

Sequencei

Sequence statusi: Complete.

P71405-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLDLSYSLER VLQEDPAARN KWEVLLLYPG IHALLCYRLA HALHKRRFYF
60 70 80 90 100
IARALSQLAR FITGIEIHPG AKIGRGLFID HGMGVVIGET TEIGDDVTIY
110 120 130 140 150
HGVTLGGTGK FKGKRHPTLG NRVVVGAGAK VLGAICVGDD VKIGANAVVL
160 170
SDLPTGSTAV GSKAKTITKD R
Length:171
Mass (Da):18,342
Last modified:November 1, 1997 - v2
Checksum:i28646D539C2250C3
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti5S → F in strain: 60190. 1
Natural varianti110K → R in strain: 60190. 1
Natural varianti162S → T in strain: 60190. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43917 Genomic DNA. Translation: AAB07027.1.
AE000511 Genomic DNA. Translation: AAD08254.1.
PIRiB64671.
RefSeqiNP_208002.1. NC_000915.1.
WP_000886346.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD08254; AAD08254; HP_1210.
GeneIDi898797.
KEGGiheo:C694_06265.
hpy:HP1210.
PATRICifig|85962.47.peg.1301.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiCYSE_HELPY
AccessioniPrimary (citable) accession number: P71405
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: June 7, 2017
This is version 102 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families